LOCUS       NM_001290403            4641 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens TAL bHLH transcription factor 1, erythroid
            differentiation factor (TAL1), transcript variant 3, mRNA.
ACCESSION   NM_001290403 XM_005271158
VERSION     NM_001290403.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4641)
  AUTHORS   Noura,M., Matsuo,H., Yasuda,T., Tsuzuki,S., Kiyoi,H. and
            Hayakawa,F.
  TITLE     Suppression of super-enhancer-driven TAL1 expression by KLF4 in
            T-cell acute lymphoblastic leukemia
  JOURNAL   Oncogene 43 (6), 447-456 (2024)
   PUBMED   38102337
  REMARK    GeneRIF: Suppression of super-enhancer-driven TAL1 expression by
            KLF4 in T-cell acute lymphoblastic leukemia.
REFERENCE   2  (bases 1 to 4641)
  AUTHORS   Smith,C., Goyal,A., Weichenhan,D., Allemand,E., Mayakonda,A.,
            Toprak,U., Riedel,A., Balducci,E., Manojkumar,M., Pejkovska,A.,
            Mucke,O., Sollier,E., Bakr,A., Breuer,K., Lutsik,P., Hermine,O.,
            Spicuglia,S., Asnafi,V., Plass,C. and Touzart,A.
  TITLE     TAL1 activation in T-cell acute lymphoblastic leukemia: a novel
            oncogenic 3' neo-enhancer
  JOURNAL   Haematologica 108 (5), 1259-1271 (2023)
   PUBMED   36632736
  REMARK    GeneRIF: TAL1 activation in T-cell acute lymphoblastic leukemia: a
            novel oncogenic 3' neo-enhancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4641)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4641)
  AUTHORS   Thoms,J.A.I., Truong,P., Subramanian,S., Knezevic,K., Harvey,G.,
            Huang,Y., Seneviratne,J.A., Carter,D.R., Joshi,S., Skhinas,J.,
            Chacon,D., Shah,A., de Jong,I., Beck,D., Gottgens,B., Larsson,J.,
            Wong,J.W.H., Zanini,F. and Pimanda,J.E.
  TITLE     Disruption of a GATA2-TAL1-ERG regulatory circuit promotes
            erythroid transition in healthy and leukemic stem cells
  JOURNAL   Blood 138 (16), 1441-1455 (2021)
   PUBMED   34075404
  REMARK    GeneRIF: Disruption of a GATA2-TAL1-ERG regulatory circuit promotes
            erythroid transition in healthy and leukemic stem cells.
REFERENCE   5  (bases 1 to 4641)
  AUTHORS   Calkhoven,C.F., Muller,C., Martin,R., Krosl,G., Pietsch,H.,
            Hoang,T. and Leutz,A.
  TITLE     Translational control of SCL-isoform expression in hematopoietic
            lineage choice
  JOURNAL   Genes Dev 17 (8), 959-964 (2003)
   PUBMED   12704079
  REMARK    Erratum:[Genes Dev. 2003 Jun 15;17(12):1554]
REFERENCE   6  (bases 1 to 4641)
  AUTHORS   Goldfarb,A.N., Goueli,S., Mickelson,D. and Greenberg,J.M.
  TITLE     T-cell acute lymphoblastic leukemia--the associated gene SCL/tal
            codes for a 42-Kd nuclear phosphoprotein
  JOURNAL   Blood 80 (11), 2858-2866 (1992)
   PUBMED   1450410
REFERENCE   7  (bases 1 to 4641)
  AUTHORS   Aplan,P.D., Nakahara,K., Orkin,S.H. and Kirsch,I.R.
  TITLE     The SCL gene product: a positive regulator of erythroid
            differentiation
  JOURNAL   EMBO J 11 (11), 4073-4081 (1992)
   PUBMED   1396592
REFERENCE   8  (bases 1 to 4641)
  AUTHORS   Green,A.R. and Begley,C.G.
  TITLE     SCL and related hemopoietic helix-loop-helix transcription factors
  JOURNAL   Int J Cell Cloning 10 (5), 269-276 (1992)
   PUBMED   1453013
  REMARK    Review article
REFERENCE   9  (bases 1 to 4641)
  AUTHORS   Aplan,P.D., Lombardi,D.P., Reaman,G.H., Sather,H.N., Hammond,G.D.
            and Kirsch,I.R.
