LOCUS       NM_003564               1375 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens transgelin 2 (TAGLN2), transcript variant 2, mRNA.
ACCESSION   NM_003564
VERSION     NM_003564.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1375)
  AUTHORS   Li,Y., Wang,X., Xu,T., Xu,F., Chen,T., Li,Z., Wang,Y., Chen,H.,
            Ming,J., Cai,J., Jiang,C. and Meng,X.
  TITLE     Unveiling the role of TAGLN2 in glioblastoma: From
            proneural-mesenchymal transition to Temozolomide resistance
  JOURNAL   Cancer Lett 598, 217107 (2024)
   PUBMED   38992489
  REMARK    GeneRIF: Unveiling the role of TAGLN2 in glioblastoma: From
            proneural-mesenchymal transition to Temozolomide resistance.
REFERENCE   2  (bases 1 to 1375)
  AUTHORS   Zhuo,H., Hou,J., Hong,Z., Yu,S., Peng,H., Zhang,L., Xie,W. and
            Hong,X.
  TITLE     TAGLN2 induces resistance signature ISGs by activating AKT-YBX1
            signal with dual pathways and mediates the IFN-related DNA damage
            resistance in gastric cancer
  JOURNAL   Cell Death Dis 15 (8), 608 (2024)
   PUBMED   39168971
  REMARK    GeneRIF: TAGLN2 induces resistance signature ISGs by activating
            AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA
            damage resistance in gastric cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1375)
  AUTHORS   Gao,Y., Hou,J., Fei,X., Ren,L., Lu,R., Liu,P., Liu,S., Zhu,C.,
            Wang,X. and Pan,Y.
  TITLE     TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK
            signaling pathway influences the proliferation, invasion, and
            metastasis of pancreatic cancer cells
  JOURNAL   Cell Signal 120, 111227 (2024)
   PUBMED   38744388
  REMARK    GeneRIF: TAGLN2 targeted control of ARPC5-mediated activation of
            the MEK/ERK signaling pathway influences the proliferation,
            invasion, and metastasis of pancreatic cancer cells.
REFERENCE   4  (bases 1 to 1375)
  AUTHORS   Ji,C., Zhao,J., Chen,H., Wang,Z., Cai,T., Tian,C., Wang,C., Liu,D.,
            Ye,B., Fu,M., Sun,J., Li,H., Wang,X. and Sun,Y.
  TITLE     Single-cell RNA sequencing reveals the lineage of malignant
            epithelial cells and upregulation of TAGLN2 promotes peritoneal
            metastasis in gastric cancer
  JOURNAL   Clin Transl Oncol 25 (12), 3405-3419 (2023)
   PUBMED   37247132
  REMARK    GeneRIF: Single-cell RNA sequencing reveals the lineage of
            malignant epithelial cells and upregulation of TAGLN2 promotes
            peritoneal metastasis in gastric cancer.
            Erratum:[Clin Transl Oncol. 2024 May;26(5):1283-1285. doi:
            10.1007/s12094-024-03402-x.. PMID: 38492153]
REFERENCE   5  (bases 1 to 1375)
  AUTHORS   He,Y., Zhang,B., Han,D., Du,Y., Zhang,X., Wang,H., Yue,Z. and
            Shang,P.
  TITLE     TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of
            Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling
            Pathway
  JOURNAL   Biochem Genet 61 (4), 1265-1281 (2023)
   PUBMED   36547768
  REMARK    GeneRIF: TAGLN2 Promotes the Proliferation, Migration, Invasion,
            and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt
            Signaling Pathway.
REFERENCE   6  (bases 1 to 1375)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1375)
  AUTHORS   Wang,L., Zhu,Y.F., Guo,X.J., Huo,R., Ma,X., Lin,M., Zhou,Z.M. and
            Sha,J.H.
  TITLE     A two-dimensional electrophoresis reference map of human ovary
  JOURNAL   J Mol Med (Berl) 83 (10), 812-821 (2005)
   PUBMED   16021519
REFERENCE   8  (bases 1 to 1375)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   9  (bases 1 to 1375)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
REFERENCE   10 (bases 1 to 1375)
  AUTHORS   Stanier,P., Abu-Hayyeh,S., Murdoch,J.N., Eddleston,J. and Copp,A.J.
  TITLE     Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and
            9: further evidence for a paralogous relationship
  JOURNAL   Genomics 51 (1), 144-147 (1998)
   PUBMED   9693045
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291562.1 and AI270594.1.
            
