LOCUS       NM_001290043            5643 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens transporter 2, ATP binding cassette subfamily B member
            (TAP2), transcript variant 1, A allele, mRNA.
ACCESSION   NM_001290043
VERSION     NM_001290043.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5643)
  AUTHORS   Kim,K., Oh,S.J., Lee,J., Kwon,A., Yu,C.Y., Kim,S., Choi,C.H.,
            Kang,S.B., Kim,T.O., Park,D.I. and Lee,C.K.
  TITLE     Regulatory Variants on the Leukocyte Immunoglobulin-Like Receptor
            Gene Cluster are Associated with Crohn's Disease and Interact with
            Regulatory Variants for TAP2
  JOURNAL   J Crohns Colitis 18 (1), 47-53 (2024)
   PUBMED   37523193
  REMARK    GeneRIF: Regulatory Variants on the Leukocyte Immunoglobulin-Like
            Receptor Gene Cluster are Associated with Crohn's Disease and
            Interact with Regulatory Variants for TAP2.
REFERENCE   2  (bases 1 to 5643)
  AUTHORS   Darazam,I.A., Hakamifard,A., Momenilandi,M., Materna,M.,
            Gharehbagh,F.J., Shahrooei,M., Olyaei,N.A., Zerehpoosh,F.B.,
            Fayand,A., Hatami,F., Lotfollahi,L., Mansouri,N., Casanova,J.L.,
            Beziat,V. and Mansouri,D.
  TITLE     Delayed Diagnosis of Chronic Necrotizing Granulomatous Skin Lesions
            due to TAP2 Deficiency
  JOURNAL   J Clin Immunol 43 (1), 217-228 (2023)
   PUBMED   36227411
  REMARK    GeneRIF: Delayed Diagnosis of Chronic Necrotizing Granulomatous
            Skin Lesions due to TAP2 Deficiency.
REFERENCE   3  (bases 1 to 5643)
  AUTHORS   Tao,Y., Han,X., Liu,N., Shi,L., Shi,L., Liu,S. and Yao,Y.
  TITLE     Association study of TAP and HLA-I gene combination with chronic
            hepatitis C virus infection in a Han population in China
  JOURNAL   Int J Immunogenet 49 (3), 169-180 (2022)
   PUBMED   35485366
  REMARK    GeneRIF: Association study of TAP and HLA-I gene combination with
            chronic hepatitis C virus infection in a Han population in China.
REFERENCE   4  (bases 1 to 5643)
  AUTHORS   Mantel,I., Sadiq,B.A. and Blander,J.M.
  TITLE     Spotlight on TAP and its vital role in antigen presentation and
            cross-presentation
  JOURNAL   Mol Immunol 142, 105-119 (2022)
   PUBMED   34973498
  REMARK    GeneRIF: Spotlight on TAP and its vital role in antigen
            presentation and cross-presentation.
            Review article
REFERENCE   5  (bases 1 to 5643)
  AUTHORS   Liu,W., Ma,Q., Li,C., Li,Y., Liu,S., Shi,L. and Yao,Y.
  TITLE     The association of TAP polymorphisms with non-small-cell lung
            cancer in the Han Chinese population
  JOURNAL   Hum Immunol 82 (12), 917-922 (2021)
   PUBMED   34373132
  REMARK    GeneRIF: The association of TAP polymorphisms with non-small-cell
            lung cancer in the Han Chinese population.
REFERENCE   6  (bases 1 to 5643)
  AUTHORS   Beck,S., Kelly,A., Radley,E., Khurshid,F., Alderton,R.P. and
            Trowsdale,J.
  TITLE     DNA sequence analysis of 66 kb of the human MHC class II region
            encoding a cluster of genes for antigen processing
  JOURNAL   J Mol Biol 228 (2), 433-441 (1992)
   PUBMED   1453454
REFERENCE   7  (bases 1 to 5643)
  AUTHORS   Colonna,M., Bresnahan,M., Bahram,S., Strominger,J.L. and Spies,T.
