LOCUS       NM_005640               4751 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor 4b (TAF4B),
            transcript variant 2, mRNA.
ACCESSION   NM_005640 XM_290809 XM_937014
VERSION     NM_005640.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4751)
  AUTHORS   Xi,Q., Zhang,H., Zhang,X., Jiang,Y., Wang,R., Liu,R. and Zhang,H.
  TITLE     Analysis of TATA-box binding protein associated factor 4b gene
            mutations in a Chinese population with nonobstructive azoospermia
  JOURNAL   Medicine (Baltimore) 99 (23), e20561 (2020)
   PUBMED   32502024
  REMARK    GeneRIF: The c.11G>T mutation of the TAF4B gene may be associated
            with NOA in a Chinese population.
REFERENCE   2  (bases 1 to 4751)
  AUTHORS   Liu,X., Xi,Q., Li,L., Wang,Q., Jiang,Y., Zhang,H., Liu,R. and
            Wang,R.
  TITLE     Targeted Next-Generation Sequencing Identifies Novel Sequence
            Variations of Genes Associated with Nonobstructive Azoospermia in
            the Han Population of Northeast China
  JOURNAL   Med Sci Monit 25, 5801-5812 (2019)
   PUBMED   31377750
  REMARK    GeneRIF: Nonobstructive Azoospermia variants included MTRR c.537T>C
            (rs161870), odds ratios (OR), 3.686, 95% confidence interval (CI),
            1.228-11.066; MTRR, c.1049A>G (rs162036), OR, 3.686, 95% CI,
            1.228-11.066; PIWIL1, c.1580G>A (rs1106042), OR, 4.737, 95% CI,
            1.314-17.072; TAF4B, c.1815T>C (rs1677016), OR, 3.599, 95% CI,
            1.255-10.327; and SOX10 c.927T>C (rs139884), OR, 3.192, 95% CI,
            1.220-8.353.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4751)
  AUTHORS   Yang,X., Zhang,H., Jiang,Y., Zhang,H., Hu,X., Zhu,D., Geng,D. and
            Liu,R.
  TITLE     Association Study Between MTRR, TAF4B, PIWIL1 Variants and
            Non-Obstructive Azoospermia in Northeast Chinese Han Population
  JOURNAL   Clin Lab 64 (10), 1731-1738 (2018)
   PUBMED   30336530
  REMARK    GeneRIF: The methionine synthase reductase (MTRR), TAF4B protein,
            PIWI protein (PIWIL1) four single nucleotide polymorphisms (SNPs)
            are not shown to be significantly related with non-obstructive
            azoospermia (NOA).
REFERENCE   4  (bases 1 to 4751)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4751)
  AUTHORS   Grive,K.J., Gustafson,E.A., Seymour,K.A., Baddoo,M., Schorl,C.,
            Golnoski,K., Rajkovic,A., Brodsky,A.S. and Freiman,R.N.
  TITLE     TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis
  JOURNAL   PLoS Genet 12 (6), e1006128 (2016)
   PUBMED   27341508
  REMARK    GeneRIF: The existence of a highly conserved TAF4b-dependent gene
            regulatory network.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4751)
  AUTHORS   Holstege,F.C., Fiedler,U. and Timmers,H.T.
  TITLE     Three transitions in the RNA polymerase II transcription complex
            during initiation
  JOURNAL   EMBO J 16 (24), 7468-7480 (1997)
   PUBMED   9405375
REFERENCE   7  (bases 1 to 4751)
  AUTHORS   Orphanides,G., Lagrange,T. and Reinberg,D.
  TITLE     The general transcription factors of RNA polymerase II
  JOURNAL   Genes Dev 10 (21), 2657-2683 (1996)
   PUBMED   8946909
  REMARK    Review article
REFERENCE   8  (bases 1 to 4751)
  AUTHORS   Dikstein,R., Zhou,S. and Tjian,R.
  TITLE     Human TAFII 105 is a cell type-specific TFIID subunit related to
            hTAFII130
  JOURNAL   Cell 87 (1), 137-146 (1996)
   PUBMED   8858156
REFERENCE   9  (bases 1 to 4751)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 4751)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016839.12, AY888048.1 and
            BC016360.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_005640.2.
