LOCUS       NM_016281               4346 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens TAO kinase 3 (TAOK3), transcript variant 2, mRNA.
ACCESSION   NM_016281
VERSION     NM_016281.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4346)
  AUTHORS   Poirier,A., Ormonde,J.V.S., Aubry,I., Abidin,B.M., Feng,C.H.,
            Martinez-Cordova,Z., Hincapie,A.M., Wu,C., Perez-Quintero,L.A.,
            Wang,C.L., Gingras,A.C., Madrenas,J. and Tremblay,M.L.
  TITLE     The induction of SHP-1 degradation by TAOK3 ensures the
            responsiveness of T cells to TCR stimulation
  JOURNAL   Sci Signal 17 (817), eadg4422 (2024)
   PUBMED   38166031
  REMARK    GeneRIF: The induction of SHP-1 degradation by TAOK3 ensures the
            responsiveness of T cells to TCR stimulation.
REFERENCE   2  (bases 1 to 4346)
  AUTHORS   Sun,M., Li,Z., Wang,X., Zhao,M., Chu,Y., Zhang,Z., Fang,K.,
            Zhao,Z., Feng,A., Leng,Z., Shi,J., Zhang,L., Chen,T. and Xu,M.
  TITLE     TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression
            and Cisplatin Resistance Through Augmenting Autophagy Mediated by
            IRGM
  JOURNAL   Adv Sci (Weinh) 10 (29), e2300864 (2023)
   PUBMED   37705061
  REMARK    GeneRIF: TAOK3 Facilitates Esophageal Squamous Cell Carcinoma
            Progression and Cisplatin Resistance Through Augmenting Autophagy
            Mediated by IRGM.
REFERENCE   3  (bases 1 to 4346)
  AUTHORS   Maes,B., Smole,U., Vanderkerken,M., Deswarte,K., Van Moorleghem,J.,
            Vergote,K., Vanheerswynghels,M., De Wolf,C., De Prijck,S.,
            Debeuf,N., Pavie,B., Toussaint,W., Janssens,S., Savvides,S.,
            Lambrecht,B.N. and Hammad,H.
  TITLE     The STE20 kinase TAOK3 controls the development of house dust
            mite-induced asthma in mice
  JOURNAL   J Allergy Clin Immunol 149 (4), 1413-1427 (2022)
   PUBMED   34506849
  REMARK    GeneRIF: The STE20 kinase TAOK3 controls the development of house
            dust mite-induced asthma in mice.
REFERENCE   4  (bases 1 to 4346)
  AUTHORS   Xia,Y., Caputo,M., Cansby,E., Anand,S.K., Sutt,S., Henricsson,M.,
            Porosk,R., Marschall,H.U., Bluher,M. and Mahlapuu,M.
  TITLE     STE20-type kinase TAOK3 regulates hepatic lipid partitioning
  JOURNAL   Mol Metab 54, 101353 (2021)
   PUBMED   34634521
  REMARK    GeneRIF: STE20-type kinase TAOK3 regulates hepatic lipid
            partitioning.
REFERENCE   5  (bases 1 to 4346)
  AUTHORS   Iizuka,S., Quintavalle,M., Navarro,J.C., Gribbin,K.P.,
            Ardecky,R.J., Abelman,M.M., Ma,C.T., Sergienko,E., Zeng,F.Y.,
            Pass,I., Thomas,G.V., McWeeney,S.K., Hassig,C.A., Pinkerton,A.B.
            and Courtneidge,S.A.
  TITLE     Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes
            Containing the Invadopodia Scaffold TKS5alpha Promotes Cancer
            Invasion and Tumor Growth
  JOURNAL   Cancer Res 81 (6), 1472-1485 (2021)
   PUBMED   33414172
  REMARK    GeneRIF: Serine-Threonine Kinase TAO3-Mediated Trafficking of
            Endosomes Containing the Invadopodia Scaffold TKS5alpha Promotes
            Cancer Invasion and Tumor Growth.
REFERENCE   6  (bases 1 to 4346)
  AUTHORS   Cook-Sather,S.D., Li,J., Goebel,T.K., Sussman,E.M., Rehman,M.A. and
            Hakonarson,H.