  TITLE     Allelic variants of the human putative peptide transporter involved
            in antigen processing
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 3932-3936 (1992)
   PUBMED   1570316
REFERENCE   8  (bases 1 to 5643)
  AUTHORS   Bodmer,J.G., Marsh,S.G., Albert,E.D., Bodmer,W.F., Dupont,B.,
            Erlich,H.A., Mach,B., Mayr,W.R., Parham,P., Sasazuki,T. et al.
  TITLE     Nomenclature for factors of the HLA system, 1991. WHO Nomenclature
            Committee for factors of the HLA system
  JOURNAL   Tissue Antigens 39 (4), 161-173 (1992)
   PUBMED   1529427
  REMARK    Erratum:[Tissue Antigens. 1992 Nov;40(5):229-43. doi:
            10.1111/j.1399-0039.1992.tb02050.x.. PMID: 1362295]
REFERENCE   9  (bases 1 to 5643)
  AUTHORS   Powis,S.H., Mockridge,I., Kelly,A., Kerr,L.A., Glynne,R.,
            Gileadi,U., Beck,S. and Trowsdale,J.
  TITLE     Polymorphism in a second ABC transporter gene located within the
            class II region of the human major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1463-1467 (1992)
   PUBMED   1741401
REFERENCE   10 (bases 1 to 5643)
  AUTHORS   Kelly,A., Powis,S.H., Kerr,L.A., Mockridge,I., Elliott,T.,
            Bastin,J., Uchanska-Ziegler,B., Ziegler,A., Trowsdale,J. and
            Townsend,A.
  TITLE     Assembly and function of the two ABC transporter proteins encoded
            in the human major histocompatibility complex
  JOURNAL   Nature 355 (6361), 641-644 (1992)
   PUBMED   1538751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC345324.1, AK292963.1 and
            AL669918.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 30, 2019 this sequence version replaced NM_001290043.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MDR/TAP subfamily. Members
            of the MDR/TAP subfamily are involved in multidrug resistance. This
            gene is located 7 kb telomeric to gene family member ABCB2. The
            protein encoded by this gene is involved in antigen presentation.
            This protein forms a heterodimer with ABCB2 in order to transport
            peptides from the cytoplasm to the endoplasmic reticulum. Mutations
            in this gene may be associated with ankylosing spondylitis,
            insulin-dependent diabetes mellitus, and celiac disease.
            Alternative splicing of this gene produces products which differ in
            peptide selectivity and level of restoration of surface expression
            of MHC class I molecules. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1, A allele) differs at 3 nt
            positions compared to variant 1, B allele. The resulting isoform
            (3) is shorter at the C-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1745725.1,
                                           SRR14372079.2900335.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374897.4/ ENSP00000364032.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                DC345324.1         85-140
            57-2355             AK292963.1         71-2369
            2356-5643           AL669918.5         27840-31127         c
FEATURES             Location/Qualifiers
     source          1..5643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..5643
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /note="transporter 2, ATP binding cassette subfamily B
                     member"
                     /db_xref="GeneID:6891"
                     /db_xref="HGNC:HGNC:44"
                     /db_xref="MIM:170261"
     exon            1..87
