LOCUS       NM_031923               4875 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TATA-box binding protein associated factor 3 (TAF3),
            mRNA.
ACCESSION   NM_031923 XM_291729 XM_943730
VERSION     NM_031923.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4875)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4875)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4875)
  AUTHORS   Louder,R.K., He,Y., Lopez-Blanco,J.R., Fang,J., Chacon,P. and
            Nogales,E.
  TITLE     Structure of promoter-bound TFIID and model of human pre-initiation
            complex assembly
  JOURNAL   Nature 531 (7596), 604-609 (2016)
   PUBMED   27007846
  REMARK    Erratum:[Nature. 2016 Aug 4;536(7614):112. doi:
            10.1038/nature17984.. PMID: 27096372]
REFERENCE   4  (bases 1 to 4875)
  AUTHORS   Pistis,G., Okonkwo,S.U., Traglia,M., Sala,C., Shin,S.Y.,
            Masciullo,C., Buetti,I., Massacane,R., Mangino,M., Thein,S.L.,
            Spector,T.D., Ganesh,S., Pirastu,N., Gasparini,P., Soranzo,N.,
            Camaschella,C., Hart,D., Green,M.R. and Toniolo,D.
  CONSRTM   CHARGE Consortium Hematology Working
  TITLE     Genome wide association analysis of a founder population identified
            TAF3 as a gene for MCHC in humans
  JOURNAL   PLoS One 8 (7), e69206 (2013)
   PUBMED   23935956
  REMARK    GeneRIF: Data show that transcription cofactor TAF3 is required for
            transcription of the alpha spectrin SPTA1 gene.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4875)
  AUTHORS   Lauberth,S.M., Nakayama,T., Wu,X., Ferris,A.L., Tang,Z.,
            Hughes,S.H. and Roeder,R.G.
  TITLE     H3K4me3 interactions with TAF3 regulate preinitiation complex
            assembly and selective gene activation
  JOURNAL   Cell 152 (5), 1021-1036 (2013)
   PUBMED   23452851
  REMARK    GeneRIF: Study shows that H3K4me3-TAF3 interactions direct global
            TFIID recruitment to active genes, some of which are p53 targets.
            Further analyses show that H3K4me3 enhances p53-dependent
            transcription by stimulating preinitiation complex formation.
REFERENCE   6  (bases 1 to 4875)
  AUTHORS   Soutoglou,E., Demeny,M.A., Scheer,E., Fienga,G., Sassone-Corsi,P.
            and Tora,L.
  TITLE     The nuclear import of TAF10 is regulated by one of its three
            histone fold domain-containing interaction partners
  JOURNAL   Mol Cell Biol 25 (10), 4092-4104 (2005)
   PUBMED   15870280
REFERENCE   7  (bases 1 to 4875)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 4875)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 4875)
  AUTHORS   Li,H.H., Li,A.G., Sheppard,H.M. and Liu,X.
  TITLE     Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a
            role for TAF1 in cell G1 progression
  JOURNAL   Mol Cell 13 (6), 867-878 (2004)
   PUBMED   15053879
REFERENCE   10 (bases 1 to 4875)
  AUTHORS   Gangloff,Y.G., Pointud,J.C., Thuault,S., Carre,L., Romier,C.,
            Muratoglu,S., Brand,M., Tora,L., Couderc,J.L. and Davidson,I.
  TITLE     The TFIID components human TAF(II)140 and Drosophila BIP2
            (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47
            containing a histone fold and a PHD finger
  JOURNAL   Mol Cell Biol 21 (15), 5109-5121 (2001)
   PUBMED   11438666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353754.10, AL159172.16 and AL390294.19.
            
            On Nov 23, 2018 this sequence version replaced NM_031923.3.
