LOCUS       NM_006473               2023 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor 6 like
            (TAF6L), mRNA.
ACCESSION   NM_006473 NM_018336
VERSION     NM_006473.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2023)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2023)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2023)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2023)
  AUTHORS   Nagy,Z., Riss,A., Romier,C., le Guezennec,X., Dongre,A.R.,
            Orpinell,M., Han,J., Stunnenberg,H. and Tora,L.
  TITLE     The human SPT20-containing SAGA complex plays a direct role in the
            regulation of endoplasmic reticulum stress-induced genes
  JOURNAL   Mol Cell Biol 29 (6), 1649-1660 (2009)
   PUBMED   19114550
REFERENCE   5  (bases 1 to 2023)
  AUTHORS   Clarke,D.L., Sutcliffe,A., Deacon,K., Bradbury,D., Corbett,L. and
            Knox,A.J.
  TITLE     PKCbetaII augments NF-kappaB-dependent transcription at the CCL11
            promoter via p300/CBP-associated factor recruitment and histone H4
            acetylation
  JOURNAL   J Immunol 181 (5), 3503-3514 (2008)
   PUBMED   18714023
  REMARK    GeneRIF: protein kinase C betaII augments NF-kappaB-mediated
            TNF-alpha-induced transcription of the target gene CCL11, promoting
            p65 association with the CCL11 promoter, in human airway smooth
            muscle cells by phosphorylating p300/CBP-associated factor
REFERENCE   6  (bases 1 to 2023)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   7  (bases 1 to 2023)
  AUTHORS   Brand,M., Moggs,J.G., Oulad-Abdelghani,M., Lejeune,F.,
            Dilworth,F.J., Stevenin,J., Almouzni,G. and Tora,L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   8  (bases 1 to 2023)
  AUTHORS   Schiltz,R.L., Mizzen,C.A., Vassilev,A., Cook,R.G., Allis,C.D. and
            Nakatani,Y.
  TITLE     Overlapping but distinct patterns of histone acetylation by the
            human coactivators p300 and PCAF within nucleosomal substrates
  JOURNAL   J Biol Chem 274 (3), 1189-1192 (1999)
   PUBMED   9880483
REFERENCE   9  (bases 1 to 2023)
  AUTHORS   Ogryzko,V.V., Kotani,T., Zhang,X., Schiltz,R.L., Howard,T.,
            Yang,X.J., Howard,B.H., Qin,J. and Nakatani,Y.
  TITLE     Histone-like TAFs within the PCAF histone acetylase complex
  JOURNAL   Cell 94 (1), 35-44 (1998)
   PUBMED   9674425
REFERENCE   10 (bases 1 to 2023)
  AUTHORS   Struhl,K. and Moqtaderi,Z.
  TITLE     The TAFs in the HAT
  JOURNAL   Cell 94 (1), 1-4 (1998)
   PUBMED   9674419
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC311213.1, BC008785.2 and
            AK289499.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006473.3.
            
            Summary: Initiation of transcription by RNA polymerase II requires
            the activities of more than 70 polypeptides. The protein that
            coordinates these activities is transcription factor IID (TFIID),
            which binds to the core promoter to position the polymerase
            properly, serves as the scaffold for assembly of the remainder of
            the transcription complex, and acts as a channel for regulatory
            signals. TFIID is composed of the TATA-binding protein (TBP) and a
            group of evolutionarily conserved proteins known as TBP-associated
            factors or TAFs. TAFs may participate in basal transcription, serve
            as coactivators, function in promoter recognition or modify general
            transcription factors (GTFs) to facilitate complex assembly and
            transcription initiation. This gene encodes a protein that is a
            component of the PCAF histone acetylase complex and structurally
            similar to one of the histone-like TAFs, TAF6. The PCAF histone
            acetylase complex, which is composed of more than 20 polypeptides
            some of which are TAFs, is required for myogenic transcription and
            differentiation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008785.2, AK289499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294168.8/ ENSP00000294168.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DC311213.1         94-100
            8-1485              BC008785.2         1-1478
            1486-2013           AK289499.1         1489-2016
            2014-2023           BC008785.2         2007-2016
FEATURES             Location/Qualifiers
     source          1..2023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..2023
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /note="TATA-box binding protein associated factor 6 like"
                     /db_xref="GeneID:10629"
                     /db_xref="HGNC:HGNC:17305"
                     /db_xref="MIM:602946"
     exon            1..95
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /inference="alignment:Splign:2.1.0"
     exon            96..255
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1977
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /note="p300/CBP-associated factor (PCAF)-associated factor
                     65; PAF65-alpha; PCAF-associated factor 65-alpha;