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     exon            88..584
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2152
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /EC_number="7.4.2.14"
                     /note="isoform 3 is encoded by transcript variant 1, A
                     allele; antigen peptide transporter 2; peptide supply
                     factor 2; peptide transporter PSF2; ABC transporter, MHC
                     2; ATP-binding cassette, sub-family B (MDR/TAP), member 3;
                     transporter 2, ABC (ATP binding cassette); really
                     interesting new gene 11 protein; peptide transporter
                     involved in antigen processing 2; transporter 2,
                     ATP-binding cassette, sub-family B (MDR/TAP)"
                     /codon_start=1
                     /product="antigen peptide transporter 2 isoform 3"
                     /protein_id="NP_001276972.1"
                     /db_xref="CCDS:CCDS78129.1"
                     /db_xref="GeneID:6891"
                     /db_xref="HGNC:HGNC:44"
                     /db_xref="MIM:170261"
                     /translation="MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTL
                     RLGGLWGLLKLRGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWL
                     LVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLV
                     LAVLGETLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTM
                     SRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLV
                     KVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVRE
                     AVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLML
                     SCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQ
                     PNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSG
                     KSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAY
                     GLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRD
                     PRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQK
                     LAQL"
     exon            585..699
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     exon            700..830
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1036
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1234
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1363
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1552
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1726
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1886
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2023
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..5643
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2456..2461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /note="hexamer: AATACA"
     polyA_site      2475
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /note="major polyA site"
     regulatory      2525..2530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /note="hexamer: TATAAA"
     polyA_site      2548
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
     regulatory      5614..5619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
                     /note="hexamer: ATTAAA"
     polyA_site      5643
                     /gene="TAP2"
                     /gene_synonym="ABC18; ABCB3; APT2; D6S217E; MHC1D2; PSF-2;
                     PSF2; RING11"
ORIGIN      
        1 agagccggta gcgaggttgg gagagacgga gcggacctca gcgctgaagc agaagtcccc
