LOCUS       NM_001292022            2186 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens transporter 1, ATP binding cassette subfamily B member
            (TAP1), transcript variant 2, mRNA.
ACCESSION   NM_001292022
VERSION     NM_001292022.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2186)
  AUTHORS   Zhu,R., Chen,Y.T., Wang,B.W., You,Y.Y., Wang,X.H., Xie,H.T.,
            Jiang,F.G. and Zhang,M.C.
  TITLE     TAP1, a potential immune-related prognosis biomarker with
            functional significance in uveal melanoma
  JOURNAL   BMC Cancer 23 (1), 146 (2023)
   PUBMED   36774490
  REMARK    GeneRIF: TAP1, a potential immune-related prognosis biomarker with
            functional significance in uveal melanoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2186)
  AUTHORS   Tu,Z., Li,K., Ji,Q., Huang,Y., Lv,S., Li,J., Wu,L., Huang,K. and
            Zhu,X.
  TITLE     Pan-cancer analysis: predictive role of TAP1 in cancer prognosis
            and response to immunotherapy
  JOURNAL   BMC Cancer 23 (1), 133 (2023)
   PUBMED   36759763
  REMARK    GeneRIF: Pan-cancer analysis: predictive role of TAP1 in cancer
            prognosis and response to immunotherapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2186)
  AUTHORS   Li,B., Feng,Y., Hou,Q., Fu,Y. and Luo,Y.
  TITLE     Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK
            Inhibitors in Pancreatic Cancers
  JOURNAL   Int J Mol Sci 23 (13), 7168 (2022)
   PUBMED   35806187
  REMARK    GeneRIF: Antigen Peptide Transporter 1 (TAP1) Promotes Resistance
            to MEK Inhibitors in Pancreatic Cancers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2186)
  AUTHORS   Tao,Y., Han,X., Liu,N., Shi,L., Shi,L., Liu,S. and Yao,Y.
  TITLE     Association study of TAP and HLA-I gene combination with chronic
            hepatitis C virus infection in a Han population in China
  JOURNAL   Int J Immunogenet 49 (3), 169-180 (2022)
   PUBMED   35485366
  REMARK    GeneRIF: Association study of TAP and HLA-I gene combination with
            chronic hepatitis C virus infection in a Han population in China.
REFERENCE   5  (bases 1 to 2186)
  AUTHORS   Mantel,I., Sadiq,B.A. and Blander,J.M.
  TITLE     Spotlight on TAP and its vital role in antigen presentation and
            cross-presentation
  JOURNAL   Mol Immunol 142, 105-119 (2022)
   PUBMED   34973498
  REMARK    GeneRIF: Spotlight on TAP and its vital role in antigen
            presentation and cross-presentation.
            Review article
REFERENCE   6  (bases 1 to 2186)
  AUTHORS   Beck,S., Kelly,A., Radley,E., Khurshid,F., Alderton,R.P. and
            Trowsdale,J.
  TITLE     DNA sequence analysis of 66 kb of the human MHC class II region
            encoding a cluster of genes for antigen processing
  JOURNAL   J Mol Biol 228 (2), 433-441 (1992)
   PUBMED   1453454
REFERENCE   7  (bases 1 to 2186)
  AUTHORS   Colonna,M., Bresnahan,M., Bahram,S., Strominger,J.L. and Spies,T.
  TITLE     Allelic variants of the human putative peptide transporter involved
            in antigen processing
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 3932-3936 (1992)
   PUBMED   1570316
REFERENCE   8  (bases 1 to 2186)
  AUTHORS   Bodmer,J.G., Marsh,S.G., Albert,E.D., Bodmer,W.F., Dupont,B.,
            Erlich,H.A., Mach,B., Mayr,W.R., Parham,P., Sasazuki,T. et al.
  TITLE     Nomenclature for factors of the HLA system, 1991. WHO Nomenclature
            Committee for factors of the HLA system
  JOURNAL   Tissue Antigens 39 (4), 161-173 (1992)
   PUBMED   1529427
  REMARK    Erratum:[Tissue Antigens. 1992 Nov;40(5):229-43. doi:
            10.1111/j.1399-0039.1992.tb02050.x.. PMID: 1362295]
REFERENCE   9  (bases 1 to 2186)
  AUTHORS   Kelly,A., Powis,S.H., Kerr,L.A., Mockridge,I., Elliott,T.,
            Bastin,J., Uchanska-Ziegler,B., Ziegler,A., Trowsdale,J. and
            Townsend,A.
  TITLE     Assembly and function of the two ABC transporter proteins encoded
            in the human major histocompatibility complex
  JOURNAL   Nature 355 (6361), 641-644 (1992)
   PUBMED   1538751
REFERENCE   10 (bases 1 to 2186)
  AUTHORS   Bahram,S., Arnold,D., Bresnahan,M., Strominger,J.L. and Spies,T.
  TITLE     Two putative subunits of a peptide pump encoded in the human major
            histocompatibility complex class II region
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10094-10098 (1991)
   PUBMED   1946428
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC354917.1, AK302340.1 and
            BC014081.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001292022.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MDR/TAP subfamily. Members
            of the MDR/TAP subfamily are involved in multidrug resistance. The
            protein encoded by this gene is involved in the pumping of degraded
            cytosolic peptides across the endoplasmic reticulum into the
            membrane-bound compartment where class I molecules assemble.
