LOCUS       NM_138572               6678 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor 8 (TAF8),
            transcript variant 1, mRNA.
ACCESSION   NM_138572
VERSION     NM_138572.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6678)
  AUTHORS   Scheer,E., Luo,J., Bernardini,A., Ruffenach,F., Garnier,J.M.,
            Kolb-Cheynel,I., Gupta,K., Berger,I., Ranish,J. and Tora,L.
  TITLE     TAF8 regions important for TFIID lobe B assembly or for TAF2
            interactions are required for embryonic stem cell survival
  JOURNAL   J Biol Chem 297 (5), 101288 (2021)
   PUBMED   34634302
  REMARK    GeneRIF: TAF8 regions important for TFIID lobe B assembly or for
            TAF2 interactions are required for embryonic stem cell survival.
REFERENCE   2  (bases 1 to 6678)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6678)
  AUTHORS   El-Saafin,F., Curry,C., Ye,T., Garnier,J.M., Kolb-Cheynel,I.,
            Stierle,M., Downer,N.L., Dixon,M.P., Negroni,L., Berger,I.,
            Thomas,T., Voss,A.K., Dobyns,W., Devys,D. and Tora,L.
  TITLE     Homozygous TAF8 mutation in a patient with intellectual disability
            results in undetectable TAF8 protein, but preserved RNA polymerase
            II transcription
  JOURNAL   Hum Mol Genet 27 (12), 2171-2186 (2018)
   PUBMED   29648665
  REMARK    GeneRIF: TAF8 mutant protein with an unrelated C-terminus. The
            mutant TAF8 protein could not be detected in extracts from the
            patient's fibroblasts, indicating a loss of TAF8 function and that
            the mutation is most likely causative
REFERENCE   4  (bases 1 to 6678)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6678)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 6678)
  AUTHORS   Li,H.H., Li,A.G., Sheppard,H.M. and Liu,X.
  TITLE     Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a
            role for TAF1 in cell G1 progression
  JOURNAL   Mol Cell 13 (6), 867-878 (2004)
   PUBMED   15053879
REFERENCE   7  (bases 1 to 6678)
  AUTHORS   Guermah,M., Ge,K., Chiang,C.M. and Roeder,R.G.
  TITLE     The TBN protein, which is essential for early embryonic mouse
            development, is an inducible TAFII implicated in adipogenesis
  JOURNAL   Mol Cell 12 (4), 991-1001 (2003)
   PUBMED   14580349
REFERENCE   8  (bases 1 to 6678)
  AUTHORS   Tora,L.
  TITLE     A unified nomenclature for TATA box binding protein
            (TBP)-associated factors (TAFs) involved in RNA polymerase II
            transcription
  JOURNAL   Genes Dev 16 (6), 673-675 (2002)
   PUBMED   11963920
REFERENCE   9  (bases 1 to 6678)
  AUTHORS   Guermah,M., Tao,Y. and Roeder,R.G.
  TITLE     Positive and negative TAF(II) functions that suggest a dynamic
            TFIID structure and elicit synergy with traps in activator-induced
            transcription
  JOURNAL   Mol Cell Biol 21 (20), 6882-6894 (2001)
   PUBMED   11564872
REFERENCE   10 (bases 1 to 6678)
  AUTHORS   Purrello,M., Di Pietro,C., Viola,A., Rapisarda,A., Stevens,S.,
            Guermah,M., Tao,Y., Bonaiuto,C., Arcidiacono,A., Messina,A.,
            Sichel,G., Grzeschik,K.H. and Roeder,R.
  TITLE     Genomics and transcription analysis of human TFIID
  JOURNAL   Oncogene 16 (12), 1633-1638 (1998)
   PUBMED   9569032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI828714.1, AF465841.1 and
            AL512274.9.
            
            On Nov 22, 2018 this sequence version replaced NM_138572.2.
