LOCUS       NM_020791              12643 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens TAO kinase 1 (TAOK1), transcript variant 1, mRNA.
ACCESSION   NM_020791 XM_290796
VERSION     NM_020791.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12643)
  AUTHORS   Du,G., Jiang,Z., Xia,T., Liu,M., Liu,Z., Zhou,H., Zhang,H., Zhai,X.
            and Jin,B.
  TITLE     lincRNA00907 promotes NASH progression by targeting
            miRNA-942-5p/TAOK1
  JOURNAL   Aging (Albany NY) 16 (8), 6868-6882 (2024)
   PUBMED   38613803
  REMARK    GeneRIF: lincRNA00907 promotes NASH progression by targeting
            miRNA-942-5p/TAOK1.
REFERENCE   2  (bases 1 to 12643)
  AUTHORS   Xia,Y., Andersson,E., Anand,S.K., Cansby,E., Caputo,M., Kumari,S.,
            Porosk,R., Kilk,K., Nair,S., Marschall,H.U., Bluher,M. and
            Mahlapuu,M.
  TITLE     Silencing of STE20-type kinase TAOK1 confers protection against
            hepatocellular lipotoxicity through metabolic rewiring
  JOURNAL   Hepatol Commun 7 (4), e0037 (2023)
   PUBMED   36930872
  REMARK    GeneRIF: Silencing of STE20-type kinase TAOK1 confers protection
            against hepatocellular lipotoxicity through metabolic rewiring.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12643)
  AUTHORS   Li,B., Sun,G., Yu,H., Meng,J. and Wei,F.
  TITLE     Exosomal circTAOK1 contributes to diabetic kidney disease
            progression through regulating SMAD3 expression by sponging
            miR-520h
  JOURNAL   Int Urol Nephrol 54 (9), 2343-2354 (2022)
   PUBMED   35142978
  REMARK    GeneRIF: Exosomal circTAOK1 contributes to diabetic kidney disease
            progression through regulating SMAD3 expression by sponging
            miR-520h.
REFERENCE   4  (bases 1 to 12643)
  AUTHORS   Hunter,J.M., Massingham,L.J., Manickam,K., Bartholomew,D.,
            Williamson,R.K., Schwab,J.L., Marhabaie,M., Siemon,A., de Los
            Reyes,E., Reshmi,S.C., Cottrell,C.E., Wilson,R.K. and Koboldt,D.C.
  TITLE     Inherited and de novo variants extend the etiology of
            TAOK1-associated neurodevelopmental disorder
  JOURNAL   Cold Spring Harb Mol Case Stud 8 (2), a006180 (2022)
   PUBMED   35091509
  REMARK    GeneRIF: Inherited and de novo variants extend the etiology of
            TAOK1-associated neurodevelopmental disorder.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12643)
  AUTHORS   Qin,W., Cai,X.H., Han,W.M., Lu,X.Z., Chen,M.Y., Jia,Z.X., Liu,J.,
            Xiao,R. and Qian,S.X.
  TITLE     [The role and mechanism of lncRNA C9ORF139 targeting
            miR-24-3P/TAOK1 in regulating the proliferation of acute myeloid
            leukemia cells]
  JOURNAL   Zhonghua Yi Xue Za Zhi 102 (8), 576-583 (2022)
   PUBMED   35196780
  REMARK    GeneRIF: [The role and mechanism of lncRNA C9ORF139 targeting
            miR-24-3P/TAOK1 in regulating the proliferation of acute myeloid
            leukemia cells].
REFERENCE   6  (bases 1 to 12643)
  AUTHORS   Mitsopoulos,C., Zihni,C., Garg,R., Ridley,A.J. and Morris,J.D.
  TITLE     The prostate-derived sterile 20-like kinase (PSK) regulates
            microtubule organization and stability
  JOURNAL   J Biol Chem 278 (20), 18085-18091 (2003)
   PUBMED   12639963
REFERENCE   7  (bases 1 to 12643)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 12643)
  AUTHORS   Berman,K.S., Hutchison,M., Avery,L. and Cobb,M.H.