            
            Summary: The highly conserved RNA polymerase II transcription
            factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding
            protein (TBP; MIM 600075) and a set of TBP-associated factors
            (TAFs), including TAF3. TAFs contribute to promoter recognition and
            selectivity and act as antiapoptotic factors (Gangloff et al., 2001
            [PubMed 11438666]).[supplied by OMIM, May 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344293.6/ ENSP00000340271.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-371               AL353754.10        29327-29697
            372-614             AL353754.10        35140-35382
            615-2437            AL159172.16        3426-5248
            2438-2520           AL159172.16        16747-16829
            2521-2773           AL390294.19        6626-6878
            2774-2880           AL390294.19        11279-11385
            2881-4875           AL390294.19        12185-14179
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p14"
     gene            1..4875
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /note="TATA-box binding protein associated factor 3"
                     /db_xref="GeneID:83860"
                     /db_xref="HGNC:HGNC:17303"
                     /db_xref="MIM:606576"
     exon            1..371
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2995
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /note="RNA polymerase II transcription factor TAFII140;
                     TBP-associated factor 3; 140 kDa TATA box-binding
                     protein-associated factor; transcription initiation factor
                     TFIID 140 kDa subunit; TAF(II)140; TAF3 RNA polymerase II,
                     TATA box binding protein (TBP)-associated factor, 140kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 3"
                     /protein_id="NP_114129.1"
                     /db_xref="CCDS:CCDS41487.1"
                     /db_xref="GeneID:83860"
                     /db_xref="HGNC:HGNC:17303"
                     /db_xref="MIM:606576"
                     /translation="MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQ
                     LGRGCHRYSELYGRTDPILDDVGEAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVS
                     KNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEE
                     DDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSS
                     INTQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKT
                     SSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTP
                     VRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASID
                     AVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTP
                     LPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKV
                     YEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDK
                     ETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDRE
                     KGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLL
                     PVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKH
                     KHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPA
                     PAPAPGPMLVSPAPVPLPLLAQAAAGPALLPSPGPAASGASAKAPVRSVVTETVSTYV
                     IRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMTAPPEEMQWFCPKCAN
                     KKKDKKHKKRKHRAH"
     exon            372..614
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     exon            615..2437
