LOCUS       NM_001365000            2394 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor 6 (TAF6),
            transcript variant 9, mRNA.
ACCESSION   NM_001365000 XM_006716101
VERSION     NM_001365000.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2394)
  AUTHORS   Tuc,E., Bengur,F.B., Aykut,A., Sahin,O. and Alanay,Y.
  TITLE     The third family with TAF6-related phenotype: Alazami-Yuan syndrome
  JOURNAL   Clin Genet 97 (5), 795-796 (2020)
   PUBMED   32030742
  REMARK    GeneRIF: The third family with TAF6-related phenotype: Alazami-Yuan
            syndrome.
REFERENCE   2  (bases 1 to 2394)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2394)
  AUTHORS   Delannoy,A., Wilhelm,E., Eilebrecht,S., Alvarado-Cuevas,E.M.,
            Benecke,A.G. and Bell,B.
  TITLE     BIM and NOXA are mitochondrial effectors of TAF6delta-driven
            apoptosis
  JOURNAL   Cell Death Dis 9 (2), 70 (2018)
   PUBMED   29358700
  REMARK    GeneRIF: BIM and NOXA contribute to TAF6delta-dependent cell death.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2394)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2394)
  AUTHORS   Bell,B., Scheer,E. and Tora,L.
  TITLE     Identification of hTAF(II)80 delta links apoptotic signaling
            pathways to transcription factor TFIID function
  JOURNAL   Mol Cell 8 (3), 591-600 (2001)
   PUBMED   11583621
REFERENCE   6  (bases 1 to 2394)
  AUTHORS   Hisatake,K., Ohta,T., Takada,R., Guermah,M., Horikoshi,M.,
            Nakatani,Y. and Roeder,R.G.
  TITLE     Evolutionary conservation of human
            TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and
            interactions of TAFII80 with other TAFs and with general
            transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 92 (18), 8195-8199 (1995)
   PUBMED   7667268
REFERENCE   7  (bases 1 to 2394)
  AUTHORS   Weinzierl,R.O., Ruppert,S., Dynlacht,B.D., Tanese,N. and Tjian,R.
  TITLE     Cloning and expression of Drosophila TAFII60 and human TAFII70
            reveal conserved interactions with other subunits of TFIID
  JOURNAL   EMBO J 12 (13), 5303-5309 (1993)
   PUBMED   8262073
REFERENCE   8  (bases 1 to 2394)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   9  (bases 1 to 2394)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
REFERENCE   10 (bases 1 to 2394)
  AUTHORS   Mathe,G., Schwarzenberg,L., Halle-Pannenko,O. and Simmler,M.C.
  TITLE     Discussion paper: experimental and clinical immunopharmacology data
            applicable to cancer immunotherapy
  JOURNAL   Ann N Y Acad Sci 277 (00), 467-484 (1976)
   PUBMED   826207
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073842.5.
            
            On Jul 20, 2018 this sequence version replaced XM_006716101.2.
            
            Summary: Initiation of transcription by RNA polymerase II requires
            the activities of more than 70 polypeptides. The protein that
            coordinates these activities is transcription factor IID (TFIID),
            which binds to the core promoter to position the polymerase
            properly, serves as the scaffold for assembly of the remainder of
            the transcription complex, and acts as a channel for regulatory
            signals. TFIID is composed of the TATA-binding protein (TBP) and a
            group of evolutionarily conserved proteins known as TBP-associated
            factors or TAFs. TAFs may participate in basal transcription, serve
            as coactivators, function in promoter recognition or modify general
            transcription factors (GTFs) to facilitate complex assembly and
            transcription initiation. This gene encodes one of the smaller
            subunits of TFIID that binds weakly to TBP but strongly to TAF1,
            the largest subunit of TFIID. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jun 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.130320.1,
                                           SRR7346977.872950.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AC073842.5         85336-85490
            156-340             AC073842.5         90426-90610
            341-427             AC073842.5         90740-90826
            428-581             AC073842.5         90925-91078
            582-638             AC073842.5         91289-91345
            639-758             AC073842.5         91777-91896
            759-904             AC073842.5         92441-92586
            905-982             AC073842.5         92695-92772
            983-1084            AC073842.5         92865-92966
            1085-1267           AC073842.5         93373-93555
            1268-1342           AC073842.5         94420-94494
            1343-1468           AC073842.5         94621-94746
            1469-1642           AC073842.5         96154-96327
            1643-1840           AC073842.5         96571-96768
            1841-2394           AC073842.5         97071-97624
FEATURES             Location/Qualifiers
     source          1..2394
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2394
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /note="TATA-box binding protein associated factor 6"
                     /db_xref="GeneID:6878"
                     /db_xref="HGNC:HGNC:11540"
                     /db_xref="MIM:602955"
     exon            1..155
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            156..340
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2218
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /note="isoform delta is encoded by transcript variant 9;
                     TATA box binding protein (TBP)-associated factor, RNA
                     polymerase II, E, 70/85kD; transcription initiation factor
                     TFIID subunit 6; RNA polymerase II TBP-associated factor