            
            Summary: This gene encodes one of several TATA-binding protein
            (TBP)-associated factors (TAFs), which are integral subunits of the
            general transcription factor complex TFIID. TFIID recognizes the
            core promoter of many genes and nucleates the assembly of a
            transcription preinitiation complex containing RNA polymerase II
            and other initiation factors. The protein encoded by this gene
            contains an H4-like histone fold domain, and interacts with several
            subunits of TFIID including TBP and the histone-fold protein TAF10.
            Alternatively spliced transcript variants have been described, but
            their biological validity has not been determined. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.214491.1,
                                           SRR1803614.40703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372977.8/ ENSP00000362068.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BI828714.1         12-26
            16-653              AF465841.1         1-638
            654-654             AL512274.9         10646-10646
            655-951             AF465841.1         640-936
            952-4312            AL512274.9         21734-25094
            4313-6678           AL512274.9         25095-27460
FEATURES             Location/Qualifiers
     source          1..6678
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..6678
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /note="TATA-box binding protein associated factor 8"
                     /db_xref="GeneID:129685"
                     /db_xref="HGNC:HGNC:17300"
                     /db_xref="MIM:609514"
     exon            1..63
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..951
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /note="isoform 1 is encoded by transcript variant 1; TATA
                     box binding protein (TBP)-associated factor, RNA
                     polymerase II, A, 45/50kDa; TBP-associated factor 8;
                     TBP-associated factor, RNA polymerase II, 43 kD;
                     transcription initiation factor TFIID subunit 8;
                     TBP-associated factor TAFII43; hTAFII43; protein taube
                     nuss; TBP-associated factor 43 kDa; transcription
                     initiation factor TFIID 43 kDa subunit; taube nuss
                     homolog; TAF8 RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 43kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 8
                     isoform 1"
                     /protein_id="NP_612639.2"
                     /db_xref="CCDS:CCDS43462.1"
                     /db_xref="GeneID:129685"
                     /db_xref="HGNC:HGNC:17300"
                     /db_xref="MIM:609514"
                     /translation="MADAAATAGAGGSGTRSGSKQSTNPADNYHLARRRTLQVVVSSL
                     LTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGF
                     NVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYI
                     KTPTYREPVSDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARP
                     FTIPYLTALLPSELEMQQMEETDSSEQDEQTDTENLALHISMEDSGAEKENTSVLQQN
                     PSLSGSRNGEENIIDNPYLRPVKKPKIRRKKSLS"
     exon            64..220
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            221..319
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            320..382
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            383..507
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            508..655
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            656..798
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            799..938
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            939..6678
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4290..4295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /note="hexamer: AATAAA"
     polyA_site      4310
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /note="major polyA site"
     regulatory      6655..6660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /note="hexamer: AATAAA"
     polyA_site      6678
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
ORIGIN      
        1 acactacgcc agaacaagat ggccgacgcg gcggccacag ctggggccgg tggctccgga
       61 acgagatcgg gaagtaaaca gtccactaac cctgccgata actatcatct ggcccggagg
      121 agaaccctgc aggtggttgt gagctccttg ctgacagagg cagggtttga gagtgccgag
      181 aaagcatccg tggaaacgct gacagagatg ctgcagagct acatttcaga aattgggaga
      241 agtgccaagt cttactgtga gcacacagcc aggacccagc ccacactgtc cgatatcgtg
      301 gtcacacttg ttgagatggg tttcaatgtg gacactctcc ctgcttatgc aaaacggtct
      361 cagaggatgg tcatcactgc tcctccggtg accaatcagc cagtgacccc caaggccctc
      421 actgcagggc agaaccgacc ccacccgccg cacatcccca gccattttcc tgagttccct
      481 gatccccaca cctacatcaa aactccgacg taccgtgagc ccgtgtcaga ctaccaggtc
      541 ctgcgggaga aggctgcatc ccagaggcgc gatgtggagc gggcacttac ccgtttcatg
      601 gccaagacag gcgagactca gagtcttttc aaagatgacg tcagcacatt tccattgatt
      661 gctgccagac ctttcaccat cccctacctg acagctcttc ttccgtctga actggagatg
      721 caacaaatgg aagagacaga ttcctcggag caggatgaac agacagacac agagaacctt
      781 gctcttcata tcagcatgga ggattctgga gccgagaagg agaacacctc tgtcctgcag
      841 cagaacccct ccttgtcggg tagccggaat ggggaggaga acatcatcga taacccttat
      901 ctgcggccgg tgaagaagcc caagatccgc aggaagaagt ccctctcctg agctgagaag
      961 gaaacctggc ttgtacaggg gcgcagattc caccctcccg gggagttaaa gccactcaag
     1021 ggaagaagag ggtgacctcc tcatggccaa gccgaggctg cagggtgtga tcggacatga
     1081 ttttcatggc aaaccgtctt attaagatga cctattttca ctggatgttt gggttgagga
     1141 agatatgaac agaataatga gaattttttt ttttattttg agatggagtc ttactctatc
     1201 acccaggctg gaatgcagtg gtgtgatctc agctcactgc agtctcagca accctgggtc
     1261 caagtgattc tcctgccttg gcctcccgag tagctgggac tagaggcaag cgccaccatg
     1321 ctggctaatt tttgtatttt gagtagagat agggtttcgc catgttggcc aggctggtct
     1381 tgaactcctg acctcaagtg atccacccgc attggcctcc caaagagttg cgattacagg
     1441 tgtgagccac cacgcccagc taatttttgt atttttaata gagataaggt ttcgccatgt
     1501 tggccaggct ggtcttgaac tcctgacctc aagtgataac ccgcctcggc ctcccaaagt
     1561 gctgagatta caggcgtgag ccaccgcacc ccaccagaga ctttcttaat caatcaggct
