LOCUS       NM_006755               1199 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens transaldolase 1 (TALDO1), mRNA.
ACCESSION   NM_006755 XM_938697
VERSION     NM_006755.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1199)
  AUTHORS   Grammatikopoulos,T., Hadzic,N., Foskett,P., Strautnieks,S.,
            Samyn,M., Vara,R., Dhawan,A., Hertecant,J., Al Jasmi,F., Rahman,O.,
            Deheragoda,M., Bull,L.N. and Thompson,R.J.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Liver Disease and Risk of Hepatocellular Carcinoma in Children With
            Mutations in TALDO1
  JOURNAL   Hepatol Commun 6 (3), 473-479 (2022)
   PUBMED   34677006
  REMARK    GeneRIF: Liver Disease and Risk of Hepatocellular Carcinoma in
            Children With Mutations in TALDO1.
REFERENCE   2  (bases 1 to 1199)
  AUTHORS   Alfarsi,L.H., El Ansari,R., Craze,M.L., Mohammed,O.J., Masisi,B.K.,
            Ellis,I.O., Rakha,E.A. and Green,A.R.
  TITLE     SLC1A5 co-expression with TALDO1 associates with endocrine therapy
            failure in estrogen receptor-positive breast cancer
  JOURNAL   Breast Cancer Res Treat 189 (2), 317-331 (2021)
   PUBMED   34282517
  REMARK    GeneRIF: SLC1A5 co-expression with TALDO1 associates with endocrine
            therapy failure in estrogen receptor-positive breast cancer.
REFERENCE   3  (bases 1 to 1199)
  AUTHORS   Shayota,B.J., Donti,T.R., Xiao,J., Gijavanekar,C., Kennedy,A.D.,
            Hubert,L., Rodan,L., Vanderpluym,C., Nowak,C., Bjornsson,H.T.,
            Ganetzky,R., Berry,G.T., Pappan,K.L., Sutton,V.R., Sun,Q. and
            Elsea,S.H.
  TITLE     Untargeted metabolomics as an unbiased approach to the diagnosis of
            inborn errors of metabolism of the non-oxidative branch of the
            pentose phosphate pathway
  JOURNAL   Mol Genet Metab 131 (1-2), 147-154 (2020)
   PUBMED   32828637
  REMARK    GeneRIF: Untargeted metabolomics as an unbiased approach to the
            diagnosis of inborn errors of metabolism of the non-oxidative
            branch of the pentose phosphate pathway.
REFERENCE   4  (bases 1 to 1199)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1199)
  AUTHORS   Ding,Y., Gong,C., Huang,D., Chen,R., Sui,P., Lin,K.H., Liang,G.,
            Yuan,L., Xiang,H., Chen,J., Yin,T., Alexander,P.B., Wang,Q.F.,
            Song,E.W., Li,Q.J., Wood,K.C. and Wang,X.F.
  TITLE     Synthetic lethality between HER2 and transaldolase in intrinsically
            resistant HER2-positive breast cancers
  JOURNAL   Nat Commun 9 (1), 4274 (2018)
   PUBMED   30323337
  REMARK    GeneRIF: these results pinpoint transaldolase as a novel metabolic
            enzyme possessing synthetic lethality with HER2 inhibition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1199)
  AUTHORS   Kusuda,J., Hirai,M., Toyoda,A., Tanuma,R., Nomura-Kitabayashi,A.
            and Hashimoto,K.
  TITLE     Cloning and chromosomal localization of a paralog and a mouse
            homolog of the human transaldolase gene
  JOURNAL   Gene 209 (1-2), 13-21 (1998)
   PUBMED   9524206
REFERENCE   7  (bases 1 to 1199)
  AUTHORS   Banki,K., Eddy,R.L., Shows,T.B., Halladay,D.L., Bullrich,F.,
            Croce,C.M., Jurecic,V., Baldini,A. and Perl,A.
  TITLE     The human transaldolase gene (TALDO1) is located on chromosome 11
            at p15.4-p15.5
  JOURNAL   Genomics 45 (1), 233-238 (1997)
   PUBMED   9339383
REFERENCE   8  (bases 1 to 1199)
  AUTHORS   Kusuda,J., Hirai,M., Toyoda,A. and Hashimoto,K.
  TITLE     Localization of the human transaldolase gene (TALDO) to chromosome
            1p33-p34.1 by fluorescence in situ hybridization and PCR analysis
            of somatic cell hybirds
  JOURNAL   Genomics 40 (2), 378-381 (1997)
   PUBMED   9119412
REFERENCE   9  (bases 1 to 1199)
  AUTHORS   Banki,K., Colombo,E., Sia,F., Halladay,D., Mattson,D.H.,
            Tatum,A.H., Massa,P.T., Phillips,P.E. and Perl,A.
  TITLE     Oligodendrocyte-specific expression and autoantigenicity of
            transaldolase in multiple sclerosis
  JOURNAL   J Exp Med 180 (5), 1649-1663 (1994)
   PUBMED   7964452
REFERENCE   10 (bases 1 to 1199)
  AUTHORS   Banki,K., Halladay,D. and Perl,A.
