LOCUS       NM_153809               6216 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor 1 like
            (TAF1L), mRNA.
ACCESSION   NM_153809
VERSION     NM_153809.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6216)
  AUTHORS   Wang,D., Qi,H., Zhang,H., Zhou,W., Li,Y., Li,A., Liu,Q. and Wang,Y.
  TITLE     TAF1L promotes development of oral squamous cell carcinoma via
            decreasing autophagy-dependent apoptosis
  JOURNAL   Int J Biol Sci 16 (7), 1180-1193 (2020)
   PUBMED   32174793
  REMARK    GeneRIF: TAF1L promotes development of oral squamous cell carcinoma
            via decreasing autophagy-dependent apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6216)
  AUTHORS   Oh,H.R., An,C.H., Yoo,N.J. and Lee,S.H.
  TITLE     Frameshift Mutations in the Mononucleotide Repeats of TAF1 and
            TAF1L Genes in Gastric and Colorectal Cancers with Regional
            Heterogeneity
  JOURNAL   Pathol Oncol Res 23 (1), 125-130 (2017)
   PUBMED   27571988
  REMARK    GeneRIF: TAF1 and TAF1L genes harbored not only somatic mutations
            but also mutational ITH.
REFERENCE   3  (bases 1 to 6216)
  AUTHORS   Xia,J., Jia,P., Hutchinson,K.E., Dahlman,K.B., Johnson,D.,
            Sosman,J., Pao,W. and Zhao,Z.
  TITLE     A meta-analysis of somatic mutations from next generation
            sequencing of 241 melanomas: a road map for the study of genes with
            potential clinical relevance
  JOURNAL   Mol Cancer Ther 13 (7), 1918-1928 (2014)
   PUBMED   24755198
REFERENCE   4  (bases 1 to 6216)
  AUTHORS   Zhang,Q., Zhang,J., Jin,H. and Sheng,S.
  TITLE     Whole transcriptome sequencing identifies tumor-specific mutations
            in human oral squamous cell carcinoma
  JOURNAL   BMC Med Genomics 6, 28 (2013)
   PUBMED   24007313
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6216)
  AUTHORS   Pajewski,N.M., Shrestha,S., Quinn,C.P., Parker,S.D., Wiener,H.,
            Aissani,B., McKinney,B.A., Poland,G.A., Edberg,J.C., Kimberly,R.P.,
            Tang,J. and Kaslow,R.A.
  TITLE     A genome-wide association study of host genetic determinants of the
            antibody response to Anthrax Vaccine Adsorbed
  JOURNAL   Vaccine 30 (32), 4778-4784 (2012)
   PUBMED   22658931
REFERENCE   6  (bases 1 to 6216)
  AUTHORS   Filippakopoulos,P., Picaud,S., Mangos,M., Keates,T., Lambert,J.P.,
            Barsyte-Lovejoy,D., Felletar,I., Volkmer,R., Muller,S., Pawson,T.,
            Gingras,A.C., Arrowsmith,C.H. and Knapp,S.
  TITLE     Histone recognition and large-scale structural analysis of the
            human bromodomain family
  JOURNAL   Cell 149 (1), 214-231 (2012)
   PUBMED   22464331
REFERENCE   7  (bases 1 to 6216)
  AUTHORS   Wang,P.J. and Page,D.C.
  TITLE     Functional substitution for TAF(II)250 by a retroposed homolog that
            is expressed in human spermatogenesis
  JOURNAL   Hum Mol Genet 11 (19), 2341-2346 (2002)
   PUBMED   12217962
  REMARK    GeneRIF: Arose by retroposition of a processed TAF(II)250 mRNA
            during primate evolution, replaces its function only in male
            meiosis.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF390562.1.
            
            On Apr 6, 2007 this sequence version replaced NM_153809.1.
