LOCUS       NM_182522               2229 bp    mRNA    linear   PRI 15-MAR-2023
DEFINITION  Homo sapiens TAFA chemokine like family member 4 (TAFA4),
            transcript variant 1, mRNA.
ACCESSION   NM_182522
VERSION     NM_182522.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2229)
  AUTHORS   Zhou C, Li M, Liu Y, Wang X, Zhang S, Guan L, Hong J, Zhou W, Wu G,
            Diao W, Huang Q and Yang P.
  TITLE     Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by
            modulating the expression of FcepsilonRI in mast cells
  JOURNAL   Clin Exp Immunol 211 (1), 15-22 (2023)
   PUBMED   36368013
  REMARK    GeneRIF: Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal
            allergy by modulating the expression of FcepsilonRI in mast cells.
REFERENCE   2  (bases 1 to 2229)
  AUTHORS   Vink FJ, Meijer CJLM, Hesselink AT, Floore AN, Lissenberg-Witte BI,
            Bonde JH, Pedersen H, Cuschieri K, Bhatia R, Poljak M, Ostrbenk
            Valencak A, Hillemanns P, Quint WGV, Del Pino M, Kenter GG,
            Steenbergen RDM, Heideman DAM and Bleeker MCG.
  TITLE     FAM19A4/miR124-2 Methylation Testing and Human Papillomavirus (HPV)
            16/18 Genotyping in HPV-Positive Women Under the Age of 30 Years
  JOURNAL   Clin Infect Dis 76 (3), e827-e834 (2023)
   PUBMED   35686306
  REMARK    GeneRIF: FAM19A4/miR124-2 Methylation Testing and Human
            Papillomavirus (HPV) 16/18 Genotyping in HPV-Positive Women Under
            the Age of 30 Years.
REFERENCE   3  (bases 1 to 2229)
  AUTHORS   Kaliff M, Lillsunde Larsson G, Helenius G, Karlsson MG and
            Bergengren L.
  TITLE     Full genotyping and FAM19A4/miR124-2 methylation analysis in
            high-risk human papillomavirus-positive samples from women over 30
            years participating in cervical cancer screening in Orebro, Sweden
  JOURNAL   PLoS One 17 (9), e0274825 (2022)
   PUBMED   36137165
  REMARK    GeneRIF: Full genotyping and FAM19A4/miR124-2 methylation analysis
            in high-risk human papillomavirus-positive samples from women over
            30 years participating in cervical cancer screening in Orebro,
            Sweden.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2229)
  AUTHORS   Kremer WW, Dick S, Heideman DAM, Steenbergen RDM, Bleeker MCG,
            Verhoeve HR, van Baal WM, van Trommel N, Kenter GG, Meijer CJLM and
            Berkhof J.
  TITLE     Clinical Regression of High-Grade Cervical Intraepithelial
            Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA
            Methylation (CONCERVE Study)
  JOURNAL   J Clin Oncol 40 (26), 3037-3046 (2022)
   PUBMED   35512257
  REMARK    GeneRIF: Clinical Regression of High-Grade Cervical Intraepithelial
            Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA
            Methylation (CONCERVE Study).
REFERENCE   5  (bases 1 to 2229)
  AUTHORS   Dick S, Vink FJ, Heideman DAM, Lissenberg-Witte BI, Meijer CJLM and
            Berkhof J.
  TITLE     Risk-stratification of HPV-positive women with low-grade cytology
            by FAM19A4/miR124-2 methylation and HPV genotyping
  JOURNAL   Br J Cancer 126 (2), 259-264 (2022)
   PUBMED   34743198
  REMARK    GeneRIF: Risk-stratification of HPV-positive women with low-grade
            cytology by FAM19A4/miR124-2 methylation and HPV genotyping.
REFERENCE   6  (bases 1 to 2229)
  AUTHORS   Wang W, Li T, Wang X, Yuan W, Cheng Y, Zhang H, Xu E, Zhang Y, Shi
            S, Ma D and Han W.
