LOCUS       NM_003184               5027 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TATA-box binding protein associated factor 2 (TAF2),
            mRNA.
ACCESSION   NM_003184
VERSION     NM_003184.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5027)
  AUTHORS   Scheer,E., Luo,J., Bernardini,A., Ruffenach,F., Garnier,J.M.,
            Kolb-Cheynel,I., Gupta,K., Berger,I., Ranish,J. and Tora,L.
  TITLE     TAF8 regions important for TFIID lobe B assembly or for TAF2
            interactions are required for embryonic stem cell survival
  JOURNAL   J Biol Chem 297 (5), 101288 (2021)
   PUBMED   34634302
  REMARK    GeneRIF: TAF8 regions important for TFIID lobe B assembly or for
            TAF2 interactions are required for embryonic stem cell survival.
REFERENCE   2  (bases 1 to 5027)
  AUTHORS   Lesieur-Sebellin,M., Capri,Y., Grisval,M., Courtin,T., Burtz,A.,
            Thevenon,J., Buratti,J., Lejeune,E., Faivre,L. and Keren,B.
  TITLE     Phenotype associated with TAF2 biallelic mutations: A clinical
            description of four individuals and review of the literature
  JOURNAL   Eur J Med Genet 64 (11), 104323 (2021)
   PUBMED   34474177
  REMARK    GeneRIF: Phenotype associated with TAF2 biallelic mutations: A
            clinical description of four individuals and review of the
            literature.
            Review article
REFERENCE   3  (bases 1 to 5027)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5027)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5027)
  AUTHORS   Louder,R.K., He,Y., Lopez-Blanco,J.R., Fang,J., Chacon,P. and
            Nogales,E.
  TITLE     Structure of promoter-bound TFIID and model of human pre-initiation
            complex assembly
  JOURNAL   Nature 531 (7596), 604-609 (2016)
   PUBMED   27007846
  REMARK    Erratum:[Nature. 2016 Aug 4;536(7614):112. doi:
            10.1038/nature17984.. PMID: 27096372]
REFERENCE   6  (bases 1 to 5027)
  AUTHORS   Wang,Z., Morris,G.F., Rice,A.P., Xiong,W. and Morris,C.B.
  TITLE     Wild-type and transactivation-defective mutants of human
            immunodeficiency virus type 1 Tat protein bind human TATA-binding
            protein in vitro
  JOURNAL   J Acquir Immune Defic Syndr Hum Retrovirol 12 (2), 128-138 (1996)
   PUBMED   8680883
REFERENCE   7  (bases 1 to 5027)
  AUTHORS   Parada,C.A., Yoon,J.B. and Roeder,R.G.
  TITLE     A novel LBP-1-mediated restriction of HIV-1 transcription at the
            level of elongation in vitro
  JOURNAL   J Biol Chem 270 (5), 2274-2283 (1995)
   PUBMED   7836461
REFERENCE   8  (bases 1 to 5027)
  AUTHORS   Zhou,Q. and Sharp,P.A.
  TITLE     Novel mechanism and factor for regulation by HIV-1 Tat
  JOURNAL   EMBO J 14 (2), 321-328 (1995)
   PUBMED   7835343
REFERENCE   9  (bases 1 to 5027)
  AUTHORS   Ou,S.H., Garcia-Martinez,L.F., Paulssen,E.J. and Gaynor,R.B.
  TITLE     Role of flanking E box motifs in human immunodeficiency virus type
            1 TATA element function
  JOURNAL   J Virol 68 (11), 7188-7199 (1994)
   PUBMED   7933101
REFERENCE   10 (bases 1 to 5027)
  AUTHORS   Kashanchi,F., Piras,G., Radonovich,M.F., Duvall,J.F., Fattaey,A.,
            Chiang,C.M., Roeder,R.G. and Brady,J.N.
  TITLE     Direct interaction of human TFIID with the HIV-1 transactivator tat
  JOURNAL   Nature 367 (6460), 295-299 (1994)
   PUBMED   8121496
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021945.14 and AC107960.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003184.3.
            
            Summary: Initiation of transcription by RNA polymerase II requires
            the activities of more than 70 polypeptides. The protein that
            coordinates these activities is transcription factor IID (TFIID),
            which binds to the core promoter to position the polymerase
            properly, serves as the scaffold for assembly of the remainder of
            the transcription complex, and acts as a channel for regulatory
            signals. TFIID is composed of the TATA-binding protein (TBP) and a
            group of evolutionarily conserved proteins known as TBP-associated
            factors or TAFs. TAFs may participate in basal transcription, serve
            as coactivators, function in promoter recognition or modify general
            transcription factors (GTFs) to facilitate complex assembly and
            transcription initiation. This gene encodes one of the larger
            subunits of TFIID that is stably associated with the TFIID complex.
