LOCUS       NM_003185               4699 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor 4 (TAF4),
            mRNA.
ACCESSION   NM_003185
VERSION     NM_003185.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4699)
  AUTHORS   Janssen,B.D.E., van den Boogaard,M.H., Lichtenbelt,K., Seaby,E.G.,
            Stals,K., Ellard,S., Newbury-Ecob,R., Dixit,A., Roht,L.,
            Pajusalu,S., Ounap,K., Firth,H.V., Buckley,M., Wilson,M.,
            Roscioli,T., Tidwell,T., Mao,R., Ennis,S., Holwerda,S.J., van
            Gassen,K. and van Jaarsveld,R.H.
  TITLE     De novo putative loss-of-function variants in TAF4 are associated
            with a neuro-developmental disorder
  JOURNAL   Hum Mutat 43 (12), 1844-1851 (2022)
   PUBMED   35904126
  REMARK    GeneRIF: De novo putative loss-of-function variants in TAF4 are
            associated with a neuro-developmental disorder.
REFERENCE   2  (bases 1 to 4699)
  AUTHORS   Friis Theisen,F., Salladini,E., Davidsen,R., Jo Rasmussen,C.,
            Staby,L., Kragelund,B.B. and Skriver,K.
  TITLE     alphaalpha-hub coregulator structure and flexibility determine
            transcription factor binding and selection in regulatory
            interactomes
  JOURNAL   J Biol Chem 298 (6), 101963 (2022)
   PUBMED   35452682
  REMARK    GeneRIF: alphaalpha-hub coregulator structure and flexibility
            determine transcription factor binding and selection in regulatory
            interactomes.
REFERENCE   3  (bases 1 to 4699)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4699)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4699)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4699)
  AUTHORS   Mengus,G., May,M., Jacq,X., Staub,A., Tora,L., Chambon,P. and
            Davidson,I.
  TITLE     Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28:
            three subunits of the human transcription factor TFIID
  JOURNAL   EMBO J 14 (7), 1520-1531 (1995)
   PUBMED   7729427
REFERENCE   7  (bases 1 to 4699)
  AUTHORS   Parada,C.A., Yoon,J.B. and Roeder,R.G.
  TITLE     A novel LBP-1-mediated restriction of HIV-1 transcription at the
            level of elongation in vitro
  JOURNAL   J Biol Chem 270 (5), 2274-2283 (1995)
   PUBMED   7836461
REFERENCE   8  (bases 1 to 4699)
  AUTHORS   Zhou,Q. and Sharp,P.A.
  TITLE     Novel mechanism and factor for regulation by HIV-1 Tat
  JOURNAL   EMBO J 14 (2), 321-328 (1995)
   PUBMED   7835343
REFERENCE   9  (bases 1 to 4699)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 4699)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137077.31 and AL109911.47.
            
            On Sep 18, 2020 this sequence version replaced NM_003185.3.
            
            Summary: Initiation of transcription by RNA polymerase II requires
            the activities of more than 70 polypeptides. The protein that
            coordinates these activities is transcription factor IID (TFIID),
            which binds to the core promoter to position the polymerase
            properly, serves as the scaffold for assembly of the remainder of
            the transcription complex, and acts as a channel for regulatory
            signals. TFIID is composed of the TATA-binding protein (TBP) and a
            group of evolutionarily conserved proteins known as TBP-associated
            factors or TAFs. TAFs may participate in basal transcription, serve
            as coactivators, function in promoter recognition or modify general
            transcription factors (GTFs) to facilitate complex assembly and
            transcription initiation. This gene encodes one of the larger
            subunits of TFIID that has been shown to potentiate transcriptional
            activation by retinoic acid, thyroid hormone and vitamin D3
            receptors. In addition, this subunit interacts with the
            transcription factor CREB, which has a glutamine-rich activation