            
            Summary: TATA binding protein (TBP) and TBP-associated factors
            (TAFs) participate in the formation of the TFIID protein complex,
            which is involved in initiation of transcription of genes by RNA
            polymerase II. This gene encodes a cell type-specific TAF that may
            be responsible for mediating transcription by a subset of
            activators in B cells. Three transcript variants encoding two
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2014].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 5' end of an exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is shorter
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY888048.1, SRR1803615.55278.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269142.10/ ENSP00000269142.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               AC016839.12        113350-113787
            439-4723            AY888048.1         1-4285
            4724-4751           BC016360.1         1027-1054
FEATURES             Location/Qualifiers
     source          1..4751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..4751
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /note="TATA-box binding protein associated factor 4b"
                     /db_xref="GeneID:6875"
                     /db_xref="HGNC:HGNC:11538"
                     /db_xref="MIM:601689"
     exon            1..832
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..3078
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /note="isoform 2 is encoded by transcript variant 2; TATA
                     box binding protein (TBP)-associated factor, RNA
                     polymerase II, C2, 105kD; transcription initiation factor
                     TFIID subunit 4B; TATA box binding protein
                     (TBP)-associated factor 4B; transcription initiation
                     factor TFIID 105 kDa subunit; TAF(II)105; TAF4b RNA
                     polymerase II, TATA box binding protein (TBP)-associated
                     factor, 105kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 4B
                     isoform 2"
                     /protein_id="NP_005631.1"
                     /db_xref="CCDS:CCDS42421.1"
                     /db_xref="GeneID:6875"
                     /db_xref="HGNC:HGNC:11538"
                     /db_xref="MIM:601689"
                     /translation="MPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGA
                     VTKAPVSVCVEPTASQPLRSPVGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTT
                     TIQFPANLQLPPGTVLIKSNSGPLMLVSPQQTVTRAETTSNITSRPAVPANPQTVKIC
                     TVPNSSSQLIKKVAVTPVKKLAQIGTTVVTTVPKPSSVQSVAVPTSVVTVTPGKPLNT
                     VTTLKPSSLGASSTPSNEPNLKAENSAAVQINLSPTMLENVKKCKNFLAMLIKLACSG
                     SQSPEMGQNVKKLVEQLLDAKIEAEEFTRKLYVELKSSPQPHLVPFLKKSVVALRQLL
                     PNSQSFIQQCVQQTSSDMVIATCTTTVTTSPVVTTTVSSSQSEKSIIVSGATAPRTVS
                     VQTLNPLAGPVGAKAGVVTLHSVGPTAATGGTTAGTGLLQTSKPLVTSVANTVTTVSL
                     QPEKPVVSGTAVTLSLPAVTFGETSGAAICLPSVKPVVSSAGTTSDKPVIGTPVQIKL
                     AQPGPVLSQPAGIPQAVQVKQLVVQQPSGGNEKQVTTISHSSTLTIQKCGQKTMPVNT
                     IIPTSQFPPASILKQITLPGNKILSLQASPTQKNRIKENVTSCFRDEDDINDVTSMAG
                     VNLNEENACILATNSELVGTLIQSCKDEPFLFIGALQKRILDIGKKHDITELNSDAVN
                     LISQATQERLRGLLEKLTAIAQHRMTTYKASENYILCSDTRSQLKFLEKLDQLEKQRK
                     DLEEREMLLKAAKSRSNKEDPEQLRLKQKAKELQQLELAQIQHRDANLTALAAIGPRK
                     KRPLESGIEGLKDNLLASGTSSLTATKQLHRPRITRICLRDLIFCMEQEREMKYSRAL
