LOCUS       NM_016151               4937 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TAO kinase 2 (TAOK2), transcript variant 1, mRNA.
ACCESSION   NM_016151
VERSION     NM_016151.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4937)
  AUTHORS   Ma,X., Mandausch,F.J., Wu,Y., Sahoo,V.K., Ma,W., Leoni,G.,
            Hostiuc,M., Wintgens,J.P., Qiu,J., Kannaiyan,N., Rossner,M.J. and
            Wehr,M.C.
  TITLE     Comprehensive split TEV based protein-protein interaction screening
            reveals TAOK2 as a key modulator of Hippo signalling to limit
            growth
  JOURNAL   Cell Signal 113, 110917 (2024)
   PUBMED   37813295
  REMARK    GeneRIF: Comprehensive split TEV based protein-protein interaction
            screening reveals TAOK2 as a key modulator of Hippo signalling to
            limit growth.
REFERENCE   2  (bases 1 to 4937)
  AUTHORS   Yang,Q., Li,Y., Wang,Y., Qiao,X., Liu,T., Wang,H. and Shen,H.
  TITLE     The circRNA circSIAE Inhibits Replication of Coxsackie Virus B3 by
            Targeting miR-331-3p and Thousand and One Amino-Acid Kinase 2
  JOURNAL   Front Cell Infect Microbiol 11, 779919 (2022)
   PUBMED   35141166
  REMARK    GeneRIF: The circRNA circSIAE Inhibits Replication of Coxsackie
            Virus B3 by Targeting miR-331-3p and Thousand and One Amino-Acid
            Kinase 2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4937)
  AUTHORS   Nourbakhsh,K., Ferreccio,A.A., Bernard,M.J. and Yadav,S.
  TITLE     TAOK2 is an ER-localized kinase that catalyzes the dynamic
            tethering of ER to microtubules
  JOURNAL   Dev Cell 56 (24), 3321-3333 (2021)
   PUBMED   34879262
  REMARK    GeneRIF: TAOK2 is an ER-localized kinase that catalyzes the dynamic
            tethering of ER to microtubules.
REFERENCE   4  (bases 1 to 4937)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4937)
  AUTHORS   Koo,C.Y., Giacomini,C., Reyes-Corral,M., Olmos,Y., Tavares,I.A.,
            Marson,C.M., Linardopoulos,S., Tutt,A.N. and Morris,J.D.H.
  TITLE     Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis
            and Induces Mitotic Cell Death in Centrosome Amplified Breast
            Cancer Cells
  JOURNAL   Mol Cancer Ther 16 (11), 2410-2421 (2017)
   PUBMED   28830982
  REMARK    GeneRIF: we characterize a compound that inhibits TAOK1 and TAOK2
            activity with IC50 values of 11 to 15 nmol/L, is ATP-competitive,
            and targets these kinases selectively. TAOK inhibition or depletion
            in centrosome-amplified SKBR3 or BT549 breast cancer cell models
            increases the mitotic population, the percentages of mitotic cells
            displaying amplified centrosomes and multipolar spindles, induces
            cell death, and inhibits cell growt
REFERENCE   6  (bases 1 to 4937)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   7  (bases 1 to 4937)
  AUTHORS   Chen,Z. and Cobb,M.H.
  TITLE     Regulation of stress-responsive mitogen-activated protein (MAP)
            kinase pathways by TAO2
  JOURNAL   J Biol Chem 276 (19), 16070-16075 (2001)
   PUBMED   11279118
REFERENCE   8  (bases 1 to 4937)
  AUTHORS   Moore,T.M., Garg,R., Johnson,C., Coptcoat,M.J., Ridley,A.J. and
            Morris,J.D.
  TITLE     PSK, a novel STE20-like kinase derived from prostatic carcinoma
            that activates the c-Jun N-terminal kinase mitogen-activated
            protein kinase pathway and regulates actin cytoskeletal
            organization
  JOURNAL   J Biol Chem 275 (6), 4311-4322 (2000)
   PUBMED   10660600
REFERENCE   9  (bases 1 to 4937)
  AUTHORS   Chen,Z., Hutchison,M. and Cobb,M.H.