            It contributes to interactions at and downstream of the
            transcription initiation site, interactions that help determine
            transcription complex response to activators. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.244309.1,
                                           SRR1803617.209544.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378164.7/ ENSP00000367406.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               AC021945.14        100686-101045       c
            361-415             AC021945.14        99881-99935         c
            416-576             AC021945.14        87550-87710         c
            577-695             AC021945.14        74487-74605         c
            696-837             AC021945.14        72082-72223         c
            838-1069            AC021945.14        69998-70229         c
            1070-1254           AC021945.14        65866-66050         c
            1255-1368           AC021945.14        65194-65307         c
            1369-1468           AC021945.14        63736-63835         c
            1469-1554           AC021945.14        61570-61655         c
            1555-1690           AC021945.14        59528-59663         c
            1691-1845           AC021945.14        57796-57950         c
            1846-1960           AC021945.14        56994-57108         c
            1961-2070           AC021945.14        56542-56651         c
            2071-2136           AC021945.14        53405-53470         c
            2137-2389           AC021945.14        51585-51837         c
            2390-2530           AC021945.14        49257-49397         c
            2531-2641           AC021945.14        46223-46333         c
            2642-2835           AC021945.14        30619-30812         c
            2836-2975           AC021945.14        28803-28942         c
            2976-3045           AC107960.3         179026-179095       c
            3046-3155           AC107960.3         176959-177068       c
            3156-3385           AC107960.3         167658-167887       c
            3386-3491           AC107960.3         165241-165346       c
            3492-3614           AC107960.3         163487-163609       c
            3615-5027           AC107960.3         151727-153139       c
FEATURES             Location/Qualifiers
     source          1..5027
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.12"
     gene            1..5027
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /note="TATA-box binding protein associated factor 2"
                     /db_xref="GeneID:6873"
                     /db_xref="HGNC:HGNC:11536"
                     /db_xref="MIM:604912"
     exon            1..360
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..3877
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /note="TATA box binding protein (TBP)-associated factor,
                     RNA polymerase II, B, 150kD; cofactor of initiator
                     function, 150kD subunit; TBP-associated factor 150 kDa;
                     150 kDa cofactor of initiator function; RNA polymerase II
                     TBP-associated factor subunit B; transcription initiation
                     factor TFIID 150 kDa subunit; TAF(II)150; TAF2 RNA
                     polymerase II, TATA box binding protein (TBP)-associated
                     factor, 150kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 2"
                     /protein_id="NP_003175.2"
                     /db_xref="CCDS:CCDS34937.1"
                     /db_xref="GeneID:6873"
                     /db_xref="HGNC:HGNC:11536"
                     /db_xref="MIM:604912"
                     /translation="MPLTGVEPARMNRKKGDKGFESPRPYKLTHQVVCINNINFQRKS
                     VVGFVELTIFPTVANLNRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRN
                     LNYFSNAYAAAVSAVDPDAGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLH
                     FVVPSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNG
                     DLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPL
                     LKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAM
                     IIDETPLTRRCLAQSLAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYR
                     HWIKEELDKIVAYELKTGGVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYSMFQ
                     CKAHLVMRLIENRISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTSGFLKSIS
                     NVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKV
                     TVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSP
                     LLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQESILALEKFPTPASRLALT
                     DILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTRMFCCKSCPNIVKTNN
                     FMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIKYNDNRKNKFSDNYYRAEM
                     IDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLR
                     AIRVLQKNGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMI
                     QNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSHDWRLRCGAV
                     DLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPESVAGNQEAANNPSSHPQL
                     VGFQNPFSSSQDEEEIDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPASSRSALIPQ
                     HSAGCDSTPTTKPQWSLELARKGTGKEQAPLEMSMHPAASAPLSVFTKESTASKHSDH
                     HHHHHHEHKKKKKKHKHKHKHKHKHDSKEKDKEPFTFSSPASGRSIRSPSLSD"
     exon            361..415
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            416..576
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            577..695
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            696..837
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1069
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1254
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1368
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1468
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1554
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1690
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1845
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1960
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2070
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2136
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2389
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2530
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2641
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2835
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2975
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3045
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3155
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3385
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3491
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3614
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..5027
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5006..5011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /note="hexamer: AATAAA"
     polyA_site      5027
                     /gene="TAF2"
                     /gene_synonym="CIF150; MRT40; TAF2B; TAFII150"
                     /note="major polyA site"
ORIGIN      
        1 agaggttaca gacaagatgt cggcggatgg tagcttcgag cccttgcgga gaggagcatc
       61 tctgtgacag aagcttgtcg acggcggctt ctaggagcta gtcgaaggag cgaggttgag
      121 gcgggcagcg acccgtcagg tcgctcacct gggcaccggc cagctgcgag acgtgacttg
      181 gggaccgcag gggagtggag agtgtgaggt gccaaagact agtaatgccc cgtatccccc
      241 taggaagccg ggaagccaag ctccgcggga ccgcttcatg ccgctgactg gtgtagagcc
      301 cgccagaatg aacaggaaga aaggagacaa gggctttgaa agcccaaggc catataaatt
      361 aacccatcag gtcgtctgca tcaacaacat aaatttccag agaaaatctg ttgtgggatt
      421 tgtggaactg actatatttc ccacagttgc aaacttgaat agaatcaagt tgaacagcaa
      481 acagtgtaga atataccgag taaggatcaa tgatttagag gctgctttta tttataatga
      541 cccaaccttg gaagtttgtc acagtgaatc aaaacagaga aacctcaatt atttttccaa
      601 tgcttatgca gctgcagtta gtgctgtgga ccctgatgca ggaaatggag aactttgcat
      661 taaggttcca tcagagctat ggaaacacgt tgatgagtta aaggtcctga agatacacat
      721 caatttttct ttggatcagc ccaaaggagg tcttcatttt gtggtaccca gtgtagaggg
      781 aagtatggca gagagaggtg ctcatgtttt ctcttgtggg tatcaaaatt ctacaagatt
      841 ttggttccct tgtgttgatt catactctga attgtgtaca tggaaattag aatttacagt
      901 agatgctgca atggttgctg tttctaatgg cgatttggtg gagacagtgt atactcatga
      961 tatgaggaag aaaactttcc attatatgct taccattcct acagcagcgt caaatatctc
     1021 cttggccatt ggaccatttg aaatactggt agatccatac atgcatgagg ttactcattt
     1081 ttgtttgccc caacttcttc cattgctgaa acataccaca tcataccttc atgaagtctt
     1141 tgaattttat gaagaaattc ttacatgtcg ttacccatac tcctgtttta agactgtctt
     1201 cattgatgag gcttatgttg aagtggctgc ttatgcttcc atgagcattt ttagcacaaa
     1261 tcttttacac agtgccatga ttatagatga gacacctttg actagaaggt gtttagccca
     1321 atccttggcc cagcagtttt ttggttgttt catatctaga atgtcttggt ctgatgaatg
     1381 ggtgctgaag ggaatttcag gctatatcta tggactttgg atgaaaaaaa cttttggtgt
