LOCUS       NM_054114               3713 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens T cell activation RhoGTPase activating protein
            (TAGAP), transcript variant 2, mRNA.
ACCESSION   NM_054114
VERSION     NM_054114.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3713)
  AUTHORS   Xu,Z., Zheng,T., Zheng,Z., Jiang,W., Huang,L., Deng,K., Yuan,L.,
            Qin,F., Sun,Y., Qin,J. and Li,S.
  TITLE     TAGAP expression influences CD4+ T cell differentiation, immune
            infiltration, and cytotoxicity in LUAD through the STAT pathway:
            implications for immunotherapy
  JOURNAL   Front Immunol 14, 1224340 (2023)
   PUBMED   37744350
  REMARK    GeneRIF: TAGAP expression influences CD4+ T cell differentiation,
            immune infiltration, and cytotoxicity in LUAD through the STAT
            pathway: implications for immunotherapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3713)
  AUTHORS   Shri Preethi,M. and Asha Devi,S.
  TITLE     An attempt to unravel the association of TAGAP gene SNPs with
            rheumatoid arthritis in the Indian population using high-resolution
            melting analysis
  JOURNAL   Gene 834, 146584 (2022)
   PUBMED   35597527
  REMARK    GeneRIF: An attempt to unravel the association of TAGAP gene SNPs
            with rheumatoid arthritis in the Indian population using
            high-resolution melting analysis.
REFERENCE   3  (bases 1 to 3713)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3713)
  AUTHORS   Arshad,M., Bhatti,A., John,P., Jalil,F., Borghese,F.,
            Kawalkowska,J.Z., Williams,R.O. and Clanchy,F.I.L.
  TITLE     T cell activation Rho GTPase activating protein (TAGAP) is
            upregulated in clinical and experimental arthritis
  JOURNAL   Cytokine 104, 130-135 (2018)
   PUBMED   29017772
  REMARK    GeneRIF: These findings indicate that increased TAGAP expression is
            a distinguishing feature of inflammatory disease and further
            highlight the role of TAGAP in rheumatoid arthritis susceptibility.
REFERENCE   5  (bases 1 to 3713)
  AUTHORS   Arshad,M., Bhatti,A. and John,P.
  TITLE     Identification and in silico analysis of functional SNPs of human
            TAGAP protein: A comprehensive study
  JOURNAL   PLoS One 13 (1), e0188143 (2018)
   PUBMED   29329296
  REMARK    GeneRIF: This is the first comprehensive study, where TAGAP gene
            variants were analyzed using in silico tools hence will be of great
            help while considering large scale studies and also in developing
            precision medicines for cure of diseases related to these
            polymorphisms
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3713)
  AUTHORS   Romanos,J., Barisani,D., Trynka,G., Zhernakova,A., Bardella,M.T.
            and Wijmenga,C.
  TITLE     Six new coeliac disease loci replicated in an Italian population
            confirm association with coeliac disease
  JOURNAL   J Med Genet 46 (1), 60-63 (2009)
   PUBMED   18805825
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3713)
  AUTHORS   Hunt,K.A., Zhernakova,A., Turner,G., Heap,G.A., Franke,L.,
            Bruinenberg,M., Romanos,J., Dinesen,L.C., Ryan,A.W., Panesar,D.,
            Gwilliam,R., Takeuchi,F., McLaren,W.M., Holmes,G.K., Howdle,P.D.,
            Walters,J.R., Sanders,D.S., Playford,R.J., Trynka,G., Mulder,C.J.,
            Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M., O'Morain,C.,
            Kennedy,N.P., Kelleher,D., Pennington,D.J., Strachan,D.P.,
            McArdle,W.L., Mein,C.A., Wapenaar,M.C., Deloukas,P., McGinnis,R.,
            McManus,R., Wijmenga,C. and van Heel,D.A.
  TITLE     Newly identified genetic risk variants for celiac disease related
            to the immune response
  JOURNAL   Nat Genet 40 (4), 395-402 (2008)
   PUBMED   18311140
  REMARK    GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 3713)
  AUTHORS   Sommer,C.A., Pavarino-Bertelli,E.C., Goloni-Bertollo,E.M. and
            Henrique-Silva,F.
  TITLE     Identification of dysregulated genes in lymphocytes from children
            with Down syndrome
  JOURNAL   Genome 51 (1), 19-29 (2008)
   PUBMED   18356936
REFERENCE   9  (bases 1 to 3713)
  AUTHORS   Chang,I.F. and Hsiao,H.Y.
  TITLE     Induction of RhoGAP and pathological changes characteristic of
            Alzheimer's disease by UAHFEMF discharge in rat brain
  JOURNAL   Curr Alzheimer Res 2 (5), 559-569 (2005)
   PUBMED   16375659
REFERENCE   10 (bases 1 to 3713)
  AUTHORS   Mao,M., Biery,M.C., Kobayashi,S.V., Ward,T., Schimmack,G.,
            Burchard,J., Schelter,J.M., Dai,H., He,Y.D. and Linsley,P.S.
