LOCUS       NM_178539               4045 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens TAFA chemokine like family member 2 (TAFA2), mRNA.
ACCESSION   NM_178539
VERSION     NM_178539.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4045)
  AUTHORS   Jafari,A., Isa,A., Chen,L., Ditzel,N., Zaher,W., Harkness,L.,
            Johnsen,H.E., Abdallah,B.M., Clausen,C. and Kassem,M.
  TITLE     TAFA2 Induces Skeletal (Stromal) Stem Cell Migration Through
            Activation of Rac1-p38 Signaling
  JOURNAL   Stem Cells 37 (3), 407-416 (2019)
   PUBMED   30485583
  REMARK    GeneRIF: interleukin-1beta was found as an upstream regulator of
            TAFA2 expression. Our findings demonstrate that TAFA2 enhances hMSC
            migration and recruitment and thus is relevant for regenerative
            medicine applications.
REFERENCE   2  (bases 1 to 4045)
  AUTHORS   Walford,G.A., Gustafsson,S., Rybin,D., Stancakova,A., Chen,H.,
            Liu,C.T., Hong,J., Jensen,R.A., Rice,K., Morris,A.P., Magi,R.,
            Tonjes,A., Prokopenko,I., Kleber,M.E., Delgado,G., Silbernagel,G.,
            Jackson,A.U., Appel,E.V., Grarup,N., Lewis,J.P., Montasser,M.E.,
            Landenvall,C., Staiger,H., Luan,J., Frayling,T.M., Weedon,M.N.,
            Xie,W., Morcillo,S., Martinez-Larrad,M.T., Biggs,M.L., Chen,Y.D.,
            Corbaton-Anchuelo,A., Faerch,K., Gomez-Zumaquero,J.M.,
            Goodarzi,M.O., Kizer,J.R., Koistinen,H.A., Leong,A., Lind,L.,
            Lindgren,C., Machicao,F., Manning,A.K., Martin-Nunez,G.M.,
            Rojo-Martinez,G., Rotter,J.I., Siscovick,D.S., Zmuda,J.M.,
            Zhang,Z., Serrano-Rios,M., Smith,U., Soriguer,F., Hansen,T.,
            Jorgensen,T.J., Linnenberg,A., Pedersen,O., Walker,M.,
            Langenberg,C., Scott,R.A., Wareham,N.J., Fritsche,A., Haring,H.U.,
            Stefan,N., Groop,L., O'Connell,J.R., Boehnke,M., Bergman,R.N.,
            Collins,F.S., Mohlke,K.L., Tuomilehto,J., Marz,W., Kovacs,P.,
            Stumvoll,M., Psaty,B.M., Kuusisto,J., Laakso,M., Meigs,J.B.,
            Dupuis,J., Ingelsson,E. and Florez,J.C.
  TITLE     Genome-Wide Association Study of the Modified Stumvoll Insulin
            Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin
            Sensitivity Loci
  JOURNAL   Diabetes 65 (10), 3200-3211 (2016)
   PUBMED   27416945
  REMARK    GeneRIF: Data identified two, BCL2 and FAM19A2, novel loci and
            replicated known variants associated with insulin sensitivity.
            Further studies are needed to clarify the causal variant and
            function at the BCL2 and FAM19A2 loci.
REFERENCE   3  (bases 1 to 4045)
  AUTHORS   Parker,M.M., Foreman,M.G., Abel,H.J., Mathias,R.A., Hetmanski,J.B.,
            Crapo,J.D., Silverman,E.K. and Beaty,T.H.
  CONSRTM   COPDGene Investigators
  TITLE     Admixture mapping identifies a quantitative trait locus associated
            with FEV1/FVC in the COPDGene Study
  JOURNAL   Genet Epidemiol 38 (7), 652-659 (2014)
   PUBMED   25112515
  REMARK    GeneRIF: Variants of FAM19A2 (rs348644) are associated with forced
            expiratory volume in COPD.
REFERENCE   4  (bases 1 to 4045)
  AUTHORS   Leger,P.D., Johnson,D.H., Robbins,G.K., Shafer,R.W., Clifford,D.B.,
            Li,J., McLaren,P.J. and Haas,D.W.