  TITLE     Involvement of the putative hematopoietic transcription factor SCL
            in T-cell acute lymphoblastic leukemia
  JOURNAL   Blood 79 (5), 1327-1333 (1992)
   PUBMED   1311214
REFERENCE   10 (bases 1 to 4641)
  AUTHORS   Aplan,P.D., Begley,C.G., Bertness,V., Nussmeier,M., Ezquerra,A.,
            Coligan,J. and Kirsch,I.R.
  TITLE     The SCL gene is formed from a transcriptionally complex locus
  JOURNAL   Mol Cell Biol 10 (12), 6426-6435 (1990)
   PUBMED   2247063
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL135960.1 and KF495937.1.
            
            On Oct 10, 2020 this sequence version replaced NM_001290403.1.
            
            Transcript Variant: This variant (3) lacks an internal exon in the
            5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the
            same isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1367768.1,
                                           SRR9304719.378131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000691006.1/ ENSP00000510655.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            regulatory uORF        :: PMID: 12704079
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AL135960.1         45726-45784
            60-215              AL135960.1         48600-48755
            216-662             AL135960.1         52062-52508
            663-757             AL135960.1         53853-53947
            758-1104            AL135960.1         57777-58123
            1105-1279           KF495937.1         1-175
            1280-4641           AL135960.1         58299-61660
FEATURES             Location/Qualifiers
     source          1..4641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..4641
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
                     /note="TAL bHLH transcription factor 1, erythroid
                     differentiation factor"
                     /db_xref="GeneID:6886"
                     /db_xref="HGNC:HGNC:11556"
                     /db_xref="MIM:187040"
     exon            1..59
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
                     /inference="alignment:Splign:2.1.0"
     exon            60..215
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      207..254
                     /regulatory_class="uORF"
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:12704079]"
                     /note="this uORF is predicted to encode a 15 aa peptide
                     (PMID:12704079)"
     exon            216..662
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1212
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
                     /note="isoform 1 is encoded by transcript variant 3;
                     T-cell acute lymphocytic leukemia protein 1; tal-1
                     product; stem cell protein; T-cell leukemia/lymphoma
                     protein 5; class A basic helix-loop-helix protein 17;
                     T-cell acute lymphocytic leukemia 1"
                     /codon_start=1
                     /product="T-cell acute lymphocytic leukemia protein 1
                     isoform 1"
                     /protein_id="NP_001277332.1"
                     /db_xref="CCDS:CCDS547.1"
                     /db_xref="GeneID:6886"
                     /db_xref="HGNC:HGNC:11556"
                     /db_xref="MIM:187040"
                     /translation="MTERPPSEAARSDPQLEGRDAAEASMAPPHLVLLNGVAKETSRA
