LOCUS       NM_001410906            4475 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor 8 (TAF8),
            transcript variant 2, mRNA.
ACCESSION   NM_001410906 XM_017010241
VERSION     NM_001410906.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4475)
  AUTHORS   Scheer,E., Luo,J., Bernardini,A., Ruffenach,F., Garnier,J.M.,
            Kolb-Cheynel,I., Gupta,K., Berger,I., Ranish,J. and Tora,L.
  TITLE     TAF8 regions important for TFIID lobe B assembly or for TAF2
            interactions are required for embryonic stem cell survival
  JOURNAL   J Biol Chem 297 (5), 101288 (2021)
   PUBMED   34634302
  REMARK    GeneRIF: TAF8 regions important for TFIID lobe B assembly or for
            TAF2 interactions are required for embryonic stem cell survival.
REFERENCE   2  (bases 1 to 4475)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4475)
  AUTHORS   El-Saafin,F., Curry,C., Ye,T., Garnier,J.M., Kolb-Cheynel,I.,
            Stierle,M., Downer,N.L., Dixon,M.P., Negroni,L., Berger,I.,
            Thomas,T., Voss,A.K., Dobyns,W., Devys,D. and Tora,L.
  TITLE     Homozygous TAF8 mutation in a patient with intellectual disability
            results in undetectable TAF8 protein, but preserved RNA polymerase
            II transcription
  JOURNAL   Hum Mol Genet 27 (12), 2171-2186 (2018)
   PUBMED   29648665
  REMARK    GeneRIF: TAF8 mutant protein with an unrelated C-terminus. The
            mutant TAF8 protein could not be detected in extracts from the
            patient's fibroblasts, indicating a loss of TAF8 function and that
            the mutation is most likely causative
REFERENCE   4  (bases 1 to 4475)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4475)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4475)
  AUTHORS   Li,H.H., Li,A.G., Sheppard,H.M. and Liu,X.
  TITLE     Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a
            role for TAF1 in cell G1 progression
  JOURNAL   Mol Cell 13 (6), 867-878 (2004)
   PUBMED   15053879
REFERENCE   7  (bases 1 to 4475)
  AUTHORS   Guermah,M., Ge,K., Chiang,C.M. and Roeder,R.G.
  TITLE     The TBN protein, which is essential for early embryonic mouse
            development, is an inducible TAFII implicated in adipogenesis
  JOURNAL   Mol Cell 12 (4), 991-1001 (2003)
   PUBMED   14580349
REFERENCE   8  (bases 1 to 4475)
  AUTHORS   Tora,L.
  TITLE     A unified nomenclature for TATA box binding protein
            (TBP)-associated factors (TAFs) involved in RNA polymerase II
            transcription
  JOURNAL   Genes Dev 16 (6), 673-675 (2002)
   PUBMED   11963920
REFERENCE   9  (bases 1 to 4475)
  AUTHORS   Guermah,M., Tao,Y. and Roeder,R.G.
  TITLE     Positive and negative TAF(II) functions that suggest a dynamic
            TFIID structure and elicit synergy with traps in activator-induced
            transcription
  JOURNAL   Mol Cell Biol 21 (20), 6882-6894 (2001)
   PUBMED   11564872
REFERENCE   10 (bases 1 to 4475)
  AUTHORS   Purrello,M., Di Pietro,C., Viola,A., Rapisarda,A., Stevens,S.,
            Guermah,M., Tao,Y., Bonaiuto,C., Arcidiacono,A., Messina,A.,
            Sichel,G., Grzeschik,K.H. and Roeder,R.
  TITLE     Genomics and transcription analysis of human TFIID
  JOURNAL   Oncogene 16 (12), 1633-1638 (1998)
   PUBMED   9569032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513008.14 and AL512274.9.
            
            On Aug 17, 2022 this sequence version replaced XM_017010241.3.
            
            Summary: This gene encodes one of several TATA-binding protein
            (TBP)-associated factors (TAFs), which are integral subunits of the
            general transcription factor complex TFIID. TFIID recognizes the
            core promoter of many genes and nucleates the assembly of a
            transcription preinitiation complex containing RNA polymerase II
            and other initiation factors. The protein encoded by this gene
            contains an H4-like histone fold domain, and interacts with several
            subunits of TFIID including TBP and the histone-fold protein TAF10.
