LOCUS       NM_001082967            2524 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens TAFA chemokine like family member 5 (TAFA5),
            transcript variant 1, mRNA.
ACCESSION   NM_001082967
VERSION     NM_001082967.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Wang,Y., Zhang,Z., Wan,W., Liu,Y., Jing,H. and Dong,F.
  TITLE     FAM19A5/S1PR1 signaling pathway regulates the viability and
            proliferation of mantle cell lymphoma
  JOURNAL   J Recept Signal Transduct Res 42 (3), 225-229 (2022)
   PUBMED   33685344
  REMARK    GeneRIF: FAM19A5/S1PR1 signaling pathway regulates the viability
            and proliferation of mantle cell lymphoma.
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Hao,Z., Yang,S., Yin,R., Wei,J., Wang,Y., Pan,X. and Ma,A.
  TITLE     Increased level of FAM19A5 is associated with cerebral small vessel
            disease and leads to a better outcome
  JOURNAL   PeerJ 10, e13101 (2022)
   PUBMED   35282278
  REMARK    GeneRIF: Increased level of FAM19A5 is associated with cerebral
            small vessel disease and leads to a better outcome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Wesolek,A., Skoracka,K., Skrypnik,K., Suliburska,J., Bogdanski,P.,
            Szulinska,M. and Skrypnik,D.
  TITLE     Assessment of progranulin and FAM19A5 protein blood levels in
            patients with metabolic syndrome
  JOURNAL   J Physiol Pharmacol 73 (1) (2022)
   PUBMED   35793765
  REMARK    GeneRIF: Assessment of progranulin and FAM19A5 protein blood levels
            in patients with metabolic syndrome.
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Yari,F.A., Shabani,P., Karami,S., Sarmadi,N., Poustchi,H. and
            Bandegi,A.R.
  TITLE     Circulating levels of FAM19A5 are inversely associated with
            subclinical atherosclerosis in non-alcoholic fatty liver disease
  JOURNAL   BMC Endocr Disord 21 (1), 153 (2021)
   PUBMED   34344333
  REMARK    GeneRIF: Circulating levels of FAM19A5 are inversely associated
            with subclinical atherosclerosis in non-alcoholic fatty liver
            disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Li,J., Li,S., Song,Y., Zhou,W., Zhu,X., Xu,S., Ma,Y. and Zhu,C.
  TITLE     Association of Serum FAM19A5 with Cognitive Impairment in Vascular
            Dementia
  JOURNAL   Dis Markers 2020, 8895900 (2020)
   PUBMED   32831973
  REMARK    GeneRIF: Association of Serum FAM19A5 with Cognitive Impairment in
            Vascular Dementia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2524)
  AUTHORS   Wang,Y., Chen,D., Zhang,Y., Wang,P., Zheng,C., Zhang,S., Yu,B.,
            Zhang,L., Zhao,G., Ma,B., Cai,Z., Xie,N., Huang,S., Liu,Z., Mo,X.,
            Guan,Y., Wang,X., Fu,Y., Ma,D., Wang,Y. and Kong,W.
  TITLE     Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury
            Through Sphingosine-1-Phosphate Receptor 2
  JOURNAL   Circulation 138 (1), 48-63 (2018)
   PUBMED   29453251
REFERENCE   7  (bases 1 to 2524)
  AUTHORS   Winham,S.J., Cuellar-Barboza,A.B., Oliveros,A., McElroy,S.L.,
            Crow,S., Colby,C., Choi,D.S., Chauhan,M., Frye,M. and
            Biernacka,J.M.
  TITLE     Genome-wide association study of bipolar disorder accounting for
            effect of body mass index identifies a new risk allele in TCF7L2
  JOURNAL   Mol Psychiatry 19 (9), 1010-1016 (2014)
   PUBMED   24322204
REFERENCE   8  (bases 1 to 2524)
  AUTHORS   Wu,C., Miao,X., Huang,L., Che,X., Jiang,G., Yu,D., Yang,X., Cao,G.,
            Hu,Z., Zhou,Y., Zuo,C., Wang,C., Zhang,X., Zhou,Y., Yu,X., Dai,W.,
            Li,Z., Shen,H., Liu,L., Chen,Y., Zhang,S., Wang,X., Zhai,K.,
            Chang,J., Liu,Y., Sun,M., Cao,W., Gao,J., Ma,Y., Zheng,X.,
            Cheung,S.T., Jia,Y., Xu,J., Tan,W., Zhao,P., Wu,T., Wang,C. and
            Lin,D.