  TITLE     FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1
            (FPR1) and is able to promote the migration and phagocytosis of
            macrophages
  JOURNAL   Cell Mol Immunol 12 (5), 615-624 (2015)
   PUBMED   25109685
  REMARK    GeneRIF: FAM19A4 is a novel ligand of formyl peptide receptor 1.
REFERENCE   7  (bases 1 to 2229)
  AUTHORS   De Strooper LM, Meijer CJ, Berkhof J, Hesselink AT, Snijders PJ,
            Steenbergen RD and Heideman DA.
  TITLE     Methylation analysis of the FAM19A4 gene in cervical scrapes is
            highly efficient in detecting cervical carcinomas and advanced
            CIN2/3 lesions
  JOURNAL   Cancer Prev Res (Phila) 7 (12), 1251-1257 (2014)
   PUBMED   25281488
  REMARK    GeneRIF: High methylation of FAM19A4 is associated with cervical
            carcinomas.
REFERENCE   8  (bases 1 to 2229)
  AUTHORS   Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida
            H, Satoh K, Aoyagi Y, Nozawa Y and Yamada Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2229)
  AUTHORS   Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida
            H, Satoh K, Aoyagi Y, Nozawa Y and Yamada Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2229)
  AUTHORS   Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE and Rupp
            F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY325117.1 and AC096922.2.
            
            On Nov 22, 2018 this sequence version replaced NM_182522.4.
            
            Summary: This gene is a member of the TAFA family which is composed
            of five highly homologous genes that encode small secreted
            proteins. These proteins contain conserved cysteine residues at
            fixed positions, and are distantly related to MIP-1alpha, a member
            of the CC-chemokine family. The TAFA proteins are predominantly
            expressed in specific regions of the brain, and are postulated to
            function as brain-specific chemokines or neurokines, that act as
            regulators of immune and nervous cells. Alternatively spliced
            transcript variants have been observed for this gene. [provided by
            RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY325117.1, SRR1803615.65086.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295569.12/ ENSP00000295569.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-922               AY325117.1         36-957
            923-2229            AC096922.2         39083-40389
FEATURES             Location/Qualifiers
     source          1..2229
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..2229
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /note="TAFA chemokine like family member 4"
                     /db_xref="GeneID:151647"
                     /db_xref="HGNC:HGNC:21591"
                     /db_xref="MIM:617498"
     exon            1..308
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     exon            309..444
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..853
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /note="chemokine-like protein TAFA-4; protein FAM19A4;
                     family with sequence similarity 19 (chemokine (C-C
                     motif)-like), member A4; family with sequence similarity
                     19 member A4, C-C motif chemokine like"
                     /codon_start=1
                     /product="chemokine-like protein TAFA-4 precursor"
                     /protein_id="NP_872328.1"
                     /db_xref="CCDS:CCDS2907.1"
                     /db_xref="GeneID:151647"
                     /db_xref="HGNC:HGNC:21591"
