LOCUS       NP_848634                131 aa            linear   PRI 30-APR-2025
DEFINITION  chemokine-like protein TAFA-2 precursor [Homo sapiens].
ACCESSION   NP_848634
VERSION     NP_848634.1
DBSOURCE    REFSEQ: accession NM_178539.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 131)
  AUTHORS   Jafari,A., Isa,A., Chen,L., Ditzel,N., Zaher,W., Harkness,L.,
            Johnsen,H.E., Abdallah,B.M., Clausen,C. and Kassem,M.
  TITLE     TAFA2 Induces Skeletal (Stromal) Stem Cell Migration Through
            Activation of Rac1-p38 Signaling
  JOURNAL   Stem Cells 37 (3), 407-416 (2019)
   PUBMED   30485583
  REMARK    GeneRIF: interleukin-1beta was found as an upstream regulator of
            TAFA2 expression. Our findings demonstrate that TAFA2 enhances hMSC
            migration and recruitment and thus is relevant for regenerative
            medicine applications.
REFERENCE   2  (residues 1 to 131)
  AUTHORS   Walford,G.A., Gustafsson,S., Rybin,D., Stancakova,A., Chen,H.,
            Liu,C.T., Hong,J., Jensen,R.A., Rice,K., Morris,A.P., Magi,R.,
            Tonjes,A., Prokopenko,I., Kleber,M.E., Delgado,G., Silbernagel,G.,
            Jackson,A.U., Appel,E.V., Grarup,N., Lewis,J.P., Montasser,M.E.,
            Landenvall,C., Staiger,H., Luan,J., Frayling,T.M., Weedon,M.N.,
            Xie,W., Morcillo,S., Martinez-Larrad,M.T., Biggs,M.L., Chen,Y.D.,
            Corbaton-Anchuelo,A., Faerch,K., Gomez-Zumaquero,J.M.,
            Goodarzi,M.O., Kizer,J.R., Koistinen,H.A., Leong,A., Lind,L.,
            Lindgren,C., Machicao,F., Manning,A.K., Martin-Nunez,G.M.,
            Rojo-Martinez,G., Rotter,J.I., Siscovick,D.S., Zmuda,J.M.,
            Zhang,Z., Serrano-Rios,M., Smith,U., Soriguer,F., Hansen,T.,
            Jorgensen,T.J., Linnenberg,A., Pedersen,O., Walker,M.,
            Langenberg,C., Scott,R.A., Wareham,N.J., Fritsche,A., Haring,H.U.,
            Stefan,N., Groop,L., O'Connell,J.R., Boehnke,M., Bergman,R.N.,
            Collins,F.S., Mohlke,K.L., Tuomilehto,J., Marz,W., Kovacs,P.,
            Stumvoll,M., Psaty,B.M., Kuusisto,J., Laakso,M., Meigs,J.B.,
            Dupuis,J., Ingelsson,E. and Florez,J.C.
  TITLE     Genome-Wide Association Study of the Modified Stumvoll Insulin
            Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin
            Sensitivity Loci
  JOURNAL   Diabetes 65 (10), 3200-3211 (2016)
   PUBMED   27416945
  REMARK    GeneRIF: Data identified two, BCL2 and FAM19A2, novel loci and
            replicated known variants associated with insulin sensitivity.
            Further studies are needed to clarify the causal variant and
            function at the BCL2 and FAM19A2 loci.
REFERENCE   3  (residues 1 to 131)
  AUTHORS   Parker,M.M., Foreman,M.G., Abel,H.J., Mathias,R.A., Hetmanski,J.B.,
            Crapo,J.D., Silverman,E.K. and Beaty,T.H.
  CONSRTM   COPDGene Investigators
  TITLE     Admixture mapping identifies a quantitative trait locus associated
            with FEV1/FVC in the COPDGene Study
  JOURNAL   Genet Epidemiol 38 (7), 652-659 (2014)
   PUBMED   25112515
  REMARK    GeneRIF: Variants of FAM19A2 (rs348644) are associated with forced
            expiratory volume in COPD.
REFERENCE   4  (residues 1 to 131)
  AUTHORS   Leger,P.D., Johnson,D.H., Robbins,G.K., Shafer,R.W., Clifford,D.B.,
            Li,J., McLaren,P.J. and Haas,D.W.