  TITLE     T lymphocyte activation gene identification by coregulated
            expression on DNA microarrays
  JOURNAL   Genomics 83 (6), 989-999 (2004)
   PUBMED   15177553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF385429.1 and AL035530.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_054114.4.
            
            Summary: This gene encodes a member of the Rho GTPase-activator
            protein superfamily. The encoded protein may function as a Rho
            GTPase-activating protein. Alterations in this gene may be
            associated with several diseases, including rheumatoid arthritis,
            celiac disease, and multiple sclerosis. Alternate splicing results
            in multiple transcript variants encoding distinct isoforms.
            [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.259414.1, AK097090.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367066.8/ ENSP00000356033.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3057              AF385429.1         162-3218
            3058-3713           AL035530.11        37653-38308
FEATURES             Location/Qualifiers
     source          1..3713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..3713
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /note="T cell activation RhoGTPase activating protein"
                     /db_xref="GeneID:117289"
                     /db_xref="HGNC:HGNC:15669"
                     /db_xref="MIM:609667"
     exon            1..113
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            114..198
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2367
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="T-cell activation Rho GTPase-activating protein
                     isoform b"
                     /protein_id="NP_473455.2"
                     /db_xref="CCDS:CCDS5261.1"
                     /db_xref="GeneID:117289"
                     /db_xref="HGNC:HGNC:15669"
                     /db_xref="MIM:609667"
                     /translation="MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDS
                     ICQLIEVKKRKKVLSWPFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPR
                     PIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKD
                     FLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHL
                     ISKNSEVNRMDSSNLAICIGPNMLTLENDQSLSFEAQKDLNNKVKTLVEFLIDNCFEI
                     FGENIPVHSSITSDDSLEHTDSSDVSTLQNDSAYDSNDPDVESNSSSGISSPSRQPQV
                     PMATAAGLDSAGPQDAREVSPEPIVSTVARLKSSLAQPDRRYSEPSMPSSQECLESRV
                     TNQTLTKSEGDFPVPRVGSRLESEEAEDPFPEEVFPAVQGKTKRPVDLKIKNLAPGSV
                     LPRALVLKAFSSSSLDASSDSSPVASPSSPKRNFFSRHQSFTTKTEKGKPSREIKKHS
                     MSFTFAPHKKVLTKNLSAGSGKSQDFTRDHVPRGVRKESQLAGRIVQENGCETHNQTA
                     RGFCLRPHALSVDDVFQGADWERPGSPPSYEEAMQGPAARLVASESQTVGSMTVGSMR
                     ARMLEAHCLLPPLPPAHHVEDSRHRGSKEPLPGHGLSPLPERWKQSRTVHASGDSLGH
                     VSGPGRPELLPLRTVSESVQRNKRDCLVRRCSQPVFEADQFQYAKESYI"
     exon            199..252
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..319
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..486
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..648
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..758
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..954
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1069
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..3713
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3171..3176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /note="hexamer: AATAAA"
     polyA_site      3202
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /note="major polyA site"
     regulatory      3689..3694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
                     /note="hexamer: AATAAA"
     polyA_site      3713
                     /gene="TAGAP"
                     /gene_synonym="ARHGAP47; FKSG15; IDDM21; TAGAP1"
ORIGIN      
        1 ggctcggtct ctctctctcc cagtggacta gaaggagcag agagttatgc tgtttctccc
       61 attctttaca gctcaccgga tgtaaaagaa ctctggctag agaccctcca aggacagagg
      121 cacagccaca cgggagtgaa atccacccct ggacagtcag ccgcaatact gatgaagctg
      181 agaagcagcc acaatgcttc aaaaacacta aacgccaata atatggagac actaatcgaa