                     AAAEPPVIELGARGGPGGGPAGGGGAARDLKGRDAATAEARHRVPTTELCRPPGPAPA
                     PAPASVTAELPGDGRMVQLSPPALAAPAAPGRALLYSLSQPLASLGSGFFGEPDAFPM
                     FTTNNRVKRRPSPYEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHP
                     PDKKLSKNEILRLAMKYINFLAKLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAP
                     PDDLLQDVLSPNSSCGSSLDGAASPDSYTEEPAPKHTARSLHPAMLPAADGAGPR"
     exon            663..757
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
                     /inference="alignment:Splign:2.1.0"
     exon            758..4641
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2244
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
     regulatory      4621..4626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
                     /note="hexamer: AATAAA"
     polyA_site      4641
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgctc aggaccgggc ctcaaaatgg ccacacgcgt acccccgtag cggaaaaaca
       61 tcgcccagga ccacaccgca gcgtaactgc aggcctctca gcgaaaaagg gggaaagcaa
      121 agacccgggt gtgcatcctc ttcctcggct tccgcccctt tccggcggag tggagatcct
      181 attcagaggg gccggtctct ctaaatatgc cccaggatga ccgagcggcc gccgagcgag
      241 gcggctcgca gtgaccccca gctagaggga cgggacgcgg ccgaggccag catggccccc
      301 ccgcacctgg tcctgctgaa cggcgtcgcc aaggagacga gccgcgcggc cgcagcggag
      361 cccccagtca tcgaactggg cgcgcgcgga ggcccggggg gcggccctgc cggtgggggc
      421 ggcgccgcga gagacttaaa gggccgcgac gcggcgacgg ccgaagcgcg ccatcgggtg
      481 cccaccaccg agctgtgcag acctcccggg cccgccccgg cccccgcgcc cgcctcggtt
      541 acagcggagc tgcccggcga cggccgcatg gtgcagctga gtcctcccgc gctggctgcc
      601 cccgccgccc ccggccgcgc gctgctctac agcctcagcc agccgctggc ctctctcggc
      661 agcgggttct ttggggagcc ggatgccttc cctatgttca ccaccaacaa tcgagtgaag
      721 aggagacctt ccccctatga gatggagatt actgatggtc cccacaccaa agttgtgcgg
      781 cgtatcttca ccaacagccg ggagcgatgg cggcagcaga atgtgaacgg ggcctttgcc
      841 gagctccgca agctgatccc cacacatccc ccggacaaga agctcagcaa gaatgagatc
      901 ctccgcctgg ccatgaagta tatcaacttc ttggccaagc tgctcaatga ccaggaggag
      961 gagggcaccc agcgggccaa gactggcaag gaccctgtgg tgggggctgg tgggggtgga
     1021 ggtgggggag ggggcggcgc gcccccagat gacctcctgc aagacgtgct ttcccccaac
     1081 tccagctgcg gcagctccct ggatggggca gccagcccgg acagctacac ggaggagccc
     1141 gcgcccaagc acacggcccg cagcctccat cctgccatgc tgcctgccgc cgatggagcc
     1201 ggccctcggt gatgggtctg ggccaccagg atcagccagg agggcgttct taggctgctg
     1261 ggatggtggg cttcagggca ggtggggtga gaattgggcg gctctgaagc aaggcggtgg
     1321 acttgaactt tcctggatgt ctgaactttg ggaagccttt actgaccctg gggctggctt
     1381 ttctgtttcc tgtaccagta ggagatcaga aaaatggagc aaagtggtag gtactttttg
     1441 tgaagacggc acggtcttcc ctcttccctc agtcccaaat ccttcccaag taagaggctg
     1501 gagttgtcac tgcttttggc ctggagtttg ggatccctgt ctttcctaag acctggggtt
     1561 gtcagctctc atctgaggca tccagcagtc tctgccttgc ctttagcccc tcccaagctg
     1621 gctggggtgg cctgtgtggc cacttctgtc catatttata ggtacccaat agctgcccat
     1681 ttcgtgagcc ccatcttcac ccaggcctat gttgatccat ccagcttgcc agatgctgca
     1741 gagtcacaag cctcgaggtg ccttcttcag ggcctggttg aagaagatga tcagtggaca
     1801 gtctgctcta gatgagctgg gccggagggt caggaaaccc agtcgccctt acttcttgcc
     1861 ctggggatca aagttctgct ttctccccaa tgagacttgc cttcctaagc ctgtggctgt
     1921 ggagacaatg tctgcagccc tgagaaagcc ctgtcgggct ttgtgtgaag gcagagaaag
