LOCUS       NM_001277224            1616 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens transgelin 2 (TAGLN2), transcript variant 1, mRNA.
ACCESSION   NM_001277224
VERSION     NM_001277224.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1616)
  AUTHORS   Li,Y., Wang,X., Xu,T., Xu,F., Chen,T., Li,Z., Wang,Y., Chen,H.,
            Ming,J., Cai,J., Jiang,C. and Meng,X.
  TITLE     Unveiling the role of TAGLN2 in glioblastoma: From
            proneural-mesenchymal transition to Temozolomide resistance
  JOURNAL   Cancer Lett 598, 217107 (2024)
   PUBMED   38992489
  REMARK    GeneRIF: Unveiling the role of TAGLN2 in glioblastoma: From
            proneural-mesenchymal transition to Temozolomide resistance.
REFERENCE   2  (bases 1 to 1616)
  AUTHORS   Zhuo,H., Hou,J., Hong,Z., Yu,S., Peng,H., Zhang,L., Xie,W. and
            Hong,X.
  TITLE     TAGLN2 induces resistance signature ISGs by activating AKT-YBX1
            signal with dual pathways and mediates the IFN-related DNA damage
            resistance in gastric cancer
  JOURNAL   Cell Death Dis 15 (8), 608 (2024)
   PUBMED   39168971
  REMARK    GeneRIF: TAGLN2 induces resistance signature ISGs by activating
            AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA
            damage resistance in gastric cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1616)
  AUTHORS   Gao,Y., Hou,J., Fei,X., Ren,L., Lu,R., Liu,P., Liu,S., Zhu,C.,
            Wang,X. and Pan,Y.
  TITLE     TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK
            signaling pathway influences the proliferation, invasion, and
            metastasis of pancreatic cancer cells
  JOURNAL   Cell Signal 120, 111227 (2024)
   PUBMED   38744388
  REMARK    GeneRIF: TAGLN2 targeted control of ARPC5-mediated activation of
            the MEK/ERK signaling pathway influences the proliferation,
            invasion, and metastasis of pancreatic cancer cells.
REFERENCE   4  (bases 1 to 1616)
  AUTHORS   Ji,C., Zhao,J., Chen,H., Wang,Z., Cai,T., Tian,C., Wang,C., Liu,D.,
            Ye,B., Fu,M., Sun,J., Li,H., Wang,X. and Sun,Y.
  TITLE     Single-cell RNA sequencing reveals the lineage of malignant
            epithelial cells and upregulation of TAGLN2 promotes peritoneal
            metastasis in gastric cancer
  JOURNAL   Clin Transl Oncol 25 (12), 3405-3419 (2023)
   PUBMED   37247132
  REMARK    GeneRIF: Single-cell RNA sequencing reveals the lineage of
            malignant epithelial cells and upregulation of TAGLN2 promotes
            peritoneal metastasis in gastric cancer.
            Erratum:[Clin Transl Oncol. 2024 May;26(5):1283-1285. doi:
            10.1007/s12094-024-03402-x.. PMID: 38492153]
REFERENCE   5  (bases 1 to 1616)
  AUTHORS   He,Y., Zhang,B., Han,D., Du,Y., Zhang,X., Wang,H., Yue,Z. and
            Shang,P.
  TITLE     TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of
            Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling
            Pathway
  JOURNAL   Biochem Genet 61 (4), 1265-1281 (2023)
   PUBMED   36547768
  REMARK    GeneRIF: TAGLN2 Promotes the Proliferation, Migration, Invasion,
            and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt
            Signaling Pathway.
REFERENCE   6  (bases 1 to 1616)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1616)
  AUTHORS   Wang,L., Zhu,Y.F., Guo,X.J., Huo,R., Ma,X., Lin,M., Zhou,Z.M. and
            Sha,J.H.
  TITLE     A two-dimensional electrophoresis reference map of human ovary
  JOURNAL   J Mol Med (Berl) 83 (10), 812-821 (2005)
   PUBMED   16021519
REFERENCE   8  (bases 1 to 1616)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   9  (bases 1 to 1616)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
REFERENCE   10 (bases 1 to 1616)
  AUTHORS   Stanier,P., Abu-Hayyeh,S., Murdoch,J.N., Eddleston,J. and Copp,A.J.
  TITLE     Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and
            9: further evidence for a paralogous relationship
  JOURNAL   Genomics 51 (1), 144-147 (1998)
   PUBMED   9693045
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513485.10 and AY007127.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001277224.1.