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2520
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2773
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2880
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..4875
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3278..3283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /note="hexamer: AATAAA"
     polyA_site      3297
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /note="major polyA site"
     regulatory      3769..3774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /note="hexamer: AATAAA"
     polyA_site      3800
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /note="major polyA site"
     regulatory      4851..4856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /note="hexamer: AATAAA"
     polyA_site      4875
                     /gene="TAF3"
                     /gene_synonym="TAF140; TAFII-140; TAFII140"
                     /note="major polyA site"
ORIGIN      
        1 agcgggaggc ggagcgagtc caaaatggcg gctctcaggc tggcgcgctc cgtgctgctg
       61 gggctttgag gtggtcgccg ggggtccggg ggaccctttc cccgccgcgg aagccctaga
      121 ggatgaatcg gggaccctgc taaggtctgg cggcggggct ggagagcagt ggcagcaagg
      181 gctgcggtgg cgtccacgca gcgggatgtg cgagagttac tccaggtcgt tgttgagggt
      241 ctcggtggcg cagatctgcc aggcgctggg ctgggactcg gtgcagctca gcgcctgcca
      301 cctcctcacg gacgtgctgc agcgctatct gcagcagctg ggccggggct gccatcggta
      361 ctctgagctc tatggccgaa cagacccaat tttggatgat gttggtgaag ctttccagct
      421 gatgggggtt agtctacatg aactagaaga ctatattcac aacattgagc ctgtcacctt
      481 cccacaccaa attccgtcat ttcctgttag caagaacaat gtacttcagt ttcctcaacc
      541 tggaagtaaa gatgcagagg aaagaaaaga atacattcct gattacctgc cacccattgt
      601 gtcttctcaa gaagaagaag aagaagagca ggtgcccact gatggaggca catcagcaga
      661 agccatgcag gttcccttgg aagaagatga tgaattggag gaggaagaaa ttattaatga
      721 tgagaatttc ctgggcaaga gaccactgga tagtcctgaa gctgaagaac tgccagccat
      781 gaagcggcct cggctattaa gcactaaagg ggacacgcta gatgttgtgt tattggaagc
      841 tcgagagcca ctcagctcaa taaatactca aaagatccca ccaatgcttt ctccagtcca
      901 tgtacaggac agtacagact tggcacctcc ctcacccgag ccgccaatgt tggctccagt
      961 tgcaaaatca caaatgccaa ctgcaaaacc attagaaaca aagtcattta cacctaaaac
     1021 aaagactaaa actagctctc caggacagaa gactaaatca cctaaaaccg cccagtcacc
     1081 agcaatggtc ggaagtccta ttcgatcacc aaaaactgta tccaaagaaa agaaatcacc
     1141 tggacgttcc aagagcccca agagtcccaa gagccccaag gtcacgactc acattcccca
     1201 aacacctgtg agacctgaaa cgcccaacag gactccttca gctacactca gtgaaaaaat
     1261 cagtaaagag actatccagg taaaacaaat acagacaccc cctgatgctg ggaaactgaa
     1321 cagtgagaat cagccgaaaa aggctgtggt agcagataaa acgattgagg cctctatcga
     1381 tgctgtgatt gcacgagcct gtgctgagcg agagccagat cctttcgaat tttcttctgg
     1441 atcggaatct gaaggagaca tttttactag ccctaagaga atttcaggcc cggagtgtac
     1501 tactcccaaa gcttccactt ccgcgaacaa tttcacaaag tcaggatcca ctcctctgcc
     1561 tctttccggt ggaacctcaa gttccgataa ctcatggaca atggatgcct ccattgatga
     1621 ggttgtacgt aaagcaaaac tgggaacacc ttcaaatatg ccccccaact ttccttatat
     1681 ctcttctccg tcagtgtctc ctcccactcc cgaacctctc cacaaggtgt atgaggagaa
     1741 aaccaagctg ccttcctccg tggaggtaaa gaagaagttg aaaaaggaac taaagactaa
     1801 aatgaaaaag aaagaaaagc agagagatag ggagagggaa aaagacaaga acaaggacaa
     1861 aagtaaggag aaggataaag tgaaagagaa agagaaagac aaggaaactg gcagggaaac
     1921 aaagtatccc tggaaggaat ttcttaaaga ggaagaggca gatccctaca agtttaaaat
     1981 caaagaattt gaagatgttg atcccaaagt gaaattgaaa gatggacttg tgaggaagga