     1621 atgtggtggg gcatagcagc agccagtgac ttcgttcatt atcacaggat ttgattcctt
     1681 tgaaactcaa gagaccaggg aaagtgacag gaaggaaagg gctctttgct gctgtgctta
     1741 ttacaaggaa gactgtttgt ccagcgtgta tttcaggata tctggatccc ttttattgac
     1801 tcacaatttg tggcaccact ttctcatccc agaacttcat tcttatttct ctcctcatct
     1861 ggcctcccaa gtgctccgtt gagctgatga aaagttcttt gtactccctc aacgtgtcgg
     1921 aaacaggagg ccacacagca cagctttgtt tggggtgggc aggagtcagg agtcttgagc
     1981 agatgcatca ctgtgaagaa gaacgacatg tcggggctgc acctgtcctc ccgtcggcat
     2041 ttgacgaaag ctccctgaag cggggcagca ctctcctcct gagagattta ccatttattg
     2101 cccctgtgag gaatgtgtgc ttgggaactg ccaagtctta ccccttctgg aagaagaggt
     2161 tttctctgac aagagcctag agcgtcggct ctattatgct gggacttgac agaggagcca
     2221 tggggtttaa acagtaggaa agaggggcta cgcgcagtgg ctcacgcctg taatcccagc
     2281 acttcgggag gcgaaggcag gtggatcact tgaggtcagg agttcgagac cagcctggcc
     2341 aacatagtga aaccccgtct ctactaaaaa tacaaaaatt agccgggtgt ggttactcat
     2401 gcctgtaatc ccagctactc gggaggctga ggcaggagaa tcacttgaac ctgggaggcg
     2461 gaggttgcag tgagccgaga tcgtgccact gcactccagc ctgggtgaca gagcgagact
     2521 ccatttcaaa aaaataaaaa aaggataaag taaacaatag gaaaggattt ggtggggtga
     2581 gggtggggtg ttgagggctg ggcctcatct tgtattctga aagctgagaa acggctggtc
     2641 agctggaagg ctggtggatg ggcaggagtg agccaagctg aggcgttctg caagaagcag
     2701 gtctgagtct gtccaaccaa tttgtatcct gtggggagaa caacttcatt cttaacatac
     2761 cctacaaacc agaaaacaag tttttaagga agatgctggg catgctgata gcttttctgg
     2821 tctcctaagg aagagttttt aaaactaaat ccaaggaaga aaaatgtaac aacacgtgga
     2881 agtgaacact ggatgaataa gcttgtttcc caaattagaa tcctaacgtc catatttagc
     2941 ttcatgtatt cccctttggc ttccacagtt caactccttt tattttgaga cagggtctcg
     3001 ctgtgtcgcc ccagctggag tatagtggca ctacctcggc tcactgcaac ctccactccc
     3061 cgggttcaag caattctcag agtagctggg attacagatg cccgccacca catctggcta
     3121 attttttttt ttttttttta gtagacacgg gattttgcta tgttgcccag gctggtcttg
     3181 aactcctggc ctcaagtgat ccacccgcct tggccttcca aagtgttgag attacaggcg
     3241 tgagccacgg tgcccagccc atctcttagt cttccattcc cttggtgaat ttggaaactt
     3301 gaaaaacttg gggacttgac agcaggctcc atgttcttct ggcctcactg tactgtgtaa
     3361 ggaaagagct gcttgtcagg aacggaagag gggacgctag taaaaaaaaa aaaattggat
     3421 tccccaactg gactaaatag gagtttttca ggtttgtagt aacgtgaaac tctcctagat
     3481 cgaagcagtt agactggcct atgtggcctt ctcagggttt gtgattcagt tcttagcgat
     3541 tcttggcctg ataagtttat gaacacagcc ccacattcaa gccgtggcca atcccagctg
     3601 ttctcactgc tcttgggagg tgttgtccca gtcagtgttt ctgcagcttc catttgttgt
     3661 tgttatccag tgtaagcacc tgttgaatgc agatgtgctg agttagaggt gggatttgga
     3721 aaagggctgc tatttctgct gttgagattt cagaggctat actctttttt tttcttttct
     3781 tttttttttt tttttgagac ggcatctcac tcttatcgcc caggctggag tgcaatggcg
     3841 tgatctcggc tcactgcaac ctccacctcc tgggttcaag ggattctcct gcctcagcct
     3901 cctgagtagc tgggattaca ggcacctacc acaattctcg gctaattttt tttgtatttt
     3961 tggtagagac ggggtttcac caggttggcc agggtggtct cgaacacctg acctcagatg
     4021 atccacccac ctcggcctcc cagtgtgggt gggattacag gcatgagcca ccgcgcctgg
     4081 cctcagaggc tatactctta taattttgtt ctgaggggag acagggaaag ggttagacaa