            
            Summary: This locus is intronless, and apparently arose in the
            primate lineage from retrotransposition of the transcript from the
            multi-exon TAF1 locus on the X chromosome. The gene is expressed in
            male germ cells, and the product has been shown to function
            interchangeably with the TAF1 product. [provided by RefSeq, Aug
            2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF390562.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242310.4/ ENSP00000418379.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6216              AF390562.1         6-6221
FEATURES             Location/Qualifiers
     source          1..6216
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.1"
     gene            1..6216
                     /gene="TAF1L"
                     /gene_synonym="TAF(II)210; TAF2A2"
                     /note="TATA-box binding protein associated factor 1 like"
                     /db_xref="GeneID:138474"
                     /db_xref="HGNC:HGNC:18056"
                     /db_xref="MIM:607798"
     exon            1..6216
                     /gene="TAF1L"
                     /gene_synonym="TAF(II)210; TAF2A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..5571
                     /gene="TAF1L"
                     /gene_synonym="TAF(II)210; TAF2A2"
                     /note="TBP-associated factor RNA polymerase 1-like;
                     TBP-associated factor 1-like; TBP-associated factor 210
                     kDa; transcription initiation factor TFIID 210 kDa
                     subunit; TAF1 RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 210kDa-like"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit
                     1-like"
                     /protein_id="NP_722516.1"
                     /db_xref="CCDS:CCDS35003.1"
                     /db_xref="GeneID:138474"
                     /db_xref="HGNC:HGNC:18056"
                     /db_xref="MIM:607798"
                     /translation="MRPGCDLLLRAAATVTAAIMSDSDSEEDSSGGGPFTLAGILFGN
                     ISGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRS
                     TEDAVDYSDINEVAEDESQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPP
                     PPGPMKKDKDQDAITCVSESGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEAT
                     QAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWR
                     SARRKRKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMV
                     PVESKFSQSTGDVDKVTDTKPRVAEWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQH
                     EPVIKSRMMEEFRKLEESNGTDLLADENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGA
                     SLAGWLPSIKTRNVMAYNVQQGFAPTLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQ
                     AMPRLLEPPVLALDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGV
                     IREEPQQNMSQPEVKDPWNLSNDEYYFPKQQGLRGTFGGNIIQHSIPAMELWQPFFPT
                     HMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGELF
                     FMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGE
                     TVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQGYYIRELVDI
                     FVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSH
                     SESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVSPEQCCAYYSMIAAK
                     QRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEVTGV
                     ADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLSLKNAKQLLRKFG
                     VPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQERYKEECQRI
                     FDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSREWEEQERK
                     ELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEYVRCETV
                     RKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKEKL
