LOCUS       NM_033394               7501 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tetratricopeptide repeat, ankyrin repeat and
            coiled-coil containing 1 (TANC1), transcript variant 1, mRNA.
ACCESSION   NM_033394 XM_043492
VERSION     NM_033394.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7501)
  AUTHORS   Wu,D., Li,Y., Ren,Q., Pei,S., Wang,L., Yang,L., Chong,Y., Sun,S.,
            Hao,J. and Feng,F.
  TITLE     TANC1 methylation as a novel biomarker for the diagnosis of
            patients with anti-tuberculosis drug-induced liver injury
  JOURNAL   Sci Rep 11 (1), 17423 (2021)
   PUBMED   34465797
  REMARK    GeneRIF: TANC1 methylation as a novel biomarker for the diagnosis
            of patients with anti-tuberculosis drug-induced liver injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7501)
  AUTHORS   Yang,Q., Liu,H., Li,Z., Wang,Y. and Liu,W.
  TITLE     Purification and mutagenesis studies of TANC1 ankyrin repeats
            domain provide clues to understand mis-sense variants from diseases
  JOURNAL   Biochem Biophys Res Commun 514 (2), 358-364 (2019)
   PUBMED   31040020
  REMARK    GeneRIF: mis-sense variants tested in this study may either affect
            protein folding or disrupt the interaction between TANC1/2 AR
            domains and their binding partners
REFERENCE   3  (bases 1 to 7501)
  AUTHORS   Sundell,G.N., Arnold,R., Ali,M., Naksukpaiboon,P., Orts,J.,
            Guntert,P., Chi,C.N. and Ivarsson,Y.
  TITLE     Proteome-wide analysis of phospho-regulated PDZ domain interactions
  JOURNAL   Mol Syst Biol 14 (8), e8129 (2018)
   PUBMED   30126976
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7501)
  AUTHORS   Fachal,L., Gomez-Caamano,A., Barnett,G.C., Peleteiro,P.,
            Carballo,A.M., Calvo-Crespo,P., Kerns,S.L., Sanchez-Garcia,M.,
            Lobato-Busto,R., Dorling,L., Elliott,R.M., Dearnaley,D.P.,
            Sydes,M.R., Hall,E., Burnet,N.G., Carracedo,A., Rosenstein,B.S.,
            West,C.M., Dunning,A.M. and Vega,A.
  TITLE     A three-stage genome-wide association study identifies a
            susceptibility locus for late radiotherapy toxicity at 2q24.1
  JOURNAL   Nat Genet 46 (8), 891-894 (2014)
   PUBMED   24974847
REFERENCE   5  (bases 1 to 7501)
  AUTHORS   Avirneni-Vadlamudi,U., Galindo,K.A., Endicott,T.R., Paulson,V.,
            Cameron,S. and Galindo,R.L.
  TITLE     Drosophila and mammalian models uncover a role for the myoblast
            fusion gene TANC1 in rhabdomyosarcoma
  JOURNAL   J Clin Invest 122 (1), 403-407 (2012)
   PUBMED   22182840
REFERENCE   6  (bases 1 to 7501)
  AUTHORS   Granot-Hershkovitz,E., Raas-Rothschild,A., Frumkin,A., Granot,D.,
            Silverstein,S. and Abeliovich,D.
  TITLE     Complex chromosomal rearrangement in a girl with
            psychomotor-retardation and a de novo inversion: inv(2)(p15;q24.2)
  JOURNAL   Am J Med Genet A 155A (8), 1825-1832 (2011)
   PUBMED   21739571
REFERENCE   7  (bases 1 to 7501)
  AUTHORS   Aouizerat,B.E., Vittinghoff,E., Musone,S.L., Pawlikowska,L.,
            Kwok,P.Y., Olgin,J.E. and Tseng,Z.H.