       61 ggagctgcgg tctccccgcc gcggctgagc catgcggctc cctgacctga gaccctggac
      121 ctccctgctg ctggtggacg cggctttact gtggctgctt cagggccctc tggggacttt
      181 gcttcctcaa gggctgccag gactatggct ggaggggacc ctgcggctgg gagggctgtg
      241 ggggctgcta aagctaagag ggctgctggg atttgtgggg acactgctgc tcccgctctg
      301 tctggccacc cccctgactg tctccctgag agccctggtc gcgggggcct cacgtgctcc
      361 cccagccaga gtcgcttcag ccccttggag ctggctgctg gtggggtacg gggctgcggg
      421 gctcagctgg tcactgtggg ctgttctgag ccctcctgga gcccaggaga aggagcagga
      481 ccaggtgaac aacaaagtct tgatgtggag gctgctgaag ctctccaggc cggacctgcc
      541 tctcctcgtt gccgccttct tcttccttgt ccttgctgtt ttgggtgaga cattaatccc
      601 tcactattct ggtcgtgtga ttgacatcct gggaggtgat tttgaccccc atgcctttgc
      661 cagtgccatc ttcttcatgt gcctcttctc ctttggcagc tcactgtctg caggctgccg
      721 aggaggctgc ttcacctaca ccatgtctcg aatcaacttg cggatccggg agcagctttt
      781 ctcctccctg ctgcgccagg acctcggttt cttccaggag actaagacag gggagctgaa
      841 ctcacggctg agctcggata ccaccctgat gagtaactgg cttcctttaa atgccaatgt
      901 gctcttgcga agcctggtga aagtggtggg gctgtatggc ttcatgctca gcatatcgcc
      961 tcgactcacc ctcctttctc tgctgcacat gcccttcaca atagcagcgg agaaggtgta
     1021 caacacccgc catcaggaag tgcttcggga gatccaggat gcagtggcca gggcggggca
     1081 ggtggtgcgg gaagccgttg gagggctgca gaccgttcgc agttttgggg ccgaggagca
     1141 tgaagtctgt cgctataaag aggcccttga acaatgtcgg cagctgtatt ggcggagaga
     1201 cctggaacgc gccttgtacc tgctcgtaag gagggtgctg cacttggggg tgcagatgct
     1261 gatgctgagc tgtgggctgc agcagatgca ggatggggag ctcacccagg gcagcctgct
     1321 ttcctttatg atctaccagg agagcgtggg gagctatgtg cagaccctgg tatacatata
     1381 tggggatatg ctcagcaacg tgggagctgc agagaaggtt ttctcctaca tggaccgaca
     1441 gccaaatctg ccttcacctg gcacgcttgc ccccaccact ctgcaggggg ttgtgaaatt
     1501 ccaagacgtc tcctttgcat atcccaatcg ccctgacagg cctgtgctca aggggctgac
     1561 gtttacccta cgtcctggtg aggtgacggc gctggtggga cccaatgggt ctgggaagag
     1621 cacagtggct gccctgctgc agaatctgta ccagcccaca gggggacagg tgctgctgga
     1681 tgaaaagccc atctcacagt atgaacactg ctacctgcac agccaggtgg tttcagttgg
     1741 gcaggagcct gtgctgttct ccggttctgt gaggaacaac attgcttatg ggctgcagag
     1801 ctgcgaagat gataaggtga tggcggctgc ccaggctgcc cacgcagatg acttcatcca
     1861 ggaaatggag catggaatat acacagatgt aggggagaag ggaagccagc tggctgcggg
     1921 acagaaacaa cgtctggcca ttgcccgggc ccttgtacga gacccgcggg tcctcatcct
     1981 ggatgaggct actagtgccc tagatgtgca gtgcgagcag gccctgcagg actggaattc
     2041 ccgtggggat cgcacagtgc tggtgattgc tcacaggctg cagacagttc agcgcgccca
     2101 ccagatcctg gtgctccagg agggcaagct gcagaagctt gcccagctct aggagggaca
     2161 ggacctctat tcccgcctgg tgcagcagcg gctgatggac tgaggcccca gggatactgg
     2221 gccctcttct caggggcgtc tccaggaccc agagctgttc ctgctttgag tttccctaga
     2281 gctgtgcggc cagatagctg ttcctgagtt gcaggcacga tggagatttg gacactgtgt
     2341 gcttttggtg gggtagagag gtggggtggg gtggggtggg ggctgtctgt gtccaggaaa
     2401 cttaattccc tggtgactag agctttgcct ggtgatgagg agtattttgt ggcataatac
     2461 atatatttta aaatattttc cttcttacat gaactgtata cattcatata gaaaatttag
     2521 acaatataaa aaagtacaaa gaagaaaagt aaaagtaccc attgtttcac ttcctggaga
     2581 taaccatagt tgctattttg ctgcctgtcc catcagtcgt ttatctgttg tttgagatag
     2641 aaattaacca aaaatgacat aaatattcat gagattgcct tcctatatcc ttccttgttc
     2701 ctaccagtgt ctgctatttt gaagaagcta gggtctggag ggacagagaa cagttccctg
     2761 attaacagta ttaatagcga cattggtaac agctaccatt tatagagttt taatgggagt
     2821 aggagctatg ctaagtgttt ttcatgtatt atcgttttta atcattatcc ccaaccctat