  TITLE     Cloning and expression of the human gene for transaldolase. A novel
            highly repetitive element constitutes an integral part of the
            coding sequence
  JOURNAL   J Biol Chem 269 (4), 2847-2851 (1994)
   PUBMED   8300619
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L19437.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006755.1.
            
            Summary: Transaldolase 1 is a key enzyme of the nonoxidative
            pentose phosphate pathway providing ribose-5-phosphate for nucleic
            acid synthesis and NADPH for lipid biosynthesis. This pathway can
            also maintain glutathione at a reduced state and thus protect
            sulfhydryl groups and cellular integrity from oxygen radicals. The
            functional gene of transaldolase 1 is located on chromosome 11 and
            a pseudogene is identified on chromosome 1 but there are
            conflicting map locations. The second and third exon of this gene
            were developed by insertion of a retrotransposable element. This
            gene is thought to be involved in multiple sclerosis. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.691487.1,
                                           SRR1163658.234642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319006.8/ ENSP00000321259.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1199              L19437.2           33-1231
FEATURES             Location/Qualifiers
     source          1..1199
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1199
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /note="transaldolase 1"
                     /db_xref="GeneID:6888"
                     /db_xref="HGNC:HGNC:11559"
                     /db_xref="MIM:602063"
     exon            1..115
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1032
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /EC_number="2.2.1.2"
                     /note="glycerone transferase; dihydroxyacetone
                     transferase; testicular secretory protein Li 56"
                     /codon_start=1
                     /product="transaldolase"
                     /protein_id="NP_006746.1"
                     /db_xref="CCDS:CCDS7712.1"
                     /db_xref="GeneID:6888"
                     /db_xref="HGNC:HGNC:11559"
                     /db_xref="MIM:602063"
                     /translation="MSSSPVKRQRMESALDQLKQFTTVVADTGDFHAIDEYKPQDATT
                     NPSLILAAAQMPAYQELVEEAIAYGRKLGGSQEDQIKNAIDKLFVLFGAEILKKIPGR
                     VSTEVDARLSFDKDAMVARARRLIELYKEAGISKDRILIKLSSTWEGIQAGKELEEQH
                     GIHCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYEPLEDPGVKSVT
                     KIYNYYKKFSYKTIVMGASFRNTGEIKALAGCDFLTISPKLLGELLQDNAKLVPVLSA
                     KAAQASDLEKIHLDEKSFRWLHNEDQMAVEKLSDGIRKFAADAVKLERMLTERMFNAE
                     NGK"
     exon            116..239
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /inference="alignment:Splign:2.1.0"
     exon            240..347
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /inference="alignment:Splign:2.1.0"
     exon            348..479
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /inference="alignment:Splign:2.1.0"
     exon            480..655
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /inference="alignment:Splign:2.1.0"
     exon            656..853
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /inference="alignment:Splign:2.1.0"
     exon            854..999
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1199
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1180..1185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /note="hexamer: ATTAAA"
     polyA_site      1199
                     /gene="TALDO1"
                     /gene_synonym="TAL; TAL-H; TALDOR; TALH"
                     /note="major polyA site"
ORIGIN      
        1 agacccctcg gtcttgctat gtcgagctca cccgtgaagc gtcagaggat ggagtccgcg
       61 ctggaccagc tcaagcagtt caccaccgtg gtggccgaca cgggcgactt ccacgccatc
      121 gacgagtaca agccccagga tgctaccacc aacccgtccc tgatcctggc cgcagcacag
      181 atgcccgctt accaggagct ggtggaggag gcgattgcct atggccggaa gctgggcggg
      241 tcacaagagg accagattaa aaatgctatt gataaacttt ttgtgttgtt tggagcagaa
      301 atactaaaga agattccggg ccgagtatcc acagaagtag acgcaaggct ctcctttgat
      361 aaagatgcga tggtggccag agccaggcgg ctcatcgagc tctacaagga agctgggatc
      421 agcaaggacc gaattcttat aaagctgtca tcaacctggg aaggaattca ggctggaaag
      481 gagctcgagg agcagcacgg catccactgc aacatgacgt tactcttctc cttcgcccag
      541 gctgtggcct gtgccgaggc gggtgtgacc ctcatctccc catttgttgg gcgcatcctt
      601 gattggcatg tggcaaacac cgacaagaaa tcctatgagc ccctggaaga ccctggggta
      661 aagagtgtca ctaaaatcta caactactac aagaagttta gctacaaaac cattgtcatg
      721 ggcgcctcct tccgcaacac gggcgagatc aaagcactgg ccggctgtga cttcctcacc
      781 atctcaccca agctcctggg agagctgctg caggacaacg ccaagctggt gcctgtgctc
      841 tcagccaagg cggcccaagc cagtgacctg gaaaaaatcc acctggatga gaagtctttc
      901 cgttggttgc acaacgagga ccagatggct gtggagaagc tctctgacgg gatccgcaag
      961 tttgccgctg atgcagtgaa gctggagcgg atgctgacag aacgaatgtt caatgcagag
     1021 aatggaaagt agcgcatccc tgaggctgga ctccagatct gcaccgccgg ccagctggga
     1081 tctgactgca cgtggcttct gatgaatctt gcgtttttta caaattggag cagggacaga
     1141 tcatagattt ctgattttat gtaaaatttt gcctaataca ttaaagcagt cacttttcc
//