  TITLE     GWAS for discovery and replication of genetic loci associated with
            sudden cardiac arrest in patients with coronary artery disease
  JOURNAL   BMC Cardiovasc Disord 11, 29 (2011)
   PUBMED   21658281
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7501)
  AUTHORS   Suzuki,T., Li,W., Zhang,J.P., Tian,Q.B., Sakagami,H., Usuda,N.,
            Kondo,H., Fujii,T. and Endo,S.
  TITLE     A novel scaffold protein, TANC, possibly a rat homolog of
            Drosophila rolling pebbles (rols), forms a multiprotein complex
            with various postsynaptic density proteins
  JOURNAL   Eur J Neurosci 21 (2), 339-350 (2005)
   PUBMED   15673434
  REMARK    GeneRIF: Discusses cloning and expression of Rat TANC1 and
            preliminary cloning of human TANC1, which resulted in recovery of a
            partial cDNA.
            Erratum:[Eur J Neurosci. 2005 Feb;21(3):825. Usada, Nobuteru
            [corrected to Usuda, Nobuteru]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC037329.1, AK128859.1, AC009307.4, BC150597.1, BX648327.1 and
            AL833258.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033394.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.84494.1,
                                           SRR1660805.205801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263635.8/ ENSP00000263635.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-631               BC037329.1         6-636
            632-1012            AK128859.1         632-1012
            1013-1020           AC009307.4         47509-47516
            1021-1397           BC037329.1         708-1084
            1398-2098           BC150597.1         1221-1921
            2099-2253           BC037329.1         1786-1940
            2254-2473           AC009307.4         62803-63022
            2474-5173           BX648327.1         1740-4439
            5174-6938           AC009307.4         114496-116260
            6939-7501           AL833258.1         1095-1657
FEATURES             Location/Qualifiers
     source          1..7501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..7501
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /note="tetratricopeptide repeat, ankyrin repeat and
                     coiled-coil containing 1"
                     /db_xref="GeneID:85461"
                     /db_xref="HGNC:HGNC:29364"
                     /db_xref="MIM:611397"
     exon            1..143
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            144..253
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            254..329
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..5854
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rolling pebbles homolog B; TPR domain, ankyrin-repeat and
                     coiled-coil-containing; protein TANC1; tetratricopeptide
                     repeat, ankyrin repeat and coiled-coil domain-containing
                     protein 1"
                     /codon_start=1
                     /product="protein TANC1 isoform 1"
                     /protein_id="NP_203752.2"
                     /db_xref="CCDS:CCDS42766.1"
                     /db_xref="GeneID:85461"
                     /db_xref="HGNC:HGNC:29364"
                     /db_xref="MIM:611397"
                     /translation="MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSS
                     LPTAEDTYRVSLAKGVSMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPG
                     DAVIMPFREVAKPTEPDEHEAKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIED
                     KNETMCTALSQGISPCSTLTSSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSST
                     LESKDSGIIATITSSSENDDRSGSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEE
                     TTGSAESTLPKAESSAGDGPVPYSQGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNA
                     PLRTSIRLPWHNTAGGRAQEVKARFAPYKPQDILLKPLLFEVPSITTDSVFVGRDWLF
                     HQIEENLRNTELAENRGAVVVGNVGFGKTAIISKLVALSCHGSRMRQIASNSPGSSPK
                     TSDPTQDLHFTPLLSPSSSTSASSTAKTPLGSISAENQRPREDAVKYLASKVVAYHYC
                     QADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQLQSMLSLRSCVQDPVAAFK
                     RGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFHKPDYGDTLSSFITKIISKFPAWLK
                     LIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDLHAYVQHRVHSSQDILSNISLNG
                     KADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYKVVPVSLSELYLLQ
                     CNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAGHIQGEQGWEDFQQRMDAL
                     SCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGHALLAFMFSRQEGKLNR
                     QQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSAALASLRNLYTPNVK
                     VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTAL
                     CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP
                     QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG
                     RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR
                     TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI
                     DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVA
                     LLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFP
                     REGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARAR
                     AKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRSQQQKQQGPLPAPL
                     NDSENEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQPSSSVPSSYIRNLQEG
                     LQSKGRPVSPQSRAGIGKSLREPVAQPGLLLQPSKQAQIVKTSQHLGSGQSAVRNGSM
                     KVQISSQNPPPSPMPGRIAATPAGSRTQHLEGTGTFTTRAGCGHFGDRLGPSQNVRLQ
                     CGENGPAHPLPSKTKTTERLLSHSSVAVDAAPPNQGGLATCSDVRHPASLTSSGSSGS
                     PSSSIKMSSSTSSLTSSSSFSDGFKVQGPDTRIKDKVVTHVQSGTAEHRPRNTPFMGI
                     MDKTARFQQQSNPPSRSWHCPAPEGLLTNTSSAAGLQSANTEKPSLMQVGGYNNQAKT
                     CSVSTLSASVHNGAQVKELEESKCQIPVHSQENRITKTVSHLYQESISKQQPHISNEA
                     HRSHLTAAKPKRSFIESNV"
     exon            330..527
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            528..632
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            633..763
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            764..950
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1214
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1337
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1619
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1771
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..2003
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2170
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2778
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2887
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3010
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3247