            domain, and binds to other proteins containing glutamine-rich
            regions. Aberrant binding to this subunit by proteins with expanded
            polyglutamine regions has been suggested as one of the pathogenetic
            mechanisms underlying a group of neurodegenerative disorders
            referred to as polyglutamine diseases. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y11354.1, SRR18074969.1800770.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252996.9/ ENSP00000252996.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1431              AL137077.31        56364-57794         c
            1432-1592           AL137077.31        6460-6620           c
            1593-1712           AL137077.31        4728-4847           c
            1713-1832           AL137077.31        1959-2078           c
            1833-1955           AL137077.31        965-1087            c
            1956-2045           AL109911.47        121342-121431       c
            2046-2294           AL109911.47        120305-120553       c
            2295-2442           AL109911.47        117526-117673       c
            2443-2557           AL109911.47        116955-117069       c
            2558-2727           AL109911.47        114347-114516       c
            2728-2858           AL109911.47        113919-114049       c
            2859-2984           AL109911.47        112778-112903       c
            2985-3041           AL109911.47        111931-111987       c
            3042-3161           AL109911.47        111345-111464       c
            3162-4699           AL109911.47        88593-90130         c
FEATURES             Location/Qualifiers
     source          1..4699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..4699
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /note="TATA-box binding protein associated factor 4"
                     /db_xref="GeneID:6874"
                     /db_xref="HGNC:HGNC:11537"
                     /db_xref="MIM:601796"
     exon            1..1431
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..3329
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /note="TATA box binding protein (TBP)-associated factor,
                     RNA polymerase II, C1, 130kD; TAF4A RNA polymerase II,
                     TATA box binding protein (TBP)-associated factor, 135 kD;
                     transcription initiation factor TFIID 135 kD subunit;
                     TBP-associated factor 4; RNA polymerase II TBP-associated
                     factor subunit C; transcription initiation factor TFIID
                     135 kDa subunit; transcription initiation factor TFIID 130
                     kDa subunit; TAF4 RNA polymerase II, TATA box binding
                     protein (TBP)-associated factor, 135kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 4"
                     /protein_id="NP_003176.2"
                     /db_xref="CCDS:CCDS33500.1"
                     /db_xref="GeneID:6874"
                     /db_xref="HGNC:HGNC:11537"
                     /db_xref="MIM:601796"
                     /translation="MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLA
                     PRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGP
                     QRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKP
                     AGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLV
                     NNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPA
                     PATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAA
                     AAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPP
                     APGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQ
                     LPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQA
                     PGTPIIARQVTPTTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTASLGTATA
                     VQTGTPQRTVPGATTTSSAATETMENVKKCKNFLSTLIKLASSGKQSTETAANVKELV
                     QNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFIQQSQQQP
                     PPPTSQATTALTAVVLSSSVQRTAGKTAATVTSALQPPVLSLTQPTQVGVGKQGQPTP
                     LVIQQPPKPGALIRPPQVTLTQTPMVALRQPHNRIMLTTPQQIQLNPLQPVPVVKPAV
                     LPGTKALSAVSAQAAAAQKNKLKEPGGGSFRDDDDINDVASMAGVNLSEESARILATN
                     SELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLV
                     EKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKS
                     RSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLTALAAIGPRKKRKVDCPGPGSGAE
                     GSGPGSVVPGSSGVGTPRQFTRQRITRVNLRDLIFCLENERETSHSLLLYKAFLK"
     exon            1432..1592
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1712
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1832
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1955
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2045
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2294
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2442
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2557
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2727
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2858
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2984
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3041
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3161
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..4699
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4678..4683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /note="hexamer: ATTAAA"
     polyA_site      4699
                     /gene="TAF4"
                     /gene_synonym="MRD73; TAF(II)130; TAF(II)135; TAF2C;
                     TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135"
                     /note="major polyA site"
ORIGIN      
        1 agtcggaacc tcctcctcgc ccaggcgcgc tcggcccgag cggcggcggc ggcggcggcc
       61 gaggaaaaaa gatggcggcg ggctcggatc tgctggacga ggtcttcttc aacagcgagg
      121 tggacgagaa agtggtgagc gacctggtgg gctcgctgga gtcgcagctg gcggccagcg
      181 cggcccacca ccaccacctc gcgccgcgca cgcccgaggt gcgggccgcg gccgccggcg
      241 cgctcgggaa ccatgttgtg agcggcagcc cggccggagc cgcgggcgca gggccggccg
      301 cccccgccga gggcgcgccc ggagcggcgc cggagccgcc ccccgcaggt agagcgcggc
      361 cggggggcgg ggggccgcag cgcccgggcc ccccctcacc gcgccgcccc cttgtccccg
      421 cagggcccgc gccgcccgcc gcgaagctga ggccgccgcc cgagggcagc gcggggtcct
      481 gcgccccggt gcccgccgcc gccgccgtcg ccgcggggcc cgagcccgcc cccgccggcc
      541 ccgccaagcc cgccggcccc gccgcgctgg ccgcccgcgc cggccccggc cccgggcccg
      601 gccccggccc cggccccggc cctggccctg gcaagcccgc cggccccggc gccgcgcaaa
      661 ctttgaatgg gagcgccgcg ctgctgaact cgcaccacgc cgccgcacct gctgtcagcc
      721 tggtcaacaa cgggcccgcc gcgctgctgc cgctgcccaa gcccgccgcc cccggcactg
      781 tcatccagac gccccccttc gtgggcgccg ccgcgccccc cgcgcccgcc gcgccctcgc
      841 cccccgccgc ccccgcgccc gccgcccccg ccgccgcccc gcccccgcca ccccccgcgc
      901 ccgccactct ggcccggccg cccggccacc ccgccggacc cccgaccgcc gcgcccgccg
      961 tgccgccccc cgccgccgcc cagaacgggg gcagcgccgg ggcagccccc gcccccgccc
     1021 cggccgccgg gggccccgcg ggggtcagcg gccaacccgg gcccggcgcg gcggctgcgg
     1081 cgccggcgcc gggggtcaag gccgagtcgc ccaagagggt ggtgcaggcg gcgcccccgg
     1141 cggcgcagac cctggcggcc agcggcccgg ccagcacggc ggccagcatg gtcatcgggc
     1201 caactatgca aggggcgctg cccagcccgg ccgccgtccc gccgcccgcc cccgggaccc
     1261 ccaccgggct gcccaaaggc gcggccggcg cagtgaccca gagcctgtcc cggacgccca
     1321 cggccaccac cagcgggatt cgggccaccc tgacgcccac cgtgctggcc ccccgcttgc
     1381 cgcagccgcc tcagaacccg accaacatcc agaacttcca gctgccccca ggaatggtcc
     1441 tcgtccgaag tgagaatggg cagttgttaa tgattcctca gcaggccttg gcccagatgc
     1501 aggcgcaggc ccatgcccag cctcagacca ccatggcgcc tcgccctgcc acccccacaa
     1561 gtgcccctcc cgtccagatc tccaccgtac aggcacctgg aacacctatc attgcacggc