      241 tgtcaatcag agggtgatat caaggaacat cccctgttgg catcatgtga gagtgaagac
      301 agtatttgcc agctcattga agttaagaag agaaagaagg tgctgtcctg gccctttctc
      361 atgagaaggc tctcccctgc atcagatttt tctggggctt tggagacaga cttgaaagca
      421 tcgctatttg atcagccctt gtcaattatc tgcggtgaca gtgacacact ccccagaccc
      481 atccaggaca ttctcactat tctatgcctt aaaggccctt caacggaagg gatattcagg
      541 agagcagcca acgagaaagc ccgtaaggag ctgaaggagg agctcaactc tggggatgcg
      601 gtggatctgg agaggctccc cgtgcacctc ctcgctgtgg tctttaagga cttcctcaga
      661 agtatccccc ggaagctact ttcaagcgac ctctttgagg agtggatggg tgctctggag
      721 atgcaggacg aggaggacag aatcgaggcc ctgaaacagg ttgcagataa gctcccccgg
      781 cccaacctcc tgctactcaa gcacttggtc tatgtgctgc acctcatcag caagaactct
      841 gaggtgaaca ggatggactc cagcaatctg gccatctgca ttggacccaa catgctcacc
      901 ctggagaatg accagagcct gtcatttgaa gcccagaagg acctgaacaa caaggtgaag
      961 acactggtgg aattcctcat tgataactgc tttgaaatat ttggggagaa cattccagtg
     1021 cattccagta tcacttctga tgactccctg gagcacactg acagttcaga tgtgtcgacc
     1081 ctgcagaatg actcagccta cgacagcaac gaccctgatg tggaatccaa cagcagcagt
     1141 ggcatcagct ctcccagcag gcagccccag gtgcccatgg ccacagctgc tggcttggat
     1201 agcgcgggcc cacaggatgc ccgagaggtc agcccagagc ccattgtgag caccgtggcc
     1261 aggctgaaaa gctccctcgc acagcccgat aggagatact cagagcccag catgccatcc
     1321 tcccaggagt gcctcgagag ccgggtgaca aaccaaacac taacaaagag tgaaggggac
     1381 ttccccgtgc cccgggtagg ctctcgtttg gaaagtgagg aggctgaaga cccatttcca
     1441 gaggaggtct tccctgcagt gcaaggcaaa accaagaggc cggtggacct gaagatcaag
     1501 aacttggccc cgggttcggt gctcccgcgg gcactggttc tcaaagcctt ctccagcagc
     1561 tcgctggacg cgtcctctga cagctcgccc gtggcttctc cttccagtcc caaaagaaat
     1621 ttcttcagca gacatcagtc tttcaccaca aagacagaga aaggcaagcc cagccgagaa
     1681 attaaaaagc actccatgtc tttcaccttt gcccctcaca aaaaagtgct gaccaaaaac
     1741 ctcagcgcgg gctctgggaa atcgcaagac tttaccaggg accacgtccc gaggggtgtc
     1801 agaaaggaaa gccagcttgc cggccgaatc gtgcaggaaa atgggtgtga aacccacaac
     1861 caaacagccc gcggcttctg cctgagaccc cacgccctct cggtggatga tgtgttccag
     1921 ggagctgact gggagaggcc tggaagccca ccctcttatg aagaggccat gcagggcccg
     1981 gcagccagac tagtggcctc cgagagccag accgtgggga gcatgacggt ggggagcatg
     2041 agggcgagga tgctggaggc gcactgcctc ctaccccctc ttccacctgc tcaccacgta
     2101 gaggactcaa gacacagggg cagcaaagag ccactccctg gccacggact ctctcccctg
     2161 cctgagcgat ggaaacagag cagaactgtc catgcttctg gggactctct ggggcacgtg
     2221 tctggcccag ggagacctga gctcctcccg ctgaggaccg tctccgagtc cgtgcagagg
     2281 aataagcggg actgtctcgt gcgacgatgt agccagccgg tctttgaggc tgaccaattc
     2341 caatatgcca aagaatcgta tatttaggag ggaggccata cgccatgcca tagcttgtgc
     2401 tatctgtaaa tatgagactt gtaaagaact gcctgtagat tgtttttaaa aggtcttgaa
     2461 taagctcctt gagaaagttg tggaaagccc tcctcagtga ggatagctac accatggcca
     2521 tggcgcatca gatagtctct gtgtacctgg atttgtgcaa tatgtaaaaa tgtatcaaat
     2581 gtattataga taaggtgtta ggtgcaaagg atgtctaata atccctgcac acgttttgaa
     2641 cttgcagtga agtacactgc tgttccttgc ttcctggggc acttttctct tggttagtgt
     2701 ttaaaaatta tcttcgcttt tttaatgtgg cctcaaatgt catgccaatt ttcacatctt
     2761 ccacaaactc catttaggga gaaatgttta aatctctggt ataagtttac tccataccag
     2821 agtaaactat atattactct atataagcag tcttgcaata actaatcacc accatagaag
     2881 aaagaaacag actgcaagga acagagttga gtgtctggag tcatcaaagg cattaaaaac
     2941 tccagtaaaa gctggggccg tagcaaaaat catgaaaaac acttcaacgt gtcctttcaa
     3001 tcatccaatt aaatgtgggt agattaatga aaatgtatta catcaatatt aactcatcta
     3061 tagcactttg agtatctttg tagttcatga tatcctatcc tataatgtgg aggtaaatga
     3121 ttttatatgc attgggggtc atatataaaa cttcaatgta atttcactac aataaattgc
     3181 cttccttatt tgaaagtaaa aatgttcttt ttttattgac atgttaactc ctttccctca
     3241 attaatagaa atccactaag aaaatcattc acatattggt tcactcaaca agcatttatt
     3301 aaatatatat tcactattct agactaatag caagaccggg gatcttgttt aggaagaagc
     3361 agtccctgtt ctccagaatt tgcaaaacca ttaaaaaagc acctacttta agccattttt
     3421 tttcagcaag gagtcattct gccagaaaaa tgtagtacac aaatacagga taatataaca
     3481 aatgtaaaat ttctcatttc tagtgaatta aactttccag taattttaca tctcacctca
     3541 ttcttatgat gctcagtttg cttaattatt ggcaaacata atggtaaaat gtttgtactg
     3601 tattagagct ttactgttcg attattaaga tatttatcca gtatcttaga gatgctggac
     3661 ttcaattttc cttattttat ctttttaaaa taaaatatca tgcatgcttc tga
//