            
            Summary: The protein encoded by this gene is similar to the protein
            transgelin, which is one of the earliest markers of differentiated
            smooth muscle. The specific function of this protein has not yet
            been determined, although it is thought to be a tumor suppressor.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Mar 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY007127.1, SRR1163658.564559.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL513485.10        11826-11842         c
            18-1616             AY007127.1         1-1599
FEATURES             Location/Qualifiers
     source          1..1616
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..1616
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /note="transgelin 2"
                     /db_xref="GeneID:8407"
                     /db_xref="HGNC:HGNC:11554"
                     /db_xref="MIM:604634"
     exon            1..299
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..927
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /note="isoform a is encoded by transcript variant 1;
                     SM22-alpha homolog; epididymis tissue protein Li 7e;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="transgelin-2 isoform a"
                     /protein_id="NP_001264153.1"
                     /db_xref="CCDS:CCDS60314.1"
                     /db_xref="GeneID:8407"
                     /db_xref="HGNC:HGNC:11554"
                     /db_xref="MIM:604634"
                     /translation="MSAFSLALALVSSPQPPPPIGMANRGPAYGLSREVQQKIEKQYD
                     ADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQ
                     ASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVAR
                     DDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQ
                     IL"
     exon            300..507
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /inference="alignment:Splign:2.1.0"
     exon            508..682
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /inference="alignment:Splign:2.1.0"
     exon            683..785
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1616
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1593..1598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /note="hexamer: AATAAA"
     polyA_site      1616
                     /gene="TAGLN2"
                     /gene_synonym="HA1756"
                     /note="major polyA site"
ORIGIN      
        1 cttctgctcc tgactctcgg tggtgagggg ctgccctacg gtggttccct taattgtggg
       61 ccgcccccca tccttgctgc tggctgtggc acctcgctct gtgggctggt gccctcactg
      121 tgctgctctt tgagaacact ccctgtccca aatctgagtt gggaagttct cctgtgttcc
      181 atctgcacgg tggatggaga gtccctttgt cttcccaatt aaacacccta gccaagaacc
      241 ctgaagtcct ccctgccccc acccatgtcc gccttttctt tggctttggc tttggtgagc
      301 tccccgcagc caccgccacc cattggaatg gccaacaggg gacctgcata tggcctgagc
      361 cgggaggtgc agcagaagat tgagaaacaa tatgatgcag atctggagca gatcctgatc
      421 cagtggatca ccacccagtg ccgaaaggat gtgggccggc cccagcctgg acgcgagaac
      481 ttccagaact ggctcaagga tggcacggtg ctatgtgagc tcattaatgc actgtacccc
      541 gaggggcagg ccccagtaaa gaagatccag gcctccacca tggccttcaa gcagatggag
      601 cagatctctc agttcctgca agcagctgag cgctatggca ttaacaccac tgacatcttc
      661 caaactgtgg acctctggga aggaaagaac atggcctgtg tgcagcggac gctgatgaat
      721 ctgggtgggc tggcagtagc ccgagatgat gggctcttct ctggggatcc caactggttc
      781 cctaagaaat ccaaggagaa tcctcggaac ttctcggata accagctgca agagggcaag
      841 aacgtgatcg ggttacagat gggcaccaac cgcggggcgt ctcaggcagg catgactggc
      901 tacgggatgc cacgccagat cctctgatcc caccccaggc cttgcccctg ccctcccacg
      961 aatggttaat atatatgtag atatatattt tagcagtgac attcccagag agccccagag
     1021 ctctcaagct cctttctgtc agggtggggg gttcagcctg tcctgtcacc tctgaggtgc
     1081 ctgctggcat cctctccccc atgcttacta atacattccc ttccccatag ccatcaaaac
     1141 tggaccaact ggcctcttcc tttcccctgg gaccaaaatt taggggcctc agtccctcac
     1201 cgccatgccc tggcctattc tgtctctcct tcttccccct ggcctgttct gtctctgagc
     1261 tctgtgtcct ccgttcattc catggctggg agtcactgat gctgcctctg ccttctgatg
     1321 ctggactggc cttgcttcta caagtatgct tctcccacag ctgtggctgc aggaacttaa
     1381 tttataggga ggagcctgtg gcagctgctg ccccagccac agctgcactg actgtgctca
     1441 ccacacatct ggggcagcct tccctggcag gggccctcgt ggcttctcat tttccattcc
     1501 cttcactgtg gctaaggggt ggggtgaggg gatggagagg gagggctgcc taccatggtc
     1561 tggggcttga ggaagatgag tttgttgatt taaataaaga atttgtcatt tttgaa
//