  TITLE     kin-18, a C. elegans protein kinase involved in feeding
  JOURNAL   Gene 279 (2), 137-147 (2001)
   PUBMED   11733138
REFERENCE   9  (bases 1 to 12643)
  AUTHORS   Chen,Z., Hutchison,M. and Cobb,M.H.
  TITLE     Isolation of the protein kinase TAO2 and identification of its
            mitogen-activated protein kinase/extracellular signal-regulated
            kinase kinase binding domain
  JOURNAL   J Biol Chem 274 (40), 28803-28807 (1999)
   PUBMED   10497253
REFERENCE   10 (bases 1 to 12643)
  AUTHORS   Hutchison,M., Berman,K.S. and Cobb,M.H.
  TITLE     Isolation of TAO1, a protein kinase that activates MEKs in
            stress-activated protein kinase cascades
  JOURNAL   J Biol Chem 273 (44), 28625-28632 (1998)
   PUBMED   9786855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068025.12, BC133039.1, AC090698.14 and CK300429.1.
            
            On Apr 2, 2020 this sequence version replaced NM_020791.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1706734.1, BC133039.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261716.8/ ENSP00000261716.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-585               AC068025.12        144759-145343
            586-2318            BC133039.1         20-1752
            2319-2319           AC090698.14        42504-42504
            2320-3689           BC133039.1         1754-3123
            3690-12618          AC090698.14        77334-86262
            12619-12643         CK300429.1         16-40               c
FEATURES             Location/Qualifiers
     source          1..12643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..12643
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /note="TAO kinase 1"
                     /db_xref="GeneID:57551"
                     /db_xref="HGNC:HGNC:29259"
                     /db_xref="MIM:610266"
     exon            1..662
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..888
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             757..3762
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine protein kinase TAO1 homolog; microtubule
                     affinity regulating kinase kinase;
                     serine/threonine-protein kinase TAO1; STE20-like kinase
                     PSK2; kinase from chicken homolog B; thousand and one
                     amino acid protein 1; MARK Kinase; prostate-derived
                     STE20-like kinase 2; prostate-derived sterile 20-like
                     kinase 2; thousand and one amino acid protein kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TAO1 isoform 1"
                     /protein_id="NP_065842.1"
                     /db_xref="CCDS:CCDS32601.1"
                     /db_xref="GeneID:57551"
                     /db_xref="HGNC:HGNC:29259"
                     /db_xref="MIM:610266"
                     /translation="MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYF
                     ARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAW
                     LVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLT
                     EPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIEL
                     AERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELL
                     KHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEE
                     QDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMS
                     NSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQ
                     MQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFA
                     AEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQL
                     KEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLL
                     GRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQH
                     QTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKAL
                     RNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAEC
                     QVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLAL
                     QNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNP
                     TGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRT
                     ASGGRTEQGMSRSTSVTSQISNGSHMSYT"
     exon            889..960
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1062
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1108
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1205
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1319
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1411
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1505
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1587
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1755
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1959
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2094
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2331
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2460
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2664
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2904
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3117
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3300
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..12643
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8753..8758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /note="hexamer: ATTAAA"
     polyA_site      8777
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
     regulatory      12622..12627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /note="hexamer: AATAAA"
     polyA_site      12643
                     /gene="TAOK1"
                     /gene_synonym="DDIB; hKFC-B; hTAOK1; KFC-B; MAP3K16;
                     MARKK; PSK-2; PSK2; TAO1"
                     /note="major polyA site"
ORIGIN      
        1 gggcagcggc cgggctctgt ggcttcaggg ctcggggaga gagagggagg gtggcaaaga
       61 gactgagtcg gtgccgccgc ctgcctgagg agagaggagg ggtcccgctc gccctgcgcc
      121 cttcgcgggc cgaaagcact aggcactcgc gaacatctga ggcctcccgg ccccggggga
      181 ccccgccccg ccgtccgccg gccggcccgc ggcctctctt ccctttgtga gcgcctcctt
      241 accaggggtg gtgttggtgg cggagggctg cgcgtgggcc cgcccgccga ggggccgcgg
