LOCUS       NM_003187               1163 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor 9 (TAF9),
            transcript variant 1, mRNA.
ACCESSION   NM_003187
VERSION     NM_003187.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1163)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1163)
  AUTHORS   Hsieh,A.H., Kuo,C.F., Chou,I.J., Tseng,W.Y., Chen,Y.F., Yu,K.H. and
            Luo,S.F.
  TITLE     Human cytomegalovirus pp65 peptide-induced autoantibodies
            cross-reacts with TAF9 protein and induces lupus-like autoimmunity
            in BALB/c mice
  JOURNAL   Sci Rep 10 (1), 9662 (2020)
   PUBMED   32541894
  REMARK    GeneRIF: Human cytomegalovirus pp65 peptide-induced autoantibodies
            cross-reacts with TAF9 protein and induces lupus-like autoimmunity
            in BALB/c mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1163)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1163)
  AUTHORS   Zeng,P., Wang,Y., Zheng,Y., Song,X. and Yin,Y.
  TITLE     Cancer-testis antigen HCA587/MAGEC2 interacts with the general
            transcription coactivator TAF9 in cancer cells
  JOURNAL   Mol Med Rep 17 (2), 3226-3231 (2018)
   PUBMED   29257297
  REMARK    GeneRIF: TAF9 directly binds HCA587/MAGEC2 through its CR domain,
            suggesting that HCA587/MAGEC2 may involve in TAF9 binding with DNA
            to regulate certain genes transcription.
REFERENCE   5  (bases 1 to 1163)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1163)
  AUTHORS   Hisatake,K., Ohta,T., Takada,R., Guermah,M., Horikoshi,M.,
            Nakatani,Y. and Roeder,R.G.
  TITLE     Evolutionary conservation of human
            TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and
            interactions of TAFII80 with other TAFs and with general
            transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 92 (18), 8195-8199 (1995)
   PUBMED   7667268
REFERENCE   7  (bases 1 to 1163)
  AUTHORS   Klemm,R.D., Goodrich,J.A., Zhou,S. and Tjian,R.
  TITLE     Molecular cloning and expression of the 32-kDa subunit of human
            TFIID reveals interactions with VP16 and TFIIB that mediate
            transcriptional activation
  JOURNAL   Proc Natl Acad Sci U S A 92 (13), 5788-5792 (1995)
   PUBMED   7597030
REFERENCE   8  (bases 1 to 1163)
  AUTHORS   Lu,H. and Levine,A.J.
  TITLE     Human TAFII31 protein is a transcriptional coactivator of the p53
            protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (11), 5154-5158 (1995)
   PUBMED   7761466
REFERENCE   9  (bases 1 to 1163)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 1163)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG490028.1, BG720149.1, BC003400.1 and AC145132.2.
            
            On Nov 22, 2018 this sequence version replaced NM_003187.4.
            
            Summary: Initiation of transcription by RNA polymerase II requires
            the activities of more than 70 polypeptides. The protein that
            coordinates these activities is transcription factor IID (TFIID),
            which binds to the core promoter to position the polymerase
            properly, serves as the scaffold for assembly of the remainder of
            the transcription complex, and acts as a channel for regulatory
            signals. TFIID is composed of the TATA-binding protein (TBP) and a
            group of evolutionarily conserved proteins known as TBP-associated
            factors or TAFs. TAFs may participate in basal transcription, serve
            as coactivators, function in promoter recognition or modify general
            transcription factors (GTFs) to facilitate complex assembly and
            transcription initiation. This gene encodes one of the smaller
            subunits of TFIID that binds to the basal transcription factor
            GTF2B as well as to several transcriptional activators such as p53
            and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two
            distinct genes that share 5' exons. A similar but distinct gene
            (TAF9L) has been found on the X chromosome and a pseudogene has
            been identified on chromosome 19. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 4. Both variants 4 and 1 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.140457.1,
                                           SRR5189658.144879.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217893.10/ ENSP00000217893.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               BG490028.1         123-273
            152-617             BG720149.1         194-659
            618-840             BC003400.1         608-830