  TITLE     Genome-wide association study of peripheral neuropathy with
            D-drug-containing regimens in AIDS Clinical Trials Group protocol
            384
  JOURNAL   J Neurovirol 20 (3), 304-308 (2014)
   PUBMED   24554482
REFERENCE   5  (bases 1 to 4045)
  AUTHORS   Ferreira,M.A., Matheson,M.C., Tang,C.S., Granell,R., Ang,W.,
            Hui,J., Kiefer,A.K., Duffy,D.L., Baltic,S., Danoy,P., Bui,M.,
            Price,L., Sly,P.D., Eriksson,N., Madden,P.A., Abramson,M.J.,
            Holt,P.G., Heath,A.C., Hunter,M., Musk,B., Robertson,C.F., Le
            Souef,P., Montgomery,G.W., Henderson,A.J., Tung,J.Y.,
            Dharmage,S.C., Brown,M.A., James,A., Thompson,P.J., Pennell,C.,
            Martin,N.G., Evans,D.M., Hinds,D.A. and Hopper,J.L.
  CONSRTM   Australian Asthma Genetics Consortium Collaborators
  TITLE     Genome-wide association analysis identifies 11 risk variants
            associated with the asthma with hay fever phenotype
  JOURNAL   J Allergy Clin Immunol 133 (6), 1564-1571 (2014)
   PUBMED   24388013
REFERENCE   6  (bases 1 to 4045)
  AUTHORS   Cho,M.H., McDonald,M.L., Zhou,X., Mattheisen,M., Castaldi,P.J.,
            Hersh,C.P., Demeo,D.L., Sylvia,J.S., Ziniti,J., Laird,N.M.,
            Lange,C., Litonjua,A.A., Sparrow,D., Casaburi,R., Barr,R.G.,
            Regan,E.A., Make,B.J., Hokanson,J.E., Lutz,S., Dudenkov,T.M.,
            Farzadegan,H., Hetmanski,J.B., Tal-Singer,R., Lomas,D.A., Bakke,P.,
            Gulsvik,A., Crapo,J.D., Silverman,E.K. and Beaty,T.H.
  CONSRTM   NETT Genetics, ICGN, ECLIPSE and COPDGene Investigators
  TITLE     Risk loci for chronic obstructive pulmonary disease: a genome-wide
            association study and meta-analysis
  JOURNAL   Lancet Respir Med 2 (3), 214-225 (2014)
   PUBMED   24621683
REFERENCE   7  (bases 1 to 4045)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 4045)
  AUTHORS   Parsa,A., Chang,Y.P., Kelly,R.J., Corretti,M.C., Ryan,K.A.,
            Robinson,S.W., Gottlieb,S.S., Kardia,S.L., Shuldiner,A.R. and
            Liggett,S.B.
  TITLE     Hypertrophy-associated polymorphisms ascertained in a founder
            cohort applied to heart failure risk and mortality
  JOURNAL   Clin Transl Sci 4 (1), 17-23 (2011)
   PUBMED   21348951
REFERENCE   9  (bases 1 to 4045)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 4045)
  AUTHORS   Tom Tang,Y., Emtage,P., Funk,W.D., Hu,T., Arterburn,M., Park,E.E.
            and Rupp,F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078789.16, AC020647.9 and
            AC137053.2.
            
            On Sep 18, 2020 this sequence version replaced NM_178539.4.
            
            Summary: This gene is a member of the TAFA family which is composed
            of five highly homologous genes that encode small secreted
            proteins. These proteins contain conserved cysteine residues at
            fixed positions, and are distantly related to MIP-1alpha, a member
            of the CC-chemokine family. The TAFA proteins are predominantly
            expressed in specific regions of the brain, and are postulated to
            function as brain-specific chemokines or neurokines, that act as
            regulators of immune and nervous cells. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050347.1, AL834160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2162568
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000416284.8/ ENSP00000393987.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1515              AC078789.16        49286-50800
            1516-1622           AC020647.9         83218-83324
            1623-1775           AC137053.2         66568-66720         c
            1776-1900           AC137053.2         65318-65442         c
            1901-4045           AC137053.2         19969-22113         c