                     KGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQEE
                     ELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG
                     TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDY
                     YKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLD
                     LCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVN
                     KKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTK
                     TAQEIVNICYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDM
                     YDTNTSLSTSRDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDE
                     EEDGKPKPPAPEGGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDN
                     PFSAIQLSESGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK"
ORIGIN      
        1 ccccgccttt attcagcttc cggtagacgc tggtagggta agggagctaa gtagatcact
       61 tccgggcgac tgttgtttta tttccggttt atgcgacccg gctgcgattt gctgctgagg
      121 gcagcagcta ccgtcactgc cgccatcatg tcagactcgg acagcgagga agattcatct
      181 ggaggtggcc catttacttt agcgggtatc cttttcggca acatcagtgg agcggggcag
      241 ctggaggggg aaagcgtctt ggatgatgag tgtaagaagc acttggcagg cttgggggct
      301 ttggggctgg gcagcctaat cactgaactc acggcaaatg aagaattgac tgggactggc
      361 ggtgccttgg taaatgatga agggtggatt aggagtacag aagatgctgt agactattca
      421 gacatcaatg aggtggcaga agatgaaagc caaagacacc agcagacgat ggggagcttg
      481 cagccccttt accactcgga ttatgatgaa gatgactatg atgctgattg tgaagacatt
      541 gattgcaagt tgatgcctcc tccacctcca cccccgggac caatgaagaa ggataaggac
      601 caagatgcta ttacctgtgt gtctgaaagt ggagaagaca tcatcttgcc ctccatcatt
      661 gccccttcct ttttggcctc agagaaagtg gatttcagta gttactctga ttcagaatct
      721 gagatgggac ctcaggaagc aacacaggca gaatctgagg atggaaagct gacccttcca
      781 ttggctggga ttatgcagca tgatgccacc aagctgttgc caagtgtcac cgaacttttt
      841 ccagaatttc gacctggaaa agtgttacgc ttcctacatc tttttggacc agggaagaat
      901 gtcccatctg tttggcggag tgctcggaga aagaggaaga agcatcgtga gctgatacag
      961 gaagagcaga tccaggaggt ggaatgctca gtagaatcag aagtcagcca gaagtctttg
     1021 tggaactatg actatgctcc accaccaccc ccagagcagt gtctcgctga tgatgaaatc
     1081 acgatgatgg ttcctgtgga gtccaaattt tcccaatcaa ctggagatgt agataaagtg
     1141 acagatacca aaccaagagt ggctgagtgg cgttatgggc ctgcccgact gtggtatgat
     1201 atgctgggtg tctccgaaga tggcagtggg tttgactatg gcttcaaact gagaaagaca
     1261 caacatgaac ctgtgataaa atctagaatg atggaggaat ttaggaaact tgaggaaagc
     1321 aatggcactg atcttctggc tgacgaaaac ttcctgatgg tgacacagct gcattgggag
     1381 gattctatca tctgggatgg ggaggatatc aaacacaaag ggacaaaacc tcagggtgca
     1441 agcctggcag gctggcttcc ttctattaag actaggaatg taatggctta caatgttcag
     1501 caaggttttg cacccactct ggatgatgac aaaccttggt actccatttt tcccattgac
     1561 aatgaggatc tggtgtatgg acgctgggag gacaatatca tttgggatgc tcaggccatg
     1621 ccccggctgt tggaacctcc tgttttggca cttgatccca atgatgagaa cctcattttg
     1681 gaaattcctg atgagaagga agaggccacc tctaactccc cctccaagga gagtaagaag
     1741 gaatcatctc tgaagaagag tcgaattctc ttgggcaaaa caggtgtcat cagggaggaa
     1801 ccacagcaga acatgtctca gccagaagtg aaagatccat ggaatctctc caatgatgag
     1861 tattatttcc ccaagcaaca gggtcttcgg ggcacctttg gagggaatat tatccagcat
     1921 tcaattcctg ctatggaatt atggcagccc ttctttccca cccacatggg gcccatcaaa
     1981 atccggcagt tccatcgccc acctctgaaa aagtactcat ttggtgcact ctctcagcca
     2041 ggtccccatt cagtccaacc tttgctaaag cacatcaaaa aaaaggccaa gatgagagaa
     2101 caagagaggc aagcctcagg tggtggagag ttgtttttta tgcgcacacc tcaggatctc
     2161 acaggcaaag atggagatct tattcttgca gaatatagtg aggaaaatgg acccttaatg
     2221 atgcaggttg gcatggcaac caagataaag aactattata aacggaaacc tggcaaagat
     2281 cctggagcac cagattgtaa atatggggaa actgtttact gccatacatc tcctttcttg
     2341 ggctctctcc atcctggcca attactgcag gcacttgaga acaacctttt tcgtgctcca
     2401 gtgtatcttc ataagatgcc agaaactgat tttctgatca ttcggacaag acagggttac
     2461 tatattcggg aattagtgga tatttttgtg gttggccagc agtgtccctt gtttgaagtt