     4141 cttgaaacat tgaccctgta taaaaatgca aaattctcaa tgtgtattta taaatttcta
     4201 ttttttataa ctttatggga cttcttagag gccaaaagta gtaaacatgc agattaaaaa
     4261 tgtttatgaa aatctcaata aaaattcata ataaaaactt tgtaaataaa tagaactgta
     4321 agctttgaac ttaatttgtg ttcaaaagtt aacagcaatg tggacaaata agtcaggctt
     4381 agcccttgtg ttggcctaag cacacctggg aacttagtaa aacttttatt ttggaaattt
     4441 tcaaatacaa aattagagag caaaatatat gaacccctgt atatgcctca tcaagcttcc
     4501 acacttgtca gtagcttgtt gattctgttt catctgtttc tcccactttt tgtcctttat
     4561 tttctttcct cctggagtgt gtgtgtgtgt gtgtgtgcgt gtgtgtgcgt gtgagacaga
     4621 gtttcgcgct ggagtgcaat ggtgcaatct tggcccactg caacttctgc ctcccgggtt
     4681 caaatgattc tactgcctca gcttcctgag tagctgggat tataggtatc taccaccacc
     4741 accacgcctg gctaattttt tctttttttt ttggagacgg agtctcgctc tgtcgcccag
     4801 gctggattgc agtggattgt caagattgca gtggtgcaat ctcagctcac cgcaagctcc
     4861 gccacccagg ttcacgccat tctcctgcct cagcctccca agtagctggg actacaggtg
     4921 cctgctacca cgcccagcta attttttgta tttttcagta gagatggagt ttcactgcat
     4981 tagccaggat ggtctcgatc tcctgacctc atgatccgcc cgcctcggcc tcccaaagtg
     5041 ctgggattac aggcatgagc caccgcacct ggcctaattt ttttgtaggt ttagtagaga
     5101 tggggtttca ccatgttggc cagactggtc tccaactcct gacctcaggt gatcacctgc
     5161 ctcagcctcc taaagtgctg aggttacagg cgtgagcccc cgcgcctggc tcttctggag
     5221 tatttttaaa tgcaaactcc agacctgtgt catttaatct aaatgtgtct atacgtatct
     5281 ctgattgatc tttctttaaa ttttaatttt ggaataatta tagattcaca agatgttgca
     5341 aaaaatgttg agagagatcc tatgtaccca tcacccactt tctcccagtg gtagcatctt
     5401 gcataactgt ggtgcaatat caaaaccctt gcattcagtt tcagtgtaca atgtagatgg
     5461 tatattagta caatgcatag agcttattta gttttcacca tgtgcacgtg tgtgttatgt
     5521 gtgtgttgtt ccgtgcagtt tcatcgtgta gatttgtgta accaccagca cacaaatggt
     5581 gaagacacag aaccattgca tcagtacagt tctccctcat gctgtctctt tgcaatcaca
     5641 tccacctctc tgctcttcca cttctctcct ggcagccact actctgttct ctatctctaa
     5701 tgttattgaa agaatgttat aaattgaatc ataaagtatg tgactttttt ctttttgaga
     5761 cagagtcttg ctctatcgcc taggctggat ggagtgcagt ggagcgatcc cagctcactg
     5821 caactcctcc acctcccggg ttcaagagat tctcctgcct cagcctccca agtagctggg
     5881 attacaggca tgtgccacca cacccagcta acttttgtat ttttagtaga gatggggttt
     5941 caccatgttg gccaggttgg tctccaactc ctgacctcaa gtgatccgcc cacctcagcc
     6001 tcccaaagtg ctaggattat aggtatgacc caccgcacct ggccgagtat gggacttttt
     6061 gacgttggct ttttcagttc tgcataattc tcttgaggtc catctaggtg gttgtgtgta
     6121 tcagtagttc ctttcttttt attgctgagt agcatggagg caccatagtt taacacagtt
     6181 tctttaacca ttcacgcatt gagacaaaaa aagttcttaa ttctgcgaac atcaacttcc
     6241 tgtgcccagg tgcaagtgcg ggggcagctg gcccagggta gagctttacc atggaccctg
     6301 gcgctcctgg aaaaaaattc aaggtatttt tcctcctctt ggagcgtgtg gcctacctca
     6361 tctccatttg attactagct tttctttttc tcctttgtta aacagttatt taattttgaa
     6421 gagataatat atgtatacag tataaaattt aaaagacaga aaaagatata agtgataaca
     6481 aaatatcttc ctcctcccct gtttcccaga ggctcagacc tcatccctgg cagctgctat
     6541 tatgttactg tcaatatgac cttatgtatt cttccagaag tattctgtgc atcaaatgca
     6601 aatacttata ttttctactt ctcagtgtat tttttggtga tgttccatgt cagtaataaa
     6661 gagcttctct gtttcgtg
//
