LOCUS       NM_005421                668 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TAL bHLH transcription factor 2 (TAL2), mRNA.
ACCESSION   NM_005421
VERSION     NM_005421.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 668)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 668)
  AUTHORS   Courtial,N., Mucke,C., Herkt,S., Kolodziej,S., Hussong,H. and
            Lausen,J.
  TITLE     The T-cell oncogene Tal2 Is a Target of PU.1 and upregulated during
            osteoclastogenesis
  JOURNAL   PLoS One 8 (9), e76637 (2013)
   PUBMED   24086757
  REMARK    GeneRIF: the expression control of Tal2 in hematopoietic cells
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 668)
  AUTHORS   Guo,Y., Fu,P., Zhu,H., Reed,E., Remick,S.C., Petros,W.,
            Mueller,M.D. and Yu,J.J.
  TITLE     Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed
            by gene signatures of histological subtypes of patients with
            epithelial ovarian cancer
  JOURNAL   Oncol Rep 27 (1), 286-292 (2012)
   PUBMED   21971700
  REMARK    GeneRIF: low expression of TAL2 and EGF was observed in human
            epithelial ovarian cancer
REFERENCE   4  (bases 1 to 668)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   5  (bases 1 to 668)
  AUTHORS   Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D.,
            Gibson,G. and Goldstein,D.B.
  TITLE     Common genetic variation and performance on standardized cognitive
            tests
  JOURNAL   Eur J Hum Genet 18 (7), 815-820 (2010)
   PUBMED   20125193
  REMARK    Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820]
REFERENCE   6  (bases 1 to 668)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 668)
  AUTHORS   Marculescu,R., Vanura,K., Le,T., Simon,P., Jager,U. and Nadel,B.
  TITLE     Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and
            individuals with T-ALL
  JOURNAL   Nat Genet 33 (3), 342-344 (2003)
   PUBMED   12567187
  REMARK    GeneRIF: Activation of the TAL2 gene in T-ALL.
REFERENCE   8  (bases 1 to 668)
  AUTHORS   Wadman,I., Li,J., Bash,R.O., Forster,A., Osada,H., Rabbitts,T.H.
            and Baer,R.
  TITLE     Specific in vivo association between the bHLH and LIM proteins
            implicated in human T cell leukemia
  JOURNAL   EMBO J 13 (20), 4831-4839 (1994)
   PUBMED   7957052
REFERENCE   9  (bases 1 to 668)
  AUTHORS   Xia,Y., Hwang,L.Y., Cobb,M.H. and Baer,R.
  TITLE     Products of the TAL2 oncogene in leukemic T cells: bHLH
            phosphoproteins with DNA-binding activity
  JOURNAL   Oncogene 9 (5), 1437-1446 (1994)
   PUBMED   8152805
REFERENCE   10 (bases 1 to 668)
  AUTHORS   Xia,Y., Brown,L., Yang,C.Y., Tsan,J.T., Siciliano,M.J., Espinosa,R.
            3rd, Le Beau,M.M. and Baer,R.J.
  TITLE     TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32)
            translocation in human T-cell leukemia
  JOURNAL   Proc Natl Acad Sci U S A 88 (24), 11416-11420 (1991)
   PUBMED   1763056
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC126373.1, AA767775.1 and
            AL158070.11.
            
            On May 17, 2019 this sequence version replaced NM_005421.2.
            
            Summary: This intronless gene encodes a helix-loop-helix protein.
            Translocations between this gene on chromosome 9 and the T-cell
            receptor beta-chain locus on chromosome 7 have been associated with
            activation of the T-cell acute lymphocytic leukemia 2 gene and
            T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC126373.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334077.6/ ENSP00000334547.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               BC126373.1         1-389
            390-656             AA767775.1         1-267               c
            657-668             AL158070.11        142567-142578
FEATURES             Location/Qualifiers
     source          1..668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.2"
     gene            1..668
                     /gene="TAL2"
                     /note="TAL bHLH transcription factor 2"
                     /db_xref="GeneID:6887"
                     /db_xref="HGNC:HGNC:11557"
                     /db_xref="MIM:186855"
     exon            1..668
                     /gene="TAL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..367
                     /gene="TAL2"
                     /note="TAL-2; class A basic helix-loop-helix protein 19;
                     T-cell acute lymphocytic leukemia 2"
                     /codon_start=1
                     /product="T-cell acute lymphocytic leukemia protein 2"
                     /protein_id="NP_005412.1"
                     /db_xref="CCDS:CCDS6767.1"
                     /db_xref="GeneID:6887"
                     /db_xref="HGNC:HGNC:11557"
                     /db_xref="MIM:186855"
                     /translation="MTRKIFTNTRERWRQQNVNSAFAKLRKLIPTHPPDKKLSKNETL
                     RLAMRYINFLVKVLGEQSLQQTGVAAQGNILGLFPQGPHLPGLEDRTLLENYQVPSPG
                     PSHHIP"
     regulatory      644..649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAL2"
                     /note="hexamer: AATAAA"
     polyA_site      668
                     /gene="TAL2"
                     /note="major polyA site"
ORIGIN      
        1 ccctgagggc cctttctctt tccatctcag gaactcaaac atgaccagga agatcttcac
       61 aaataccagg gagcggtgga ggcagcagaa tgtcaacagc gcctttgcca agctgaggaa
      121 gctcatcccc actcaccctc cagacaaaaa gctgagcaaa aatgaaacgc ttcgcctggc
      181 aatgaggtat atcaacttct tggtcaaggt cttgggggag caaagcctgc aacaaacggg
      241 agtggctgct caggggaaca ttctggggct cttccctcaa ggaccccacc tgccaggcct
      301 ggaggacaga actctgcttg agaactacca ggttccttca cctggtccaa gccaccacat
      361 tccttagtgt ggctctggct gtcatctccc agggcagcac ttgcccagaa atcactgcct
      421 gtggacagac ttttgcatgt tccagagttg acctgatgat aactcgtgaa gcatgaattc
      481 tagcttcctg ggaggtggct cagagacagc tgcagggagc tgaaagaagc catgaggaat
      541 gtcacttgtg ggccgccacc ccccagggat gtcaggtaga gcggcctacc tctgcctatt
      601 ttaaatccag gttctgcata agacttttgg agaaaaaatt ctaaataaaa aaaaaaaaag
      661 gctgaaaa
//