     2881 gaggttggtt attatcccca ttttacagat gaggaaactg aagctcaaag aggctcaatg
     2941 actttcccaa ggtggtcgta gtggtggagt tggagtttga acacaggcct gaccctagag
     3001 tccacaccct gacccaatca attatattgc atcttgggtc cataaaccct aatccataat
     3061 cccatcaaga aaagctctgc tgctcttagc tctaaataat tcagaatcta ttctcttctc
     3121 tccagtcccg ttgttatagt cttcactcat agacttaaga tgatcccatc accagagagg
     3181 tttctctacc attagcttcc ctcttccggc cattcttcac aaagtcattt ttctaaattc
     3241 tgtgtcacat acgatgatgg catttctgga aattccttca ggtgctctca agccctgctg
     3301 cagagatcct tttcagagca cacactgttc cagcccatct gtctcaccct ctcctgttgt
     3361 atccagctcc acgacaaact tctgccttcc ccaacacctt tgtgcctttg catatggtgt
     3421 tttcttgccc attttctgct cgactcgccc ctgattttca agttcaagac ttaactcagg
     3481 gttcaggtct tccaggaggc cttacttatg tcgtcagtct ggggaactct ccatgtgctt
     3541 ctatcactgt gcggttacct ctttcacagc ccttttaaag ttctatcttc cctttcccac
     3601 cttttttgac cttccactag accatgagca cctgggcgga aagccatata tcttattaag
     3661 ctttatatct gctacctggc cgagggccta attcatagtg gagaataaat agtcaattga
     3721 ataaatgaat aaatatctcc accatcgtac taatcttaat cctccctgcc cactcccacc
     3781 actgaaaatg caacattgta cacatcactg gttgttggga gggacttacc ttggaaagtt
     3841 gctattctag gaaagagaaa ccttcatatt cctggaaaca gcaggtagtt tccagtgctg
     3901 gcaatgaatt ccccagaact gctgttttgg attttttctt gcctggcagc tgttgggagc
     3961 agggtgcagt gaggatgggg tgagagtggg cagtttcttg tgcagatttg cctttctttc
     4021 atcctggggc tgacttgcag ctccacaccc atccatctct caaatttcac agagggtaaa
     4081 ataggcattt ggagagaaag aactctggcc tgattccttt ctctcccaca aatgtccttt
     4141 attcataaaa caggaataat aattcctgta tctcccaact acatggaagc tgcagccctc
     4201 acagaagaag atgatctgag aaattctttg atttcctcag tacagttata cccatgcatc
     4261 ataatacttt aagcctggaa ggcatcttaa aaataatgca acagtcaaac ctaattttac
     4321 agagaaactg acatgaaatc acgcagctaa tcatgataaa gctgggtgga aaacttatct
     4381 tgatgggcag tacaggaaga tgcagtagac cttaagatgt cctgaaagtt tcttatctca
     4441 ggggaaactc ccaggtaggc tttatgtcag ggacacagaa aaatgctccc tgaaagtcaa
     4501 aatattcggg ctagacagac aaattcctgt aagtgtggtt tgtctgggaa ccacagatgt
     4561 cactaatcct ggtttgctcc agagttcttt ttgttcactc ctacccccca tcaccatttg
     4621 attgatctcc ttaccctgta atttcccctt cttgtcgctt acctgcagta tctttcccac
     4681 ccaggcatgc cttattcttt ctaaaggaaa gtatgaatgg agaggggaaa gcttgggaaa
     4741 ctgatagatt tccttggatg ccaaaacacc tccatagcct gtctgcccgg ccctatgtgg
     4801 aaacagcatt gagtttcaag tcctttatgc ctccacccag ggatagccac ttgtaatcca
     4861 catggcaatt gtgaaacaag caggaaatgc gtaattgtca gaattttgtg gggaaaggac
     4921 tagggaataa ggaaaacaaa gatcttcctt gtgttttaga gctgtcagct agaggagcac
     4981 ctgcttgagt ctgatgccat ctaatggtcc cagaagaaac tgggttttga acctagagtt
     5041 ccatggactc ttaggaatta gactactact actactaagc attcactggt gcttactatg
     5101 tgctattgct gtgccaagta tctgaaacct gtcttcttac cttatttttc aagataattc
     5161 tatgtggcag gtattactat ctcaattcta agagtgagaa aatggagttt tagaaacatt
     5221 tactaacttg cctgggtcac atagctaagg aagaggtgga cttgcccagc tttgcataaa
     5281 actcctcaaa agagttgcct atactccctg actccactta tcttcctact atcctctttt
     5341 taaaatatat tatttattta tttaaataag caatatatga atgtggtttg aaattcaaaa
     5401 gacacaaaga agtatacaga ggaaagcctc actctcaatc cttctcaagg tttgctaatt
     5461 cctcttgcat aggcaatccg ttcttccagc tttgtgttta tctttccaga gaagtttact
     5521 gtgtattaag caaatatgta tatctttatt cttgctcagt attttcgcaa acagcagctg
     5581 tctaagttca ctgttctgaa ctttattttt taaattaaaa atatatggct atgtagtatt
     5641 cta
//