  TITLE     Genome-wide association study of peripheral neuropathy with
            D-drug-containing regimens in AIDS Clinical Trials Group protocol
            384
  JOURNAL   J Neurovirol 20 (3), 304-308 (2014)
   PUBMED   24554482
REFERENCE   5  (residues 1 to 131)
  AUTHORS   Ferreira,M.A., Matheson,M.C., Tang,C.S., Granell,R., Ang,W.,
            Hui,J., Kiefer,A.K., Duffy,D.L., Baltic,S., Danoy,P., Bui,M.,
            Price,L., Sly,P.D., Eriksson,N., Madden,P.A., Abramson,M.J.,
            Holt,P.G., Heath,A.C., Hunter,M., Musk,B., Robertson,C.F., Le
            Souef,P., Montgomery,G.W., Henderson,A.J., Tung,J.Y.,
            Dharmage,S.C., Brown,M.A., James,A., Thompson,P.J., Pennell,C.,
            Martin,N.G., Evans,D.M., Hinds,D.A. and Hopper,J.L.
  CONSRTM   Australian Asthma Genetics Consortium Collaborators
  TITLE     Genome-wide association analysis identifies 11 risk variants
            associated with the asthma with hay fever phenotype
  JOURNAL   J Allergy Clin Immunol 133 (6), 1564-1571 (2014)
   PUBMED   24388013
REFERENCE   6  (residues 1 to 131)
  AUTHORS   Cho,M.H., McDonald,M.L., Zhou,X., Mattheisen,M., Castaldi,P.J.,
            Hersh,C.P., Demeo,D.L., Sylvia,J.S., Ziniti,J., Laird,N.M.,
            Lange,C., Litonjua,A.A., Sparrow,D., Casaburi,R., Barr,R.G.,
            Regan,E.A., Make,B.J., Hokanson,J.E., Lutz,S., Dudenkov,T.M.,
            Farzadegan,H., Hetmanski,J.B., Tal-Singer,R., Lomas,D.A., Bakke,P.,
            Gulsvik,A., Crapo,J.D., Silverman,E.K. and Beaty,T.H.
  CONSRTM   NETT Genetics, ICGN, ECLIPSE and COPDGene Investigators
  TITLE     Risk loci for chronic obstructive pulmonary disease: a genome-wide
            association study and meta-analysis
  JOURNAL   Lancet Respir Med 2 (3), 214-225 (2014)
   PUBMED   24621683
REFERENCE   7  (residues 1 to 131)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (residues 1 to 131)
  AUTHORS   Parsa,A., Chang,Y.P., Kelly,R.J., Corretti,M.C., Ryan,K.A.,
            Robinson,S.W., Gottlieb,S.S., Kardia,S.L., Shuldiner,A.R. and
            Liggett,S.B.
  TITLE     Hypertrophy-associated polymorphisms ascertained in a founder
            cohort applied to heart failure risk and mortality
  JOURNAL   Clin Transl Sci 4 (1), 17-23 (2011)
   PUBMED   21348951
REFERENCE   9  (residues 1 to 131)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (residues 1 to 131)
  AUTHORS   Tom Tang,Y., Emtage,P., Funk,W.D., Hu,T., Arterburn,M., Park,E.E.
            and Rupp,F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078789.16, AC020647.9 and
            AC137053.2.
            
            Summary: This gene is a member of the TAFA family which is composed
            of five highly homologous genes that encode small secreted
            proteins. These proteins contain conserved cysteine residues at
            fixed positions, and are distantly related to MIP-1alpha, a member
            of the CC-chemokine family. The TAFA proteins are predominantly
            expressed in specific regions of the brain, and are postulated to
            function as brain-specific chemokines or neurokines, that act as
            regulators of immune and nervous cells. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050347.1, AL834160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2162568
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000416284.8/ ENSP00000393987.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..131
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.1"
     Protein         1..131
                     /product="chemokine-like protein TAFA-2 precursor"
                     /note="chemokine-like protein TAFA-2; protein FAM19A2;
                     family with sequence similarity 19 member A2, C-C motif
                     chemokine like; family with sequence similarity 19
                     (chemokine (C-C motif)-like), member A2"
                     /calculated_mol_wt=11216
     sig_peptide     1..30
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3422
     mat_peptide     31..131
                     /product="Chemokine-like protein TAFA-2.
                     /id=PRO_0000042723"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N3H0.1)"
                     /calculated_mol_wt=11216
     Region          41..129
                     /region_name="TAFA"
                     /note="TAFA family; pfam12020"
                     /db_xref="CDD:432266"
     CDS             1..131
                     /gene="TAFA2"
                     /gene_synonym="FAM19A2; TAFA-2"
                     /coded_by="NM_178539.5:1517..1912"
                     /db_xref="CCDS:CCDS8962.1"
                     /db_xref="GeneID:338811"
                     /db_xref="HGNC:HGNC:21589"
                     /db_xref="MIM:617496"
ORIGIN      
        1 mskrylqkat kgklliiifi vtlwgkvvss anhhkahhvk tgtcevvalh rccnknkiee
       61 rsqtvkcscf pgqvagttra apscvdasiv eqkwwchmqp clegeeckvl pdrkgwscss
      121 gnkvkttrvt h
//