                     /db_xref="MIM:617498"
                     /translation="MRSPRMRVCAKSVLLSHWLFLAYVLMVCCKLMSASSQHLRGHAG
                     HHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEASIVIQK
                     WWCHMNPCLEGEDCKVLPDYSGWSCSSGNKVKTTKVTR"
     exon            445..560
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     exon            561..716
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     exon            717..841
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     exon            842..2229
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2202..2207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /note="hexamer: AGTAAA"
     polyA_site      2229
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /note="major polyA site"
ORIGIN      
        1 gcactgctag ctgcgcgccg ccctggacgg ggcgcaccga ctgcgcgcgc ggctgcgggc
       61 aaacatcggg agtcctgcct cagctgccgc ttctccagca gcagcttcag gcttctcccg
      121 caggagcttc gggcttctcc tggtagagac gtgggaactt ttcttctcct ggcgaggctg
      181 cagaggtgat gggccgctcc cggggctccc gcggggaggc ggcacggtga gcgtcctcgg
      241 gctccggtgc ggcgatcagt acctagttcc ggacgcgccg gtccgacttg gatgccggct
      301 ctagtcgagt cttctgagct acgataattt tttggaacgg cagaaatgat tggttctagc
      361 aacagatggg aatttggagt cactctgaaa tatatcctgg aataagtgtg tttgactaga
      421 accacatctt atgaggtccc caaggatgag agtctgtgct aagtcagtgt tgctgtcgca
      481 ctggctcttt ctagcctacg tgttaatggt gtgctgtaag ctgatgtccg cctcaagcca
      541 gcacctccgg ggacatgcag gtcaccacca aatcaagcaa gggacctgtg aggtggtcgc
      601 cgtgcacagg tgctgcaata agaaccgcat agaagagcgg tcacaaacgg tcaagtgctc
      661 ttgcttcccg ggacaggtgg cgggcacaac tcgggctcaa ccttcttgtg ttgaagcttc
      721 cattgtgatt cagaaatggt ggtgtcacat gaatccgtgt ttggaaggag aggattgtaa
      781 agtgctgcca gattactcag gttggtcctg tagcagtggc aataaagtca aaactacgaa
      841 ggtaacgcgg tagcgaagag agaggtgtgc ttcaatcctg gaggggcagc aggaggcgga
      901 gctcttttgc ttggattccc atcatggccc ctttgcagaa aattgtctag gatttcagca
      961 acttcatatt tgtatatgtg agctgtgaga ggtggcattc acttaactgg cccagccctc
     1021 tctgcttcgt gattttattt cattgaatta taaccacaag ccaccaccca tttgacatcc
     1081 tctctggatt cccaaggagc atacctccaa aatccgagaa gagcaaatca gagtcttcaa
     1141 aatggatcac cactaagggc atgttcattc ttcactttct ttctgctttt acaaaagaac
     1201 ttggatgtat gttccaaagg gtcctcattc tgttcctctt ttgaactttt ccttttgtcc
     1261 ttgtattaaa gtggttttaa aggggtctaa aaagattttg gcaaaacata tttgcagatg
     1321 tagattagct ggtgaagaaa attactgcta gagatcaact gattaactgg taaagaacgt
     1381 ttattttata acccttgaag aatagaagga catagttgga ttattgtgtg tgcattgtat
     1441 ttttacttct attttttttt tgctttccat tttccagtta gcagagataa aatgagagcg
     1501 ttttaacttc aatgtaccat tttactgagt gctaaggaag catatcaatt ccaatatttt
     1561 ataaccaaag ctctatcaga acatatttat aaaacttgtt ggaattttta cggcttttgt
     1621 gtagtcatgt aggtaaatca tttaaaatat aaaacaatct caatttagat caagggttat
     1681 ttcttagatc aaatttatgc caattatatg aaaagatttt aactccgaga caggagtctt
     1741 tcagtgctga atttttagac tgtaaatgag ttcttcttaa cttagctgtt tccctacttc
     1801 tgtgacttct gtgttagcca tcttatttct ttaaaatctg agtcctgatt ggcttaatga
     1861 ttttgcagca gacatgtctc cacatattct caaatgctgt catgcggaaa cgtatgaaac
     1921 agatgaagaa tgactgaccc agattttaga tgtataatgt tgttaaagta catactactg
     1981 taaaaatatg ggatgaattt tatatattaa gaaatgccaa aaacatagtt tctgcaccaa
     2041 gttaattatc cctgtccttt cacatttata gggggaaaat aaatacttta atgttgttta
     2101 tagcctaaca gttatttgat tttattcttg cagagggaat ggaaaggaat ggaaagattt
     2161 gttggcgtaa tttttgaata tttgttatga tcatatgaat aagtaaaaaa attcatcctg
     2221 ctgatggca
//