  TITLE     TAOK3, a novel genome-wide association study locus associated with
            morphine requirement and postoperative pain in a retrospective
            pediatric day surgery population
  JOURNAL   Pain 155 (9), 1773-1783 (2014)
   PUBMED   24909733
REFERENCE   7  (bases 1 to 4346)
  AUTHORS   Raman,M., Earnest,S., Zhang,K., Zhao,Y. and Cobb,M.H.
  TITLE     TAO kinases mediate activation of p38 in response to DNA damage
  JOURNAL   EMBO J 26 (8), 2005-2014 (2007)
   PUBMED   17396146
REFERENCE   8  (bases 1 to 4346)
  AUTHORS   Yustein,J.T., Xia,L., Kahlenburg,J.M., Robinson,D., Templeton,D.
            and Kung,H.J.
  TITLE     Comparative studies of a new subfamily of human Ste20-like kinases:
            homodimerization, subcellular localization, and selective
            activation of MKK3 and p38
  JOURNAL   Oncogene 22 (40), 6129-6141 (2003)
   PUBMED   13679851
REFERENCE   9  (bases 1 to 4346)
  AUTHORS   Zhang,W., Chen,T., Wan,T., He,L., Li,N., Yuan,Z. and Cao,X.
  TITLE     Cloning of DPK, a novel dendritic cell-derived protein kinase
            activating the ERK1/ERK2 and JNK/SAPK pathways
  JOURNAL   Biochem Biophys Res Commun 274 (3), 872-879 (2000)
   PUBMED   10924369
REFERENCE   10 (bases 1 to 4346)
  AUTHORS   Tassi,E., Biesova,Z., Di Fiore,P.P., Gutkind,J.S. and Wong,W.T.
  TITLE     Human JIK, a novel member of the STE20 kinase family that inhibits
            JNK and is negatively regulated by epidermal growth factor
  JOURNAL   J Biol Chem 274 (47), 33287-33295 (1999)
   PUBMED   10559204
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB066061.1, BC002756.2,
            AL833460.1, AI057643.1 and AA744362.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016281.3.
            
            Summary: The protein encoded by this gene is a serine/threonine
            protein kinase that activates the p38/MAPK14 stress-activated MAPK
            cascade but inhibits the basal activity of the MAPK8/JNK cascade.
            The encoded protein is a member of the GCK subfamily of STE20-like
            kinases. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (2), as well as variants 3 and 4,
            encodes isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF181985.1, BC002756.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392533.8/ ENSP00000376317.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                DB066061.1         39-89
            52-3190             BC002756.2         1-3139
            3191-3704           AL833460.1         3325-3838
            3705-4226           AI057643.1         1-522               c
            4227-4346           AA744362.1         16-135              c
FEATURES             Location/Qualifiers
     source          1..4346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.23"
     gene            1..4346
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /note="TAO kinase 3"
                     /db_xref="GeneID:51347"
                     /db_xref="HGNC:HGNC:18133"
                     /db_xref="MIM:616711"
     exon            1..260
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            261..365
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            366..573
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..3150
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /EC_number="2.7.11.1"
                     /note="isoform b is encoded by transcript variant 2;
                     STE20-like kinase; serine/threonine-protein kinase TAO3;
                     JNK/SAPK-inhibitory kinase; jun kinase-inhibitory kinase;
                     kinase from chicken homolog A; CTCL-associated antigen
                     HD-CL-09; dendritic cell-derived protein kinase; thousand
                     and one amino acid protein 3; cutaneous T-cell
                     lymphoma-associated antigen HD-CL-09"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TAO3 isoform b"
                     /protein_id="NP_057365.3"
                     /db_xref="CCDS:CCDS9188.1"
                     /db_xref="GeneID:51347"
                     /db_xref="HGNC:HGNC:18133"