     2041 gaaagagaag cataaagata agaagaaaga tagagagaaa ggcaagaaag ataaagataa
     2101 gagagagaaa gaaaaagtga aagataaagg cagagaagat aagatgaaag ccccagcacc
     2161 cccactggtg ttgcccccaa aagagttggc cctgcccttg ttcagccctg ccacagcctc
     2221 cagggtccca gccatgctgc catctttgtt gccagtgctt ccggaaaaac tgtttgagga
     2281 gaaagagaag gtgaaggaga aagaaaagaa aaaggacaaa aaggagaaga agaaaaagaa
     2341 ggaaaaagag aaggagaaga aggagaagga aagagagaaa gagaagagag agcgagagaa
     2401 gagagaaaaa gagaaggaga aacacaagca tgaaaaaata aaagtggaac cagtcgctct
     2461 ggccccgagt ccagttatcc ccagattaac tctccgagtc ggtgctggcc aagacaagat
     2521 tgtcatcagc aaggtggtcc ctgcccccga ggccaagccg gcgccctcgc agaacaggcc
     2581 gaagacccca ccgccggccc ccgcgcccgc ccccggcccc atgctcgtca gccctgcgcc
     2641 cgtgccgctg ccgctgctcg cccaggccgc cgcgggccct gccctgctgc cctccccggg
     2701 tcccgccgcc tccggggcca gtgccaaagc ccccgtgcgc agcgtggtga ctgagacggt
     2761 cagcacctac gtgatccgag atgagtgggg caatcagatc tggatctgcc ctgggtgtaa
     2821 caagcctgac gatgggagtc ccatgattgg gtgtgacgac tgcgatgact ggtaccactg
     2881 gccctgtgtt ggaatcatga ctgcaccccc agaagagatg cagtggttct gccccaagtg
     2941 tgcgaacaag aagaaggaca aaaagcacaa gaagaggaag catcgagccc actgacgact
     3001 cccgaggggc tggaccaagc ggggtcagcc cgggcttctt ccctggcgcc tctggaaggg
     3061 agctggtgca agtctgccgt cacatccacc cccagatgcc tgtggataaa gaacccagga
     3121 ggactgaggc tggaacacac cgcgcacctg gattgttcac tcccgagccg ccttggcctg
     3181 tggctccgtg gcagtgcgac agaaggaaac tcaagcagag gcgtggcctg ggggctgccc
     3241 ctcctccact tctctaatac cagtgacaag tattattaat aaagagcgta catcttccct
     3301 tttgatttcc tttattctct ccagggcctt ttcattgagg tattagatga gaagataatg
     3361 tacaaactgc ctcaactgta atttaaggat gatagagtct gtatacagtt ttcagcccct
     3421 ttccctctat agtaagataa tcagaataac ataaaagaaa actccagttg gagtaccggt
     3481 aaatattttt gtgataagaa tatatgaagc ttccctcctt cccccgtttt tagtactaac
     3541 atgtaaaatg ttcaggcttt tgtgaaatac cttatatttt ttaagaaaaa ggtttctatc
     3601 atgtcctgtt tgcttttgtg caaattattt ttgtttaatg tattttatat cttcgttgca
     3661 ttctaatttt gcccttcttt aaactgctgg agtctcttct cactgcttgt acatttcatc
     3721 aacttgtata aaaactcttc agactaaaag attgccccta atgtaaataa taaatattta
     3781 tgaagtagtt attttttaaa tttttatcgt gtttaattct ggctttctct gaaatccact
     3841 gtgatttcag ccaggtctgt aatgacgctg gacagaaaca aggctagaga aaaagccatc
     3901 gttcaaagaa atttcccttg agctcagcct gcgcagtgcc cggaaacatg gtggggaaag
     3961 ggcccgagca gttggaagga aaacaaggca atttaaattt agagtttatg acttgaagtt
     4021 gttttgtttg ttgtctattt tgtttttgta aatttctttg acagactttt actaaaagga
     4081 catgtagttt ccatgaaagt aaaaaaaaaa aacaacaaaa aacccacata tactgtagca
     4141 ttttgtcttt atattgtttt atttctacaa atctgttcat taatattgtg ctttaaggct
     4201 gaaatgaagt atattatgaa tttttttaag aaaactcatc aaatttcagg gtatcacaaa
     4261 actttattat attattatac tgcccactat ttattatatg ttatagatgt ctgagaggta
     4321 aaccaaatat tttattttta atgttaaaaa aacatcaaat ttaactttat tagcatattt
     4381 tagcaacttt gggataaata cggactttta cttgattttg aaataatccc agtgtaggcc
     4441 catgtgctgg atctgttgga tgctagaata tgggctttga acctaataca aatatattac
     4501 tagaaaatgt gattttttta aatgccaagt aaattgatat tagtgtatga attagtcata
     4561 ttttaaaaca ttatgtggtt agagaaatgc ggttttctgc catgaatgtt aagttgcaaa
     4621 tcagtggaaa tggagtcgac ctcttcggag cacagggtgt cattgccctc gttgttcaag
     4681 aggccagaat ttttctatcc ccgctaagaa acaaagcatc tatgttgaga tatgtgtttt
     4741 tttgtttgat taatttgaga tcattctaaa tactttatac aatattttca catgcacaaa
     4801 aatgcgcgtt agtggttttt ggagaggggt gaggggtggg ggaagtgcaa aataaagatt
     4861 attggctatt tcata
//