            Mutations in this gene may be associated with ankylosing
            spondylitis, insulin-dependent diabetes mellitus, and celiac
            disease. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302340.1, SRR14038193.1834091.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DC354917.1         27-29
            4-917               AK302340.1         1-914
            918-2186            BC014081.2         1684-2952
FEATURES             Location/Qualifiers
     source          1..2186
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..2186
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /note="transporter 1, ATP binding cassette subfamily B
                     member"
                     /db_xref="GeneID:6890"
                     /db_xref="HGNC:HGNC:43"
                     /db_xref="MIM:170260"
     exon            1..167
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            168..282
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1816
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /EC_number="7.4.2.14"
                     /note="isoform 2 is encoded by transcript variant 2;
                     antigen peptide transporter 1; transporter, ATP-binding
                     cassette, major histocompatibility complex, 1; ABC
                     transporter, MHC 1; peptide supply factor 1; ATP-binding
                     cassette, sub-family B (MDR/TAP), member 2; transporter 1,
                     ATP-binding cassette, sub-family B (MDR/TAP); transporter
                     associated with antigen processing; peptide transporter
                     PSF1; peptide transporter TAP1; really interesting new
                     gene 4 protein; ATP-binding cassette sub-family B member
                     2; peptide transporter involved in antigen processing 1;
                     transporter 1 ATP-binding cassette sub-family B"
                     /codon_start=1
                     /product="antigen peptide transporter 1 isoform 2"
                     /protein_id="NP_001278951.1"
                     /db_xref="GeneID:6890"
                     /db_xref="HGNC:HGNC:43"
                     /db_xref="MIM:170260"
                     /translation="MAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVG
                     DGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENL
                     SLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLA
                     KSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISG
                     MLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK
                     IFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTA
                     LVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGR
                     SLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAV
                     ALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQA
                     DHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPADAPE"
     exon            283..413
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            414..619
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            620..817
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            818..946
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1135
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1309
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1472
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1609
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..2186
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2167..2172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /note="hexamer: AATAAA"
     polyA_site      2186
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /note="major polyA site"
ORIGIN      
        1 ctcatctcta acaggaggct tttctacttc atgatctcca gccttcctaa taaaatcctg
       61 aaagttctgg tagagcaacc acagggtagt gagttccagg gcagcctatt taggttcggg
      121 attgagacgt cagtgtttcc tttctgctga tgccctccag gataatgggg agatggccat
      181 tccattcttt acgggccgcc tcactgactg gattctacaa gatggctcag ccgatacctt
      241 cactcgaaac ttaactctca tgtccattct caccatagcc agtgcagtgc tggagttcgt
      301 gggtgacggg atctataaca acaccatggg ccacgtgcac agccacttgc agggagaggt
      361 gtttggggct gtcctgcgcc aggagacgga gtttttccaa cagaaccaga caggtaacat
      421 catgtctcgg gtaacagagg acacgtccac cctgagtgat tctctgagtg agaatctgag
      481 cttatttctg tggtacctgg tgcgaggcct atgtctcttg gggatcatgc tctggggatc
      541 agtgtccctc accatggtca ccctgatcac cctgcctctg cttttccttc tgcccaagaa
      601 ggtgggaaaa tggtaccagt tgctggaagt gcaggtgcgg gaatctctgg caaagtccag
      661 ccaggtggcc attgaggctc tgtcggccat gcctacagtt cgaagctttg ccaacgagga
      721 gggcgaagcc cagaagttta gggaaaagct gcaagaaata aagacactca accagaagga
      781 ggctgtggcc tatgcagtca actcctggac cactagtatt tcaggtatgc tgctgaaagt
      841 gggaatcctc tacattggtg ggcagctggt gaccagtggg gctgtaagca gtgggaacct
      901 tgtcacattt gttctctacc agatgcagtt cacccaggct gtggaggtac tgctctccat
      961 ctaccccaga gtacagaagg ctgtgggctc ctcagagaaa atatttgagt acctggaccg
     1021 cacccctcgc tgcccaccca gtggtctgtt gactccctta cacttggagg gccttgtcca
     1081 gttccaagat gtctcctttg cctacccaaa ccgcccagat gtcttagtgc tacaggggct
     1141 gacattcacc ctacgccctg gcgaggtgac ggcgctggtg ggacccaatg ggtctgggaa
     1201 gagcacagtg gctgccctgc tgcagaatct gtaccagccc accgggggac agctgctgtt
     1261 ggatgggaag ccccttcccc aatatgagca ccgctacctg cacaggcagg tggctgcagt
     1321 gggacaagag ccacaggtat ttggaagaag tcttcaagaa aatattgcct atggcctgac
     1381 ccagaagcca actatggagg aaatcacagc tgctgcagta aagtctgggg cccatagttt
     1441 catctctgga ctccctcagg gctatgacac agaggtagac gaggctggga gccagctgtc
     1501 agggggtcag cgacaggcag tggcgttggc ccgagcattg atccggaaac cgtgtgtact
     1561 tatcctggat gatgccacca gtgccctgga tgcaaacagc cagttacagg tggagcagct
     1621 cctgtacgaa agccctgagc ggtactcccg ctcagtgctt ctcatcaccc agcacctcag
     1681 cctggtggag caggctgacc acatcctctt tctggaagga ggcgctatcc gggagggggg
     1741 aacccaccag cagctcatgg agaaaaaggg gtgctactgg gccatggtgc aggctcctgc
     1801 agatgctcca gaatgaaagc cttctcagac ctgcgcactc catctccctc ccttttcttc
     1861 tctctgtggt ggagaaccac agctgcagag taggcagctg cctccaggat gagttacttg
     1921 aaatttgcct tgagtgtgtt acctcctttc caagctcctc gtgataatgc agacttcctg
     1981 gagtacaaac acaggatttg taattcctta ctgtaacgga gtttagagcc agggctgatg
     2041 ctttggtgtg gccagcactc tgaaactgag aaatgttcag aatgtacgga aagatgatca
     2101 gctattttca acataactga aggcatatgc tggcccataa acaccctgta ggttcttgat
     2161 atttataata aaattggtgt tttgta
//