                     /db_xref="MIM:616711"
                     /translation="MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNA
                     HTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVME
                     YCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQ
                     VKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERK
                     PPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDF
                     VRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHG
                     TSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSS
                     SVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHE
                     HEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIEL
                     EKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEE
                     MNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRH
                     EVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTE
                     LENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNH
                     QLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQAL
                     RLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKE
                     RSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR"
     exon            574..645
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            646..747
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            748..793
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            794..890
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1004
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1096
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1190
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1272
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1440
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1647
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1782
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2019
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2148
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2352
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2592
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2805
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2988
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..4346
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4328..4333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /note="hexamer: AATAAA"
     polyA_site      4346
                     /gene="TAOK3"
                     /gene_synonym="DPK; hKFC-A; JIK; MAP3K18"
                     /note="major polyA site"
ORIGIN      
        1 aggagccgca cctcggacag cagcagcggc ggcggccgcg ggagggtcct tgtggcgccg
       61 ggcggcgggg tcctgcgtgg agagtgggac gcaacgccga gaccgcgagc agaggctgcg
      121 cacagccgga tccggcactc agcgaccgga cccaaggatc cgccggggaa caagccacag
      181 gagagcgact caggaacaag tgtgggagag gaagcggcgg cggcggcgcc gggcccgggg
      241 gtggtgacag caggtctgag gttgcatcat aaatacaaag gactgaagtt ataaaagaga
      301 aaagagaagt ttgctgctaa aatgaatctg agcaatatgg aatattttgt gccacacaca
      361 aaaaggtact gaagatttac cccccaaaaa aaattgtcaa tgagaaataa agctaactga
      421 tatcaaaaag cagagcctgc tctactggcc atcatgcgta aaggggtgct gaaggaccca
      481 gagattgccg atctattcta caaagatgat cctgaggaac tttttattgg tttgcatgaa
      541 attggacatg gaagttttgg agcagtttat tttgctacaa atgctcacac cagtgaggtg
      601 gtggcaatta agaagatgtc ctatagtggg aagcagaccc atgagaaatg gcaagatatt
      661 cttaaggaag ttaaattttt acgacaattg aagcatccta atactattga gtacaaaggc
      721 tgttacttga aagaacacac tgcttggttg gtgatggaat attgcttagg ctcagcctct
      781 gatttattag aagttcataa aaaaccactt caggaagtgg agatcgctgc cattactcat
      841 ggagccttgc atggactagc ctacctacat tctcatgcat tgattcatag ggatattaaa
      901 gcaggaaata ttcttctaac agagccaggt caggtaaaac tagctgattt tggatctgct
      961 tcaatggctt ctcctgccaa ctccttcgtg ggcacacctt actggatggc tccagaggtg
     1021 atcttagcta tggatgaagg acagtatgat gggaaagttg atatttggtc acttggcatc
