LOCUS       NM_001008272            1129 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transgelin 3 (TAGLN3), transcript variant 2, mRNA.
ACCESSION   NM_001008272
VERSION     NM_001008272.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1129)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1129)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1129)
  AUTHORS   Ito,M., Depaz,I., Wilce,P., Suzuki,T., Niwa,S. and Matsumoto,I.
  TITLE     Expression of human neuronal protein 22, a novel
            cytoskeleton-associated protein, was decreased in the anterior
            cingulate cortex of schizophrenia
  JOURNAL   Neurosci Lett 378 (3), 125-130 (2005)
   PUBMED   15781144
  REMARK    GeneRIF: Altered expression of hNP22 may be associated with
            modifications in neuronal cytoarchitecture leading to dysregulation
            of neural signal transduction in the anterior cingulate cortex of
            the schizophrenia brain.
REFERENCE   4  (bases 1 to 1129)
  AUTHORS   Depaz,I., Ito,M., Matsumoto,I., Niwa,S., Kroon,P. and Wilce,P.A.
  TITLE     Expression of hNP22 is altered in the frontal cortex and
            hippocampus of the alcoholic human brain
  JOURNAL   Alcohol Clin Exp Res 27 (9), 1481-1488 (2003)
   PUBMED   14506410
  REMARK    GeneRIF: Western blots revealed a significant increase in hNP22
            protein levels in the frontal cortex but not the motor cortex of
            alcoholic cases.
            Erratum:[Alcohol Clin Exp Res. 2004 Sep;28(9):1431]
REFERENCE   5  (bases 1 to 1129)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1129)
  AUTHORS   Fan,L., Jaquet,V., Dodd,P.R., Chen,W. and Wilce,P.A.
  TITLE     Molecular cloning and characterization of hNP22: a gene
            up-regulated in human alcoholic brain
  JOURNAL   J Neurochem 76 (5), 1275-1281 (2001)
   PUBMED   11238712
REFERENCE   7  (bases 1 to 1129)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   8  (bases 1 to 1129)
  AUTHORS   Ren,W.Z., Ng,G.Y., Wang,R.X., Wu,P.H., O'Dowd,B.F., Osmond,D.H.,
            George,S.R. and Liew,C.C.
  TITLE     The identification of NP25: a novel protein that is differentially
            expressed by neuronal subpopulations
  JOURNAL   Brain Res Mol Brain Res 22 (1-4), 173-185 (1994)
   PUBMED   8015377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI752099.1, BC015329.1 and BM894229.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001008272.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087855.1, SRR5189652.253305.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000478951.6/ ENSP00000419105.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BI752099.1         259-319
            62-1004             BC015329.1         1-943
            1005-1129           BM894229.1         18-142              c
FEATURES             Location/Qualifiers
     source          1..1129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..1129
                     /gene="TAGLN3"
                     /gene_synonym="NP22; NP24; NP25"
                     /note="transgelin 3"
                     /db_xref="GeneID:29114"
                     /db_xref="HGNC:HGNC:29868"
                     /db_xref="MIM:607953"
     exon            1..193
                     /gene="TAGLN3"
                     /gene_synonym="NP22; NP24; NP25"
                     /inference="alignment:Splign:2.1.0"
     exon            194..375
                     /gene="TAGLN3"
                     /gene_synonym="NP22; NP24; NP25"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..795
                     /gene="TAGLN3"
                     /gene_synonym="NP22; NP24; NP25"
                     /note="neuronal protein 22; neuronal protein NP25"
                     /codon_start=1
                     /product="transgelin-3"
                     /protein_id="NP_001008273.1"
                     /db_xref="CCDS:CCDS33816.1"
                     /db_xref="GeneID:29114"
                     /db_xref="HGNC:HGNC:29868"
                     /db_xref="MIM:607953"
                     /translation="MANRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEH
                     PPPGRAHFQKWLMDGTVLCKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAET
                     YGVRTTDIFQTVDLWEGKDMAAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRR
                     GFSEEQLRQGQNVIGLQMGSNKGASQAGMTGYGMPRQIM"
     exon            376..550
                     /gene="TAGLN3"
                     /gene_synonym="NP22; NP24; NP25"
                     /inference="alignment:Splign:2.1.0"
     exon            551..653
                     /gene="TAGLN3"
                     /gene_synonym="NP22; NP24; NP25"
                     /inference="alignment:Splign:2.1.0"
     exon            654..1129
                     /gene="TAGLN3"
                     /gene_synonym="NP22; NP24; NP25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1107..1112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAGLN3"
                     /gene_synonym="NP22; NP24; NP25"
                     /note="hexamer: AATAAA"
     polyA_site      1129
                     /gene="TAGLN3"
                     /gene_synonym="NP22; NP24; NP25"
                     /note="major polyA site"
ORIGIN      
        1 aaatcaatgt gccattcttc caggcgcgag gcagcagcgg ctgcagttca acatgaaagg
       61 aggcttcctc cctgcctgct aattacctgc tcttcccgat ctcatcgttt ctgcctttgc
      121 aaagtgctac tgagaagggg gaagaaacgt ccgccaccca tcccccttgc tgcctggggg
      181 ttcagacttg attagatggc taacaggggc ccgagctatg gcttaagccg agaggtgcag
      241 gagaagatcg agcagaagta tgatgcggac ctggagaaca agctggtgga ctggatcatc
      301 ctgcagtgcg ccgaggacat agagcacccg ccccccggca gggcccattt tcagaaatgg
      361 ttaatggacg ggacggtcct gtgcaagctg ataaatagtt tatacccacc aggacaagag
      421 cccataccca agatctcaga gtcaaagatg gcttttaagc agatggagca aatctcccag
      481 ttcctaaaag ctgcggagac ctatggtgtc agaaccaccg acatctttca gacggtggat
      541 ctatgggaag ggaaggacat ggcagctgtg cagaggaccc tgatggcttt aggcagcgtt
      601 gcagtcacca aggatgatgg ctgctatcgg ggagagccat cctggtttca caggaaagcc
      661 cagcagaatc ggagaggctt ttccgaggag cagcttcgcc agggacagaa cgtaataggc
      721 ctgcagatgg gcagcaacaa gggagcctcc caggcgggca tgacagggta cgggatgccc
      781 aggcagatca tgtaggacgc ggcatcctgc ccctggtaga gaggacgaat gttccacacc
      841 atggtctcta cgaaaaagaa atagttagtc accttctgac cttctcctct ttctcaaagc
      901 cttctgtccc tggtttttgc aagtgctgca tttccgccga gaatccgcgt tgcctactgc
      961 tgccacctcc tgttcattta gaactatgca aagactccgc ttccgttttc ctgagctcct
     1021 cgggccccag agtctctgtt tgattattta tttatttatt tatttatttg ccaaaaattc
     1081 tcctcttcaa cttatagaat gcacctaata aagtaattag tcttgtgtc
//