      301 cgggggaccg agagggcctc ggctgtgtga ggactagagg cggccgaggc ccgggccggt
      361 tcccccgagg cggcgacgga gacggctccc ggcacttccc cgcgccatct taactgagcc
      421 caagcgctga gggcgcctcc tcgaccccgg tcgtcccctc gccccccccc ccaccccccg
      481 ccgccgccgc cccttgttgc agagcttggg ctgggcggct tgctggggct cgggggtggg
      541 gggcggcgat ctgtcgccgg gccccctcct cctcctcact cctcaccctc cagggtagcg
      601 gctaccggag cgctgcaggg ggctgcgcct gcctgctccg ccccagacct gtcggcgaaa
      661 ggtagtttat gccaacgtga cttcattcat acagatgaac caaggatcgg gatagcagta
      721 taaaattaga atcaagacag ctgactgctc agcaggatgc catcaactaa cagagcaggc
      781 agcctgaagg accctgaaat tgcagagctc ttcttcaaag aagatccaga gaagctcttc
      841 acagatctca gagaaattgg ccatggaagc tttggagcag tgtattttgc acgagatgtg
      901 cgtaccaatg aagtggtggc catcaagaaa atgtcttata gtggaaagca gtctactgag
      961 aaatggcagg atattattaa ggaagtcaag tttctacaaa gaataaaaca tcccaacagt
     1021 atagaataca aaggctgtta tttacgtgaa cacacagcat ggcttgtaat ggaatattgt
     1081 ttaggatctg cttcggattt actagaagtt cacaaaaagc cattacaaga agtggaaata
     1141 gcagcaatta cacatggtgc tcttcaggga ttagcctact tacattctca tactatgatt
     1201 catagagata tcaaagcagg aaatatcctt ctgacagaac caggccaggt gaaacttgct
     1261 gactttggct ctgcttccat ggcatcacct gccaattcct ttgtgggaac gccgtattgg
     1321 atggccccag aagtaatttt agccatggat gaaggacaat atgatggcaa agtagatgtg
     1381 tggtctcttg gaataacatg tattgaacta gcggaaagga agcctccttt atttaatatg
     1441 aatgcaatga gtgccttata tcacatagcc caaaatgaat cccctacact acagtctaat
     1501 gaatggtctg attattttcg caactttgta gattcttgcc tccagaaaat ccctcaagat
     1561 cgacctacat cagaggaact tttaaagcac atatttgttc ttcgggagcg ccctgaaacc
     1621 gtgttaatag atctcattca gaggacaaag gatgcagtaa gagagctgga caatctgcag
     1681 tatcgaaaga tgaagaaact ccttttccag gaggcacata atggaccagc agtagaagca
     1741 caggaagaag aagaggaaca agatcatggt gttggccgga caggaacagt taatagtgtt
     1801 ggaagtaatc aatccattcc cagcatgtcc atcagtgcca gcagccaaag cagtagtgtt
     1861 aacagtcttc cagatgtctc agatgacaag agtgagctag acatgatgga gggagaccac
     1921 acagtgatgt ctaacagttc tgttatccat ttaaaaccag aggaagaaaa ttacagagaa
     1981 gagggagatc ctagaacaag agcatcagat ccacaatctc caccccaagt atctcgtcac
     2041 aaatcacact atcgtaatcg agaacacttt gctactatac ggacagcatc actggttacg
     2101 aggcaaatgc aagaacatga gcaggactct gagcttagag aacaaatgtc tggctataag
     2161 cgaatgaggc gacaacatca aaagcaactg atgactctgg aaaacaagct aaaggctgag
     2221 atggatgaac atcgcctcag attagacaaa gatcttgaaa ctcagcgtaa caattttgct
     2281 gcagaaatgg agaaacttat caagaaacac caggctgcca tggagaaaga ggctaaagtg
     2341 atgtccaatg aagagaaaaa atttcagcaa catattcagg cccaacagaa gaaagaactg
     2401 aatagttttc tcgagtccca gaaaagagag tataaacttc gaaaagagca gcttaaagag
     2461 gagctaaatg aaaaccagag tacccccaaa aaagaaaaac aggagtggct ttcaaagcag
     2521 aaggagaata tacagcattt ccaagcagaa gaagaagcta accttcttcg acgtcaaaga
     2581 caatacctag agctggaatg ccgtcgcttc aagagaagaa tgttacttgg gcgtcataac
     2641 ttagagcagg accttgtcag ggaggagtta aacaaaagac agactcagaa ggacttagag
     2701 catgccatgc tactccgaca gcatgaatct atgcaagaac tggagttccg ccacctcaac