  TITLE     Isolation of the protein kinase TAO2 and identification of its
            mitogen-activated protein kinase/extracellular signal-regulated
            kinase kinase binding domain
  JOURNAL   J Biol Chem 274 (40), 28803-28807 (1999)
   PUBMED   10497253
REFERENCE   10 (bases 1 to 4937)
  AUTHORS   Hutchison,M., Berman,K.S. and Cobb,M.H.
  TITLE     Isolation of TAO1, a protein kinase that activates MEKs in
            stress-activated protein kinase cascades
  JOURNAL   J Biol Chem 273 (44), 28625-28632 (1998)
   PUBMED   9786855
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP233788.1, BC136653.1 and
            BC151221.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016151.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also known as PSK1-alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF061943.1, BC136653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308893.9/ ENSP00000310094.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               BP233788.1         3-316
            315-4730            BC136653.1         1-4416
            4731-4937           BC151221.1         4072-4278
FEATURES             Location/Qualifiers
     source          1..4937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..4937
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /note="TAO kinase 2"
                     /db_xref="GeneID:9344"
                     /db_xref="HGNC:HGNC:16835"
                     /db_xref="MIM:613199"
     exon            1..781
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            782..948
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             817..4524
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     prostate derived STE20-like kinase PSK;
                     serine/threonine-protein kinase TAO2; PSK-1; hKFC-C;
                     kinase from chicken homolog C; prostate-derived STE20-like
                     kinase 1; prostate-derived sterile 20-like kinase 1;
                     thousand and one amino acid protein kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TAO2 isoform 1"
                     /protein_id="NP_057235.2"
                     /db_xref="CCDS:CCDS10663.1"
                     /db_xref="GeneID:9344"
                     /db_xref="HGNC:HGNC:16835"
                     /db_xref="MIM:613199"
                     /translation="MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYF
                     ARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAW
                     LVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLS
                     EPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIEL
                     AERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLL
                     KHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEE
                     AEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEE
                     GPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAPAPTST
                     TSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLA
                     LESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQ
                     HILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQ
                     AEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLR
                     QHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQP
                     KSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVGE
                     RRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVP
                     QERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPEEEEEEEEGAPIGTP
                     RDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVGSSSGLLPLLLLL
                     LLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLLAQGTALGAVL
                     GLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRGISRLWLRV
                     LLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTTQHPLAL
                     LARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPRSQRQ
                     LGPPASRQPLPGTLAGRRSRTRQSRALPPWR"
     exon            949..1020
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1122
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1168
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1265
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1379
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1471
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1565
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1647
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1815
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2076
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2238
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2604
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2808
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..4937
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4918..4923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /note="hexamer: AATAAA"
     polyA_site      4937
                     /gene="TAOK2"
                     /gene_synonym="MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;
                     Tao2beta"
                     /note="major polyA site"
ORIGIN      
        1 ctccatcttg gaattgggag gaagagggag agggagaccg ggacgagacc ggggctgtgg
       61 tgcggagaga ggctgagacg gagaagagga gaggcagaga gggcgcgggg accgtcagca
      121 gcaccttagc tacaatcgtt cagctattct cggaagagag aagggagagg gaggaggccg
      181 gggcgggagt gggggctgtc accctcggac cccggcgtga gaggggccgt gcggccggac
      241 gtcctcgggg tgggccccca gtcggtggcc gaagacctac agctcaggcc cctgggtccc
      301 aaatttccag gctttgcccc tcctcctttc tcagataccc gggtaacagt cctcatagtc
      361 cagatatccg ggactcgggt cccaacctct ctaaacctgg gtctctgttt catagaattt
      421 caaatatcag gttcaggccc ctgcgtgcac cagtatccgg ggttcattcc ccgggcgttc
      481 aaatatcgga ttcagtctcc atcccgttca gatattcggg gttcagaccc cacaatcaga
      541 aatccggaat tcggcagctg tcgccctcga cgagggggag gactggaccg cgaggtcaga
      601 ttaggttgtc accccctccc ctccagggga ggcttcccgg gcccgcccct caggaagggc
      661 gaaagccgag gaagaggtgg caaggggaaa ggtctccttg cccctctccc tgcttggcag
      721 agccgctgga ggaccccagg cggaagcgga ggcgctgggg caccatagtg acccctacca
      781 ggccaggccc cactctcagg gcccccaggg gccaccatgc cagctggggg ccgggccggg
      841 agcctgaagg acccagatgt ggctgagctc ttcttcaagg atgacccaga aaagctcttc
      901 tctgacctcc gggaaattgg ccatggcagc tttggagccg tatactttgc ccgggatgtc
      961 cggaatagtg aggtggtggc catcaagaag atgtcctaca gtgggaagca gtccaatgag
     1021 aaatggcaag acatcatcaa ggaggtgcgg ttcttacaga agctccggca tcccaacacc
     1081 attcagtacc ggggctgtta cctgagggag cacacggctt ggctggtaat ggagtattgc
     1141 ctgggctcag cttctgacct tctagaagtg cacaagaaac cccttcagga ggtagagatc
     1201 gcagctgtga cccacggggc gcttcagggc ctggcatatc tgcactccca caacatgatc
     1261 catagggatg tgaaggctgg aaacatcctg ctgtcagagc cagggttagt gaagctaggg
     1321 gactttggtt ctgcgtccat catggcacct gccaactcct tcgtgggcac cccatactgg
     1381 atggcacccg aggtgatcct ggccatggat gaggggcagt acgatggcaa agtggacgtc
     1441 tggtccttgg ggataacctg catcgagctg gctgaacgga aaccaccgct ctttaacatg
     1501 aatgcgatga gtgccttata ccacattgca cagaacgaat cccccgtgct ccagtcagga
     1561 cactggtctg agtacttccg gaattttgtc gactcctgtc ttcagaaaat ccctcaagac
     1621 agaccaacct cagaggttct cctgaagcac cgctttgtgc tccgggagcg gccacccaca
     1681 gtcatcatgg acctgatcca gaggaccaag gatgccgtgc gggagctgga caacctgcag
     1741 taccgcaaga tgaagaagat cctgttccaa gaggcaccca acggccctgg tgccgaggcc
     1801 ccagaggagg aagaggaggc cgagccctac atgcaccggg ccgggactct gaccagcctc
     1861 gagagtagcc actcagtgcc cagcatgtcc atcagcgcct ccagccagag cagctccgtc
