LOCUS       NM_001199135            2098 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TRAF family member associated NFKB activator (TANK),
            transcript variant 3, mRNA.
ACCESSION   NM_001199135
VERSION     NM_001199135.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2098)
  AUTHORS   Li,S., Guo,Y., Hu,H., Gao,N., Yan,X., Zhou,Q. and Liu,H.
  TITLE     TANK shapes an immunosuppressive microenvironment and predicts
            prognosis and therapeutic response in glioma
  JOURNAL   Front Immunol 14, 1138203 (2023)
   PUBMED   37215097
  REMARK    GeneRIF: TANK shapes an immunosuppressive microenvironment and
            predicts prognosis and therapeutic response in glioma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2098)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2098)
  AUTHORS   Sui,L., Zhao,Y., Wang,W., Wu,P., Wang,Z., Yu,Y., Hou,Z., Tan,G. and
            Liu,Q.
  TITLE     SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production
            Through Ubiquitin-Mediated Degradation of TBK1
  JOURNAL   Front Immunol 12, 662989 (2021)
   PUBMED   34084167
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2098)
  AUTHORS   Mazzone,P., Congestri,M., Scudiero,I., Polvere,I., Voccola,S.,
            Zerillo,L., Telesio,G., Vito,P., Stilo,R. and Zotti,T.
  TITLE     UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes through
            Functional Interaction with the CARD14/CARMA2sh-TANK Complex
  JOURNAL   Int J Mol Sci 21 (24), 9365 (2020)
   PUBMED   33316896
  REMARK    GeneRIF: UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes
            through Functional Interaction with the CARD14/CARMA2sh-TANK
            Complex.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2098)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2098)
  AUTHORS   Nomura,F., Kawai,T., Nakanishi,K. and Akira,S.
  TITLE     NF-kappaB activation through IKK-i-dependent I-TRAF/TANK
            phosphorylation
  JOURNAL   Genes Cells 5 (3), 191-202 (2000)
   PUBMED   10759890
REFERENCE   7  (bases 1 to 2098)
  AUTHORS   Pomerantz,J.L. and Baltimore,D.
  TITLE     NF-kappaB activation by a signaling complex containing TRAF2, TANK
            and TBK1, a novel IKK-related kinase
  JOURNAL   EMBO J 18 (23), 6694-6704 (1999)
   PUBMED   10581243
REFERENCE   8  (bases 1 to 2098)
  AUTHORS   Chin,A.I., Shu,J., Shan Shi,C., Yao,Z., Kehrl,J.H. and Cheng,G.
  TITLE     TANK potentiates tumor necrosis factor receptor-associated
            factor-mediated c-Jun N-terminal kinase/stress-activated protein
            kinase activation through the germinal center kinase pathway
  JOURNAL   Mol Cell Biol 19 (10), 6665-6672 (1999)
   PUBMED   10490605
REFERENCE   9  (bases 1 to 2098)
  AUTHORS   Kaye,K.M., Devergne,O., Harada,J.N., Izumi,K.M., Yalamanchili,R.,
            Kieff,E. and Mosialos,G.
  TITLE     Tumor necrosis factor receptor associated factor 2 is a mediator of
            NF-kappa B activation by latent infection membrane protein 1, the
            Epstein-Barr virus transforming protein
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 11085-11090 (1996)
   PUBMED   8855313
REFERENCE   10 (bases 1 to 2098)
  AUTHORS   Rothe,M., Xiong,J., Shu,H.B., Williamson,K., Goddard,A. and
            Goeddel,D.V.
  TITLE     I-TRAF is a novel TRAF-interacting protein that regulates
            TRAF-mediated signal transduction
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8241-8246 (1996)
   PUBMED   8710854
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009313.4 and AC009299.5.
            
            On May 17, 2019 this sequence version replaced NM_001199135.2.