                     YLALLK"
     exon            833..978
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1086
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1248
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1371
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1461
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..2079
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2215
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2321
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2491
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2622
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2748
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2805
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2910
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..4751
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4730..4735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /note="hexamer: AATAAT"
     polyA_site      4751
                     /gene="TAF4B"
                     /gene_synonym="SPGF13; TAF2C2; TAFII105"
                     /note="major polyA site"
ORIGIN      
        1 gtggctatat aaacatggct ggcgtggccg cgcggcgggg ccgtgccaat cgcgcgtagg
       61 gggctgtggg cactcggggt tcgtagtttt gaaatttctg gcgggggagc agctgcgcag
      121 ttaggctcga ggtgtgagcg acgaccttcc gggagccgca agtccaggct cccccgcagc
      181 gggacccgag cctgaggcgc agggctgagg cagcgcacgt gtgagcgccg ctgaggaagc
      241 tgcgagaggt cgggcgggtg tcgctccggg ggcagcccag gctcgcgcgg acgagaggaa
      301 ggtccgggac gcgcgtgtcc tgccgtgcag cgggcgcccg tcactgactt cgctgctgcg
      361 gcccccgcgc ctctccccag cgatgctgtg gaacccgaac cgcaccggag tcggctgccg
      421 cgcgccaagc ctcccctcac ctctgctccc ggaaccgcag cgccaaagct gccgctgagc
      481 ccctggggga tgcccgccgg cctcaccgaa cccgccggcg ccgctccccc ggctgctgtg
      541 agcgcctcgg ggaccgtgac catggccccg gccggggcgc tgccggtgcg ggtggagagc
      601 actccggtgg ccctgggcgc cgtgactaag gctcctgtca gcgtctgcgt ggagcccacg
      661 gcgtcccagc ccctgcggtc ccccgtgggg accctggtga ccaaagtggc tccggtcagc
      721 gcccctccta aagtcagcag cggccctagg ctgcctgctc ctcagatagt cgccgtgaaa
      781 gcccccaaca ccacgacaat ccagtttcct gctaatttgc agcttcctcc aggaaccgtt
      841 ttgattaaaa gtaacagtgg tccgttgatg ttggtatctc ctcagcaaac tgtaacaaga
      901 gccgagacca caagtaacat aacctcaagg ccagcagtac cagcgaatcc tcaaacagtc
      961 aaaatctgta cagtgccgaa ctctagctca caattaatca agaaagtggc agtgacacct
     1021 gttaaaaaat tggcacaaat aggaactact gtggtaacca ctgttccgaa gccttcctca
     1081 gtacaatctg tggctgtgcc aaccagtgtc gtcacagtta ctcctggaaa gccattgaat
     1141 actgtaacta ccctgaagcc ttcaagtttg ggagcatcat ccactccttc aaatgagccc
     1201 aatcttaaag cagagaactc agcagctgtt cagattaatc tttctccgac aatgctagaa
     1261 aatgtgaaga aatgcaagaa cttccttgca atgttaataa aactagcatg tagtggatca
     1321 cagtccccag aaatggggca aaatgtgaag aagctggtgg aacaactttt ggatgcaaaa
     1381 atcgaagcag aagaatttac taggaaactg tatgttgaac tcaagtcttc acctcagcct
     1441 cacctggttc cttttcttaa gaaaagcgtg gttgccttac gacaacttct gcctaactcc
     1501 cagagcttca tccagcaatg tgttcagcag acttctagtg acatggtcat tgctacctgt
     1561 actacaacag taacaacttc tcctgtggtg acaactacag tgtcctcaag ccagtctgaa
     1621 aagtcaatta ttgtttctgg agcaacagca cccagaactg tgtcagtgca aactttgaac
     1681 ccacttgctg gtccagtggg agcaaaagct ggagttgtga cacttcattc tgtgggccca
     1741 actgctgcaa caggaggaac aacagctgga actggtttgc ttcagacttc aaaaccactt
     1801 gtgacatctg tggcaaacac agtgaccacg gtctcactgc aacctgaaaa gccagttgtc
     1861 tctggaacag cagtaacact gtcccttcca gcagtaactt ttggagaaac ttcaggtgca
