LOCUS       NM_003190               3450 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens TAP binding protein (TAPBP), transcript variant 1,
            mRNA.
ACCESSION   NM_003190
VERSION     NM_003190.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3450)
  AUTHORS   Hu,J., Wang,S., Zhang,X., Yan,W., Liu,H., Chen,X., Nie,Y., Liu,F.,
            Zheng,Y., Lu,Y. and Jin,H.
  TITLE     A genetic variant in the TAPBP gene enhances cervical cancer
            susceptibility by increasing m6A modification
  JOURNAL   Arch Toxicol 98 (10), 3425-3438 (2024)
   PUBMED   38992170
  REMARK    GeneRIF: A genetic variant in the TAPBP gene enhances cervical
            cancer susceptibility by increasing m[6]A modification.
REFERENCE   2  (bases 1 to 3450)
  AUTHORS   Wang,Y. and Seliger,B.
  TITLE     Identification of RNA-binding protein hnRNP C targeting the 3'UTR
            of the TAP-associated glycoprotein tapasin in melanoma
  JOURNAL   Oncoimmunology 13 (1), 2370928 (2024)
   PUBMED   38948930
  REMARK    GeneRIF: Identification of RNA-binding protein hnRNP C targeting
            the 3'UTR of the TAP-associated glycoprotein tapasin in melanoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3450)
  AUTHORS   Chen,J., Shen,L., Guo,Q., Ma,S., Zhang,Y., Chen,J., Qu,L., Ng,S.S.
            and Chen,X.
  TITLE     The downregulation of Tapasin in dendritic cell regulates CD8+ T
            cell autophagy to hamper hepatitis B viral clearance in the induced
            pluripotent stem cell-derived hepatocyte organoid
  JOURNAL   J Med Virol 96 (3), e29546 (2024)
   PUBMED   38516804
  REMARK    GeneRIF: The downregulation of Tapasin in dendritic cell regulates
            CD8[+] T cell autophagy to hamper hepatitis B viral clearance in
            the induced pluripotent stem cell-derived hepatocyte organoid.
REFERENCE   4  (bases 1 to 3450)
  AUTHORS   Muller,I.K., Winter,C., Thomas,C., Spaapen,R.M., Trowitzsch,S. and
            Tampe,R.
  TITLE     Structure of an MHC I-tapasin-ERp57 editing complex defines
            chaperone promiscuity
  JOURNAL   Nat Commun 13 (1), 5383 (2022)
   PUBMED   36104323
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3450)
  AUTHORS   Lindquist,J.A., Jensen,O.N., Mann,M. and Hammerling,G.J.
  TITLE     ER-60, a chaperone with thiol-dependent reductase activity involved
            in MHC class I assembly
  JOURNAL   EMBO J 17 (8), 2186-2195 (1998)
   PUBMED   9545232
REFERENCE   6  (bases 1 to 3450)
  AUTHORS   Herberg,J.A., Sgouros,J., Jones,T., Copeman,J., Humphray,S.J.,
            Sheer,D., Cresswell,P., Beck,S. and Trowsdale,J.
  TITLE     Genomic analysis of the Tapasin gene, located close to the TAP loci
            in the MHC
  JOURNAL   Eur J Immunol 28 (2), 459-467 (1998)
   PUBMED   9521053
REFERENCE   7  (bases 1 to 3450)
  AUTHORS   Ortmann,B., Copeman,J., Lehner,P.J., Sadasivan,B., Herberg,J.A.,
            Grandea,A.G., Riddell,S.R., Tampe,R., Spies,T., Trowsdale,J. and
            Cresswell,P.
  TITLE     A critical role for tapasin in the assembly and function of
            multimeric MHC class I-TAP complexes
  JOURNAL   Science 277 (5330), 1306-1309 (1997)
   PUBMED   9271576
REFERENCE   8  (bases 1 to 3450)
  AUTHORS   Li,S., Sjogren,H.O., Hellman,U., Pettersson,R.F. and Wang,P.
  TITLE     Cloning and functional characterization of a subunit of the
            transporter associated with antigen processing
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8708-8713 (1997)
   PUBMED   9238042
REFERENCE   9  (bases 1 to 3450)
  AUTHORS   Sadasivan,B., Lehner,P.J., Ortmann,B., Spies,T. and Cresswell,P.
  TITLE     Roles for calreticulin and a novel glycoprotein, tapasin, in the
            interaction of MHC class I molecules with TAP
  JOURNAL   Immunity 5 (2), 103-114 (1996)
   PUBMED   8769474
REFERENCE   10 (bases 1 to 3450)
  AUTHORS   Lewis,J.W., Neisig,A., Neefjes,J. and Elliott,T.
  TITLE     Point mutations in the alpha 2 domain of HLA-A2.1 define a
            functionally relevant interaction with TAP
  JOURNAL   Curr Biol 6 (7), 873-883 (1996)
   PUBMED   8805302
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF029750.1, AB010639.1 and
            AL662820.6.
