LOCUS       NM_213609               1979 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens TAFA chemokine like family member 1 (TAFA1),
            transcript variant 1, mRNA.
ACCESSION   NM_213609
VERSION     NM_213609.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1979)
  AUTHORS   Wang,Y., Chen,D., Zhang,Y., Wang,P., Zheng,C., Zhang,S., Yu,B.,
            Zhang,L., Zhao,G., Ma,B., Cai,Z., Xie,N., Huang,S., Liu,Z., Mo,X.,
            Guan,Y., Wang,X., Fu,Y., Ma,D., Wang,Y. and Kong,W.
  TITLE     Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury
            Through Sphingosine-1-Phosphate Receptor 2
  JOURNAL   Circulation 138 (1), 48-63 (2018)
   PUBMED   29453251
REFERENCE   2  (bases 1 to 1979)
  AUTHORS   Lin,H.J., Huang,Y.C., Lin,J.M., Wu,J.Y., Chen,L.A., Lin,C.J.,
            Tsui,Y.P., Chen,C.P. and Tsai,F.J.
  TITLE     Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are
            associated with susceptibility of type 2 diabetes with cataract
  JOURNAL   Mol Vis 16, 1206-1214 (2010)
   PUBMED   20664687
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1979)
  AUTHORS   Tom Tang,Y., Emtage,P., Funk,W.D., Hu,T., Arterburn,M., Park,E.E.
            and Rupp,F.
  TITLE     TAFA: a novel secreted family with conserved cysteine residues and
            restricted expression in the brain
  JOURNAL   Genomics 83 (4), 727-734 (2004)
   PUBMED   15028294
REFERENCE   4  (bases 1 to 1979)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA484048.1, DA485098.1,
            AK290446.1 and BC025746.1.
            
            On Nov 22, 2018 this sequence version replaced NM_213609.3.
            
            Summary: This gene is a member of the TAFA family which is composed
            of five highly homologous genes that encode small secreted
            proteins. These proteins contain conserved cysteine residues at
            fixed positions, and are distantly related to MIP-1alpha, a member
            of the CC-chemokine family. The TAFA proteins are predominantly
            expressed in specific regions of the brain, and are postulated to
            function as brain-specific chemokines or neurokines that act as
            regulators of immune and nervous cells. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.261435.1,
                                           SRR1660809.770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000478136.6/ ENSP00000418575.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                DA484048.1         33-73
            42-322              DA485098.1         1-281
            323-1235            AK290446.1         276-1188
            1236-1979           BC025746.1         1169-1912
FEATURES             Location/Qualifiers
     source          1..1979
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..1979
                     /gene="TAFA1"
                     /gene_synonym="FAM19A1; TAFA-1"
                     /note="TAFA chemokine like family member 1"
                     /db_xref="GeneID:407738"
                     /db_xref="HGNC:HGNC:21587"
                     /db_xref="MIM:617495"
     exon            1..456
                     /gene="TAFA1"
                     /gene_synonym="FAM19A1; TAFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..577
                     /gene="TAFA1"
                     /gene_synonym="FAM19A1; TAFA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..861
                     /gene="TAFA1"
                     /gene_synonym="FAM19A1; TAFA-1"
                     /note="chemokine-like protein TAFA-1; protein FAM19A1;
                     family with sequence similarity 19 (chemokine (C-C
                     motif)-like), member A1; family with sequence similarity
                     19 member A1, C-C motif chemokine like"