     2761 acaattcaga agatgcgctg tgagttgatc agattacagc atcaaactga gctcactaac
     2821 cagctggaat ataataagcg aagagaacga gaactaagac gaaagcatgt catggaagtt
     2881 cgacaacagc ctaagagttt gaagtctaaa gaactccaaa taaaaaagca gtttcaggat
     2941 acctgcaaaa tccaaaccag acagtacaaa gcattaagaa atcacctgct ggagactaca
     3001 ccaaagagtg agcacaaagc tgttctgaaa cggctcaagg aggaacagac ccggaaatta
     3061 gctatcttgg ctgagcagta tgatcacagc attaatgaaa tgctctccac acaagccctg
     3121 cgtttggatg aagcacagga agcagagtgc caggttttga agatgcagct gcagcaggaa
     3181 ctggagctgt tgaatgcgta tcagagcaaa atcaagatgc aagctgaggc acaacatgat
     3241 cgagagcttc gcgagcttga acagagggtc tccctccgga gggcactctt agaacaaaag
     3301 attgaagaag agatgttggc tttgcagaat gagcgcacag aacgaatacg aagcctgttg
     3361 gaacgtcaag ccagagagat tgaagctttt gactctgaaa gcatgagact aggttttagt
     3421 aatatggtcc tttctaatct ctcccctgag gcattcagcc acagctaccc gggagcttct
     3481 ggttggtcac acaaccctac tgggggtcca ggacctcact ggggtcatcc catgggtggc
     3541 ccaccacaag cttggggcca tccaatgcaa ggtggacccc agccatgggg tcacccttca
     3601 gggccaatgc aaggggtacc tcgaggtagc agtatgggag tccgcaatag cccccaggct
     3661 ctgaggcgga cagcttctgg gggacggacg gagcagggca tgagcagaag cacgagtgtc
     3721 acttcacaaa tatccaatgg gtcacacatg tcttatacat aacttaataa ttgagagtgg
     3781 caattccgct ggagctgtct gccaaaagaa actgcctaca gacatcatca cagcagcctc
     3841 ctcacttggg tactacagtg tggaagctga gtgcatatgg tatattttat tcatttttgt
     3901 aaagcgttct gttttgtgtt tactaattgg gatgtcatag tacttggctg ccgggtttgt
     3961 ttgtttttgg ggaaattttg aaaagtggag ttgatattaa aaataaatgt gtatgtgtgt
     4021 acatatatat acacacacat acacatatat tatgcatgtg gtgaaaagaa ttggctagat
     4081 aggggatttt tctgaacact gcaaaaatag aacgtagcaa aatggcttca gttatcactt
     4141 ttgggtgtct gtatcctaag aagtttctga aaagatctaa agccttttta tcccatatcc
     4201 caaattctta tgagccactc acagcaggca gcatatgttg aaataagtta ttactggtac
     4261 acacctgcat tgcctcacca gtgtatttat ttgttattaa attgatctga cttctcagcc
     4321 tcatttggac taaaaaaaga aagcagaaat ccatgaacac attgcttctc ggccttttgg
     4381 ctaagatcaa gtgtagaaat ccatgaacac taaaggactt cattgatttt ttcagagagt
     4441 agaaaacaac ttagtttttc ttttttcctg aatgcgtcat aggcttgtga gtgatttttg
     4501 tccattcaat tgtgccttct ttgtattatg ataagatggg ggtacttaag gagatcacaa
     4561 gttgtgtgag gattgcatta acaaacctat gagccttcaa tggggaagac cagaagggtg
     4621 agaggggccc tgaaagttca tatggtgggt atgtcccgca gcagagtgag gagatgaagc
     4681 ttacgtgtcc tgacgttttg ttgcttatac tgtgatatct catcctagct aagctctata
     4741 atgcccaaga ccccaaacag tacttttact ttgtttgtac aaaaacaaag acatatagcc
     4801 aatacaaatc aaatgccgga ggtgtttgat gccatatttg caaattgcca tctattgaaa
     4861 ttctcgtcac actacataga cataattgtt atctcctttt ggcttatgtg attttctgtt
     4921 tacaagtaga atagccaatt atttaaatgt ttagttgcca cagtgaacca ggagtcactg
     4981 agccaatgac tttaccagct gctgactaat cttcatcacc actgtagatt ttgctgcatg
     5041 tgcaggtcct ctatttttaa ttgctgtttt cgttgctgca gtactttaca aacttctagt
     5101 tcgttgagac ttagtgacca tttggcatca agttaacatc acacaatagg aaacaccact
     5161 tccacaagtc tcaagcctca gtgctaaagt actactgaaa aggaactagg aagtttggcc
