LOCUS       NM_000593               2685 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens transporter 1, ATP binding cassette subfamily B member
            (TAP1), transcript variant 1, mRNA.
ACCESSION   NM_000593
VERSION     NM_000593.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2685)
  AUTHORS   Zhu,R., Chen,Y.T., Wang,B.W., You,Y.Y., Wang,X.H., Xie,H.T.,
            Jiang,F.G. and Zhang,M.C.
  TITLE     TAP1, a potential immune-related prognosis biomarker with
            functional significance in uveal melanoma
  JOURNAL   BMC Cancer 23 (1), 146 (2023)
   PUBMED   36774490
  REMARK    GeneRIF: TAP1, a potential immune-related prognosis biomarker with
            functional significance in uveal melanoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2685)
  AUTHORS   Tu,Z., Li,K., Ji,Q., Huang,Y., Lv,S., Li,J., Wu,L., Huang,K. and
            Zhu,X.
  TITLE     Pan-cancer analysis: predictive role of TAP1 in cancer prognosis
            and response to immunotherapy
  JOURNAL   BMC Cancer 23 (1), 133 (2023)
   PUBMED   36759763
  REMARK    GeneRIF: Pan-cancer analysis: predictive role of TAP1 in cancer
            prognosis and response to immunotherapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2685)
  AUTHORS   Li,B., Feng,Y., Hou,Q., Fu,Y. and Luo,Y.
  TITLE     Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK
            Inhibitors in Pancreatic Cancers
  JOURNAL   Int J Mol Sci 23 (13), 7168 (2022)
   PUBMED   35806187
  REMARK    GeneRIF: Antigen Peptide Transporter 1 (TAP1) Promotes Resistance
            to MEK Inhibitors in Pancreatic Cancers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2685)
  AUTHORS   Tao,Y., Han,X., Liu,N., Shi,L., Shi,L., Liu,S. and Yao,Y.
  TITLE     Association study of TAP and HLA-I gene combination with chronic
            hepatitis C virus infection in a Han population in China
  JOURNAL   Int J Immunogenet 49 (3), 169-180 (2022)
   PUBMED   35485366
  REMARK    GeneRIF: Association study of TAP and HLA-I gene combination with
            chronic hepatitis C virus infection in a Han population in China.
REFERENCE   5  (bases 1 to 2685)
  AUTHORS   Mantel,I., Sadiq,B.A. and Blander,J.M.
  TITLE     Spotlight on TAP and its vital role in antigen presentation and
            cross-presentation
  JOURNAL   Mol Immunol 142, 105-119 (2022)
   PUBMED   34973498
  REMARK    GeneRIF: Spotlight on TAP and its vital role in antigen
            presentation and cross-presentation.
            Review article
REFERENCE   6  (bases 1 to 2685)
  AUTHORS   Beck,S., Kelly,A., Radley,E., Khurshid,F., Alderton,R.P. and
            Trowsdale,J.
  TITLE     DNA sequence analysis of 66 kb of the human MHC class II region
            encoding a cluster of genes for antigen processing
  JOURNAL   J Mol Biol 228 (2), 433-441 (1992)
   PUBMED   1453454
REFERENCE   7  (bases 1 to 2685)
  AUTHORS   Colonna,M., Bresnahan,M., Bahram,S., Strominger,J.L. and Spies,T.
  TITLE     Allelic variants of the human putative peptide transporter involved
            in antigen processing
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 3932-3936 (1992)
   PUBMED   1570316
REFERENCE   8  (bases 1 to 2685)
  AUTHORS   Bodmer,J.G., Marsh,S.G., Albert,E.D., Bodmer,W.F., Dupont,B.,
            Erlich,H.A., Mach,B., Mayr,W.R., Parham,P., Sasazuki,T. et al.
  TITLE     Nomenclature for factors of the HLA system, 1991. WHO Nomenclature
            Committee for factors of the HLA system
  JOURNAL   Tissue Antigens 39 (4), 161-173 (1992)
   PUBMED   1529427
  REMARK    Erratum:[Tissue Antigens. 1992 Nov;40(5):229-43. doi:
            10.1111/j.1399-0039.1992.tb02050.x.. PMID: 1362295]
REFERENCE   9  (bases 1 to 2685)
  AUTHORS   Kelly,A., Powis,S.H., Kerr,L.A., Mockridge,I., Elliott,T.,
            Bastin,J., Uchanska-Ziegler,B., Ziegler,A., Trowsdale,J. and
            Townsend,A.
