LOCUS       NM_182759               1451 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens TAFA chemokine like family member 3 (TAFA3),
            transcript variant 1, mRNA.
ACCESSION   NM_182759 XM_005270766
VERSION     NM_182759.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1451)
  AUTHORS   Shao,Y., Deng,T., Zhang,T., Li,P. and Wang,Y.
  TITLE     FAM19A3, a novel secreted protein, modulates the
            microglia/macrophage polarization dynamics and ameliorates cerebral
            ischemia
  JOURNAL   FEBS Lett 589 (4), 467-475 (2015)
   PUBMED   25595455
  REMARK    GeneRIF: FAM19A3 modulates the microglia/macrophage polarization
            dynamics and ameliorates cerebral ischemia.
REFERENCE   2  (bases 1 to 1451)
  AUTHORS   Tom Tang,Y., Emtage,P., Funk,W.D., Hu,T., Arterburn,M., Park,E.E.
            and Rupp,F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
REFERENCE   3  (bases 1 to 1451)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL603832.28.
            
            On or before Jul 10, 2020 this sequence version replaced
            XM_005270766.3, NM_182759.2.
            
            Summary: This gene is a member of the TAFA family which is composed
            of five highly homologous genes that encode small secreted
            proteins. These proteins contain conserved cysteine residues at
            fixed positions, and are distantly related to MIP-1alpha, a member
            of the CC-chemokine family. The TAFA proteins are predominantly
            expressed in specific regions of the brain, and are postulated to
            function as brain-specific chemokines or neurokines, that act as
            regulators of immune and nervous cells. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Nov 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138512.274422.1,
                                           SRR7410570.21754.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361886.4/ ENSP00000355042.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               AL603832.28        71463-71857
            396-453             AL603832.28        73135-73192
            454-569             AL603832.28        74791-74906
            570-719             AL603832.28        75574-75723
            720-844             AL603832.28        76571-76695
            845-1451            AL603832.28        79187-79793
FEATURES             Location/Qualifiers
     source          1..1451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..1451
                     /gene="TAFA3"
                     /gene_synonym="FAM19A3; TAFA-3"
                     /note="TAFA chemokine like family member 3"
                     /db_xref="GeneID:284467"
                     /db_xref="HGNC:HGNC:21590"
                     /db_xref="MIM:617497"
     exon            1..395
                     /gene="TAFA3"
                     /gene_synonym="FAM19A3; TAFA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            396..453
                     /gene="TAFA3"
                     /gene_synonym="FAM19A3; TAFA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            454..569
                     /gene="TAFA3"
                     /gene_synonym="FAM19A3; TAFA-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..856
                     /gene="TAFA3"
                     /gene_synonym="FAM19A3; TAFA-3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; chemokine-like protein TAFA-3; protein FAM19A3;
                     family with sequence similarity 19 (chemokine (C-C
                     motif)-like), member A3; family with sequence similarity
                     19 member A3, C-C motif chemokine like"
                     /codon_start=1
                     /product="chemokine-like protein TAFA-3 isoform 1
                     precursor"
                     /protein_id="NP_877436.1"
                     /db_xref="CCDS:CCDS856.1"
                     /db_xref="GeneID:284467"
                     /db_xref="HGNC:HGNC:21590"
                     /db_xref="MIM:617497"
                     /translation="MSERVERNWSTGGWLLALCLAWLWTHLTLAALQPPTATVLVQQG
                     TCEVIAAHRCCNRNRIEERSQTVKCSCFSGQVAGTTRAKPSCVDASIVLQRWWCQMEP
                     CLPGEECKVLPDLSGWSCSSGHKVKTTKVTR"
     exon            570..719
                     /gene="TAFA3"
                     /gene_synonym="FAM19A3; TAFA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            720..844
                     /gene="TAFA3"
                     /gene_synonym="FAM19A3; TAFA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1451
                     /gene="TAFA3"
                     /gene_synonym="FAM19A3; TAFA-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1428..1433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAFA3"
                     /gene_synonym="FAM19A3; TAFA-3"
                     /note="hexamer: AATAAA"
     polyA_site      1451
                     /gene="TAFA3"
                     /gene_synonym="FAM19A3; TAFA-3"
                     /note="major polyA site"
ORIGIN      
        1 actgtcccga aggaggcggc ggcgcccacg cggggctgga ggagcggggg tagcccgggg
       61 cgaggcggcg gttgcggcgg cggctgcgcg ctccccggcc tgccggcagg aaccttggaa
      121 aaaacccggc tgagttctgc agagctggcg gggccgggcc cagagctccc ctgtgcccag
      181 agcccggccc gccctgcgga tgatgccaac ctgaccagaa ccccgctgtc ccgggggcgc
      241 agcaacttgg tgaaggggac agggctccgg actagacagc acccaagctg gccgctccct
      301 cccaaagtct gtctttcgga gtgctggtcc ctggctcagt ggcaaggaag acttcaggcc
      361 agcagatcga accagtgggc atcaccgtgg accaggtgga gtgagtctga ggacagcaga
      421 tgaacagaca gaaactgaaa gatccccaaa aaggatgagt gagagggtcg agcggaactg
      481 gagcacgggc ggctggctgc tggcactgtg cctggcctgg ctgtggaccc acctgacctt
      541 ggctgccttg cagcctccca ctgccacagt gcttgtgcag cagggcacct gcgaggtgat
      601 tgcggctcac cgctgctgca accggaaccg catcgaggag cgctcccaga cggtgaaatg
      661 ctcctgtttt tctggccagg tggccggcac cacgcgggca aagccctcct gcgtggacgc
      721 ctccatcgtc ctgcagagat ggtggtgtca gatggagccc tgcctgccgg gggaggagtg
      781 taaggtgctc ccggacctgt cgggatggag ctgcagcagt ggacacaaag tcaaaaccac
      841 caaggtcaca cgatagctct tgggggtcac ggcctggaca agaaaggctt gactgagccg
      901 tgaactgaag aatggtatcc agtcatcagc caggaaagat ggggattcac ttacatgcct
      961 catgtcaaat gcagcatcag tctttccggg gcatttcagt taagctgctc agcagatatg
     1021 gatggatctg caatcacata cctaatgtgg agctgggctt ttctggagac acgaaggtca
     1081 acacacaatt cctgccctta aggaatgtcc agttgaattg gagagttgat gacagacaat
     1141 ttagataatt taggttaaag tacttgatac cagactgcgg cttctgggcc acatgctatg
     1201 gcatgatggg ggtttgggaa tgagattccc acagttcttc agataccctg tggccacagg
     1261 gcatagaaac aagaggtcac attcagcacc caccacctcc ctctttcgca tcagttctga
     1321 atccccagca agctgttaac atgttgcagg aaaacactct ccccttatgc cagaccagca
     1381 gtatctcatt tggatgggat tggattgact tgcggaagga aagtaaaaat aaagccaaat
     1441 aacttcccaa a
//