                     TAF6-like RNA polymerase II, p300/CBP-associated factor
                     (PCAF)-associated factor, 65kDa"
                     /codon_start=1
                     /product="TAF6-like RNA polymerase II p300/CBP-associated
                     factor-associated factor 65 kDa subunit 6L"
                     /protein_id="NP_006464.1"
                     /db_xref="CCDS:CCDS8035.1"
                     /db_xref="GeneID:10629"
                     /db_xref="HGNC:HGNC:17305"
                     /db_xref="MIM:602946"
                     /translation="MSEREERRFVEIPRESVRLMAESTGLELSDEVAALLAEDVCYRL
                     REATQNSSQFMKHTKRRKLTVEDFNRALRWSSVEAVCGYGSQEALPMRPAREGELYFP
                     EDREVNLVELALATNIPKGCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKY
                     YHQVTRAVLGDDPQLMKVALQDLQTNSKIGALLPYFVYVVSGVKSVSHDLEQLHRLLQ
                     VARSLFRNPHLCLGPYVRCLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFW
                     THGDLVSGLYQHILLSLQKILADPVRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYW
                     TNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPNRGGPGGRGCRRL
                     DDLPWDSLLFQESSSGGGAEPSFGSGLPLPPGGAGPEDPSLSVTLADIYRELYAFFGD
                     SLATRFGTGQPAPTAPRPPGDKKEPAAAPDSVRKMPQLTASAIVSPHGDESPRGSGGG
                     GPASASGPAASESRPLPRVHRARGAPRQQGPGTGTRDVFQKSRFAPRGAPHFRFIIAG
                     RQAGRRCRGRLFQTAFPAPYGPSPASRYVQKLPMIGRTSRPARRWALSDYSLYLPL"
     exon            256..342
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /inference="alignment:Splign:2.1.0"
     exon            343..493
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /inference="alignment:Splign:2.1.0"
     exon            494..544
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /inference="alignment:Splign:2.1.0"
     exon            545..639
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /inference="alignment:Splign:2.1.0"
     exon            640..714
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /inference="alignment:Splign:2.1.0"
     exon            715..935
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1068
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1197
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..2023
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2003..2008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /note="hexamer: AATAAA"
     polyA_site      2023
                     /gene="TAF6L"
                     /gene_synonym="PAF65A"
                     /note="major polyA site"
ORIGIN      
        1 agagggaatg agtgtgagct cgtgagtggg cgccgccgcc accgcccccg ccgccgtcgt
       61 ctcggtagca gccttcgcca cgccggggtc ttcagctcca ctggggccat gtcagagcga
      121 gaagagcggc ggtttgtgga gatccctcgg gagtctgtcc ggctcatggc ggagagcacg
      181 ggcctggagc tgagcgatga ggtggcggcg ctgctcgcag aggacgtgtg ctatcgtctg
      241 agagaggcca cgcagaatag ctctcagttc atgaagcaca ccaaacgccg gaagctgacg
      301 gttgaggact tcaacagggc cctcagatgg agcagcgtgg aggctgtgtg tggttacgga
      361 tcacaggagg cactgcccat gcgccccgcc agggagggtg aactctactt tcctgaggat
      421 cgagaggtga acctggtgga gctggccctg gctaccaaca tccccaaagg ctgtgctgag
      481 acagctgtca gagttcatgt ctcctacctg gatggcaaag ggaacctggc acctcaagga
      541 tcggtgccca gtgctgtgtc ttcactgaca gatgaccttc tcaagtacta tcaccaggtg
      601 actcgtgctg tgctagggga tgatccgcaa ctgatgaagg ttgcactcca ggacttgcag
      661 acgaactcca agattggggc actcctgcct tactttgttt atgtggtcag tggggtgaaa
      721 tctgtaagcc atgacctgga gcaactgcac cggctgctgc aggtggcacg gagcctattt
      781 cgtaatccgc acctgtgctt ggggccctat gtccgctgtc tggtgggcag tgtcctctac
      841 tgtgtcctgg agccactggc tgcctccatc aaccccctga atgaccactg gactctgcgg
      901 gatggggctg ccctcctgct cagccacatc ttctggactc atggggacct tgtaagtggc
      961 ctctatcagc atatcctgct atccctgcag aagatcctgg cagatcctgt gcggccgctc
     1021 tgctgccact atggagccgt ggtggggctg catgctcttg gctggaaggc agtagaacga
     1081 gtcctgtacc cacacctgtc cacctactgg acaaacttgc aggctgtgct ggatgattat
     1141 tcagtatcta atgcccaggt caaagcagat ggacacaaag tctatggagc cattctggtg
     1201 gcggtagagc gactgctgaa gatgaaggcc caggcagcag agcccaacag gggtggccca
     1261 ggtggcaggg ggtgccggcg cctggacgac ctgccatggg acagccttct ctttcaagag
     1321 tcgtcctccg ggggcggtgc agaacccagc tttgggtccg gcctcccgct gccgccaggg
     1381 ggcgcggggc cggaggaccc ttctctttcg gtgaccctgg ccgacatcta ccgggagctc
     1441 tacgccttct tcggtgacag cttggccaca cgctttggca ccggccagcc tgcacccacg
     1501 gctccgcggc cgcccgggga caagaaggag ccggcggcag ccccggactc ggtgcggaag
     1561 atgccgcagc tgacggcaag cgccatagtc agcccgcacg gcgacgagag cccccggggc
     1621 agcggcggag gcggccccgc gtcggcctct gggcccgccg cctctgagag caggcccttg
     1681 ccgcgcgtgc atcgggcgcg cggggcaccc cggcagcagg gccccgggac cggcacccgc
     1741 gacgttttcc agaagagccg tttcgccccg cgcggcgccc cgcactttcg tttcatcata
     1801 gccgggcggc aggctgggag gcgctgccgc gggcgccttt tccagactgc cttccccgcg
     1861 ccgtacgggc ctagcccggc ctcgcgctac gtgcagaaac tgcccatgat cggccgtacc
     1921 agccgccccg cccgccggtg ggcgctctcg gactactcgc tgtacttgcc gctctgagtc
     1981 agtggcccct tcgttccttg taaataaatc ccgcccccgg aaa
//