     1081 acttgtattg aattggcgga acggaagccg ccccttttca acatgaatgc aatgagtgcc
     1141 ttatatcaca ttgcccagaa tgactcccca acgttacagt ctaatgaatg gacagactcc
     1201 tttaggagat ttgttgatta ctgcttgcag aaaatacctc aggaaaggcc aacatcagca
     1261 gaactattaa ggcatgactt tgttcgacga gaccggccac tacgtgtcct cattgacctc
     1321 atacagagga caaaagatgc agttcgtgag ctagataacc tacagtaccg aaaaatgaaa
     1381 aaaatacttt tccaagagac acggaatgga cccttgaatg agtcacagga ggatgaggaa
     1441 gacagtgaac atggaaccag cctgaacagg gaaatggaca gcctgggcag caaccattcc
     1501 attccaagca tgtccgtgag cacaggcagc cagagcagca gtgtgaacag catgcaggaa
     1561 gtcatggacg agagcagttc cgaacttgtc atgatgcacg atgacgaaag cacaatcaat
     1621 tccagctcct ccgtcgtgca taagaaagat catgtattca taagggatga ggcgggccac
     1681 ggcgatccca ggcctgagcc gcggcctacc cagtcagttc agagccaggc cctccactac
     1741 cggaacagag agcgctttgc cacgatcaaa tcagcatctt tggttacacg acagatccat
     1801 gagcatgagc aggagaacga gttgcgggaa cagatgtcag gttataagcg gatgcggcgc
     1861 cagcaccaga agcagctgat cgccctggag aacaagctga aggctgagat ggacgagcac
     1921 cgcctcaagc tacagaagga ggtggagacg catgccaaca actcgtccat cgagctggag
     1981 aagctggcca agaagcaagt ggctatcata gaaaaggagg caaaggtagc tgcagcagat
     2041 gagaagaagt tccagcaaca gatcttggcc cagcagaaga aagatttgac aactttctta
     2101 gaaagtcaga agaagcagta taagatttgt aaggaaaaaa taaaagagga aatgaatgag
     2161 gaccatagca cacccaagaa agagaagcaa gagcggatct ccaaacataa agagaacttg
     2221 cagcacacac aggctgaaga ggaagcccac cttctcactc aacagagact gtactacgac
     2281 aaaaattgtc gtttcttcaa gcggaaaata atgatcaagc ggcacgaggt ggagcagcag
     2341 aacattcggg aggaactaaa taaaaagagg acccagaagg agatggagca tgccatgcta
     2401 atccggcacg acgagtccac ccgagagcta gagtacaggc agctgcacac gttacagaag
     2461 ctacgcatgg atctgatccg tttacagcac cagacggaac tggaaaacca gctggagtac
     2521 aataagaggc gagaaagaga actgcacaga aagcatgtca tggaacttcg gcaacagcca
     2581 aaaaacttaa aggccatgga aatgcaaatt aaaaaacagt ttcaggacac ttgcaaagta
     2641 cagaccaaac agtataaagc actcaagaat caccagttgg aagttactcc aaagaatgag
     2701 cacaaaacaa tcttaaagac actgaaagat gagcagacaa gaaaacttgc cattttggca
     2761 gagcagtatg aacagagtat aaatgaaatg atggcctctc aagcgttacg gctagatgag
     2821 gctcaagaag cagaatgcca ggccttgagg ctacagctcc agcaggaaat ggagctgctc
     2881 aacgcctacc agagcaaaat caagatgcaa acagaggcac aacatgaacg tgagctccag
     2941 aagctagagc agagagtgtc tctgcgcaga gcacaccttg agcagaagat tgaagaggag
     3001 ctggctgccc ttcagaagga acgcagcgag agaataaaga acctattgga aaggcaagag
     3061 cgagagattg aaacttttga catggagagc ctcagaatgg gatttgggaa tttggttaca
     3121 ttagattttc ctaaggagga ctacagatga gattaaattt tttgccattt acaaaaaaaa
     3181 aaaaaaaaaa gaaaacagaa aaaaattcag accctgcaaa accacattcc ccattttaac
     3241 gggcgttgct ctcactctct ctctctctta ctcttactga catcgtgtcg gactagtgcc
     3301 tgtttattct tactccatca ggggccccct tcctcccccc gtgtcaactt tcagtgctgg
     3361 ccaaaacctg gccgtctctt ctattcacag tacacgtcac agtattgatg tgattcaaaa
     3421 tgtttcagtg aaaactttgg agacagtttt aacaaaacca ataaaccaac aacaaaaaaa
     3481 gtggatgtat attgctttaa gcaatcactc attaccacca atctgtgaaa gtaaagcaaa
     3541 aaataataat aataaatgcc aagggggaga gagacacaat atccgcagcc ttacacctta
     3601 actagctgct gcattatttt attttatttt atttttttgg tatttattca tcaggaataa
     3661 aaaaaacaaa gttttattaa agattgaaaa tttgatacat tttacagaaa ctaattgtga
     3721 tgtacatatc agtggtgaca tattattact tttttgggga cggggggtgg gtggggtgaa
     3781 gagatcttgt gatttttaag aacctgctgg caagagttta acttgtcttc agcatattct
     3841 gattgtatca taatcatttt ctgctgttgc agaggatgtg aatacactta aggagctcac
     3901 agaatcccag tagcacaaat tgggctttgg caaatcgtgt attttgtgta tagaaggaat
     3961 ttaaggagag gtattactta ttttcatatt gtattttaac tgtttctctg atcaaatttt
     4021 tttacttcct cctcctgttc ctccccacct ccctcctttt ccagttcagt atttggagtt
     4081 caacactgtc tctcaatcag atcatcttga tctttttctt tatctccctt ccccttccta
     4141 agtcccattt cttggtcata aatattgcat tattcacact ttcaaactgt gtattttctt
     4201 acaataaaaa atgatgaaaa aaaaaaaggc tttacttctt ttgcatgcac tttaaaaaca
     4261 aaacaaaaca tttttcaggt tccaaggaag agcatgataa ctgtcagagc ttttaattat
     4321 atttgtaaat aaaagtgttc atcaca
//