            
            On Oct 15, 2019 this sequence version replaced NM_003190.4.
            
            Summary: This gene encodes a transmembrane glycoprotein which
            mediates interaction between newly assembled major
            histocompatibility complex (MHC) class I molecules and the
            transporter associated with antigen processing (TAP), which is
            required for the transport of antigenic peptides across the
            endoplasmic reticulum membrane. This interaction is essential for
            optimal peptide loading on the MHC class I molecule. Up to four
            complexes of MHC class I and this protein may be bound to a single
            TAP molecule. This protein contains a C-terminal double-lysine
            motif (KKKAE) known to maintain membrane proteins in the
            endoplasmic reticulum. This gene lies within the major
            histocompatibility complex on chromosome 6. Alternative splicing
            results in three transcript variants encoding different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF029750.1, SRR14038194.3668324.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434618.7/ ENSP00000395701.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-815               AF029750.1         2-816
            816-1419            AB010639.1         792-1395
            1420-3034           AL662820.6         29114-30728         c
            3035-3450           AF029750.1         3040-3455
FEATURES             Location/Qualifiers
     source          1..3450
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..3450
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /note="TAP binding protein"
                     /db_xref="GeneID:6892"
                     /db_xref="HGNC:HGNC:11566"
                     /db_xref="MIM:601962"
     exon            1..74
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1384
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; TAP-associated protein; NGS-17; TAP binding
                     protein (tapasin)"
                     /codon_start=1
                     /product="tapasin isoform 1 precursor"
                     /protein_id="NP_003181.3"
                     /db_xref="CCDS:CCDS34426.1"
                     /db_xref="GeneID:6892"
                     /db_xref="HGNC:HGNC:11566"
                     /db_xref="MIM:601962"
                     /translation="MKSLSLLLAVALGLATAVSAGPAVIECWFVEDASGKGLAKRPGA
                     LLLRQGPGEPPPRPDLDPELYLSVHDPAGALQAAFRRYPRGAPAPHCEMSRFVPLPAS
                     AKWASGLTPAQNCPRALDGAWLMVSISSPVLSLSSLLRPQPEPQQEPVLITMATVVLT
                     VLTHTPAPRVRLGQDALLDLSFAYMPPTSEAASSLAPGPPPFGLEWRRQHLGKGHLLL
                     AATPGLNGQMPAAQEGAVAFAAWDDDEPWGPWTGNGTFWLPTVQPFQEGTYLATIHLP
                     YLQGQVTLELAVYKPPKVSLMPATLARAAPGEAPPELLCLVSHFYPSGGLEVEWELRG
                     GPGGRSQKAEGQRWLSALRHHSDGSVSLSGHLQPPPVTTEQHGARYACRIHHPSLPAS
                     GRSAEVTLEVAGLSGPSLEDSVGLFLSAFLLLGLFKALGWAAVYLSTCKDSKKKAE"
     exon            75..245
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /inference="alignment:Splign:2.1.0"
     exon            246..506
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /inference="alignment:Splign:2.1.0"
     exon            507..905
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1247
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1337
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1372
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..3450
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3423..3428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /note="hexamer: AATAAA"
     polyA_site      3450
                     /gene="TAPBP"
                     /gene_synonym="MHC1D3; NGS17; TAPA; TPN; TPSN"
                     /note="major polyA site"
ORIGIN      
        1 gaagaggagg cttcatggct gaggaggtcg cagcgccatg aagtccctgt ctctgctcct
       61 cgctgtggct ttgggcctgg cgaccgccgt ctcagcagga cccgcggtga tcgagtgttg
      121 gttcgtggag gatgcgagcg gaaagggcct ggccaagaga cccggtgcac tgctgttgcg
