LOCUS       NM_001284401            1326 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens TAM41 mitochondrial translocator assembly and
            maintenance homolog (TAMM41), transcript variant 1, mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001284401 XM_005264874
VERSION     NM_001284401.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1326)
  AUTHORS   Ikari,N., Honjo,K., Sagami,Y., Nakamura,Y. and Arakawa,H.
  TITLE     Mieap forms membrane-less organelles involved in cardiolipin
            metabolism
  JOURNAL   iScience 27 (2), 108916 (2024)
   PUBMED   38322995
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1326)
  AUTHORS   Zhang,X., Farrell,J.J., Tong,T., Hu,J., Zhu,C., Wang,L.S.,
            Mayeux,R., Haines,J.L., Pericak-Vance,M.A., Schellenberg,G.D.,
            Lunetta,K.L. and Farrer,L.A.
  CONSRTM   Alzheimer's Disease Sequencing Project
  TITLE     Association of mitochondrial variants and haplogroups identified by
            whole exome sequencing with Alzheimer's disease
  JOURNAL   Alzheimers Dement 18 (2), 294-306 (2022)
   PUBMED   34152079
  REMARK    GeneRIF: Association of mitochondrial variants and haplogroups
            identified by whole exome sequencing with Alzheimer's disease.
REFERENCE   3  (bases 1 to 1326)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1326)
  AUTHORS   Blunsom,N.J., Gomez-Espinosa,E., Ashlin,T.G. and Cockcroft,S.
  TITLE     Mitochondrial CDP-diacylglycerol synthase activity is due to the
            peripheral protein, TAMM41 and not due to the integral membrane
            protein, CDP-diacylglycerol synthase 1
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (3), 284-298 (2018)
   PUBMED   29253589
REFERENCE   5  (bases 1 to 1326)
  AUTHORS   Floyd,B.J., Wilkerson,E.M., Veling,M.T., Minogue,C.E., Xia,C.,
            Beebe,E.T., Wrobel,R.L., Cho,H., Kremer,L.S., Alston,C.L.,
            Gromek,K.A., Dolan,B.K., Ulbrich,A., Stefely,J.A., Bohl,S.L.,
            Werner,K.M., Jochem,A., Westphall,M.S., Rensvold,J.W., Taylor,R.W.,
            Prokisch,H., Kim,J.P., Coon,J.J. and Pagliarini,D.J.
  TITLE     Mitochondrial Protein Interaction Mapping Identifies Regulators of
            Respiratory Chain Function
  JOURNAL   Mol Cell 63 (4), 621-632 (2016)
   PUBMED   27499296
REFERENCE   6  (bases 1 to 1326)
  AUTHORS   Kendler,K.S., Kalsi,G., Holmans,P.A., Sanders,A.R., Aggen,S.H.,
            Dick,D.M., Aliev,F., Shi,J., Levinson,D.F. and Gejman,P.V.
  TITLE     Genomewide association analysis of symptoms of alcohol dependence
            in the molecular genetics of schizophrenia (MGS2) control sample
  JOURNAL   Alcohol Clin Exp Res 35 (5), 963-975 (2011)
   PUBMED   21314694
REFERENCE   7  (bases 1 to 1326)
  AUTHORS   Gohil,V.M. and Greenberg,M.L.
  TITLE     Mitochondrial membrane biogenesis: phospholipids and proteins go
            hand in hand
  JOURNAL   J Cell Biol 184 (4), 469-472 (2009)
   PUBMED   19237595
  REMARK    Review article
REFERENCE   8  (bases 1 to 1326)
  AUTHORS   Tamura,Y., Harada,Y., Yamano,K., Watanabe,K., Ishikawa,D.,
            Ohshima,C., Nishikawa,S., Yamamoto,H. and Endo,T.