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3433
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3512
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3646
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3770
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3946
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4079
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            4080..4171
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            4172..4318
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..4419
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..7501
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7482..7487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /note="hexamer: AATAAA"
     polyA_site      7501
                     /gene="TANC1"
                     /gene_synonym="ROLSB; TANC"
                     /note="major polyA site"
ORIGIN      
        1 ggctttgctg tggcagctgc tggagcggcg gccgcctcgg gagccggagg agaggcagcc
       61 gcggagcgcc gagctggcct cgccccgagg cccggccctg ggtgtgggga accgcgctga
      121 ggagctggaa actttcccgg caggagctga ctgctgggca ggaacgtctc tcaggagaaa
      181 gagtggaaga gaaaattgtg aactaaggcc ccctgccccc ttttcctggt gcatgtgaag
      241 ttatcaaaaa cagaaacaag tgttgaaaat gttaaaggct gtgctgaaga agagccgaga
      301 gggaggaaag ggaggcaaga aggaagcagg aagtgacttt ggtccagaga cttctccagt
      361 cctgcacctt gaccacagtg ctgactctcc tgtgagcagt cttcccacag cagaggacac
      421 ctatagggtg agcttggcca aaggtgtctc gatgtctctg ccttcctcac ctttgctgcc
      481 tcgacagtct cacttggtgc aatcaagagt gaacaaaaaa tccccaggtc ccgtcaggaa
      541 gcccaagtat gtggaaagcc ccagagtgcc tggagatgca gttataatgc cattcagaga
      601 agtagccaag ccaacagagc ctgatgagca tgaagcaaag gccgataatg aaccgagctg
      661 ttcgccggca gctcaagaac tgttgacaag gctgggattt ttactgggag aagggatccc
      721 aagtgccaca cacataacca ttgaagacaa aaatgaaacc atgtgcacag ctctgagtca
      781 aggcatcagt ccttgctcca cactaacaag cagcaccgca tctcctagca ccgatagccc
      841 ctgctcaacc ttgaatagct gtgtcagcaa gacggcagcc aacaaaagtc cctgtgagac
      901 cattagcagc cctagttcca ccctggaaag caaggacagt ggaattatag ccacaattac
      961 aagttcatcc gaaaatgatg accggagtgg ctccagtttg gaatggaata aagatggaaa
     1021 cctaagatta ggggttcaga agggagtgct tcatgaccgc agggcagata actgctcccc
     1081 agtggcagaa gaggagacca ccgggtcagc agagagcacg ctgcccaaag cagaatcctc
     1141 agctggagat ggtccagtcc cttattctca gggctccagc tcactaataa tgccacggcc
     1201 caactcagtt gcagcaacaa gctcaaccaa attggaagat ctgagttatt tagacgggca
     1261 gagaaatgct cctctacgga cgtcaattag attaccatgg cacaatacgg ccggaggtag
     1321 ggcacaggaa gttaaagcac gatttgctcc ctacaagcca caagacattt tgttgaaacc
     1381 cttgttgttt gaagtaccaa gcataacaac agactctgtg tttgtgggaa gggattggct
     1441 ctttcaccag atagaagaaa acttgaggaa cacagaactg gcagaaaaca gaggcgcggt
     1501 ggtggttggc aatgtgggat ttgggaagac ggcaatcatt tccaagttgg tggccctgag
     1561 ctgccacgga agccgcatga ggcagattgc ttccaacagc ccgggttcat cacctaaaac
     1621 ctctgacccc actcaggatc ttcatttcac tccgttgctt tcaccgagtt cttccacaag
     1681 tgcttccagc acagctaaaa cacctcttgg gtctatcagt gctgaaaacc agagaccaag
     1741 agaggatgca gtgaaatatc ttgcttctaa ggtggtggcc taccactact gccaggctga
     1801 caacacgtac acttgcctgg tgcccgagtt tgtgcacagc atcgcagctt tgctctgccg
     1861 gtcccatcag ctggccgcct acagagacct tctgataaag gagccccaac tacagagcat
     1921 gctgagcctc cgatcctgtg tgcaggaccc ggtggcagct ttcaagaggg gagtgctgga
     1981 gccactcaca aacctgagaa atgagcagaa aattcctgaa gaagaataca ttattttgat