            On Jun 2, 2019 this sequence version replaced NM_003564.2.
            
            Summary: The protein encoded by this gene is similar to the protein
            transgelin, which is one of the earliest markers of differentiated
            smooth muscle. The specific function of this protein has not yet
            been determined, although it is thought to be a tumor suppressor.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Mar 2013].
            
            Transcript Variant: This variant (2) uses an alternate first exon
            and begins translation at a downstream AUG compared to variant 1.
            The resulting isoform (b) is shorter at the N-terminus compared to
            isoform a. Variants 2 and 3 both encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009357.2, AK291562.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368097.9/ ENSP00000357077.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1134              AK291562.1         1-1134
            1135-1375           AI270594.1         10-250              c
FEATURES             Location/Qualifiers
     source          1..1375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..1375
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /note="transgelin 2"
                     /db_xref="GeneID:8407"
                     /db_xref="HGNC:HGNC:11554"
                     /db_xref="MIM:604634"
     exon            1..58
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /inference="alignment:Splign:2.1.0"
     exon            59..266
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..686
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /note="isoform b is encoded by transcript variant 2;
                     SM22-alpha homolog; epididymis tissue protein Li 7e;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="transgelin-2 isoform b"
                     /protein_id="NP_003555.1"
                     /db_xref="CCDS:CCDS1189.1"
                     /db_xref="GeneID:8407"
                     /db_xref="HGNC:HGNC:11554"
                     /db_xref="MIM:604634"
                     /translation="MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGR
                     PQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAER
                     YGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPR
                     NFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL"
     exon            267..441
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /inference="alignment:Splign:2.1.0"
     exon            442..544
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /inference="alignment:Splign:2.1.0"
     exon            545..1375
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1352..1357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /note="hexamer: AATAAA"
     polyA_site      1375
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /note="major polyA site"
ORIGIN      
        1 acttgcagct gcagcccttg ccttgagtca gtgcgccgct ctccagcccg cttgaacgct
       61 ccccgcagcc accgccaccc attggaatgg ccaacagggg acctgcatat ggcctgagcc
      121 gggaggtgca gcagaagatt gagaaacaat atgatgcaga tctggagcag atcctgatcc
      181 agtggatcac cacccagtgc cgaaaggatg tgggccggcc ccagcctgga cgcgagaact
      241 tccagaactg gctcaaggat ggcacggtgc tatgtgagct cattaatgca ctgtaccccg
      301 aggggcaggc cccagtaaag aagatccagg cctccaccat ggccttcaag cagatggagc
      361 agatctctca gttcctgcaa gcagctgagc gctatggcat taacaccact gacatcttcc
      421 aaactgtgga cctctgggaa ggaaagaaca tggcctgtgt gcagcggacg ctgatgaatc
      481 tgggtgggct ggcagtagcc cgagatgatg ggctcttctc tggggatccc aactggttcc
      541 ctaagaaatc caaggagaat cctcggaact tctcggataa ccagctgcaa gagggcaaga
      601 acgtgatcgg gttacagatg ggcaccaacc gcggggcgtc tcaggcaggc atgactggct
      661 acgggatgcc acgccagatc ctctgatccc accccaggcc ttgcccctgc cctcccacga
      721 atggttaata tatatgtaga tatatatttt agcagtgaca ttcccagaga gccccagagc
      781 tctcaagctc ctttctgtca gggtgggggg ttcagcctgt cctgtcacct ctgaggtgcc
      841 tgctggcatc ctctccccca tgcttactaa tacattccct tccccatagc catcaaaact
      901 ggaccaactg gcctcttcct ttcccctggg accaaaattt aggggcctca gtccctcacc
      961 gccatgccct ggcctattct gtctctcctt cttccccctg gcctgttctg tctctgagct
     1021 ctgtgtcctc cgttcattcc atggctggga gtcactgatg ctgcctctgc cttctgatgc
     1081 tggactggcc ttgcttctac aagtatgctt ctcccacagc tgtggctgca ggaacttaat
     1141 ttatagggag gagcctgtgg cagctgctgc cccagccaca gctgcactga ctgtgctcac
     1201 cacacatctg gggcagcctt ccctggcagg ggccctcgtg gcttctcatt ttccattccc
     1261 ttcactgtgg ctaaggggtg gggtgagggg atggagaggg agggctgcct accatggtct
     1321 ggggcttgag gaagatgagt ttgttgattt aaataaagaa tttgtcattt ttgaa
//