            
            Summary: The TRAF (tumor necrosis factor receptor-associated
            factor) family of proteins associate with and transduce signals
            from members of the tumor necrosis factor receptor superfamily. The
            protein encoded by this gene is found in the cytoplasm and can bind
            to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by
            sequestering the TRAFs in a latent state in the cytoplasm. For
            example, the protein encoded by this gene can block TRAF2 binding
            to LMP1, the Epstein-Barr virus transforming protein, and inhibit
            LMP1-mediated NF-kappa-B activation. Three alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (3) has an alternate 5' UTR exon
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.241497.1,
                                           SRR1660807.157603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392749.7/ ENSP00000376505.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC009313.4         128722-128780
            60-207              AC009313.4         147908-148055
            208-316             AC009299.5         100-208
            317-435             AC009299.5         1288-1406
            436-512             AC009299.5         20528-20604
            513-628             AC009299.5         21244-21359
            629-1209            AC009299.5         27584-28164
            1210-2098           AC009299.5         31955-32843
FEATURES             Location/Qualifiers
     source          1..2098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..2098
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /note="TRAF family member associated NFKB activator"
                     /db_xref="GeneID:10010"
                     /db_xref="HGNC:HGNC:11562"
                     /db_xref="MIM:603893"
     exon            1..59
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            60..207
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1386
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /note="isoform a is encoded by transcript variant 3; TRAF
                     family member-associated NF-KAPPA-B activator;
                     TRAF-interacting protein"
                     /codon_start=1
                     /product="TRAF family member-associated NF-kappa-B
                     activator isoform a"
                     /protein_id="NP_001186064.1"
                     /db_xref="CCDS:CCDS2215.1"
                     /db_xref="GeneID:10010"
                     /db_xref="HGNC:HGNC:11562"
                     /db_xref="MIM:603893"
                     /translation="MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKTENYEQRIREQ
                     QEQLSLQQTIIDKLKSQLLLVNSTQDNNYGCVPLLEDSETRKNNLTLDQPQDKVISGI
                     AREKLPKVRRQEVSSPRKETSARSLGSPLLHERGNIEKTFWDLKEEFHKICMLAKAQK
                     DHLSKLNIPDTATETQCSVPIQCTDKTDKQEALFKPQAKDDINRGAPSITSVTPRGLC
                     RDEEDTSFESLSKFNVKFPPMDNDSTFLHSTPERPGILSPATSEAVCQEKFNMEFRDN
                     PGNFVKTEETLFEIQGIDPIASAIQNLKTTDKTKPSNLVNTCIRTTLDRAACLPPGDH
                     NALYVNSFPLLDPSDAPFPSLDSPGKAIRGPQQPIWKPFPNQDSDSVVLSGTDSELHI
                     PRVCEFCQAVFPPSITSRGDFLRHLNSHFNGET"
     exon            208..316
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..435
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..512
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..628
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..1209
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..2098
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2023..2028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /note="hexamer: ATTAAA"
     polyA_site      2040
                     /gene="TANK"
                     /gene_synonym="I-TRAF; ITRAF; TRAF2"
                     /note="major polyA site"
ORIGIN      
        1 actcggccag gcgccggcga cctgagggga gagggaacgc agctgaaagc gtgaactgta
       61 cctgtcattt actccatcct ttatagtgat gctacaggac gaagaggaat ggataaaaac
      121 attggcgagc aactcaataa agcgtatgaa gccttccggc aggcatgcat ggatagagat
      181 tctgcagtaa aagaattaca gcaaaagact gagaactatg agcagagaat acgtgaacaa
      241 caggaacagc tgtcacttca acagactatt attgacaagc taaaatctca gttacttctt
      301 gtgaattcca ctcaagataa caattatggc tgtgttcctc tgcttgaaga cagtgaaaca
      361 agaaagaata atttgactct tgatcagcca caagataaag tgatttcagg aatagcaaga
      421 gaaaaactac caaaggtaag aagacaagag gtttcttctc ctagaaaaga aacttcagca
      481 aggagtcttg gcagtccttt gctccatgaa aggggtaata tagagaagac tttctgggat
      541 ctgaaagaag aatttcataa aatatgcatg ctagcaaaag cacagaaaga ccacttaagc
      601 aaacttaata taccagacac tgcaactgaa acacagtgct ctgtgcctat acagtgtacg
      661 gataaaacag ataaacaaga agcgctgttt aagcctcagg ctaaagatga tataaataga
      721 ggtgcaccat ccatcacatc tgtcacacca agaggactgt gcagagatga ggaagacacc
      781 tcttttgaat cactttctaa attcaatgtc aagtttccac ctatggacaa tgactcaact
      841 ttcttacata gcactccaga gagacccggc atccttagtc ctgccacgtc tgaggcagtg
      901 tgccaagaga aatttaatat ggagttcaga gacaacccag ggaactttgt taaaacagaa
      961 gaaactttat ttgaaattca gggaattgac cccatagctt cagctataca aaaccttaaa
     1021 acaactgaca aaacaaagcc ctcaaatctc gtaaacactt gtatcaggac aactctggat
     1081 agagctgcgt gtttgccacc tggagaccat aatgcattat atgtaaatag cttcccactt
     1141 ctggacccat ctgatgcacc ttttccctca ctcgattccc cgggaaaagc aatccgagga
     1201 ccacagcagc ccatttggaa gccctttcct aatcaagaca gtgactcggt ggtactaagt
     1261 ggcacagact cagaactgca tatacctcga gtatgtgaat tctgtcaagc agttttccca
     1321 ccatccatta catccagggg ggatttcctt cggcatctta attcacactt caatggagag
     1381 acttaagaca catttgaaaa cagacatatc aagttctatg tgatgatttt gggtttttaa
     1441 tactataaat acttgattgt aaactaaatt caagatcatt tataggaaaa tctagtttca
     1501 cagctatttg aatttttttc tggatttact atataactct tattttttaa aagatcattc
     1561 tgttctttca aggagaaata agcctaaaag aagaaaaaca aaaaaaattc tgtataaaac
     1621 tgtaatcctt tgtattcatg tttacagtgc tattactata attcaaaatt atgtatgtga
     1681 cttagagtta tataatcata atttatgttt atttcaaata tctaagttta ttgcttggat
     1741 ttctagtgag agctgttgaa tttggtgatg tcaaatgttt ctagggtttt tttagtttgt
     1801 ttttattgaa aaatttaatt atttatgcta taggtgatat tctctttgaa taaacctata
     1861 atagaaaata gcagacaaca taaacatctt tgtaaatatc aaacctaata catttcttgt
     1921 ccagtgataa aacaactggt agaattattt aaacacttta gatttttaaa taatatacat
     1981 ggctttaatt tttactgtgt gtatagctac atgatgaaat taattaaata ttaagaggta
     2041 cttatgttgt gatcatttgt atgtcctttg ttcctgagta aaaaaaaaaa aaaaaaaa
//