  TITLE     Identification of Tam41 maintaining integrity of the TIM23 protein
            translocator complex in mitochondria
  JOURNAL   J Cell Biol 174 (5), 631-637 (2006)
   PUBMED   16943180
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB475191.1, BC015088.2, AL561371.3, AL561480.3, AK092776.1 and
            BM678701.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001284401.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1079853.1, AL561371.3
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000455809.6/
                                                  ENSP00000398596.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DB475191.1         37-43
            8-369               BC015088.2         1-362
            370-955             AL561371.3         60-645
            956-1143            AL561371.3         647-834
            1144-1178           AL561480.3         110-144             c
            1179-1202           AL561371.3         870-893
            1203-1322           AK092776.1         2439-2558
            1323-1326           BM678701.1         15-18               c
FEATURES             Location/Qualifiers
     source          1..1326
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.2"
     gene            1..1326
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /note="TAM41 mitochondrial translocator assembly and
                     maintenance homolog"
                     /db_xref="GeneID:132001"
                     /db_xref="HGNC:HGNC:25187"
                     /db_xref="MIM:614948"
     exon            1..384
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1263
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /EC_number="2.7.7.41"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; MMP37-like protein, mitochondrial;
                     mitochondrial translocator assembly and maintenance
                     protein 41 homolog; CDP-DAG synthase; CDP-diacylglycerol
                     synthase; phosphatidate cytidylyltransferase,
                     mitochondrial; TAM41, mitochondrial translocator assembly
                     and maintenance protein, homolog"
                     /codon_start=1
                     /product="phosphatidate cytidylyltransferase,
                     mitochondrial isoform a precursor"
                     /protein_id="NP_001271330.1"
                     /db_xref="CCDS:CCDS68345.1"
                     /db_xref="GeneID:132001"
                     /db_xref="HGNC:HGNC:25187"
                     /db_xref="MIM:614948"
                     /translation="MALQTLQSSWVTFRKILSHFPEELSLAFVYGSGVYRQAGPSSDQ
                     KNAMLDFVFTVDDPVAWHSKNLKKNWSHYSFLKVLGPKIITSIQNNYGAGVYYNSLIM
                     CNGRLIKYGVISTNVLIEDLLNWNNLYIAGRLQKPVKIISVNEDVTLRSALDRNLKSA
                     VTAAFLMLPESFSEEDLFIEIAGLSYSGDFRMVVGEDKTKVLNIVKPNIAHFRELYGS
                     ILQENPQVVYKSQQGWLEIDKSPEGQFTQLMTLPKTLQQQINHIMDPPGKNRDVEETL
                     FQVAHDPDCGDVVRLGLSAIVRPSSIRQSTKGIFTAGLKKSVIYSSLKLHKMWKGWLR
                     KTS"
     exon            385..567
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /inference="alignment:Splign:2.1.0"
     exon            568..660
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /inference="alignment:Splign:2.1.0"
     exon            661..811
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /inference="alignment:Splign:2.1.0"
     exon            812..957
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1123
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1186
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1326
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1298..1303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /note="hexamer: AATAAA"
     polyA_site      1326
                     /gene="TAMM41"
                     /gene_synonym="C3orf31; COXPD56; RAM41; TAM41"
                     /note="major polyA site"
ORIGIN      
        1 acggaagctc tgcctgtgcg accgccgccc acccgagcct atctgggctg cgtcttctcg
       61 ccgctgctct tcgtggccca acgccccaat ccttgcgtgt gcttgcagtc ccaccccaca
      121 ctcagccttg tgtccctcga tccagtctcc gacttccatt tcccacccta aaccgcctac
      181 ccggtgtctg ttccccgccc ggttgtcctc gccctgctgc gctgagtgtc ccctgttagc
      241 ctcgacccca tggcgctgca gacgctgcag agctcgtggg tgaccttccg caagatcctg
      301 tctcacttcc ccgaggagct gagtctggct ttcgtctacg gctccggggt gtaccgccag
      361 gcagggccga gttcagacca gaagaatgct atgctggact ttgtgttcac agtagatgac
      421 cctgtcgcat ggcattcaaa gaacctgaag aaaaattgga gtcactactc tttcctaaaa
      481 gttttagggc ccaagattat cacgtccatc cagaataact atggcgctgg agtttactac
      541 aattcattga tcatgtgtaa tggtaggctt atcaaatatg gagttattag cactaacgtt
      601 ctgattgaag atctcctcaa ctggaataac ttatacattg ctggacgact ccaaaaaccg
      661 gtgaaaatta tctcagtgaa cgaggatgtc actcttagat cagccctcga tagaaatctg
      721 aagagtgctg tgaccgctgc tttcctcatg ctccccgaaa gcttttctga agaagacctc
      781 ttcatagaga ttgccggtct ctcctattca ggtgactttc ggatggtggt tggagaagat
      841 aaaacaaaag tgttgaatat tgtgaagccc aatatagccc actttcgaga gctctatggc
      901 agcatactac aggaaaatcc tcaagtggtg tataaaagcc agcaaggctg gctggagata
      961 gataaaagcc cagaaggaca gttcactcag ctgatgacat tgcccaaaac cttacagcaa
     1021 cagataaatc atattatgga ccctcctgga aaaaacagag atgtggaaga aactttattc
     1081 caagtggctc atgatcccga ctgtggagat gtggtgcgac tagggctttc agcaatcgtg
     1141 agaccgtcta gtataagaca gagcacgaaa ggcattttta ctgctggcct gaagaagtca
     1201 gtgatttata gttcactaaa actgcacaaa atgtggaaag ggtggctgag gaaaacatcc
     1261 tgattttgct tgcttttata tatgttatgt gtagatgaat aaagtgtttg atcctttttg
     1321 acagaa
//