     1621 aggtgacccc aactaccata attaagcaag tgtctcaggc ccagacaacg gtgcagccca
     1681 gtgcaaccct gcagcgctcg cccggcgtcc agcctcagct cgttctgggt ggcgctgccc
     1741 agacggcttc acttgggacg gcgacggctg ttcagacggg gactcctcag cgcacggtac
     1801 caggggcgac caccacttcc tcagctgcca cggaaactat ggaaaacgtg aagaaatgta
     1861 aaaatttcct atctacgtta ataaaactgg cttcatctgg caagcagtct acagagacag
     1921 cagctaatgt gaaagagctc gtgcagaatt tactggatgg aaaaatagaa gcagaagatt
     1981 tcacaagcag gttataccga gaacttaatt cttcacctca accttacctt gtgcctttcc
     2041 tgaagaggag cttacccgcc ttgagacagc tgacccccga ctccgcggcc ttcatccagc
     2101 agagccagca gcagccgcca ccgcccacct cgcaggccac cactgcgctc acggccgtgg
     2161 tgctgagtag ctcggtccag cgcacggccg ggaagacggc ggccaccgtg accagtgccc
     2221 tccagccccc tgtgctcagc ctcacgcagc ccacgcaggt cggcgtcggc aagcaggggc
     2281 aacccacacc gctggtcatc cagcagcctc cgaagccagg agccctgatc cggcccccgc
     2341 aggtgacgtt gacgcagaca cccatggtcg ccctgcggca gcctcacaac cggatcatgc
     2401 tcaccacgcc tcagcagatc cagctgaacc cactgcagcc agtccctgtg gtgaaacccg
     2461 ccgtgttacc tggaaccaaa gccctttctg ctgtctcggc acaagcagct gctgcacaga
     2521 aaaataaact caaggagcct gggggaggtt cgtttcggga cgatgatgac attaatgatg
     2581 ttgcatcgat ggctggagta aacttgtcag aagaaagtgc aagaatatta gccacgaact
     2641 ctgaattggt gggcacgcta acgcggtcct gtaaagatga aaccttcctc ctccaagcgc
     2701 ctttgcagag aagaatatta gaaataggta aaaaacatgg tataacggaa ttacatccag
     2761 atgtagtaag ttatgtatca catgccacgc aacaaaggct acagaatctt gtagagaaaa
     2821 tatcagaaac agctcagcag aagaactttt cttacaagga tgacgacaga tatgagcagg
     2881 cgagtgacgt ccgggcacag ctcaagtttt ttgaacagct tgatcaaatc gaaaagcaga
     2941 ggaaggatga gcaggagcgg gagatcctga tgagggcagc aaagtctcgg tcaagacaag
     3001 aagatccaga acagttaagg ctgaaacaga aggcaaagga gatgcagcaa caggaactgg
     3061 cacaaatgag acagcgggac gccaacctca cagcactagc agcgatcggg cccaggaaaa
     3121 agaggaaagt ggactgtccg gggccgggct caggagcaga ggggtcgggc cccggctcag
     3181 tggtcccagg cagctcgggt gtcggaaccc ccagacagtt cacgcgacaa agaatcacgc
     3241 gggtcaacct cagggacctc atattttgtt tagaaaatga acgtgagaca agccattcac
     3301 tgctgctcta caaagcattc cttaagtgac acaggaggac gcctggggac tttttatata
     3361 tttgcagatt acgccttttt gtaacgagca aatgggatat tgtttaaaaa acagccacct
     3421 ctttacaatg gaacagtttt atattcctgt ttctaaatca gctcttcagt gtgaaagaaa
     3481 acacgtttct gtaacagaga gaacacaaag gcctgtggat actcttaaag gacaattaaa
     3541 tcttaactca tcttgattga gtggccttcc tgccaaacaa gccatatata aagactgatg
     3601 gaatcgttag caaataatta gctgccctct gtcaactcat agcagtttct gcattatttg
     3661 tgcattttgg tttagttcta cctaacttac tatgtaggtg tatgtctaca gccgatgacc
     3721 tcatttcgtt tattttattt ttgtaatagt cagttggcaa agcaaactga ttttttagac
     3781 tatttatctt ccttcccttc ccctcccacc ccgctctcct ctctgccccc tgccctcccc
     3841 tcccctccct tcccctccac tccgctgaga atcctggagg aatacacaat tcatcgttgc
     3901 acccccacct cagagtgtaa tcgcatttct gcttggtaga ggccgagccc agcaaaggtg
     3961 gctccttctg aatgtgtggt cagcatctgt acaaatgcat tttatttgct atagtttgta
     4021 aagctgtaaa gttaaaagag atgaaaacct tttcagcata aatatatttt acttgcactg
     4081 tgttttttag ctaaaagtga aaacctagat taaataaaat caaagttgag aagaatcatc
     4141 aaaagactgt ttctcggtgt gaatcaagtg ttgaaaaatg gttggtgtat tttgtcagta
     4201 attgtacata acttttggca catgacatag aaatggctat gtaaactata attattttgc
     4261 taagagactg tatgcaagcc ttgggccgac tttacagacg tccagagcaa agccccttct
     4321 ttgtacctat ttttttatta caaatatact aattggttct ttctattttc agaggttatt
     4381 gtatgaaatt gtctattgat agtactttta tgactgtaaa tactctggct ttctccgtgt
     4441 gaattctcac attagacttt aattcgagcg cgtgtgaact gaacgctgat cagtattttt
     4501 tatcaacacc tgagaactgt tacacctttt attttgtctt ttaggaaatc cctgtctttc
     4561 cattttttca tgtaaatttt gcacagttac ttgttcatat gtaaatattt tactttcaga
     4621 aatgaagttt ttaattgcta ttgttttata taggattgaa agaaaattaa ctcctttatt
     4681 aaaaacaaat ttatctgta
//
