LOCUS       NM_001005527            2147 bp    mRNA    linear   PRI 20-MAR-2023
DEFINITION  Homo sapiens TAFA chemokine like family member 4 (TAFA4),
            transcript variant 2, mRNA.
ACCESSION   NM_001005527
VERSION     NM_001005527.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2147)
  AUTHORS   Zhou C, Li M, Liu Y, Wang X, Zhang S, Guan L, Hong J, Zhou W, Wu G,
            Diao W, Huang Q and Yang P.
  TITLE     Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by
            modulating the expression of FcepsilonRI in mast cells
  JOURNAL   Clin Exp Immunol 211 (1), 15-22 (2023)
   PUBMED   36368013
  REMARK    GeneRIF: Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal
            allergy by modulating the expression of FcepsilonRI in mast cells.
REFERENCE   2  (bases 1 to 2147)
  AUTHORS   Vink FJ, Meijer CJLM, Hesselink AT, Floore AN, Lissenberg-Witte BI,
            Bonde JH, Pedersen H, Cuschieri K, Bhatia R, Poljak M, Ostrbenk
            Valencak A, Hillemanns P, Quint WGV, Del Pino M, Kenter GG,
            Steenbergen RDM, Heideman DAM and Bleeker MCG.
  TITLE     FAM19A4/miR124-2 Methylation Testing and Human Papillomavirus (HPV)
            16/18 Genotyping in HPV-Positive Women Under the Age of 30 Years
  JOURNAL   Clin Infect Dis 76 (3), e827-e834 (2023)
   PUBMED   35686306
  REMARK    GeneRIF: FAM19A4/miR124-2 Methylation Testing and Human
            Papillomavirus (HPV) 16/18 Genotyping in HPV-Positive Women Under
            the Age of 30 Years.
REFERENCE   3  (bases 1 to 2147)
  AUTHORS   Kaliff M, Lillsunde Larsson G, Helenius G, Karlsson MG and
            Bergengren L.
  TITLE     Full genotyping and FAM19A4/miR124-2 methylation analysis in
            high-risk human papillomavirus-positive samples from women over 30
            years participating in cervical cancer screening in Orebro, Sweden
  JOURNAL   PLoS One 17 (9), e0274825 (2022)
   PUBMED   36137165
  REMARK    GeneRIF: Full genotyping and FAM19A4/miR124-2 methylation analysis
            in high-risk human papillomavirus-positive samples from women over
            30 years participating in cervical cancer screening in Orebro,
            Sweden.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2147)
  AUTHORS   Kremer WW, Dick S, Heideman DAM, Steenbergen RDM, Bleeker MCG,
            Verhoeve HR, van Baal WM, van Trommel N, Kenter GG, Meijer CJLM and
            Berkhof J.
  TITLE     Clinical Regression of High-Grade Cervical Intraepithelial
            Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA
            Methylation (CONCERVE Study)
  JOURNAL   J Clin Oncol 40 (26), 3037-3046 (2022)
   PUBMED   35512257
  REMARK    GeneRIF: Clinical Regression of High-Grade Cervical Intraepithelial
            Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA
            Methylation (CONCERVE Study).
REFERENCE   5  (bases 1 to 2147)
  AUTHORS   Dick S, Vink FJ, Heideman DAM, Lissenberg-Witte BI, Meijer CJLM and
            Berkhof J.
  TITLE     Risk-stratification of HPV-positive women with low-grade cytology
            by FAM19A4/miR124-2 methylation and HPV genotyping
  JOURNAL   Br J Cancer 126 (2), 259-264 (2022)
   PUBMED   34743198
  REMARK    GeneRIF: Risk-stratification of HPV-positive women with low-grade
            cytology by FAM19A4/miR124-2 methylation and HPV genotyping.
REFERENCE   6  (bases 1 to 2147)
  AUTHORS   Wang W, Li T, Wang X, Yuan W, Cheng Y, Zhang H, Xu E, Zhang Y, Shi
            S, Ma D and Han W.