     5221 aattaaaaaa aaaaagtaaa ataagttata gtggtcaggg aatctcttga cgaaagctaa
     5281 ctcttatttt tcagggggca catgttttgt tttgttatgt tttgttgtac aatgaaggat
     5341 gaacccaatg ctaaaaagtc agttattttc ttggttttcc atttcttgta tataaattgt
     5401 gttggaggtg ggtaggaagc tgtgagtatg acttgaagaa aaatatcctt ttcagtgaca
     5461 aatcagagtt tcttacaagt tattgtcctg ctcccttcca agttgtcttg aagaatcctt
     5521 gctgctaact ctggatcctg cttttcctat agtcagaggg ctccaaggta gaactctcta
     5581 agtccctctc aatggcactc tttgcctaga ccaaactaat gaccaaacag taatcaatct
     5641 atcactgttg aagtcctggt tttctcaacc aaattttaag tctttcccag gtatgtcagt
     5701 cgagttgcca tgaatcctca cctgtaggag tttctgggat tcattttaag gaaactggaa
     5761 gaaaattaat gttttaatgt aaatgttttt aaaaccaaga tcaccataga gttcacacaa
     5821 aattttaggc agtgtttcaa gaagcactct tatgtgttgt tctttcagcc catgctccag
     5881 gtcaccggtt tttaggtaaa catgacatga catgtacttg taatatcagt gaaaggggct
     5941 tttagtcgtc tcagtatctt ttttgcattc aggtattata gcgtttccaa caaattgaga
     6001 aattacttat ttggtgtaaa atgacgagag agctttagaa tttaataaaa tgtcaaaaat
     6061 acaatttgat acccttaaaa attattcata gatctggctg ctctgtacta ctggatgggt
     6121 ggaataggga agcagatcac ttttgcatac aaaaactctt tcaaacccaa aatattattg
     6181 gtggtacatt ttaaagtcca attgtggact taaattagtc aaattgagag ttactgagtc
     6241 cattcagatc tccagtaggg ttttgtatct aatgtatttg gccaccagtt ttacatgtag
     6301 gtcatgacta tacctggatt ttatcattaa gttaacttta aagtatatac agtttgcaaa
     6361 aaatgattca aattaattgg tttgtatatg tttgtgagat ctagcttctg aggaatctca
     6421 tacatagtag gaaccatcat agagtaaagc ttgtagcaga aaaattggaa gggttttgag
     6481 atatcctaga gaaagagcaa gcactttctg aatcagtggg gaaatatcaa tatttgatca
     6541 aattaacact acctccttcc cagtgttggt gttcactcac tatatgtctt taagaaaatt
     6601 aaaactatgg aaaatttgtc tagcatatca gaagttgtaa atgctatatc tggtatccag
     6661 aggctggctg taaaaagttc cttggggtca ctctatctca catttttttt ggttagcatt
     6721 ttaaaaatgc aaagccacat actttgaaat atattattcc aaattgagct cccttccctt
     6781 tgcacatatt ttttcctccc cttattgaag tcagctctaa ccccaaattc tagtatccaa
     6841 aagtattttt atttgtataa tgctatctga aaaatgtgtt tatattatat tttcagagct
     6901 gcaattctta ttcgccattt caatacctag agatagagag tcttgtattt gaagccacac
     6961 acactggtgt aatatgctta gtactctagg tcaaggattt gttggtaaat ggaacatttt
     7021 agcatagtca tgatttttgg ttgcctagac atcaggtaaa cattcagtac actaaagaaa
     7081 ctatcctgga cactccctcc tgcttccacc aatttttttc tcaccccctt ttcaaaaatt
     7141 gaaaactcta tgagtgtctt tttgagacca taaagcagac tttagtaact ttctatttct
     7201 gtaagtacta aatgtctggc attttaaact tttgtagaat acattatgtt ggacactgga
     7261 ataatactat ttattttcac ctgtgaaaaa tgacttcatt gtacttgaaa cacctccttt
     7321 gcatttctcc atttgtgcca ttcactagtg gaaataaatt gtattatacc atgatctact
     7381 ggctttttaa aactgtatta aatatgcaca tttttggtat agctattatc atttgtatgt
     7441 atatattgta tatacatatg agtgtctgta tgtgtgtata gatggatgga tgtaactcat
     7501 actgtacatt tccatcaggg cacttaaaag ttctgttatt tttgtttggt tttgttattt
     7561 cagtcctcag ttaaggcaag aatgcatgtg tttcttaaga atgagtactc tgcgttgatg
     7621 tttatgagaa ggtggtcatt agatgcagtc ttttcctttt taatcccctc ttagcacttc
     7681 tgtgagtgga gaggacatta agtaaaattt ggaatcataa gttgcaatgc agtaaaatgg