  TITLE     Assembly and function of the two ABC transporter proteins encoded
            in the human major histocompatibility complex
  JOURNAL   Nature 355 (6361), 641-644 (1992)
   PUBMED   1538751
REFERENCE   10 (bases 1 to 2685)
  AUTHORS   Bahram,S., Arnold,D., Bresnahan,M., Strominger,J.L. and Spies,T.
  TITLE     Two putative subunits of a peptide pump encoded in the human major
            histocompatibility complex class II region
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10094-10098 (1991)
   PUBMED   1946428
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from KU178346.1 and AL669918.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 25, 2020 this sequence version replaced NM_000593.5.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MDR/TAP subfamily. Members
            of the MDR/TAP subfamily are involved in multidrug resistance. The
            protein encoded by this gene is involved in the pumping of degraded
            cytosolic peptides across the endoplasmic reticulum into the
            membrane-bound compartment where class I molecules assemble.
            Mutations in this gene may be associated with ankylosing
            spondylitis, insulin-dependent diabetes mellitus, and celiac
            disease. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014081.2, BX648013.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354258.5/ ENSP00000346206.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2312              KU178346.1         113-2424
            2313-2685           AL669918.5         47634-48006         c
FEATURES             Location/Qualifiers
     source          1..2685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..2685
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /note="transporter 1, ATP binding cassette subfamily B
                     member"
                     /db_xref="GeneID:6890"
                     /db_xref="HGNC:HGNC:43"
                     /db_xref="MIM:170260"
     exon            1..666
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2315
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /EC_number="7.4.2.14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     antigen peptide transporter 1; transporter, ATP-binding
                     cassette, major histocompatibility complex, 1; ABC
                     transporter, MHC 1; peptide supply factor 1; ATP-binding
                     cassette, sub-family B (MDR/TAP), member 2; transporter 1,
                     ATP-binding cassette, sub-family B (MDR/TAP); transporter
                     associated with antigen processing; peptide transporter
                     PSF1; peptide transporter TAP1; really interesting new
                     gene 4 protein; ATP-binding cassette sub-family B member
                     2; peptide transporter involved in antigen processing 1;
                     transporter 1 ATP-binding cassette sub-family B"
                     /codon_start=1
                     /product="antigen peptide transporter 1 isoform 1"
                     /protein_id="NP_000584.3"
                     /db_xref="CCDS:CCDS4758.2"
                     /db_xref="GeneID:6890"
                     /db_xref="HGNC:HGNC:43"
                     /db_xref="MIM:170260"
                     /translation="MASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIF
                     SLLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAA
                     LGLALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSL
                     WVPGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQD
                     GSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFF
                     QQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLIT
                     LPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFRE
                     KLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLY
                     QMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDV
                     SFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDG
                     KPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSF
                     ISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVE
                     QLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMV
                     QAPADAPE"