     2041 agatggctta aatgaagctg agtttcataa acctgattat ggagatacgc tttcttcatt
     2101 tattaccaaa attatttcta aatttcctgc ctggttgaag ttgattgtga ctgtaagagc
     2161 aaattttcag gaaatcataa gtgcgctgcc atttgtcaag ctttccttag atgacttccc
     2221 agacaacaaa gacatccaca gtgacctgca cgcctacgtc cagcacaggg tgcacagcag
     2281 ccaggacatc ctcagcaaca tctccctgaa tggcaaggcc gatgccacac tcattggaaa
     2341 agtgagcagc cacctggtgc tgcggagcct cggctcctac ctgtacctca agctcaccct
     2401 ggaccttttc cagaggggcc acttggtcat taagagtgcc agctacaagg tggtgcccgt
     2461 gtctctctct gagctctatt tgcttcagtg caacatgaag ttcatgaccc agtccgcctt
     2521 tgagagggca cttccgattc tcaacgtggc cctcgcatcc ctccacccca tgacagacga
     2581 gcagatcttt caggctatta atgctggcca catccagggg gagcagggat gggaagactt
     2641 tcagcagagg atggacgccc tctcctgctt cctcattaag aggcgagaca aaacccgcat
     2701 gttctgccac ccgtccttca gggagtggct tgtatggaga gcagacgggg aaaacacggc
     2761 cttcctgtgt gagcccagga acgggcacgc gctcttggca ttcatgttct cgcgtcagga
     2821 gggcaagttg aaccgccagc agaccatgga gcttggccac cacatcctga aggcgcacat
     2881 tttcaagggc ctcagtaaga agacgggaat ttcttcaagc catctccaag ccctgtggat
     2941 cggctacagc accgaggggc tgtccgccgc cctggcctct ctcaggaatc tctatactcc
     3001 caacgtgaag gtgagccgtc tcctgatttt gggaggggcc aacgtgaact acaggacaga
     3061 agtgttaaat aatgccccaa tcctgtgcgt ccagtctcac cttggccacg aggaagttgt
     3121 cactctgctc ctggaatttg gtgcctgcct ggacggaacg tcagagaacg gcatgactgc
     3181 cctctgttac gcagcagctg ctggccacat gaagctggtg tgtctgctga ccaagaaggg
     3241 agtgagagtg gaccacttgg ataagaaggg ccagtgtgcg cttgtccaca gtgccctacg
     3301 gggccacggt gacattctcc agtacctgct gacttgtgag tggtcgccgg gtcctcccca
     3361 gccaggcacc ctgaggaaga gccacgccct gcagcaggcg ctgaccgcgg cggccagcat
     3421 gggccacagc tcggtggtcc agtgcttgct ggggatggag aaggaacatg aagtagaagt
     3481 caatggcacc gacacattgt ggggagaaac agccctgact gccgccgcag gaagagggaa
     3541 gctggaggtc tgtgagctgc tgctggggca tggagctgct gtgtcgcgga caaacaggag
     3601 aggggttcca cctttgtttt gtgcagcacg ccaggggcat tggcagattg ttagactgct
     3661 gttggaacgc ggctgtgatg tgaacctaag tgacaagcaa ggccggacgc ccctcatggt
     3721 ggctgcttgt gaagggcact tgagcaccgt ggaattcctc ctttcaaaag gtgcagccct
     3781 ttcttctcta gacaaagagg gtctgtcagc attaagctgg gcttgtctga aaggtcacag
     3841 ggcagtggtc cagtatctgg ttgaagaagg agctgcaata gaccagacag acaagaatgg
     3901 ccgcacaccc ttggacctgg ctgccttcta tggcgatgcc gagactgtgc tgtacctggt
     3961 ggagaaggga gccgtgatcg agcatgtgga ccacagcggg atgcggccct tggacagagc
     4021 catcggctgc cggaacacat ctgtagtggt ggcgctactc agaaagggag ccaagttagg
     4081 aaatgctgct tgggcgatgg ccacttccaa acctgatatc ttgattatac ttttacagaa
     4141 attaatggag gaaggaaatg tgatgtacaa aaaagggaaa atgaaagagg cagcccagag
     4201 gtaccagtat gccttaagaa agtttcctcg agaaggattc ggagaggaca tgagaccctt
     4261 caatgaatta agggtttccc tctatctcaa tttgtcgcga tgccgaagaa aaacaaatga
     4321 ctttggcatg gcagaggaat ttgcttccaa ggctctcgaa ttgaagccca agtcctatga
     4381 agccttttat gccagagcaa gagcgaagag aaatagcagg caattcgtgg cagctctggc
     4441 tgacctgcaa gaggctgtga aactctgtcc caccaatcag gaagtcaaga ggcttctggc
     4501 ccgcgtagaa gaggagtgca aacaactcca gaggagtcaa cagcaaaaac agcagggccc
     4561 gctaccagct ccactcaacg actccgagaa cgaagaggac accccaaccc ctggcttaag
     4621 tgaccacttt cactctgagg agactgaaga ggaagaaact tctccccagg aagaatctgt
     4681 ttccccaact cccaggtccc agccatcctc atctgtccct tcctcataca tccgaaacct