                     subunit E; transcription initiation factor TFIID 70 kDa
                     subunit; TAF6 RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 80kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 6
                     isoform delta"
                     /protein_id="NP_001351929.1"
                     /db_xref="CCDS:CCDS94153.1"
                     /db_xref="GeneID:6878"
                     /db_xref="HGNC:HGNC:11540"
                     /db_xref="MIM:602955"
                     /translation="MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEDA
                     LKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEV
                     DLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKP
                     GQEEDGPLKGKGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSVEQQLYYKEIT
                     EACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMV
                     KALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHF
                     STTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGER
                     IRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRAEFGSLGPLLC
                     SQVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQ
                     TLVSARAAAPPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTSPVTTTVP
                     SVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSLPPTGEGKGGPTSHPSPVPPPASS
                     PSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGSPQPAP"
     exon            341..427
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            428..581
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            582..638
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            639..758
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            759..904
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            905..982
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1084
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1267
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1342
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1468
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1642
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1840
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2394
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2368..2373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /note="hexamer: AATAAA"
     polyA_site      2394
                     /gene="TAF6"
                     /gene_synonym="ALYUS; MGC:8964; TAF(II)70; TAF(II)80;
                     TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85"
                     /note="major polyA site"
ORIGIN      
        1 gggcggggcc aagatggcgc cgagcgccgg gtgagcagcg tctcggctgc cgctagagtt
       61 ttcctgctcc ccgcgctcgg gtggcggggg cgggtctgag tggtaccccg gaggagaccc
      121 tttgaaggtc ccttgtgggg actggaaaga ggacgggtct ccgtctctcc accgggggct
      181 tcatccttcc agggaggaga agagggactc cagaatggct gaggagaaga agctgaagct
      241 tagcaacact gtgctgccct cggagtccat gaaggtggtg gctgaatcca tgggcatcgc
      301 ccagattcag gaggagacct gccagctgct aacggatgag gatgccttga agttcatgca
      361 catggggaag cggcagaagc tcaccaccag tgacattgac tacgccttga agctaaagaa
      421 tgtcgagcca ctctatggct tccacgccca ggagttcatt cctttccgct tcgcctctgg
      481 tgggggccgg gagctttact tctatgagga gaaggaggtt gatctgagcg acatcatcaa
      541 tacccctctg ccccgggtgc ccctggacgt ctgcctcaaa gctcattggc tgagcatcga
      601 gggctgccag ccagctatcc ccgagaaccc gcccccagct cccaaagagc aacagaaggc
      661 tgaagccaca gaacccctga agtcagccaa gccaggccag gaggaagacg gacccctgaa
      721 gggcaaaggt caaggggcca ccacagccga cggcaaaggg aaagagaaga aggcgccgcc
      781 cttgctggag ggggccccct tgcgactgaa gccccggagc atccacgagt tgtctgtgga
      841 gcagcagctc tactacaagg agatcaccga ggcctgcgtg ggctcctgcg aggccaagag
      901 ggcggaagcc ctgcaaagca ttgccacgga ccctggactg tatcagatgc tgccacggtt
      961 cagtaccttt atctcggagg gggtccgtgt gaacgtggtt cagaacaacc tggccctact
     1021 catctacctg atgcgtatgg tgaaagcgct gatggacaac cccacgctct atctagaaaa
     1081 atacgtccat gagctgattc cagctgtgat gacctgcatc gtgagcagac agttgtgcct
     1141 gcgaccagat gtggacaatc actgggcact ccgagacttt gctgcccgcc tggtggccca
     1201 gatctgcaag cattttagca caaccactaa caacatccag tcccggatca ccaagacctt
     1261 caccaagagc tgggtggacg agaagacgcc ctggacgact cgttatggct ccatcgcagg
     1321 cttggctgag ctgggacacg atgttatcaa gactctgatt ctgccccggc tgcagcagga
     1381 aggggagcgg atccgcagtg tgctggacgg ccctgtgctg agcaacattg accggattgg
     1441 agcagaccat gtgcagagcc tcctgctgaa acactgtgct cctgttctgg caaagctgcg
     1501 cccaccgcct gacaatcagg acgcctatcg ggcagaattc gggtcccttg ggcccctcct
     1561 ctgctcccag gtggtcaagg ctcgggccca ggctgctctg caggctcagc aggtcaacag
     1621 gaccactctg accatcacgc agccccggcc cacgctgacc ctctcgcagg ccccacagcc
     1681 tggccctcgc acccctggct tgctgaaggt tcctggctcc atcgcacttc ctgtccagac
     1741 actggtgtct gcacgagcgg ctgccccacc acagccttcc cctcctccaa ccaagtttat
     1801 tgtaatgtca tcgtcctcca gcgccccatc cacccagcag gtcctgtccc tcagcacctc
     1861 ggcccccggc tcaggttcca ccaccacttc gcccgtcacc accaccgtcc ccagcgtgca
     1921 gcccatcgtc aagttggtct ccaccgccac caccgcaccc cccagcactg ctccctctgg
     1981 tcctgggagt gtccagaagt acatcgtggt ctcacttccc ccaacagggg agggcaaagg
     2041 aggccccacc tcccatcctt ctccagttcc tcccccggca tcgtccccgt ccccactcag
     2101 cggcagtgcc ctttgtgggg ggaagcagga ggctggggac agtccccctc cagctccagg
     2161 gactccaaaa gccaatggct cccagcccaa ctccggctcc cctcagcctg ctccgtgatg
     2221 ctccacctgc cagcccccgg attcccacac atgcagacat gtacacacgt gcacgtacac
     2281 acatgcatgc tcgctaagcg gaaggaagtt gtagattgct tccttcatgt cactttcttt
     2341 ttagatattg tacagccagt ttctcagaat aaaagtttgg tttgtaagtt ctga
//