  TITLE     Genome-wide association study identifies five loci associated with
            susceptibility to pancreatic cancer in Chinese populations
  JOURNAL   Nat Genet 44 (1), 62-66 (2011)
   PUBMED   22158540
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2524)
  AUTHORS   Paulsen,S.J., Christensen,M.T., Vrang,N. and Larsen,L.K.
  TITLE     The putative neuropeptide TAFA5 is expressed in the hypothalamic
            paraventricular nucleus and is regulated by dehydration
  JOURNAL   Brain Res 1199, 1-9 (2008)
   PUBMED   18275939
REFERENCE   10 (bases 1 to 2524)
  AUTHORS   Tom Tang,Y., Emtage,P., Funk,W.D., Hu,T., Arterburn,M., Park,E.E.
            and Rupp,F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF131851.1, Z83837.1 and DB541899.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001082967.2.
            
            Summary: This gene is a member of the TAFA family which is composed
            of five highly homologous genes that encode small secreted
            proteins. These proteins contain conserved cysteine residues at
            fixed positions, and are distantly related to MIP-1alpha, a member
            of the CC-chemokine family. The TAFA proteins are predominantly
            expressed in specific regions of the brain, and are postulated to
            function as brain-specific chemokines or neurokines that act as
            regulators of immune and nervous cells. [provided by RefSeq, Sep
            2013].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1091141.1,
                                           SRR3476690.742040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402357.6/ ENSP00000383933.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1158              AF131851.1         60-1217
            1159-2063           Z83837.1           1450-2354
            2064-2524           DB541899.1         1-461
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.32"
     gene            1..2524
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
                     /note="TAFA chemokine like family member 5"
                     /db_xref="GeneID:25817"
                     /db_xref="HGNC:HGNC:21592"
                     /db_xref="MIM:617499"
     exon            1..152
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..439
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; TAFA protein 5; chemokine-like protein TAFA-5;
                     protein FAM19A5; family with sequence similarity 19
                     (chemokine (C-C motif)-like), member A5; family with
                     sequence similarity 19 member A5, C-C motif chemokine
                     like"
                     /codon_start=1
                     /product="chemokine-like protein TAFA-5 isoform 1
                     precursor"
                     /protein_id="NP_001076436.1"
                     /db_xref="CCDS:CCDS46728.1"
                     /db_xref="GeneID:25817"
                     /db_xref="HGNC:HGNC:21592"
                     /db_xref="MIM:617499"
                     /translation="MAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGT
                     CEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIKTKQWCDMLPC
                     LEGEGCDLLINRSGWTCTQPGGRIKTTTVS"
     exon            153..302
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
                     /inference="alignment:Splign:2.1.0"
     exon            303..430
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
                     /inference="alignment:Splign:2.1.0"
     exon            431..2524
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1390..1395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
                     /note="hexamer: ATTAAA"
     polyA_site      1415
