LOCUS       NM_139315               2424 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor 6 (TAF6),
            transcript variant 2, mRNA.
ACCESSION   NM_139315
VERSION     NM_139315.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2424)
  AUTHORS   Tuc,E., Bengur,F.B., Aykut,A., Sahin,O. and Alanay,Y.
  TITLE     The third family with TAF6-related phenotype: Alazami-Yuan syndrome
  JOURNAL   Clin Genet 97 (5), 795-796 (2020)
   PUBMED   32030742
  REMARK    GeneRIF: The third family with TAF6-related phenotype: Alazami-Yuan
            syndrome.
REFERENCE   2  (bases 1 to 2424)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2424)
  AUTHORS   Delannoy,A., Wilhelm,E., Eilebrecht,S., Alvarado-Cuevas,E.M.,
            Benecke,A.G. and Bell,B.
  TITLE     BIM and NOXA are mitochondrial effectors of TAF6delta-driven
            apoptosis
  JOURNAL   Cell Death Dis 9 (2), 70 (2018)
   PUBMED   29358700
  REMARK    GeneRIF: BIM and NOXA contribute to TAF6delta-dependent cell death.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2424)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2424)
  AUTHORS   Bell,B., Scheer,E. and Tora,L.
  TITLE     Identification of hTAF(II)80 delta links apoptotic signaling
            pathways to transcription factor TFIID function
  JOURNAL   Mol Cell 8 (3), 591-600 (2001)
   PUBMED   11583621
REFERENCE   6  (bases 1 to 2424)
  AUTHORS   Hisatake,K., Ohta,T., Takada,R., Guermah,M., Horikoshi,M.,
            Nakatani,Y. and Roeder,R.G.
  TITLE     Evolutionary conservation of human
            TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and
            interactions of TAFII80 with other TAFs and with general
            transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 92 (18), 8195-8199 (1995)
   PUBMED   7667268
REFERENCE   7  (bases 1 to 2424)
  AUTHORS   Weinzierl,R.O., Ruppert,S., Dynlacht,B.D., Tanese,N. and Tjian,R.
  TITLE     Cloning and expression of Drosophila TAFII60 and human TAFII70
            reveal conserved interactions with other subunits of TFIID
  JOURNAL   EMBO J 12 (13), 5303-5309 (1993)
   PUBMED   8262073
REFERENCE   8  (bases 1 to 2424)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   9  (bases 1 to 2424)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
REFERENCE   10 (bases 1 to 2424)
  AUTHORS   Mathe,G., Schwarzenberg,L., Halle-Pannenko,O. and Simmler,M.C.
  TITLE     Discussion paper: experimental and clinical immunopharmacology data
            applicable to cancer immunotherapy
  JOURNAL   Ann N Y Acad Sci 277 (00), 467-484 (1976)
   PUBMED   826207
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA776355.1, DA150478.1,
            BC018115.1 and CX782724.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_139315.2.
            
            Summary: Initiation of transcription by RNA polymerase II requires
            the activities of more than 70 polypeptides. The protein that
            coordinates these activities is transcription factor IID (TFIID),
            which binds to the core promoter to position the polymerase
            properly, serves as the scaffold for assembly of the remainder of
            the transcription complex, and acts as a channel for regulatory
            signals. TFIID is composed of the TATA-binding protein (TBP) and a
            group of evolutionarily conserved proteins known as TBP-associated
            factors or TAFs. TAFs may participate in basal transcription, serve
            as coactivators, function in promoter recognition or modify general
            transcription factors (GTFs) to facilitate complex assembly and
            transcription initiation. This gene encodes one of the smaller
            subunits of TFIID that binds weakly to TBP but strongly to TAF1,
            the largest subunit of TFIID. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform
            (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.391292.1,
                                           SRR3476690.597784.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453269.7/ ENSP00000389575.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                DA776355.1         41-120
            81-81               DA150478.1         79-79
            82-2289             BC018115.1         65-2272
            2290-2424           CX782724.1         26-160              c
FEATURES             Location/Qualifiers
     source          1..2424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2424
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /note="TATA-box binding protein associated factor 6"
                     /db_xref="GeneID:6878"
                     /db_xref="HGNC:HGNC:11540"
                     /db_xref="MIM:602955"
     exon            1..155
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            156..370
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2248
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /note="isoform alpha is encoded by transcript variant 2;
                     TATA box binding protein (TBP)-associated factor, RNA
                     polymerase II, E, 70/85kD; transcription initiation factor
                     TFIID subunit 6; RNA polymerase II TBP-associated factor
                     subunit E; transcription initiation factor TFIID 70 kDa