                     /codon_start=1
                     /product="chemokine-like protein TAFA-1 precursor"
                     /protein_id="NP_998774.2"
                     /db_xref="CCDS:CCDS54606.1"
                     /db_xref="GeneID:407738"
                     /db_xref="HGNC:HGNC:21587"
                     /db_xref="MIM:617495"
                     /translation="MAMVSAMSWVLYLWISACAMLLCHGSLQHTFQQHHLHRPEGGTC
                     EVIAAHRCCNKNRIEERSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCL
                     EGEECKTLPDNSGWMCATGNKIKTTRIHPRT"
     exon            578..718
                     /gene="TAFA1"
                     /gene_synonym="FAM19A1; TAFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..843
                     /gene="TAFA1"
                     /gene_synonym="FAM19A1; TAFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1979
                     /gene="TAFA1"
                     /gene_synonym="FAM19A1; TAFA-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1951..1956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAFA1"
                     /gene_synonym="FAM19A1; TAFA-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1979
                     /gene="TAFA1"
                     /gene_synonym="FAM19A1; TAFA-1"
                     /note="major polyA site"
ORIGIN      
        1 agactactgc tacttacagc accgtatagc agccctgctc ctacattttg ctgccttact
       61 ctgccccgaa tgcactggag tggggatggt ccatcggcaa ctataaactg attctcatca
      121 ggaaactgca cattatctcc ccatcacttc aaaggtctcg tcaggcagag gtgacgccag
      181 gagatgattt aaaggtgaaa atgacaaggt ttccacccct caaaccttgg ctccttttct
      241 gacaatacag tctgaatgaa cccgatgtct ttttttttac tgtggaaata ggatcggaag
      301 agagtaacat tttttttttt ttaatcctga taaagaagat tgttgggaag ctctttgaaa
      361 aaaaatttta aattgtggca cagatggatt ttaaaaagtg ttagatcttt ccaatgaaca
      421 ctaatagagt actctgctct tggctggatt tttcagagaa tggcaatggt ctctgcgatg
      481 tcctgggtcc tgtatttgtg gataagtgct tgtgcaatgc tactctgcca tggatccctt
      541 cagcacactt tccagcagca tcacctgcac agaccagaag gagggacgtg tgaagtgata
      601 gcagcacacc gatgttgtaa caagaatcgc attgaggagc ggtcacaaac agtaaagtgt
      661 tcctgtctac ctggaaaagt ggctggaaca acaagaaacc ggccttcttg cgtcgatgcc
      721 tccatagtga ttgggaaatg gtggtgtgag atggagcctt gcctagaagg agaagaatgt
      781 aagacactcc ctgacaattc tggatggatg tgcgcaacag gcaacaaaat taagaccacg
      841 agaattcacc caagaaccta acagaagcat ttgtggtagt aaaggaaaac caaccctctg
      901 gaaaatacat tttgagaatc tcaaacatct cacatatata caagccaaat ggatttctta
      961 cttgcacttt gactggctac cagataatca cagtgcgttt actgtgtgta acgaaatatc
     1021 ctacagtgag aagacacagc gttttggcaa caccatggaa agtgggctta aaaaagggtt
     1081 ttctcagtga aatttttggg catcatgaag aacgatcaac tatcttctaa tttgaatcta
     1141 tagttacttt gtaccatttg aaatatatgt atatatatat atataatatt ttgaaatatt
     1201 atctattctc ttcaagaaat gaacagtacc acagtttgag acggctggtg tacccctttg
     1261 agttttggat gttttgtctg ttttgctttg ttttgttagt catttctttt tctaacggca
     1321 aggaagatat gtgccctttt gagaattcaa gatggcactg acacgggaag gccagctaca
     1381 ggtggactcc tggaatttga ggcatcataa tgatactgaa tcaagaactt ccttctgctt
     1441 ctaccagatg gcccaaggaa gcacatcgtc ctgttttatt gctttctacc ctgtgcaata
     1501 ttagcatgca agcttggctt acatagtcat actttatatt caattgatat ataataaccg
     1561 ttctaacctc ttccaggaaa atatttttag aactactagc ttttccactt agaagaaaat
     1621 gaggattctt aagggagcca ctccaccatg ctattaagac tctggcagag ttatgggtag
     1681 gatatggatc cctacatgaa taagtcctgt aaatacaatg tcttaaggct ttgtatagct
     1741 gtcctagact gcagaaatgt cctctgatta aatccaaagt ctggcatcgt taactacata
     1801 gtgctgtagc aacaagtctt atcatggcat ctctttctat gtttggtttg ctttttccaa
     1861 gagtattcag gtctcctctt gtgagatagg aaggccatga aaacaattag atttcaagat
     1921 gatctatgtg accaaatgtt ggacagccct attaaagtgg taaacaactt ctttctaaa
//