     1441 taatgagtac cgccattgga ttaaagagga gctagacaaa atagtggcat atgaactaaa
     1501 aactggtggg gttttactac atcccatatt tggtggagga aaagagaagg ataatccggc
     1561 ttcccatcta cacttttcaa taaagcatcc acatacactg tcctgggaat actacagtat
     1621 gtttcagtgt aaagcccacc ttgtgatgag attgattgaa aataggatca gtatggaatt
     1681 tatgctacaa gttttcaata aactgctaag tctggctagt actgcttcat ctcagaagtt
     1741 ccagtcacat atgtggagtc agatgttggt ttccacatct gggtttttga aatccatttc
     1801 aaatgtctct ggcaaagata ttcagccgtt aataaagcag tgggtagatc agagtggagt
     1861 ggtaaaattt tatggaagtt ttgcatttaa tagaaaacga aatgtcttgg aactggaaat
     1921 aaaacaggac tatacatctc ctggaactca gaaatacgtg ggaccactta aagtgacagt
     1981 gcaggagtta gatggatcct tcaatcatac actgcaaatt gaagaaaaca gccttaaaca
     2041 tgatataccc tgccattcca aaagtagaag gaataaaaag aaaaaaatcc cactgatgaa
     2101 tggagaagaa gttgatatgg atctttctgc aatggatgct gattcccctt tgctgtggat
     2161 aaggatagac ccagatatgt cagtattgag gaaggtagaa tttgagcaag ctgattttat
     2221 gtggcagtat cagctccgct atgagagaga tgttgttgca cagcaggaat ccattttggc
     2281 tttggaaaaa ttccctactc cagcatctcg gcttgcactc actgatatat tagaacaaga
     2341 gcagtgtttc tacagagtaa gaatgtcagc ttgcttctgt cttgcaaaga ttgcaaattc
     2401 aatggtgagc acatggacag gaccaccagc catgaagtca ctcttcacta ggatgttttg
     2461 ttgtaaaagt tgtccaaaca ttgtgaaaac aaacaacttt atgagctttc aaagctattt
     2521 tctacagaag actatgccag ttgcaatggc tttattaaga gatgttcata atctttgtcc
     2581 taaagaagtc ttaacattta ttttagactt aatcaagtac aatgacaaca ggaaaaataa
     2641 gttttcagat aactattatc gtgcagaaat gattgatgcc ctggccaact ctgttacacc
     2701 tgcagtcagt gtgaataatg aagttagaac tttggataac ttaaatcctg atgtgcgact
     2761 cattcttgaa gaaatcacca gatttttgaa tatggaaaaa cttcttccga gttacaggca
     2821 taccatcact gtcagttgtt tgagagccat acgggtactt cagaagaacg gacatgtgcc
     2881 aagtgatcca gctcttttta aatcttatgc tgaatatggc cactttgtgg acattaggat
     2941 agcagctttg gaagcagttg ttgattatac taaagtggac agaagttatg aagaactgca
     3001 atggctactt aatatgattc agaatgaccc tgtaccctat gtaaggcata agattctcaa
     3061 catgttgact aagaacccac catttactaa gaacatggag tctcccttat gcaatgaagc
     3121 cctggtagat caactttgga aacttatgaa ttctggtact tcacatgact ggaggttacg
     3181 gtgtggtgct gtggacttgt acttcacact ttttggcctc agtagacctt cctgtttacc
     3241 cttgccagag cttgggttgg ttcttaatct aaaggagaaa aaagctgtct tgaatcctac
     3301 cataattcca gagtcagtag caggcaacca agaagctgca aataatccaa gcagtcaccc
     3361 acagctagtt ggatttcaga accctttttc cagttctcaa gatgaggagg agattgatat
     3421 ggatactgtt catgatagcc aggccttcat ttcccatcat ttaaacatgc ttgaaaggcc
     3481 gtcaactcca gggctctcga aatatcggcc agctagctcc cgatctgctt taatacccca
     3541 gcactcagca ggctgtgaca gcacacccac cacaaaaccc cagtggagtt tggaacttgc
     3601 acggaaggga acaggtaaag aacaagcacc tttggagatg agtatgcatc cagcggcaag
     3661 cgctccactc tcagtcttta ctaaggaatc tacagcctcc aaacacagtg accaccatca
     3721 ccaccatcac catgagcaca agaaaaagaa gaagaagcat aaacataagc acaaacacaa
     3781 gcataagcat gacagtaaag aaaaggacaa ggagcctttc actttctcca gccctgccag
     3841 tggcaggtct attcgttctc cttccctttc agactgagaa ggggacaaaa agacctttcc
     3901 tttcatgtcc agaagaatgt atgtaactaa agctttgtcc tctgtgaaga attataaaag
     3961 ggagggggga aaggattcgc ctctcctaca gaaattctga attcatttaa gttctaagca
     4021 tttgatttat gttatttata cagttgggat ctaattagga aaatgtgttt tgtagttctg
     4081 gataaactat ttcatccgct gtttcctccc caaaacacac acacagagca aactcccttt
     4141 cataaaagcc ctcatatcca ctggcagtcc ccgttcgcat catggtctcc atgtgtaccg
     4201 ccaaagtcaa ttatgtttga aagcctttgg tggatgttat ggggcaaagt tatgatttac
     4261 acagaagcaa ctgccaaatc tgtggtgcaa ccactatctc cagtgaaata ttgtataaca
     4321 ccatttggaa ctactgaaaa gacagtggct tttctacagt actcttcctt attgcaccat
     4381 ttttgtatta acgtagaaac taagcatcag aatttatgaa caaagaatat gttatttttc
     4441 cttttgctct aaaatactga gatttgggga agcaattctt ttttaaaaaa attttgaata
     4501 actatctttt gataacacat tcggcggtta cgatgttgga atttagcaga actatcaaat
     4561 ccaaaattat tttcaaatca agatgtttaa attataagtt tttttgtttt gttttccagt
     4621 aagtataaat gaaaatattc atatgtaaaa tatgttttgc ttaatgtgga caatttacac
     4681 acccaacaca tactgtttcc aaaattattt ctatatgaca caaagtatga tacctttaaa
     4741 aaggtgagct tatatattgt ttattaacct ggaaatagac aatttggctc tcataccata
     4801 agcatttaaa aacatatgaa atattttgat ttctttatat ggtggtgtgt ttttatttct
     4861 gaattttcca tgtgctttaa tatttgttta agaatatttt ttatatctgt tcaattttta
     4921 tcattcccct tatcattaga aagtttgaca aaaatacttg aatcttggac ctctaaatat
     4981 acttttagtt gtgtttaact tgtttaataa ataacttttt aagttga
//
