LOCUS       NP_001277332             331 aa            linear   PRI 12-JUN-2024
DEFINITION  T-cell acute lymphocytic leukemia protein 1 isoform 1 [Homo
            sapiens].
ACCESSION   NP_001277332 XP_005271215
VERSION     NP_001277332.1
DBSOURCE    REFSEQ: accession NM_001290403.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Noura,M., Matsuo,H., Yasuda,T., Tsuzuki,S., Kiyoi,H. and
            Hayakawa,F.
  TITLE     Suppression of super-enhancer-driven TAL1 expression by KLF4 in
            T-cell acute lymphoblastic leukemia
  JOURNAL   Oncogene 43 (6), 447-456 (2024)
   PUBMED   38102337
  REMARK    GeneRIF: Suppression of super-enhancer-driven TAL1 expression by
            KLF4 in T-cell acute lymphoblastic leukemia.
REFERENCE   2  (residues 1 to 331)
  AUTHORS   Smith,C., Goyal,A., Weichenhan,D., Allemand,E., Mayakonda,A.,
            Toprak,U., Riedel,A., Balducci,E., Manojkumar,M., Pejkovska,A.,
            Mucke,O., Sollier,E., Bakr,A., Breuer,K., Lutsik,P., Hermine,O.,
            Spicuglia,S., Asnafi,V., Plass,C. and Touzart,A.
  TITLE     TAL1 activation in T-cell acute lymphoblastic leukemia: a novel
            oncogenic 3' neo-enhancer
  JOURNAL   Haematologica 108 (5), 1259-1271 (2023)
   PUBMED   36632736
  REMARK    GeneRIF: TAL1 activation in T-cell acute lymphoblastic leukemia: a
            novel oncogenic 3' neo-enhancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 331)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 331)
  AUTHORS   Thoms,J.A.I., Truong,P., Subramanian,S., Knezevic,K., Harvey,G.,
            Huang,Y., Seneviratne,J.A., Carter,D.R., Joshi,S., Skhinas,J.,
            Chacon,D., Shah,A., de Jong,I., Beck,D., Gottgens,B., Larsson,J.,
            Wong,J.W.H., Zanini,F. and Pimanda,J.E.
  TITLE     Disruption of a GATA2-TAL1-ERG regulatory circuit promotes
            erythroid transition in healthy and leukemic stem cells
  JOURNAL   Blood 138 (16), 1441-1455 (2021)
   PUBMED   34075404
  REMARK    GeneRIF: Disruption of a GATA2-TAL1-ERG regulatory circuit promotes
            erythroid transition in healthy and leukemic stem cells.
REFERENCE   5  (residues 1 to 331)
  AUTHORS   Calkhoven,C.F., Muller,C., Martin,R., Krosl,G., Pietsch,H.,
            Hoang,T. and Leutz,A.
  TITLE     Translational control of SCL-isoform expression in hematopoietic
            lineage choice
  JOURNAL   Genes Dev 17 (8), 959-964 (2003)
   PUBMED   12704079
  REMARK    Erratum:[Genes Dev. 2003 Jun 15;17(12):1554]
REFERENCE   6  (residues 1 to 331)
  AUTHORS   Goldfarb,A.N., Goueli,S., Mickelson,D. and Greenberg,J.M.
  TITLE     T-cell acute lymphoblastic leukemia--the associated gene SCL/tal
            codes for a 42-Kd nuclear phosphoprotein
  JOURNAL   Blood 80 (11), 2858-2866 (1992)
   PUBMED   1450410
REFERENCE   7  (residues 1 to 331)
  AUTHORS   Aplan,P.D., Nakahara,K., Orkin,S.H. and Kirsch,I.R.
  TITLE     The SCL gene product: a positive regulator of erythroid
            differentiation
  JOURNAL   EMBO J 11 (11), 4073-4081 (1992)
   PUBMED   1396592
REFERENCE   8  (residues 1 to 331)
  AUTHORS   Green,A.R. and Begley,C.G.
  TITLE     SCL and related hemopoietic helix-loop-helix transcription factors
  JOURNAL   Int J Cell Cloning 10 (5), 269-276 (1992)
   PUBMED   1453013
  REMARK    Review article
REFERENCE   9  (residues 1 to 331)
  AUTHORS   Aplan,P.D., Lombardi,D.P., Reaman,G.H., Sather,H.N., Hammond,G.D.
            and Kirsch,I.R.
  TITLE     Involvement of the putative hematopoietic transcription factor SCL
            in T-cell acute lymphoblastic leukemia
  JOURNAL   Blood 79 (5), 1327-1333 (1992)
   PUBMED   1311214
REFERENCE   10 (residues 1 to 331)
  AUTHORS   Aplan,P.D., Begley,C.G., Bertness,V., Nussmeier,M., Ezquerra,A.,
            Coligan,J. and Kirsch,I.R.
  TITLE     The SCL gene is formed from a transcriptionally complex locus
  JOURNAL   Mol Cell Biol 10 (12), 6426-6435 (1990)
   PUBMED   2247063
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL135960.1 and KF495937.1.
            
            On Mar 13, 2014 this sequence version replaced XP_005271215.1.
            
            Transcript Variant: This variant (3) lacks an internal exon in the
            5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the
            same isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1367768.1,
                                           SRR9304719.378131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000691006.1/ ENSP00000510655.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            regulatory uORF        :: PMID: 12704079
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     Protein         1..331
                     /product="T-cell acute lymphocytic leukemia protein 1
                     isoform 1"
                     /note="T-cell acute lymphocytic leukemia protein 1; tal-1
                     product; stem cell protein; T-cell leukemia/lymphoma
                     protein 5; class A basic helix-loop-helix protein 17;
                     T-cell acute lymphocytic leukemia 1"
                     /calculated_mol_wt=34140
     Region          1..27
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17542.2)"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P17542.2)"
     Region          40..86
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17542.2)"
     Site            122
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P17542.2)"
     Site            172
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P22091; propagated from
                     UniProtKB/Swiss-Prot (P17542.2)"
     Region          185..249
                     /region_name="bHLH_TS_TAL1"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     T-cell acute lymphocytic leukemia protein 1 (TAL-1) and
                     similar proteins; cd19706"
                     /db_xref="CDD:381549"
     Site            order(189,193,195..197,199,204,222,224..225)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381549"
     Site            order(202..203,206..207,210,213,226,229..230,233,235..237,
                     239..240,243,246..247)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381549"
     Site            order(213,215..217,219,235,238..239,241..242,245..246)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:381549"
     Region          249..331
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17542.2)"
     CDS             1..331
                     /gene="TAL1"
                     /gene_synonym="bHLHa17; SCL; tal-1; TCL5"
                     /coded_by="NM_001290403.2:217..1212"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS547.1"
                     /db_xref="GeneID:6886"
                     /db_xref="HGNC:HGNC:11556"
                     /db_xref="MIM:187040"
ORIGIN      
        1 mterppseaa rsdpqlegrd aaeasmapph lvllngvake tsraaaaepp vielgarggp
       61 gggpagggga ardlkgrdaa taearhrvpt telcrppgpa papapasvta elpgdgrmvq
      121 lsppalaapa apgrallysl sqplaslgsg ffgepdafpm fttnnrvkrr pspyemeitd
      181 gphtkvvrri ftnsrerwrq qnvngafael rklipthppd kklskneilr lamkyinfla
      241 kllndqeeeg tqraktgkdp vvgagggggg ggggappddl lqdvlspnss cgssldgaas
      301 pdsyteepap khtarslhpa mlpaadgagp r
//