  TITLE     FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1
            (FPR1) and is able to promote the migration and phagocytosis of
            macrophages
  JOURNAL   Cell Mol Immunol 12 (5), 615-624 (2015)
   PUBMED   25109685
  REMARK    GeneRIF: FAM19A4 is a novel ligand of formyl peptide receptor 1.
REFERENCE   7  (bases 1 to 2147)
  AUTHORS   De Strooper LM, Meijer CJ, Berkhof J, Hesselink AT, Snijders PJ,
            Steenbergen RD and Heideman DA.
  TITLE     Methylation analysis of the FAM19A4 gene in cervical scrapes is
            highly efficient in detecting cervical carcinomas and advanced
            CIN2/3 lesions
  JOURNAL   Cancer Prev Res (Phila) 7 (12), 1251-1257 (2014)
   PUBMED   25281488
  REMARK    GeneRIF: High methylation of FAM19A4 is associated with cervical
            carcinomas.
REFERENCE   8  (bases 1 to 2147)
  AUTHORS   Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida
            H, Satoh K, Aoyagi Y, Nozawa Y and Yamada Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2147)
  AUTHORS   Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida
            H, Satoh K, Aoyagi Y, Nozawa Y and Yamada Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2147)
  AUTHORS   Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE and Rupp
            F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA017279.1, BC031566.1 and
            AC096922.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001005527.2.
            
            Summary: This gene is a member of the TAFA family which is composed
            of five highly homologous genes that encode small secreted
            proteins. These proteins contain conserved cysteine residues at
            fixed positions, and are distantly related to MIP-1alpha, a member
            of the CC-chemokine family. The TAFA proteins are predominantly
            expressed in specific regions of the brain, and are postulated to
            function as brain-specific chemokines or neurokines, that act as
            regulators of immune and nervous cells. Alternatively spliced
            transcript variants have been observed for this gene. [provided by
            RefSeq, Nov 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031566.1, SRR1660805.41302.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267755, SAMN03267762
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DA017279.1         64-86
            24-850              BC031566.1         1-827
            851-2147            AC096922.2         39093-40389
FEATURES             Location/Qualifiers
     source          1..2147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..2147
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /note="TAFA chemokine like family member 4"
                     /db_xref="GeneID:151647"
                     /db_xref="HGNC:HGNC:21591"
                     /db_xref="MIM:617498"
     exon            1..226
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     exon            227..362
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..771
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /note="chemokine-like protein TAFA-4; protein FAM19A4;
                     family with sequence similarity 19 (chemokine (C-C
                     motif)-like), member A4; family with sequence similarity
                     19 member A4, C-C motif chemokine like"
                     /codon_start=1
                     /product="chemokine-like protein TAFA-4 precursor"
                     /protein_id="NP_001005527.1"
                     /db_xref="CCDS:CCDS2907.1"
                     /db_xref="GeneID:151647"