            Alternatively spliced transcript variants have been described, but
            their biological validity has not been determined. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3655563.1,
                                           SRR18074969.988072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL513008.14        99691-99753
            64-220              AL513008.14        100524-100680
            221-319             AL513008.14        104698-104796
            320-382             AL512274.9         140-202
            383-507             AL512274.9         1577-1701
            508-655             AL512274.9         10500-10647
            656-798             AL512274.9         12653-12795
            799-938             AL512274.9         21288-21427
            939-4475            AL512274.9         23924-27460
FEATURES             Location/Qualifiers
     source          1..4475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..4475
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /note="TATA-box binding protein associated factor 8"
                     /db_xref="GeneID:129685"
                     /db_xref="HGNC:HGNC:17300"
                     /db_xref="MIM:609514"
     exon            1..63
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..978
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /note="isoform 2 is encoded by transcript variant 2; TATA
                     box binding protein (TBP)-associated factor, RNA
                     polymerase II, A, 45/50kDa; TBP-associated factor 8;
                     TBP-associated factor, RNA polymerase II, 43 kD;
                     transcription initiation factor TFIID subunit 8;
                     TBP-associated factor TAFII43; hTAFII43; protein taube
                     nuss; TBP-associated factor 43 kDa; transcription
                     initiation factor TFIID 43 kDa subunit; taube nuss
                     homolog; TAF8 RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 43kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 8
                     isoform 2"
                     /protein_id="NP_001397835.1"
                     /db_xref="CCDS:CCDS93918.1"
                     /db_xref="GeneID:129685"
                     /db_xref="HGNC:HGNC:17300"
                     /db_xref="MIM:609514"
                     /translation="MADAAATAGAGGSGTRSGSKQSTNPADNYHLARRRTLQVVVSSL
                     LTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGF
                     NVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYI
                     KTPTYREPVSDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARP
                     FTIPYLTALLPSELEMQQMEETDSSEQDEQTDTENLALHISMEDSGAEKENTSVLQQN
                     PSLSGSRNGEENIIDNPYLRPVKKPKIRRKNRHGILLCCPGWS"
     exon            64..220
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            221..319
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            320..382
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            383..507
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            508..655
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            656..798
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            799..938
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     exon            939..4475
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2087..2092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /note="hexamer: AATAAA"
     polyA_site      2107
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /note="major polyA site"
     regulatory      4452..4457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
                     /note="hexamer: AATAAA"
     polyA_site      4475
                     /gene="TAF8"
                     /gene_synonym="II; NEDMLHB; TAF; TAF(II)43; TAFII-43;
                     TAFII43; TBN"
ORIGIN      
        1 acactacgcc agaacaagat ggccgacgcg gcggccacag ctggggccgg tggctccgga
       61 acgagatcgg gaagtaaaca gtccactaac cctgccgata actatcatct ggcccggagg
      121 agaaccctgc aggtggttgt gagctccttg ctgacagagg cagggtttga gagtgccgag
      181 aaagcatccg tggaaacgct gacagagatg ctgcagagct acatttcaga aattgggaga
      241 agtgccaagt cttactgtga gcacacagcc aggacccagc ccacactgtc cgatatcgtg
      301 gtcacacttg ttgagatggg tttcaatgtg gacactctcc ctgcttatgc aaaacggtct
      361 cagaggatgg tcatcactgc tcctccggtg accaatcagc cagtgacccc caaggccctc
      421 actgcagggc agaaccgacc ccacccgccg cacatcccca gccattttcc tgagttccct
      481 gatccccaca cctacatcaa aactccgacg taccgtgagc ccgtgtcaga ctaccaggtc
      541 ctgcgggaga aggctgcatc ccagaggcgc gatgtggagc gggcacttac ccgtttcatg
      601 gccaagacag gcgagactca gagtcttttc aaagatgacg tcagcacatt tccattgatt
      661 gctgccagac ctttcaccat cccctacctg acagctcttc ttccgtctga actggagatg