            841-841             AC145132.2         12958-12958
            842-1163            BC003400.1         832-1153
FEATURES             Location/Qualifiers
     source          1..1163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..1163
                     /gene="TAF9"
                     /gene_synonym="MGC:5067; STAF31/32; TAF2G; TAFII-31;
                     TAFII-32; TAFII31; TAFII32; TAFIID32"
                     /note="TATA-box binding protein associated factor 9"
                     /db_xref="GeneID:6880"
                     /db_xref="HGNC:HGNC:11542"
                     /db_xref="MIM:600822"
     exon            1..58
                     /gene="TAF9"
                     /gene_synonym="MGC:5067; STAF31/32; TAF2G; TAFII-31;
                     TAFII-32; TAFII31; TAFII32; TAFIID32"
                     /inference="alignment:Splign:2.1.0"
     exon            59..151
                     /gene="TAF9"
                     /gene_synonym="MGC:5067; STAF31/32; TAF2G; TAFII-31;
                     TAFII-32; TAFII31; TAFII32; TAFIID32"
                     /inference="alignment:Splign:2.1.0"
     exon            152..1163
                     /gene="TAF9"
                     /gene_synonym="MGC:5067; STAF31/32; TAF2G; TAFII-31;
                     TAFII-32; TAFII31; TAFII32; TAFIID32"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..963
                     /gene="TAF9"
                     /gene_synonym="MGC:5067; STAF31/32; TAF2G; TAFII-31;
                     TAFII-32; TAFII31; TAFII32; TAFIID32"
                     /EC_number="2.7.4.3"
                     /note="transcription initiation factor TFIID 31 kD
                     subunit; RNA polymerase II TBP-associated factor subunit
                     G; transcription initiation factor TFIID 31 kDa subunit;
                     transcription initiation factor TFIID 32 kDa subunit; TAF9
                     RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 32kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 9"
                     /protein_id="NP_003178.1"
                     /db_xref="CCDS:CCDS4002.1"
                     /db_xref="GeneID:6880"
                     /db_xref="HGNC:HGNC:11542"
                     /db_xref="MIM:600822"
                     /translation="MESGKTASPKSMPKDAQMMAQILKDMGITEYEPRVINQMLEFAF
                     RYVTTILDDAKIYSSHAKKATVDADDVRLAIQCRADQSFTSPPPRDFLLDIARQRNQT
                     PLPLIKPYSGPRLPPDRYCLTAPNYRLKSLQKKASTSAGRITVPRLSVGSVTSRPSTP
                     TLGTPTPQTMSVSTKVGTPMSLTGQRFTVQMPTSQSPAVKASIPATSAVQNVLINPSL
                     IGSKNILITTNMMSSQNTANESSNALKRKREDDDDDDDDDDDYDNL"
     regulatory      1142..1147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF9"
                     /gene_synonym="MGC:5067; STAF31/32; TAF2G; TAFII-31;
                     TAFII-32; TAFII31; TAFII32; TAFIID32"
                     /note="hexamer: AATAAA"
     polyA_site      1163
                     /gene="TAF9"
                     /gene_synonym="MGC:5067; STAF31/32; TAF2G; TAFII-31;
                     TAFII-32; TAFII31; TAFII32; TAFIID32"
                     /note="major polyA site"
ORIGIN      
        1 gaggcgcccg aagccgtcgc ggcggggacc atgttgcttc cgaacatcct gctcaccggt
       61 acaccagggg ttggaaaaac cacactaggc aaagaacttg cgtcaaaatc aggactgaaa
      121 tacattaatg tgggtgattt agctcgagaa gtctgatcat cggatatcat ggagtctggc
      181 aagacggctt ctcccaagag catgccgaaa gatgcacaga tgatggcaca aatcctgaag
      241 gatatgggga ttacagaata tgagccaaga gttataaatc agatgttgga gtttgccttc
      301 cgatatgtga ccacaattct agatgatgca aaaatttatt caagccatgc taagaaagct
      361 actgttgatg cagatgatgt gcgattggca atccagtgcc gcgctgatca gtcttttacc
      421 tctcctcccc caagagattt tttattagat attgcaaggc aaagaaatca aacccctttg
      481 ccattgatca agccatattc aggtcctagg ttgccacctg atagatactg cttaacagct
      541 ccaaactata ggctgaaatc tttacagaaa aaggcatcaa cttctgcggg aagaataaca
      601 gtcccgcggt taagtgttgg ttcagttact agcagaccaa gtactcccac actaggcaca
      661 ccaaccccac agaccatgtc tgtttcaact aaagtaggga ctcccatgtc cctcacaggt
      721 caaaggttta cagtacagat gcctacttct cagtctccag ctgtaaaagc ttcaattcct
      781 gcaacctcag cagttcagaa tgttctgatt aatccatcat taatcgggtc caaaaacatt
      841 cttattacca ctaatatgat gtcatcacaa aatactgcca atgaatcatc aaatgcattg
      901 aaaagaaaac gtgaagatga tgatgatgac gatgatgatg atgatgacta tgataatctg
      961 taatctagcc ttgctgaatg taacatgtat acttggtctt gaattcattg tactgatatt
     1021 aaacatgcat gctggatgtt ttcaagttgt gttttagaaa actaataata atgagtaaac
     1081 acagttacca tacttttcaa ttgaaatgaa ggtttttcat cagccttaaa agtgtaagaa
     1141 aaataaagtt gtcattcatt cga
//