     1921 gctatttgtc ttccatctgt gaaacctgtt gtttcttctg ctgggaccac atctgacaag
     1981 cctgttattg ggactccagt tcaaatcaaa cttgcccagc cgggccctgt cctttcacaa
     2041 ccagctggga ttccacaggc agttcaagtc aagcaactag tagttcagca gccttcagga
     2101 ggcaatgaaa aacaagtgac cacaatttca cattcctcaa cattgaccat tcagaaatgt
     2161 ggacagaaga cgatgccagt gaacaccata atacctacta gtcagtttcc tccagcttcc
     2221 attctaaagc aaattactct gcctggaaat aaaattctgt cacttcaagc atctcctact
     2281 cagaaaaata gaataaaaga gaatgtaaca tcatgcttcc gagatgagga tgacatcaat
     2341 gatgtgactt ctatggcagg ggtcaacctt aatgaagaaa atgcctgcat cttagcaaca
     2401 aactctgaat tggttggcac actcattcag tcatgtaaag atgaaccatt tctttttatt
     2461 ggagctctac aaaagagaat tttagacatt ggtaaaaagc atgacattac agaacttaac
     2521 tctgatgctg tgaacttgat ctcccaagca acacaggaac gactacgagg ccttctagaa
     2581 aaactgactg caattgctca gcatcgaatg actacttaca aggcaagtga aaattacatc
     2641 ctgtgtagtg ataccaggtc acagctcaaa tttcttgaaa agctggatca attggagaag
     2701 cagagaaagg atttggaaga aagagaaatg ttacttaagg cagccaagag tcgttctaat
     2761 aaagaagatc cagaacagct gagattaaag cagaaagcca aagagttaca gcaattggaa
     2821 cttgcacaga tacagcatag agacgctaat ctcacagctc ttgcagctat tggaccaagg
     2881 aagaagagac cactagaatc tggaattgag ggcttaaaag acaaccttct tgcttctggg
     2941 acatccagcc tgacagccac caaacagttg catcgtccaa gaatcacgag aatctgcctc
     3001 agggacttga tattttgtat ggaacaggaa cgggagatga agtattctcg agctctatac
     3061 ctggcccttc tgaagtgacc actccactct tccatccaga tccttgctat ttactgccaa
     3121 agaagacaca aagcattgtt gcactgtcct gaaatttcaa tttctggaaa ataatcacca
     3181 acatgaaaga gcattgttta cagttagaaa ctttattaac tcttacctat ccatctcatg
     3241 ggactcttac agactcagat tcatctttgt cttctgaaaa tcagttatga aatacacttt
     3301 gcacagaatt aggcatctgc ctatctgtgc attaaattaa agcaagttaa ggccctattt
     3361 gttactacct gcctcatttg ccaaattgta gcaggtgagg tgtccttccc taatacagca
     3421 tgcattgaga tgcaggagaa aggaagaggc ataagaaaat acaagaatga ctatttcatt
     3481 ctatattgaa cctgtcccaa agtggtaggt tttctgggct ggaatcagaa gttgcttagc
     3541 taactatgac agtcaccctc tgtacgtgac aggccactgt ggtgactttg gtcggctgag
     3601 ttccagtgtt gtcaaaacaa gacaaatggg gatagattgt gcctggggtt gctaattctc
     3661 tgcttcatat caccatatgc cgtttctggt accaagtgag gggacatgct tgtcagggaa
     3721 accttaaaat tgaatctact gatatatctt gttgaaaaaa tggaaaaggt gcaaagtatt
     3781 agaaggaacg ttagggcgtt gctttcaaac tgatgagggg aatgtgaaaa tggtatcata
     3841 aaacaggaaa tgtgcttcat atgcccaaga ggggaagagg tggaatcgga actccaaaac
     3901 aactggtaca tgttttgttg atgggcaaaa aaaatcacag cacaaccaga aaggagaatg
     3961 taccagatgt tttcaaatta gagtatttca aaaggaaaat gttatttttt gttttgtatt
     4021 gttttaaatc ccaaggatag tttttatagt tccttctgtc ataatatatt ttagttatcc
     4081 taatttttaa gcatgttggc acatttaaaa aatcctaatt gatgatgaga aatttttaac
     4141 aataggactt tatgttggat tctgtactta aaaggtactg tcaatatctc actcttgggg
     4201 atatgagctc taaatatgag aagcaagtta tatgtgttca cctgaggaag aagctgacgg
     4261 acaaagcaaa ccctctttaa aaaaaaaaaa aagaaaattc cacgtgtgtg gaatacagcc
     4321 ggtgaaaaat aatcactgta gttagaatca catacagaaa aaaaatgatt gaatcctcca
     4381 agaaggtatt tcaaaaatgg gaaatgctat acttataaga attgaaggaa aaaaaaaaaa
     4441 acacctcacg tatgttattc ttcatcctgt tcttcccatt gggactgtta tggccatatt
     4501 ctacagtata gtaaatttta aattggccac attttttttt gtttcagcaa gttatgtaaa
     4561 atgctataaa ttatgtgtat gttaaaggag tactttaaga agagatcttt atccaaagtt
     4621 gtttttgtat atttaaatgc ttacctttat tttttgtaaa gtgcagcata ctcatttgtg
     4681 tataatctta ctgatcagat gtttaaaatt attccaaata cttcattaaa ataattattt
     4741 tattataaga a
//