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
                     /note="major polyA site"
     regulatory      2501..2506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
                     /note="hexamer: AATAAA"
     regulatory      2505..2510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
                     /note="hexamer: AAGAAA"
     polyA_site      2521
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
     polyA_site      2524
                     /gene="TAFA5"
                     /gene_synonym="FAM19A5; QLLK5208; TAFA-5; UNQ5208"
ORIGIN      
        1 gagacgcgct gctgcccccc gcgcgggcgc cgcggcttca atggcgccat cgcccaggac
       61 cggcagccgg caagatgcga ccgccctgcc cagcatgtcc tcaactttct gggcgttcat
      121 gatcctggcc agcctgctca tcgcctactg cagtcagctg gccgccggca cctgtgagat
      181 tgtgaccttg gaccgggaca gcagccagcc tcggaggacg atcgcccggc agaccgcccg
      241 ctgtgcgtgt agaaaggggc agatcgccgg caccacgaga gcccggcccg cctgtgtgga
      301 cgcaagaatc atcaagacca agcagtggtg tgacatgctt ccgtgtctgg agggggaagg
      361 ctgcgacttg ttaatcaacc ggtcaggctg gacgtgcacg cagcccggcg ggaggataaa
      421 gaccaccacg gtctcctgac aaacacagcc cctgaggggc cccgggagtg gccttggctc
      481 cctggagagc ccacgtctca gccacagttc tccactcgcc tcggacttca cccgttctct
      541 gccgcccgcc cactccgttt ccctgtggtc cgtgaaggac ggcctcaggc cttggcatcc
      601 tgagcttcgg tctgtccagc cgacccgagg aggccggact cagacacata ggcggggggc
      661 ggcacctggc atcagcaata cgcagtctgt gggagcccgg ccgcgcccag cccccgccga
      721 ccgtggcgtt ggccctgctg tcctcagagg aggaggagga ggaggcagct ccggcagcca
      781 cagaaggctg cagcccagcc cgcctgagac acgacgcctg ccccagggga ctgtcaggca
      841 cagaagcggc ctcctcccgt gccccagact gtccgaattg cttttatttt cttatacttt
      901 cagtatactc catagaccaa agagcaaaat ctatctgaac ctggacgcac cctcactgtc
      961 agggtccctg gggtcgcttg tgcgggcggg agggcaatgg tggcagagac atgctggtgg
     1021 ccccggcgga gcggagaggg cggccgtggt ggaggcctcc accccaggag caccccgcgc
     1081 accctcggag gacgggcttc ggctgcgcgg aggccgtggc acacctgcgg gaggcagcga
     1141 cggcccccac gcagacgccg ggaacgcagg ccgctttatt cctctgtact tagatcaact
     1201 tgaccgtact aaaatccctt tctgttttaa ccagttaaac atgcctcttc tacagctcca
     1261 tttttgatag ttggataatc cagtatctgc caagagcatg ttgggtctcc cgtgactgct
     1321 gcctcatcga taccccattt agctccagaa agcaaagaaa actcgagtaa cacttgtttg
     1381 aaagagatca ttaaatgtat tttgcaaagc ctaaagttat atatttaaca gtttttatat
     1441 gttgtatatt tgtagaaaat cctatttaac aattaacgtg gcagtcccgg ccgtcctgag
     1501 agtcgggccg agccccgtgt gtttctgaag actctggggg tgggacacgg cggggaggtg
     1561 gtgccccgcg gaccccgggg tgccaggcac ggaaggcggg actctgggag aagcgtgcgg
     1621 aggaccgtgg cgtcggcgtc ccggatgtgt cggtcgtgcc cggggaggcc gggttcccct
     1681 cgctgcgggc caggcttggc tcctgattcc ctctctggtc cctgtattgg tcaacacttg
     1741 agcgtacaat atcttgaaca tgcttcttcc aatgggtttt gtttcccatt tcctgcccct
     1801 ttcgccactc acggaccttg aggccagttg acggcccttc tccccacgcc tgtgtccccg
     1861 cgttctgaga agtcctctgt cttcgtgtca ctaggtccag aaagtcgcgc cgggcagagg
     1921 cgcaggcggg gccggcaggg ccgaggaata agcgacaatt ctggtttttc tcccctggcc
     1981 gtcgttcgcc agcctccttc attttcctga gttcccgctg aagtatatac tacctatgag
     2041 tccaattaac atgagtatta tgctagttct atcctactaa aaaaaacgta aaaaaataac
     2101 tatatagaag ctgttccagc aaccatagac tgaagatacg aaagaaaatc catttattta
     2161 agacctgttc cggtatccat gaggacataa tttacctttc agtcaccaca aatttatagg
     2221 catttgtatc ctggactaaa agaaggggct gaggttgggt ttgtcatcac agagggggtg
     2281 ggcctggaaa gggtccttcc caagctgccc cggctccggc ggcccgggcc ggcagcctct
     2341 gccagccagc gtcctcacgg cctccccctc gcctgtttct tttgaaagca agtgtagaca
     2401 ccttcgaggg cagagatcgg gagatttaag atgttacagc atattttttt ttcttgtttt
     2461 acagtattca attttgtgtt gattcagcta aattatgaaa aataaagaaa aactcctttg
     2521 ataa
//