FEATURES             Location/Qualifiers
     source          1..4045
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.1"
     gene            1..4045
                     /gene="TAFA2"
                     /gene_synonym="FAM19A2; TAFA-2"
                     /note="TAFA chemokine like family member 2"
                     /db_xref="GeneID:338811"
                     /db_xref="HGNC:HGNC:21589"
                     /db_xref="MIM:617496"
     exon            1..1515
                     /gene="TAFA2"
                     /gene_synonym="FAM19A2; TAFA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1622
                     /gene="TAFA2"
                     /gene_synonym="FAM19A2; TAFA-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1517..1912
                     /gene="TAFA2"
                     /gene_synonym="FAM19A2; TAFA-2"
                     /note="chemokine-like protein TAFA-2; protein FAM19A2;
                     family with sequence similarity 19 member A2, C-C motif
                     chemokine like; family with sequence similarity 19
                     (chemokine (C-C motif)-like), member A2"
                     /codon_start=1
                     /product="chemokine-like protein TAFA-2 precursor"
                     /protein_id="NP_848634.1"
                     /db_xref="CCDS:CCDS8962.1"
                     /db_xref="GeneID:338811"
                     /db_xref="HGNC:HGNC:21589"
                     /db_xref="MIM:617496"
                     /translation="MSKRYLQKATKGKLLIIIFIVTLWGKVVSSANHHKAHHVKTGTC
                     EVVALHRCCNKNKIEERSQTVKCSCFPGQVAGTTRAAPSCVDASIVEQKWWCHMQPCL
                     EGEECKVLPDRKGWSCSSGNKVKTTRVTH"
     exon            1623..1775
                     /gene="TAFA2"
                     /gene_synonym="FAM19A2; TAFA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1900
                     /gene="TAFA2"
                     /gene_synonym="FAM19A2; TAFA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..4045
                     /gene="TAFA2"
                     /gene_synonym="FAM19A2; TAFA-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4022..4027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAFA2"
                     /gene_synonym="FAM19A2; TAFA-2"
                     /note="hexamer: AATAAA"
     polyA_site      4045
                     /gene="TAFA2"
                     /gene_synonym="FAM19A2; TAFA-2"
                     /note="major polyA site"
ORIGIN      
        1 acggcagttg ctggggctaa cagaactggc tgttgggaga gagaggcgag gcaacgccgc
       61 ccggccctgc cattccattt tactgcttaa ctcaacctgg agtgtcagga cctattctcc
      121 tgcattctcg ctgcactata cgggggagcc aagtcactct gtactcactg gacagccagg
      181 ctgggtggaa tagggttcta gagtggagca ggggctctgc cctttatggc gactttctaa
      241 aagattagca tcagtgtctt ttgacagtat agcatctggg gtgggacgcg gagaggaggc
      301 tttgcttgct aaacggcttc tttctccgcc ggtgatctgg atttgtttcc tcggccccct
      361 ccccccgctc ctttctttct cccctcccgc ctttagcaaa gtgacacagg cgacacctgc
      421 tcgcttgtgt tcgatgttgg aactcgcacc tcctcggtgg tgacggtgcc agggcactgc
      481 taccaggggg acatcggcgg gtttcccttc cttccagccc acgatgccta gaagggcagc
      541 gggtgggctg cgtggggctc tgcccgcagc acttcgaggc gggattgagg ggctgaagct
      601 ggccaggagt tgctgctaag tggattcgag tggaaggcgc caagtctccg cgagggcacc
      661 agcggggacc tatctgcgag cagtgggaac aggggcacct ggacggagga acgcgggcgt
      721 ctggaggggg gacatcggct gagctcagag cctctcctcc ttcctgtccc gagcttccca
      781 gcaactccgc cacgttggag acccggtacc tgcgagagcc agggaactcg agaagtgcgt
      841 ggccgaggct gctttcctga aggtgaatca ttctgtccaa ttgcctttcc ccagagaaca
      901 agagggaggg cgggagagag ggaacggagg atgtgtgagt gtgtgtgtgt gtgagaggga
      961 gagacgacgt gaggcgagag gaaaagtctt tagtcggcct taaaagcaaa caaatcagag