                     subunit; TAF6 RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 80kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 6
                     isoform alpha"
                     /protein_id="NP_647476.1"
                     /db_xref="CCDS:CCDS5686.1"
                     /db_xref="GeneID:6878"
                     /db_xref="HGNC:HGNC:11540"
                     /db_xref="MIM:602955"
                     /translation="MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVS
                     YRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGR
                     ELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAE
                     ATEPLKSAKPGQEEDGPLKGKGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSV
                     EQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNL
                     ALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAA
                     RLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLI
                     LPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRA
                     EFGSLGPLLCSQVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLK
                     VPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGST
                     TTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSLPPTGEGKGGPTSH
                     PSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGSPQPAP"
     exon            371..457
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            458..611
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            612..668
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            669..788
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            789..934
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1012
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1114
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1297
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1372
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1498
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1672
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1870
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2424
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /note="hexamer: AATAAA"
     polyA_site      2424
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /note="major polyA site"
ORIGIN      
        1 gggcggggcc aagatggcgc cgagcgccgg gtgagcagcg tctcggctgc cgctagagtt
       61 ttcctgctcc ccgcgctcgg gtggcggggg cgggtctgag tggtaccccg gaggagaccc
      121 tttgaaggtc ccttgtgggg actggaaaga ggacgggtct ccgtctctcc accgggggct
      181 tcatccttcc agggaggaga agagggactc cagaatggct gaggagaaga agctgaagct
      241 tagcaacact gtgctgccct cggagtccat gaaggtggtg gctgaatcca tgggcatcgc
      301 ccagattcag gaggagacct gccagctgct aacggatgag gtcagctacc gcatcaaaga
      361 gatcgcacag gatgccttga agttcatgca catggggaag cggcagaagc tcaccaccag
      421 tgacattgac tacgccttga agctaaagaa tgtcgagcca ctctatggct tccacgccca
      481 ggagttcatt cctttccgct tcgcctctgg tgggggccgg gagctttact tctatgagga
      541 gaaggaggtt gatctgagcg acatcatcaa tacccctctg ccccgggtgc ccctggacgt
      601 ctgcctcaaa gctcattggc tgagcatcga gggctgccag ccagctatcc ccgagaaccc
      661 gcccccagct cccaaagagc aacagaaggc tgaagccaca gaacccctga agtcagccaa
      721 gccaggccag gaggaagacg gacccctgaa gggcaaaggt caaggggcca ccacagccga
      781 cggcaaaggg aaagagaaga aggcgccgcc cttgctggag ggggccccct tgcgactgaa
      841 gccccggagc atccacgagt tgtctgtgga gcagcagctc tactacaagg agatcaccga
      901 ggcctgcgtg ggctcctgcg aggccaagag ggcggaagcc ctgcaaagca ttgccacgga
      961 ccctggactg tatcagatgc tgccacggtt cagtaccttt atctcggagg gggtccgtgt
     1021 gaacgtggtt cagaacaacc tggccctact catctacctg atgcgtatgg tgaaagcgct
     1081 gatggacaac cccacgctct atctagaaaa atacgtccat gagctgattc cagctgtgat
     1141 gacctgcatc gtgagcagac agttgtgcct gcgaccagat gtggacaatc actgggcact
     1201 ccgagacttt gctgcccgcc tggtggccca gatctgcaag cattttagca caaccactaa
     1261 caacatccag tcccggatca ccaagacctt caccaagagc tgggtggacg agaagacgcc
     1321 ctggacgact cgttatggct ccatcgcagg cttggctgag ctgggacacg atgttatcaa
     1381 gactctgatt ctgccccggc tgcagcagga aggggagcgg atccgcagtg tgctggacgg
     1441 ccctgtgctg agcaacattg accggattgg agcagaccat gtgcagagcc tcctgctgaa
     1501 acactgtgct cctgttctgg caaagctgcg cccaccgcct gacaatcagg acgcctatcg
     1561 ggcagaattc gggtcccttg ggcccctcct ctgctcccag gtggtcaagg ctcgggccca
     1621 ggctgctctg caggctcagc aggtcaacag gaccactctg accatcacgc agccccggcc
     1681 cacgctgacc ctctcgcagg ccccacagcc tggccctcgc acccctggct tgctgaaggt
     1741 tcctggctcc atcgcacttc ctgtccagac actggtgtct gcacgagcgg ctgccccacc
     1801 acagccttcc cctcctccaa ccaagtttat tgtaatgtca tcgtcctcca gcgccccatc
     1861 cacccagcag gtcctgtccc tcagcacctc ggcccccggc tcaggttcca ccaccacttc
     1921 gcccgtcacc accaccgtcc ccagcgtgca gcccatcgtc aagttggtct ccaccgccac
     1981 caccgcaccc cccagcactg ctccctctgg tcctgggagt gtccagaagt acatcgtggt
     2041 ctcacttccc ccaacagggg agggcaaagg aggccccacc tcccatcctt ctccagttcc
     2101 tcccccggca tcgtccccgt ccccactcag cggcagtgcc ctttgtgggg ggaagcagga
     2161 ggctggggac agtccccctc cagctccagg gactccaaaa gccaatggct cccagcccaa
     2221 ctccggctcc cctcagcctg ctccgtgatg ctccacctgc cagcccccgg attcccacac
     2281 atgcagacat gtacacacgt gcacgtacac acatgcatgc tcgctaagcg gaaggaagtt
     2341 gtagattgct tccttcatgt cactttcttt ttagatattg tacagccagt ttctcagaat
     2401 aaaagtttgg tttgtaagtt ctga
//