     7741 tgctggggaa ggagccagtt agtgtttctg tgagtttgtg ttgtgatgca ataagagata
     7801 agtaatgcag agagaaatga accatggaaa gtaagaacac tgatggtgat tcctctgcaa
     7861 agatgataag aaaaagaacc aataaatcac acaatcttta tgtgctttct atatgtattt
     7921 cttagtagtg ataccattga tcctcttact ttttttactc cattaatact aataattata
     7981 tactttgctg aggatcaaaa cagccaagaa aggaattact gctaaagcat ctaagattct
     8041 cctgaactgt aaaatcaaca ggaaatggcc actgggagag aaggatttgg tattgggtga
     8101 ggggctttct ccctttacct gcctcttctt gcttgctaat agtaagttct ttgtgcacct
     8161 tccaccactt ctgagccact actattcaag tagagatttg ccccaacaca ttaacttttt
     8221 ccttggagat ttatatggtc ctgcattttg tcctgtgctc acaatgtgaa gtgtcttctg
     8281 tattcaaatc aaaaaataat atatttaagg tatataagtg tgaatctcct ataatgatgg
     8341 aagaagaggt tctcttgtct tagatagaaa agagccttct ccaagagcaa tgtcaaaact
     8401 tgggctgtca tctttgagct gtttaccaaa atacagacca ttattgaaga aaaacaaatt
     8461 atctattttg ttttccccca tctaacatga tagtgccccc aaccaggttg tagcattgcc
     8521 ttttaaaaga gactcactca ctcttagttt ttaagaactg gaaatttccc atcctcagat
     8581 cccttaaagg atgaagagtt ggctgtacac ttagcggact tgcctcttgt atgcaaggac
     8641 tactgattga agtctgtttt gctgtgtctg gttatgttgt ctgcactttt atgaaatcac
     8701 tacaataggt ctgcattgga aatgactatt aatttgtaaa gaagtaagtt ttattaaaca
     8761 ctgtctagaa aaagaaagtg aagctgagaa ctcttccttt attgtgcatt tatattttct
     8821 gctgaattcc ggtagttccc tttaaagtca tgttgactaa tgttttcctc cttgtttgta
     8881 ttcagatttc caaaatttca ctcatacaag ggaagagact ccatttagct taacggtagt
     8941 ctttagatca taagaaatat ataaattagt atgcacctta tctgcctgtt gtgggtttct
     9001 taaacttgca cttcctaccc acccaaagat agatatcctt taaagaaaat aaaggcagag
     9061 aattaaaact ggggagccat ttactatgtc accatcactg ttaactgttt cccagcaatc
     9121 taaacttttt gaagtttcag aggtgtattt tttttttgta tatatgtctg tgtgattgta
     9181 ttgttttgtt tctaaatata caaggaattc tttaaataga gaaaaaggtt aatcctcact
     9241 gaaacaccag gatgcccact ggatatacta atctgaacat ctgtaggtag tttgtcatga
     9301 aaaagtggag agaagatgag acttttgaat gaatgaaaaa gggtatcttg atacccagaa
     9361 ttccccccaa agtacgggta attcaacctg cacagttttc tttcactcaa agtgttcagc
     9421 acttgtgagt gaaaaatcat gtaattatct gtaaatatgt agctaacaaa ttgacctagt
     9481 ttctgtattt ttttgttttt gtactaaagt ttataggtct gtgccagcta gagagaagtt
     9541 gctgtcatta ccagttgtgg tcctagcatc taaccctgaa accatcctag gtgacatttt
     9601 tagaattaat acttaaatgt taaacagggg gaaatgaagc ttaatcatgg tcaggtttga
     9661 gatcttttgc agtgaaataa ttttatttaa tataaatgat cacatgtcct caatcatgaa
     9721 tgaggtaggg agcctctctc ccccagtggc catgtttaca aaagtgtgtt ttgtctataa
     9781 agtgcaagtg ttttaatgtt tatgtaaatt atgcaggtga taacatggtt tggaactgtt
     9841 tattgggctc tttaactgaa ttttcaaatg aaatgaacta tgcttattgc tggcacattg
     9901 atcccatttc tggaacattt ttcctatttc cagagttaca tatgttcttt tgtcattacc
     9961 caatttaacc tccctttctc tgatatgcct tgtagccaaa gtattaaagg ctgatgaaca
    10021 tagacaaggg aaatgcattt cttagaaatc cgtgaaccct cagttgtatg ctttcagtac
    10081 tcgtgttaat atgtttctat ggcaactctg aggtcagtgg tttagaaatg agataccagt
    10141 gttaatgaaa agtgtgtgct ctttgctttt gcatggcttg gcttagtatc caaggtatat