     1981 ggacaatgat agtagagtga tatggagcaa gagatatttt gggcatgtgg gcttcaactc
     2041 ctcgacatca ctgttcatgc tggcgagtga atgccagtgt gctgatgggc gtacgctggt
     2101 gctgagtaga tgcgcagccc catctgtgca ttctcctgga tgcttagagg gatttctttg
     2161 ctgtaagatg tctgtttgct gatggtctgg tctatgttcc gaattgagca caaaacctgt
     2221 cctatgaatg ctttgcattt ggaatttttg cttgacttca gttattggtg gaatctttag
     2281 cgctcaatag gaccaggatc cagcctcact tctagggtat gggaaatcca atcagagacc
     2341 aggccctggc taagacccaa acatatgcac attcacttag cagaacctta aacacccctc
     2401 agttgtgcag cttttggtca tcaagggtgc gtctgggagg ttggtttaat gcaatagaag
     2461 tgctcccctc tgaaagttgt acatgaaatt tttgtaaatc acatccttat ccttcatctt
     2521 ttaaagaaat aaccactgca agtccttttg taaagtgaag aatccttttg tagaatgaac
     2581 cactgcccct tcattgattt cctgtgtcaa tccagatggt gggatgtggt tttcttaagg
     2641 tgaggcctgt ctgtgacctg catctaagcc catgggacaa attgcacaga agtcctgtat
     2701 gtctgtcatt gtacccttaa gtcaccctag ccctctccct ctaggctctg ccttcgaggt
     2761 cagaggagag atagcctgtg gccctgtcct gccatgcaag aactcatcac tgtggctgtc
     2821 tggaaagccc ccccttatag tttgggcttc agcctagtgg cttgtcctca ccatgatggg
     2881 gccctaattc agccatgtac agacagagaa tatgtctgct cctttcccct tccttttaag
     2941 taaggtccaa ttctcgagct tggggcaaca ttgttcacct ttgtagcact caggctctcc
     3001 attcaatttc aggctcccca gatcatgttt tggtgaaaat tagggttggt tcctttccaa
     3061 cgtttggaag atcctgtgag gagccccatc tgtctaaaga tagagtcatt gctgtaggat
     3121 ctaaggctgt ttgcttcacc gtggattcgc ttgagttagg aatgagaagt agccacagta
     3181 tggatgggtg gatgggtttt atgagatgga tcacatattt tattaagaac tcaaacttct
     3241 ggctccctct tctttcagac ttgccatgtg actctggctt ggcctatctc ctagggctat
     3301 ggtgtggact gaatgggatc atgaaagtag acagttttga gaacgtaaag aactttttct
     3361 tttccctcaa tctcaatcct gcagtggggt ttcgcagcct gagtccacga cctaggcagt
     3421 aggccggtgt gcctgactgc ccagcatttg ggtaatttag attgtaaacc gctttggcct
     3481 gagttattga gattgtcctc atttctccag attatctatt tgtgtgtgtg tgtgtgtgtg
     3541 tgtgagagac ggtgtcttgt tctgtcactc aggctggagt acagtggtgc catcattgct
     3601 gtctgcagcc ttgaactctg ggctcaagca atcctctcac ctcagcctcc cgagtaggga
     3661 ggaccacagg tgtgagccac cacacctggc taatttttac tttttttttt ttttggtaga
     3721 gatggagtct tgctatattg cccaggctgg tcttgaagtc ctggcttcag gcaattctcc
     3781 tgcctttgcc tccagaagca ctgggatcac aggtgtcagc cattgcaccc agcccagatt
     3841 gtcttaattt ctatcttgtt ccaaggccag ggacagtaat aagaatggaa aagagatatg
     3901 ggaacactgg cagactgtgt aaaatgtaat gcaactaccc aaaacaagcc tggtaggaaa
     3961 gggcaagtct ttaggtcttt gtaagaacta aagaagatct gtaattttta ttttcaccct
     4021 ctgtacccca tgaccttatc cttcctctcc ttccttgtta cccatgaaaa actggcaaca
     4081 ttccaagaat agcatctgta caaaggggaa agaacataaa ggtaaaacaa aacaaaacaa
     4141 cattttgaga acaaagatga ccataaccac tgaagggaat cacatctttt aagacaaatt
     4201 catattcttt tatttgttat ggcagatgac aagatggtac aacctttatt cttttccaaa
     4261 ataaaacaaa gggcacagca tctgtagtca gccgacaact atttcggcct tttgggggtg
     4321 ggtctggccg tacttgtgat ttcgatggta cgtgaccctc tgctgaagac ttgccccctg
     4381 cccgtgtaca tagtgcattg tttctgtggg cgggcccagc actttccgtc aacgttgtac
     4441 tgtatgtgat gaattgcgtt ggtctctgca tttttctgca gaagaggagt aaccgctcca
     4501 ggtaccttga cctttgtaca gcccagaggc caacactgtg ggtgtgtgac tctttagcaa
     4561 aaaaaaccca tgtggtgatg atgtgtatat atatgtgagg atgtatcggg aagatttcta
     4621 aataaaagtt ttacaaaggg g
//