     1021 atggaataag agcggtaatt gcagcaagac cgccttgatt cttgcagtcc agggagctga
     1081 gcgcaccgcg cgcatccggc gaggacagga ggcgaccgcg ggcgctgcca agggctgcgg
     1141 gactttggct tttcctcagt aaacaaatct tttgattact ttgacactgt ggaataaaga
     1201 agcggggaga aggatcaggc tcaccttcac ccgcttcagg gggattccag cttggatgtc
     1261 agattcctga accgtctttg ccatcggagg aggaaacaca tccacacacg cgcgcgcaca
     1321 ctcgcacgct cagggccaca ctcacacgcc gccctccacg atcacacagc accagacttc
     1381 ggttccctat gcccctggat ggtgacggcg gattggcatc ttggaagcga tgcgagagcg
     1441 ataaggctgg cgccggcccg caaaagctgc aggagcatcg ctaggtgttg ccgccaccgg
     1501 gaagcggggc tgcaggatga gtaagagata cttacagaaa gcaacaaaag gaaaactgct
     1561 aataataata tttattgtaa ccttgtgggg gaaagttgta tccagtgcaa accatcataa
     1621 agctcaccat gttaaaacgg gaacttgtga ggtggtggca ctccacagat gctgtaataa
     1681 gaacaagata gaagaacggt cacaaacagt caagtgctcc tgcttccctg ggcaggtggc
     1741 aggcaccacg cgagctgctc catcatgtgt ggatgcttca atagtggaac agaaatggtg
     1801 gtgccatatg cagccatgtc tagagggaga agaatgtaaa gttcttccgg atcggaaagg
     1861 atggagctgt tcctctggga ataaagtcaa aacaactagg gtaacccatt aacccaggag
     1921 aaatcaagtg atcctcaagg ctgatgacat tgaacatgcg catagaaact taactcaact
     1981 cctgaggtga tcttgaagat ttttatacca cttgaaagag gcgctcaata gtctatttcc
     2041 aagggatttc atggcctctt cttgaaatca agacttttta aaagtcagac atgaacttgc
     2101 atgtcatgaa gatttcagca gatttgaact gtgttcaact tgtaaattgt taaaagaatt
     2161 tgaagtcact gtctgaggag ctggtgaaga gttgtttttt tcagggtgat gttagagaca
     2221 gtcacctttt gagttattgg ctccagatgt gactactttt cttgtttctg caagctgtat
     2281 cccaagtgca ctgtccttct gtcctggatg tgttcctggg tcctatgttc atttgctagt
     2341 gggactacac atggctttaa tgacatttcc tttgagaact tttcctctgg catggtgtag
     2401 actgagacaa ttttatttat atcctaatct tggagctcag aaagcctaca tgttttaaca
     2461 tcttaaagtt gcttttgtta aaggaatgga aatatatatc cattggtaat aatgttggca
     2521 agtaatagtt atctgaataa atcaatcata taagaatgta tagacaagct gacatatttc
     2581 cctaaggcta acaacaccct gctgaagctc tttgtcaaat aggtagtagt tagaactgga
     2641 ttgccatttt cattatataa tactttgtac ctctagagca ctctcccttt ctgttttttt
     2701 ttaagtgagc ttttctttaa ttttttatgt ttacttattc ccttcacaga aatcagcagt
     2761 gagcagtcaa gttaatgggt agccttcagt ttcaaaaaaa ttgacaggga tgcatgtgag
     2821 tttctgattt cttagcttga acattattca cttagatttc ttccagtatt ttttaaaaaa
     2881 ctgtcctatc tcattttaaa agactttctt ttgcttgatc ccaatgactg tttgaatgct
     2941 tatatatttg ttcaatctgt tgatagaaaa aattgttcat tttcctcagt ctcaaattta
     3001 taaatatttg cttacagttt tcctattcaa acaatttgtt aggccaatat tttgtgacat
     3061 ttttgtagcg attttaacgt ttatggtttt ggttctacag gaaagtcata aatatttaaa
     3121 ggccttaaac atgtatgtac tttttttttc taagttatag aatgtataat tttgtactac
     3181 atttattttg tttcatttgt gatatgaagg gagagaagaa agaaaagtgc atagccattc
     3241 tgtaacaata ttgtgtaaac ctatagtttg aaggaatgca aggagaagga tttctgtgtt
     3301 ttactcattt taggctgttc agaagatgct tcaaaaattg tcctgttaga atttccatca
     3361 tggaaggtgg tatggaagaa ggtatggaaa tactttgtat tctaaaaact cactgacgtg
     3421 gtcagttaga catacgttgg tttccaggat agaggcccat atatcctggg gagctttggt
     3481 ctattagttt gtgacaatat tcaaaggcca aaacactact cagacacttt cctgggaaga
     3541 gcaactaaaa atgtaaaatt ggttaaaaat aaaatctgaa aagtatgtat ctcacattga
     3601 actaaaatcc actgtctcat aagttcatgg aatgaaatgg ctttctgcct ccattttaat
     3661 catgcataaa atgaattaga tggctttgag tggattttca caatggctca agactatatg
     3721 aaattataaa aaaaaagttg ccctggggtt tctgcatcaa ttagaatatc attaatttct
     3781 ttgtaaccaa gtgaaaaact atactttttg gaaattatga atttgtccta ggtttgtttg
     3841 agatttgaaa ttatacatca tgcttctcat tttttaaact atgttcttta aatcaacact
     3901 ggaaactctg tattatatac aagtgtaata catgcatata atagaaaaaa aacatggaat
     3961 ttcaaatata ctaactagat tatccccagt agattaatgt tgtgactatt cagaaaaggt
     4021 gaataaaatt gggatataaa atgga
//