     4741 tcaagaaggg ttacagtcca aaggaaggcc ggtatcgcca cagagcaggg caggaatcgg
     4801 caagtccctg agagagcctg tggcccagcc agggctgctc ctgcagccct ccaagcaggc
     4861 ccagatcgtg aaaaccagcc agcacctggg ctctggccag tcggcagtga gaaatggcag
     4921 tatgaaagtt cagatctctt ctcagaaccc tcctccaagt cccatgccag ggagaatcgc
     4981 tgccactcct gctgggagca gaacccagca tttagaggga acaggtactt tcactacaag
     5041 agctggttgt ggccactttg gggatcggct gggccccagc cagaatgtcc gcctgcagtg
     5101 tggtgagaat ggccctgcac accctttacc aagtaagacg aaaaccacag agaggcttct
     5161 gtctcattcc tccgtggctg tggacgcagc ccctccaaac caaggtgggc tggcgacctg
     5221 cagcgacgtg cgacacccag cttccctcac cagctcaggc tcttctggtt ctccatccag
     5281 cagcataaag atgtcaagtt caaccagtag tttgacttcg agcagcagtt tttcagatgg
     5341 cttcaaggtc caaggaccag atactagaat taaagacaag gttgtaaccc acgttcagag
     5401 cggtacagct gagcacagac cccgcaacac gccgttcatg ggcatcatgg ataagactgc
     5461 gaggttccaa cagcagagca atcctccaag ccgcagctgg cactgtccgg caccagaggg
     5521 gctgctgaca aacacgtctt ctgcagctgg cctgcagtct gctaacactg agaagccctc
     5581 tctcatgcaa gtgggaggat ataataacca agccaaaacc tgttctgttt ctaccctgag
     5641 tgcaagtgtc cacaatgggg cacaagtgaa ggagctagaa gaaagcaagt gccaaattcc
     5701 agtccactct caagagaaca ggataactaa gactgtttct catctgtacc aggaaagtat
     5761 ctccaaacag cagcctcata ttagtaatga agcccacagg agccacctca ctgcagccaa
     5821 accaaagcga tcatttatag agtcaaatgt gtgaacctta agaaatcccc atttgtggaa
     5881 tttggaaacg tgtgttgact cctggtggta aattaaatag tttttttcat cagaaaaatt
     5941 attttttagc catttttttt ctttggggtg gatctgatgc cattgatata tctaaaatgt
     6001 gggataaaac ttctttaata gctagaaatc accataaata agaatgctaa acagaattga
     6061 aaattatatc aacttaaaat tttaagacag cccagaagac attaatgact ctcacttatg
     6121 aaattgtttg gcttttgcca ctttcttcct tgcctttgct atatggtaga atcacagaac
     6181 ttacttagag aataaatatg tctattgttc aagagtaaca ggtttaactc atgaccaagt
     6241 gatgtacatc caagtgatgt attctggaaa cgatggaatt ttacagttac agttccattg
     6301 agtcaaatcc cattttatat atacataaaa attaagttct gagtgagttc tagctaaata
     6361 taagtgcgac tgtaaacgca gccaattttt ttaagcagaa tatgagaaca cctaagtatt
     6421 ctcttcatag cagttcctat aaagggatta aacacttatt tctgtgttat ggttcttatt
     6481 catatatttt tatagcactt ttggaaccta tatttgtgct tgaaggtgtt tttgatattt
     6541 ggaaacagta taagccattt ggagtcatga ttggtggtca agtggattca agctaaaata
     6601 ctaagaccag cattcttagt ggcgcttata aattagctct cacctggttt ccaaactgct
     6661 tttaacaatg gtagtgctcc tggaacaatc cttccaagct cctctaagga caatatttaa
     6721 ttcagatact aaaggtaaga ctggttgtta cttttgtttt gttgtacaat tagtacttta
     6781 tagtcacatg ttgtatatat taaatagccc agttttattc agacttgtaa atagaactat
     6841 ttcaatgtag ttaatctaaa aacaaaaaag aaaaccccag tcacgatttg catgttctct
     6901 gtaagcttca tccatgctgg ttattgcact gaatgatata ttattagggc atgttaacag
     6961 tataccagta acagcacttt atctcattta tatgaacacc tttgaggtgc tacttaagtc
     7021 caagctctga tgtattattc atttgtaaag ataaggtaca ggaatgaacc ttggtttaaa
     7081 ggtattttta tatgaaaatg gtgtgttatt ggaagatgtt aaaatgctaa tttgagagaa
     7141 gtaggagtgt atctgtttta tatgttggga tgtgaaattt attttctaaa attgaggaga
     7201 aggaagttat atatttgcag aatgttttaa agtgaattgt tgtaatgaag ttcctgtgaa
     7261 catcattatg gttttgtaca aataggaacc tctgatgtca ttcttcaacg tttgttcctg
     7321 tgtgtacaat tgtactttgt atgaacagct ttatcatttt tataggcttt ccatgagttt
     7381 tgctgtaact actatggctt atttattttc tttaatattt gtgaaagtct tactcctttg
     7441 ttagttttgt ttctgcacaa ctactgtact tttccatatg gaataaagac tattaataga
     7501 a
//