                     /db_xref="HGNC:HGNC:21591"
                     /db_xref="MIM:617498"
                     /translation="MRSPRMRVCAKSVLLSHWLFLAYVLMVCCKLMSASSQHLRGHAG
                     HHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEASIVIQK
                     WWCHMNPCLEGEDCKVLPDYSGWSCSSGNKVKTTKVTR"
     exon            363..478
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     exon            479..634
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     exon            635..759
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     exon            760..2147
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2120..2125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /note="hexamer: AGTAAA"
     polyA_site      2147
                     /gene="TAFA4"
                     /gene_synonym="FAM19A4; TAFA-4"
                     /note="major polyA site"
ORIGIN      
        1 gcactgctag ctgcgcgccg ccctggacgg ggcgcaccga ctgcgcgcgc ggctgcgggc
       61 aaacatcggg agtcctgcct cagctgccgc ttctccagca gcagcttcag gcttctcccg
      121 caggagcttc gggcttctcc tggtagagac gtgggaactt ttcttctcct ggcgaggctg
      181 cagaggtgat gggccgctcc cggggctccc gcggggaggc ggcacggtct tctgagctac
      241 gataattttt tggaacggca gaaatgattg gttctagcaa cagatgggaa tttggagtca
      301 ctctgaaata tatcctggaa taagtgtgtt tgactagaac cacatcttat gaggtcccca
      361 aggatgagag tctgtgctaa gtcagtgttg ctgtcgcact ggctctttct agcctacgtg
      421 ttaatggtgt gctgtaagct gatgtccgcc tcaagccagc acctccgggg acatgcaggt
      481 caccaccaaa tcaagcaagg gacctgtgag gtggtcgccg tgcacaggtg ctgcaataag
      541 aaccgcatag aagagcggtc acaaacggtc aagtgctctt gcttcccggg acaggtggcg
      601 ggcacaactc gggctcaacc ttcttgtgtt gaagcttcca ttgtgattca gaaatggtgg
      661 tgtcacatga atccgtgttt ggaaggagag gattgtaaag tgctgccaga ttactcaggt
      721 tggtcctgta gcagtggcaa taaagtcaaa actacgaagg taacgcggta gcgaagagag
      781 aggtgtgctt caatcctgga ggggcagcag gaggcggagc tcttttgctt ggattcccat
      841 catggcccct ttgcagaaaa ttgtctagga tttcagcaac ttcatatttg tatatgtgag
      901 ctgtgagagg tggcattcac ttaactggcc cagccctctc tgcttcgtga ttttatttca
      961 ttgaattata accacaagcc accacccatt tgacatcctc tctggattcc caaggagcat
     1021 acctccaaaa tccgagaaga gcaaatcaga gtcttcaaaa tggatcacca ctaagggcat
     1081 gttcattctt cactttcttt ctgcttttac aaaagaactt ggatgtatgt tccaaagggt
     1141 cctcattctg ttcctctttt gaacttttcc ttttgtcctt gtattaaagt ggttttaaag
     1201 gggtctaaaa agattttggc aaaacatatt tgcagatgta gattagctgg tgaagaaaat
     1261 tactgctaga gatcaactga ttaactggta aagaacgttt attttataac ccttgaagaa
     1321 tagaaggaca tagttggatt attgtgtgtg cattgtattt ttacttctat tttttttttg
     1381 ctttccattt tccagttagc agagataaaa tgagagcgtt ttaacttcaa tgtaccattt
     1441 tactgagtgc taaggaagca tatcaattcc aatattttat aaccaaagct ctatcagaac
     1501 atatttataa aacttgttgg aatttttacg gcttttgtgt agtcatgtag gtaaatcatt
     1561 taaaatataa aacaatctca atttagatca agggttattt cttagatcaa atttatgcca
     1621 attatatgaa aagattttaa ctccgagaca ggagtctttc agtgctgaat ttttagactg
     1681 taaatgagtt cttcttaact tagctgtttc cctacttctg tgacttctgt gttagccatc
     1741 ttatttcttt aaaatctgag tcctgattgg cttaatgatt ttgcagcaga catgtctcca
     1801 catattctca aatgctgtca tgcggaaacg tatgaaacag atgaagaatg actgacccag
     1861 attttagatg tataatgttg ttaaagtaca tactactgta aaaatatggg atgaatttta
     1921 tatattaaga aatgccaaaa acatagtttc tgcaccaagt taattatccc tgtcctttca
     1981 catttatagg gggaaaataa atactttaat gttgtttata gcctaacagt tatttgattt
     2041 tattcttgca gagggaatgg aaaggaatgg aaagatttgt tggcgtaatt tttgaatatt
     2101 tgttatgatc atatgaataa gtaaaaaaat tcatcctgct gatggca
//