    10201 tagggccact tgaaagcatg aagaccagtt atatagggaa caggtttctc tcagtggcac
    10261 attttgcttt ttctgagccc caaatacatt gcctgggcat gaacattgtt accgtaaatt
    10321 gcacatggtc atggactgaa ttatgtgact ttaaaggatg taactgccca acatttgcag
    10381 attctgggtg gtctatgtga ccatttgtct cgtatccaaa aaccccgggg ctattggaac
    10441 ccttccaaca ctttttcctt tgtcatagac aagtttatat ataacttacc aagatgttgg
    10501 ctgtcctggt gtattgccag acagctctct tttggttccc attccaaatg tgctgctgtc
    10561 cttctttgca tttcacaata tcaaagaaac caccaccctt cttcctaaca gcattttatg
    10621 ccttttattc cacattaaat gggaattgtg cctacttagg agtgcccctc caattaatta
    10681 catgtgtcca agaataatcc aagctagaga cacaaggtgg gaaaacattt caaaaaaaaa
    10741 aagtcctctt aaggccagta atttatctga aaaggtattt tatcacacct tgacacctta
    10801 tatatgagcc tattaggagc tgcaggtggt ttcatagggt aaaatccaag aaaagagaag
    10861 gatgtgtggg gtttctatta gaagataatt ttgttctcat tttacctttt cttttatgat
    10921 ccttctctgc tagaacaggt taattctcca aatttgtttt gttttgtttt gttatttttt
    10981 agggaactct tttgcaaaag caatggtcgg atgtaaataa catttaaagt atagtgcaca
    11041 taacttcccc ggactgttcc aatctgataa tttgtaaatg ctttagagtt tttttaatta
    11101 acacttgtgt tgctaaattc tatttatgta agtctgctaa agttttttag cccacttaaa
    11161 acttaagaca accatttaaa ataatggatg ggttactatg agcaatttcg ctttcagaac
    11221 ccccttgttt tagtatatga aaaagcctaa tgcgcattaa tgaggttgaa gagactatga
    11281 gaaatatgta tagtgtatat tttaaaacag ctttgcttgt attgtgaaga tttaaaaaca
    11341 aacttgagat ttttaacgta actattaaca cagttttaac ataagttatc ccactgggtt
    11401 taagagcatc ttgaatgtat aatccttttt gtaacccagg ttggtttcta cttttaccag
    11461 tcacccaaac atatttatgt ttttagtttt atgtactcat ttccctttgt tttcctcaaa
    11521 cagcatgatt tttttgcaca tgtagaaatt ttttaaaaga aagaaattag tacatcattt
    11581 tctctggatt ttcttcactt ccctcttcct ttctactaac tccttcctta aaggccatat
    11641 cactccattt gcattatttg tgcaaatgcc agggttggtt tttattttta tttttgctat
    11701 ttacctaaaa aaagaaaatg cttcagtcaa ttgctttttt atttaaaaaa aaaaagaaaa
    11761 aaagctgtaa ccttatcatt tctgagtaga ccattgagcg atgaatgcac acctgtagta
    11821 gcccaggacc agctgtggtg gctaaaggga atatgttaat taagcaagag gttcttttct
    11881 aaaagtggta tctgttatcc acaatgtatt ttagttattc ccacaagtca ggggtccaga
    11941 taaaatgagg gttatcagct aactgatatg ctatcattga ggttcatcaa tgaatttgta
    12001 catttctagt tccctttggt gaagggaaaa atgatgattt tgcaagacct agattttggc
    12061 ttggtttctt gcctcctttt ttggcagcct tcatcttctc atctcccaaa ccccctgagc
    12121 ccgtagggtt ttcatagtgg acaaagaact tgtggtcttt taaaactggg actgatactt
    12181 ttttgagaga gtatcgtgtc gaaagtgtga tgttctacca ctttaccaat aactaatttt
    12241 aaatacacat tgtcctctcg atttttggac caaacagacg ctcacagtgg aggcttatca
    12301 agggttgcat tggggaagaa gcctctccct ctctgtcagc accagctggt aaaggtgact
    12361 gtacagatgt gcattttcct tttggtataa atggtccaca gcactaactg gtaaggctta
    12421 ttgtacagta tattgtcagt attcttctgg ttcagcatac cttatagttc atatataacc
    12481 tgtattaatt gtatagattg tgcattaaaa gctgttacca agttgtcaga acataagagc
    12541 gaaaacaagg tcatatgtaa tattttgttt gtaagtatcc tttgtatcat agcaaaggaa
    12601 atgtttaaaa aaatcaactg taataaagta attttagtac aca
//