      721 caacaaatgg aagagacaga ttcctcggag caggatgaac agacagacac agagaacctt
      781 gctcttcata tcagcatgga ggattctgga gccgagaagg agaacacctc tgtcctgcag
      841 cagaacccct ccttgtcggg tagccggaat ggggaggaga acatcatcga taacccttat
      901 ctgcggccgg tgaagaagcc caagatccgc aggaagaata gacacgggat tttgctatgt
      961 tgcccaggct ggtcttgaac tcctggcctc aagtgatcca cccgccttgg ccttccaaag
     1021 tgttgagatt acaggcgtga gccacggtgc ccagcccatc tcttagtctt ccattccctt
     1081 ggtgaatttg gaaacttgaa aaacttgggg acttgacagc aggctccatg ttcttctggc
     1141 ctcactgtac tgtgtaagga aagagctgct tgtcaggaac ggaagagggg acgctagtaa
     1201 aaaaaaaaaa attggattcc ccaactggac taaataggag tttttcaggt ttgtagtaac
     1261 gtgaaactct cctagatcga agcagttaga ctggcctatg tggccttctc agggtttgtg
     1321 attcagttct tagcgattct tggcctgata agtttatgaa cacagcccca cattcaagcc
     1381 gtggccaatc ccagctgttc tcactgctct tgggaggtgt tgtcccagtc agtgtttctg
     1441 cagcttccat ttgttgttgt tatccagtgt aagcacctgt tgaatgcaga tgtgctgagt
     1501 tagaggtggg atttggaaaa gggctgctat ttctgctgtt gagatttcag aggctatact
     1561 cttttttttt cttttctttt tttttttttt ttgagacggc atctcactct tatcgcccag
     1621 gctggagtgc aatggcgtga tctcggctca ctgcaacctc cacctcctgg gttcaaggga
     1681 ttctcctgcc tcagcctcct gagtagctgg gattacaggc acctaccaca attctcggct
     1741 aatttttttt gtatttttgg tagagacggg gtttcaccag gttggccagg gtggtctcga
     1801 acacctgacc tcagatgatc cacccacctc ggcctcccag tgtgggtggg attacaggca
     1861 tgagccaccg cgcctggcct cagaggctat actcttataa ttttgttctg aggggagaca
     1921 gggaaagggt tagacaactt gaaacattga ccctgtataa aaatgcaaaa ttctcaatgt
     1981 gtatttataa atttctattt tttataactt tatgggactt cttagaggcc aaaagtagta
     2041 aacatgcaga ttaaaaatgt ttatgaaaat ctcaataaaa attcataata aaaactttgt
     2101 aaataaatag aactgtaagc tttgaactta atttgtgttc aaaagttaac agcaatgtgg
     2161 acaaataagt caggcttagc ccttgtgttg gcctaagcac acctgggaac ttagtaaaac
     2221 ttttattttg gaaattttca aatacaaaat tagagagcaa aatatatgaa cccctgtata
     2281 tgcctcatca agcttccaca cttgtcagta gcttgttgat tctgtttcat ctgtttctcc
     2341 cactttttgt cctttatttt ctttcctcct ggagtgtgtg tgtgtgtgtg tgtgcgtgtg
     2401 tgtgcgtgtg agacagagtt tcgcgctgga gtgcaatggt gcaatcttgg cccactgcaa
     2461 cttctgcctc ccgggttcaa atgattctac tgcctcagct tcctgagtag ctgggattat
     2521 aggtatctac caccaccacc acgcctggct aattttttct tttttttttg gagacggagt
     2581 ctcgctctgt cgcccaggct ggattgcagt ggattgtcaa gattgcagtg gtgcaatctc
     2641 agctcaccgc aagctccgcc acccaggttc acgccattct cctgcctcag cctcccaagt
     2701 agctgggact acaggtgcct gctaccacgc ccagctaatt ttttgtattt ttcagtagag
     2761 atggagtttc actgcattag ccaggatggt ctcgatctcc tgacctcatg atccgcccgc
     2821 ctcggcctcc caaagtgctg ggattacagg catgagccac cgcacctggc ctaatttttt
     2881 tgtaggttta gtagagatgg ggtttcacca tgttggccag actggtctcc aactcctgac
     2941 ctcaggtgat cacctgcctc agcctcctaa agtgctgagg ttacaggcgt gagcccccgc
     3001 gcctggctct tctggagtat ttttaaatgc aaactccaga cctgtgtcat ttaatctaaa
     3061 tgtgtctata cgtatctctg attgatcttt ctttaaattt taattttgga ataattatag
     3121 attcacaaga tgttgcaaaa aatgttgaga gagatcctat gtacccatca cccactttct
     3181 cccagtggta gcatcttgca taactgtggt gcaatatcaa aacccttgca ttcagtttca
     3241 gtgtacaatg tagatggtat attagtacaa tgcatagagc ttatttagtt ttcaccatgt
     3301 gcacgtgtgt gttatgtgtg tgttgttccg tgcagtttca tcgtgtagat ttgtgtaacc
     3361 accagcacac aaatggtgaa gacacagaac cattgcatca gtacagttct ccctcatgct
     3421 gtctctttgc aatcacatcc acctctctgc tcttccactt ctctcctggc agccactact
     3481 ctgttctcta tctctaatgt tattgaaaga atgttataaa ttgaatcata aagtatgtga
     3541 cttttttctt tttgagacag agtcttgctc tatcgcctag gctggatgga gtgcagtgga
     3601 gcgatcccag ctcactgcaa ctcctccacc tcccgggttc aagagattct cctgcctcag
     3661 cctcccaagt agctgggatt acaggcatgt gccaccacac ccagctaact tttgtatttt
     3721 tagtagagat ggggtttcac catgttggcc aggttggtct ccaactcctg acctcaagtg
     3781 atccgcccac ctcagcctcc caaagtgcta ggattatagg tatgacccac cgcacctggc
     3841 cgagtatggg actttttgac gttggctttt tcagttctgc ataattctct tgaggtccat
     3901 ctaggtggtt gtgtgtatca gtagttcctt tctttttatt gctgagtagc atggaggcac
     3961 catagtttaa cacagtttct ttaaccattc acgcattgag acaaaaaaag ttcttaattc
     4021 tgcgaacatc aacttcctgt gcccaggtgc aagtgcgggg gcagctggcc cagggtagag
     4081 ctttaccatg gaccctggcg ctcctggaaa aaaattcaag gtatttttcc tcctcttgga
     4141 gcgtgtggcc tacctcatct ccatttgatt actagctttt ctttttctcc tttgttaaac
     4201 agttatttaa ttttgaagag ataatatatg tatacagtat aaaatttaaa agacagaaaa
     4261 agatataagt gataacaaaa tatcttcctc ctcccctgtt tcccagaggc tcagacctca
     4321 tccctggcag ctgctattat gttactgtca atatgacctt atgtattctt ccagaagtat
     4381 tctgtgcatc aaatgcaaat acttatattt tctacttctc agtgtatttt ttggtgatgt
     4441 tccatgtcag taataaagag cttctctgtt tcgtg
//