      181 ccagggaccg ggggaaccgc cgccccggcc ggacctcgac cctgagctct atctcagtgt
      241 acacgacccc gcgggcgccc tccaggctgc cttcaggcgg tatccccggg gcgcccccgc
      301 accacactgc gagatgagcc gcttcgtgcc tctccccgcc tctgcgaaat gggccagcgg
      361 cctgaccccc gcgcagaact gcccgcgggc cctggatggg gcttggctga tggtcagcat
      421 atccagccca gtcctcagcc tctccagcct cttgcgacca cagccagagc ctcagcagga
      481 gcctgttctc atcaccatgg caacagtggt actgactgtc ctcacccaca cccctgcccc
      541 tcgagtgaga ctgggacaag atgctctgct ggacttgagc tttgcctaca tgccccccac
      601 ctccgaggcc gcctcatctc tggctccggg tccccctccc tttgggctag agtggcgacg
      661 ccagcacctg ggtaagggac atctgctcct ggctgcaact cctgggctga atggccagat
      721 gccagcagcc caagaagggg ccgtggcatt tgctgcttgg gatgatgatg agccatgggg
      781 cccatggacc ggaaatggga ccttctggct gcctacagtt caaccctttc aggagggcac
      841 ctatctggcc accatacacc tgccatacct gcaaggacag gtcaccctgg agcttgctgt
      901 gtacaaaccc cccaaagtgt ccctgatgcc agcaaccctt gcacgggccg ccccagggga
      961 ggcacccccg gaattgctct gccttgtgtc ccacttctac ccttctgggg gcctggaggt
     1021 ggagtgggaa ctccggggtg gcccaggggg ccgctctcag aaggccgagg ggcagaggtg
     1081 gctctcggcc ctgcgccacc attccgatgg ctctgtcagc ctctctgggc acttgcagcc
     1141 gcccccagtc accactgagc agcatggggc acgctatgcc tgtcgaattc accatcccag
     1201 cctgcctgcc tcggggcgca gcgctgaggt caccctggag gtagcaggtc tttcagggcc
     1261 ctcccttgag gacagcgtag gccttttcct gtctgccttt cttctgcttg ggctcttcaa
     1321 ggcactgggc tgggctgctg tctacctgtc cacctgcaag gattcaaaga agaaagcaga
     1381 gtgagggcac tcactgccat cctgtggaag ccaccatcat ctctggccca agcttctgta
     1441 gtagctccct aaaataatac cctatcatct gctcctaatc cctccaatct ctctccactg
     1501 agtggctgga atgctttttt ttttttcttt cacttatata agggataatt tttctttttt
     1561 tttttttttt gagacggagt ctcactcttc cgcccaggct gcagtgcagt ggcatgatct
     1621 tggcttactg caacctccgc ctcctgggtt caagcaattc tgtggcttca gcctccggag
     1681 tagctgggat tacaggcaca tgccaccaca cccagtgaat ttttgtattt ttagtagaga
     1741 cggggtttca ccatgttggc caggctggtc ttgaattcct gacctcaggt gatctgccca
     1801 cctcagcctc ccaaagtgct gggattacag gcgtgagcca ccacaccagg cccgagaaat
     1861 gcttttttaa aaaacacaca tcttatggca ttcaccttct tggagctcta ggacagtggt
     1921 tctcaaaatt tttttctctc aggacctctt aaaaatcatc aaggacccca aaaagctttt
     1981 gggtatgtgg gttatagcta tcaatattta tggtactaga acttaaaagt gagaaaaatt
     2041 taaaacacga gaatacatag gcacacattc tattcatcgt gggaaccatg gtgtcaatac
     2101 atatcatgta gcttctgaaa aactccactg tacacttata gaatgaagaa ggcaaaaaac
     2161 tttttttttt ttttttttga gacggagtct cgctctgtcg cccaggctgg agtgcagtgg
     2221 cgcgatctcg gctcactgca agctccgcct ctcgggttca cgccattctc ctgcctcagc
     2281 ctcccaagta gctcggacta caggcgtcct ccaccatgcc tggctaatat tttgtatttt
     2341 ttagtagaga cggggtttca ccgtgttagc caggatggtc tcgatctcct aacctggtga
     2401 tccgcccgcc tcggcctccc aaagtattgg gattacccgc gtgagccacc gcgcccggct
     2461 gcaaataatc tttctttttt tctgagacag agtctcgctc tgttgcccag gctggagtgc
     2521 agtggcacga tctcggctca cggcacgctc cgcctcccgg gttcacgcca ttctcctgcc
     2581 tcagcttccc gagtagctgg gactacaggg gcccgccacc acgcccggct aactttttgt
     2641 gtttttagta gagacggggt ttcaccgtgt tagccaggat ggtctcgatc tcctgacctt
     2701 gtgatctgcc cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc caccgcgccc
     2761 ggcggcgaaa cacgatattg tactaacatc ttaattttgt tataaaatct cacaaacccc
     2821 ctgacatagt ctcagagatc tgtagggccg aggttacatt tggagaaccc gtactctagg
     2881 gccaaatcca ttcttcttgc cctggctcac ttgtcccccc caccgccccg cgctggagcc
     2941 actgcctagt tcttcagccc tagatggtgc tcgccagacc tcctctcaat gctcatcaca
     3001 cacagggcta ttcctttcct ccaatgaacc aaacgcctcc cgcccacctc caggtcccag
     3061 tcctctgttc cctttgcctg gtccaccctt gccctccctg ggtcgcagac gaggtcggcc
     3121 tcgtcattcc ccgcagaccg ccgcgcgtcc ctcttgtgcg gttcaccaca gttgtattta
     3181 agtgatcgtg tgagtcgtcg ttaaatgcct gtctccccgc ggatcatggg ctcctcgagg
     3241 acagggactg gcctgtctgt ccactgctgt aaccccgcgc cggcataggg acctaaggcc
     3301 cactggaggg cgctcatcaa gtagctgctg gatgttgacg aaggaagcgg cggcgcagct
     3361 cagggatctc cgagtcagga cggtcggcca gacccacggg gtaacgggtc taatcgtgta
     3421 ggaataaagc tgtattccag tgcttccaaa
//