     1921 aacagcctag cagatgcctc agacaacgag gaagaggagg aggaggagga ggaagaggag
     1981 gaggaggaag aaggccctga agcccgggag atggccatga tgcaggaggg ggagcacaca
     2041 gtcacctctc acagctccat tatccaccgg ctgccgggct ctgacaacct atatgatgac
     2101 ccctaccagc cagagataac ccccagccct ctccagccgc ctgcagcccc agctcccact
     2161 tccaccacct cttccgcccg ccgccgggcc tactgccgta accgagacca ctttgccacc
     2221 atccgaaccg cctccctggt cagccgtcag atccaggagc atgagcagga ctctgcgctg
     2281 cgggagcagc tgagcggcta taagcggatg cgacgacagc accagaagca gctgctggcc
     2341 ctggagtcac ggctgagggg tgaacgggag gagcacagtg cacggctgca gcgggagctt
     2401 gaggcgcagc gggctggctt tggggcagag gcagaaaagc tggcccggcg gcaccaggcc
     2461 ataggtgaga aggaggcacg agctgcccag gccgaggagc ggaagttcca gcagcacatc
     2521 cttgggcagc agaagaagga gctggctgcc ctgctggagg cacagaagcg gacctacaaa
     2581 cttcgcaagg aacagctgaa ggaggagctc caggagaacc ccagcactcc caagcgggag
     2641 aaggccgagt ggctgctgcg gcagaaggag cagctccagc agtgccaggc ggaggaggaa
     2701 gcagggctgc tgcggcggca gcgccagtac tttgagctgc agtgtcgcca gtacaagcgc
     2761 aagatgttgc tggctcggca cagcctggac caggacctgc tgcgggagga cctgaacaag
     2821 aagcagaccc agaaggactt ggagtgtgca ctgctgcttc ggcagcacga ggccacgcgg
     2881 gagctggagc tgcggcagct ccaggccgtg cagcgcacgc gggctgagct cacccgcctg
     2941 cagcaccaga cggagctggg caaccagctg gagtacaaca agcggcgtga gcaagagttg
     3001 cggcagaagc atgcggccca ggttcgccag cagcccaaga gcctcaaagt acgtgcaggc
     3061 cagcgccccc cgggccttcc actccccatt cctggggctc tgggcccacc caacacaggc
     3121 acccctatag aacagcagcc ctgctcacct ggccaggagg cagtcctgga ccaaagaatg
     3181 cttggcgagg aggaggaagc agttggagag agaaggattc tgggaaagga aggggccact
     3241 ttggagccca agcagcagag gattctgggg gaagaatcag gagcccctag tcccagtcca
     3301 caaaaacatg ggagcctggt tgatgaggaa gtttggggtc tgcctgagga gatagaggag
     3361 cttagggtgc cctcccttgt accccaggag aggagcattg ttggccagga ggaggctggg
     3421 acatggagct tgtgggggaa ggaggatgag agtcttctgg atgaggagtt tgagcttggc
     3481 tgggtccagg gcccagcact gactcccgtc cctgaggagg aggaagaaga ggaagagggg
     3541 gctccgattg ggacccctag ggatcctgga gatggttgtc cttcccccga catccctcct
     3601 gaaccccctc caacacacct gaggccctgc cctgccagcc agctccctgg actcctgtcc
     3661 catggcctcc tggccggcct ctcctttgca gtggggtcct cctctggcct cctgcccctc
     3721 ctgctgctgc tgctgcttcc attgctggca gcccagggtg ggggtggcct gcaggcagcg
     3781 ctgctggccc ttgaggtggg gctggtgggt ctgggggcct cctacctgct cctttgtaca
     3841 gccctgcacc tgccctccag tcttttccta ctcctggccc agggtaccgc actgggggcc
     3901 gtcctgggcc tgagctggcg ccgaggcctc atgggtgttc ccctgggcct tggagctgcc
     3961 tggctcttag cttggccagg cctagctcta cctctggtgg ctatggcagc ggggggcaga
     4021 tgggtgcggc agcagggccc ccgggtgcgc cggggcatat ctcgactctg gttgcgggtt
     4081 ctgctgcgcc tgtcacccat ggccttccgg gccctgcagg gctgtggggc tgtgggggac
     4141 cggggtctgt ttgcactgta ccccaaaacc aacaaggatg gcttccgcag ccgcctgccc
     4201 gtccctgggc cccggcggcg taatccccgc accacccaac acccattagc tctgttggca
     4261 agggtctggg tcctgtgcaa gggctggaac tggcgtctgg cacgggccag ccagggttta
     4321 gcatcccact tgcccccgtg ggccatccac acactggcca gctggggcct gcttcggggt
     4381 gaacggccca cccgaatccc ccggctacta ccacgcagcc agcgccagct agggccccct
     4441 gcctcccgcc agccactgcc agggactcta gccgggcgga ggtcacgcac ccgccagtcc
     4501 cgggccctgc ccccctggag gtagctgact ccagcccttc cagcccaaat ctagagcatt
     4561 gagcacttta tctcccacga ctcagtgaag tttctccagt ccctagtcct ctcttttcac
     4621 ccaccttcct cagtttgctc acttacccca ggcccagccc ttcggacctc tagacaggca
     4681 gcctcctcag ctgtggagtc cagcagtcac tctgtgttct cctggcgctc ctcccctaag
     4741 ttattgctgt tcgcccgctg tgtgtgctca tcctcaccct cattgactca ggcctggggc
     4801 caggggtggt ggagggtggg aagagtcatg ttttttttct cctctttgat tttgtttttc
     4861 tgtctccctt ccaacctgtc cccttccccc caccaaaaaa agaaaaagac aaacacaaat
     4921 aaaatatctg agcggaa
//