     exon            667..781
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            782..912
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1118
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1316
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1445
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1634
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1808
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1971
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2108
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2685
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2666..2671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /note="hexamer: AATAAA"
     polyA_site      2685
                     /gene="TAP1"
                     /gene_synonym="ABC17; ABCB2; APT1; D6S114E; MHC1D1; PSF-1;
                     PSF1; RING4; TAP1*0102N; TAP1N"
                     /note="major polyA site"
ORIGIN      
        1 gcttcaggcc ccaccggggc gcggagagtc ccaggcccgg ccgggaccgg gacggcgtcc
       61 gagtgccaat ggctagctct aggtgtcccg ctccccgcgg gtgccgctgc ctccccggag
      121 cttctctcgc atggctgggg acagtactgc tacttctcgc cgactgggtg ctgctccgga
      181 ccgcgctgcc ccgcatattc tccctgctgg tgcccaccgc gctgccactg ctccgggtct
      241 gggcggtggg cctgagccgc tgggccgtgc tctggctggg ggcctgcggg gtcctcaggg
      301 caacggttgg ctccaagagc gaaaacgcag gtgcccaggg ctggctggct gctttgaagc
      361 cattagctgc ggcactgggc ttggccctgc cgggacttgc cttgttccga gagctgatct
      421 catggggagc ccccgggtcc gcggatagca ccaggctact gcactgggga agtcacccta
      481 ccgccttcgt tgtcagttat gcagcggcac tgcccgcagc agccctgtgg cacaaactcg
      541 ggagcctctg ggtgcccggc ggtcagggcg gctctggaaa ccctgtgcgt cggcttctag
      601 gctgcctggg ctcggagacg cgccgcctct cgctgttcct ggtcctggtg gtcctctcct
      661 ctcttgggga gatggccatt ccattcttta cgggccgcct cactgactgg attctacaag
      721 atggctcagc cgataccttc actcgaaact taactctcat gtccattctc accatagcca
      781 gtgcagtgct ggagttcgtg ggtgacggga tctataacaa caccatgggc cacgtgcaca
      841 gccacttgca gggagaggtg tttggggctg tcctgcgcca ggagacggag tttttccaac
      901 agaaccagac aggtaacatc atgtctcggg taacagagga cacgtccacc ctgagtgatt
      961 ctctgagtga gaatctgagc ttatttctgt ggtacctggt gcgaggccta tgtctcttgg
     1021 ggatcatgct ctggggatca gtgtccctca ccatggtcac cctgatcacc ctgcctctgc
     1081 ttttccttct gcccaagaag gtgggaaaat ggtaccagtt gctggaagtg caggtgcggg
     1141 aatctctggc aaagtccagc caggtggcca ttgaggctct gtcggccatg cctacagttc
     1201 gaagctttgc caacgaggag ggcgaagccc agaagtttag ggaaaagctg caagaaataa
     1261 agacactcaa ccagaaggag gctgtggcct atgcagtcaa ctcctggacc actagtattt
     1321 caggtatgct gctgaaagtg ggaatcctct acattggtgg gcagctggtg accagtgggg
     1381 ctgtaagcag tgggaacctt gtcacatttg ttctctacca gatgcagttc acccaggctg
     1441 tggaggtact gctctccatc taccccagag tacagaaggc tgtgggctcc tcagagaaaa
     1501 tatttgagta cctggaccgc acccctcgct gcccacccag tggtctgttg actcccttac
     1561 acttggaggg ccttgtccag ttccaagatg tctcctttgc ctacccaaac cgcccagatg
     1621 tcttagtgct acaggggctg acattcaccc tacgccctgg cgaggtgacg gcgctggtgg
     1681 gacccaatgg gtctgggaag agcacagtgg ctgccctgct gcagaatctg taccagccca
     1741 ccgggggaca gctgctgttg gatgggaagc cccttcccca atatgagcac cgctacctgc
     1801 acaggcaggt ggctgcagtg ggacaagagc cacaggtatt tggaagaagt cttcaagaaa
     1861 atattgccta tggcctgacc cagaagccaa ctatggagga aatcacagct gctgcagtaa
     1921 agtctggggc ccatagtttc atctctggac tccctcaggg ctatgacaca gaggtagacg
     1981 aggctgggag ccagctgtca gggggtcagc gacaggcagt ggcgttggcc cgagcattga
     2041 tccggaaacc gtgtgtactt atcctggatg atgccaccag tgccctggat gcaaacagcc
     2101 agttacaggt ggagcagctc ctgtacgaaa gccctgagcg gtactcccgc tcagtgcttc
     2161 tcatcaccca gcacctcagc ctggtggagc aggctgacca catcctcttt ctggaaggag
     2221 gcgctatccg ggagggggga acccaccagc agctcatgga gaaaaagggg tgctactggg
     2281 ccatggtgca ggctcctgca gatgctccag aatgaaagcc ttctcagacc tgcgcactcc
     2341 atctccctcc cttttcttct ctctgtggtg gagaaccaca gctgcagagt aggcagctgc
     2401 ctccaggatg agttacttga aatttgcctt gagtgtgtta cctcctttcc aagctcctcg
     2461 tgataatgca gacttcctgg agtacaaaca caggatttgt aattccttac tgtaacggag
     2521 tttagagcca gggctgatgc tttggtgtgg ccagcactct gaaactgaga aatgttcaga
     2581 atgtacggaa agatgatcag ctattttcaa cataactgaa ggcatatgct ggcccataaa
     2641 caccctgtag gttcttgata tttataataa aattggtgtt ttgta
//