     2521 cctgggccta actccagaag ggccaatatg catattcgag actttctaca ggtttttatt
     2581 taccgccttt tctggaagag taaagatcgg ccacggagga tacgaatgga agatataaaa
     2641 aaagcctttc cttcccattc agaaagcagc atccggaaga ggctaaagct ctgcgctgac
     2701 ttcaaacgca cagggatgga ttcaaactgg tgggtgctta agtctgattt tcgtttacca
     2761 acggaagaag agatcagagc taaggtgtca ccagagcagt gctgtgctta ttatagcatg
     2821 atagctgcaa agcaacgact gaaggatgct ggctatggtg agaaatcctt ttttgcccca
     2881 gaagaagaaa atgaggaaga tttccagatg aagattgatg atgaagttca cgctgctcct
     2941 tggaacacca caagggcctt cattgctgcc atgaagggca agtgtctcct agaggtgact
     3001 ggggtggcag atcccacagg gtgtggtgaa ggattctcct atgtgaagat tccaaataaa
     3061 ccaacacagc agaaggatga taaagagcca caggcagtga agaagacagt gacaggaaca
     3121 gatgcagacc ttcgtcgcct ttccctgaaa aatgccaagc aacttctacg taaatttggt
     3181 gtgcctgagg aagagattaa aaagttgtcc cgctgggaag tgattgatgt ggtgcgcaca
     3241 atgtcaacag aacaggctca ttctggagag gggcccatga gtaaatttgc ccgtggatca
     3301 aggttttctg tggctgagca tcaagagcgt tacaaagagg aatgtcagcg tatctttgac
     3361 ctacagaaca aggttctgtc atcaactgag gtcttatcaa ctgacacaga cagcatctca
     3421 gctgaagata gtgactttga agaaatggga aagaacattg agaacatgtt gcagaacaag
     3481 aaaaccagct ctcagctgtc acgtgaatgg gaggagcagg agcggaagga actacggcga
     3541 atgctactgg tagcaggctc agcagcatca ggaaacaatc acagagatga tgtcacagct
     3601 tccatgacta gccttaagtc ttctgccact ggacactgtc tcaagattta tcgcacattt
     3661 cgagatgaag aggggaaaga gtatgttcgc tgtgagacag tccgaaaacc agctgtcatt
     3721 gatgcctatg tgcgcatacg gactacaaaa gatgagaaat tcattcaaaa atttgccctt
     3781 tttgatgaaa aacatcggga agagatgcgg aaagaacggc ggaggattca agagcaactg
     3841 aggcggctta agcggaacca ggaaaaggag aagcttaagg gtcctcctga gaagaagccc
     3901 aagaaaatga aagagcgtcc tgacctaaaa ctgaaatgtg gggcatgtgg tgccattgga
     3961 catatgagga ctaacaaatt ctgccccctc tattatcaaa caaatgtgcc accttcgaaa
     4021 cctgttgcca tgacagaaga gcaggaggag gagttggaaa agacagtcat tcataatgat
     4081 aatgaagaac ttatcaaggt tgaagggacc aaaattgtct tcgggaaaca gctaattgag
     4141 aatgtgcatg aggttcgcag aaaatctctg gttctcaagt ttcctaaaca gcagcttcct
     4201 ccaaagaaga aacggcgagt tggaaccact gttcattgtg actatttgaa tatacctcat
     4261 aagtccatcc accgacgccg cacagaccct atggtgacgc tgtcatccat cctggagtct
     4321 atcatcaatg acatgagaga tcttccaaat acacaccctt tccacactcc agtcaatgca
     4381 aaggttgtaa aggactacta caaaatcatc actcggccaa tggacctaca aacactccgt
     4441 gaaaatgtgc gtaaatgcct ctacccatct cgggaagagt tcagagagca tctggagcta
     4501 attgtgaaaa acagtgcgac ctacaatggg ccaaaacatt cattgactca gatctctcaa
     4561 tccatgctgg atctctgtga tgaaaaactt aaagagaaag aagacaaatt agctcgctta
     4621 gagaaagcta tcaacccctt gctggatgat gatgaccaag tggcattttc tttcattctg
     4681 gacaacattg tcacccagaa aatgatggca gttccagatt cttggccatt tcatcaccca
     4741 gttaataaga agtttgttcc agattattac aaaatgattg tcaatccagt ggatttagag
     4801 accatacgta agaacatctc caagcacaag tatcagagtc gggagagttt tctagatgat
     4861 gtaaacctta ttcttgccaa cagtgttaag tataatggac ctgagagtca gtacactaag
     4921 actgctcagg agattgtgaa catctgttac cagacaatta ctgagtatga tgagcatttg
     4981 actcaacttg agaaggatat ttgtacagct aaagaagcag ctttggagga agcagaatta
     5041 gaaagcctgg acccaatgac cccagggccc tacacatctc agcctcctga tatgtatgat
     5101 accaacacat ccctcagtac gtctcgagat gcctctgtat ttcaagatga gagcaatttg
     5161 tctgtcttgg atatttccac tgccactcca gaaaaacaga tgtgccaggg ccaaggtagg
     5221 ctgggtgagg aagactctga tgtggatgtt gaagggtatg atgatgagga ggaggatggg
     5281 aaacctaagc ctccagcccc agaaggggga gatggtgatc ttgcagatga agaggaagga
     5341 actgtacaac aacctgaagc cagtgtcctg tatgaggatt tgcttatatc tgaaggagaa
     5401 gatgatgagg aagatgctgg gagtgacgaa gaaggagaca atcctttctc tgctatccag
     5461 ctgagtgaaa gtggaagtga ctctgatgtg ggatatggtg gaataagacc caaacaaccc
     5521 ttcatgcttc agcatgcttc aggagaacac aaggatgggc acggaaaatg aagaaagcat
     5581 gatgtcccat gagggagacg gtggggaggc ttcccatgat ttggaggata gcaacatcag
     5641 ttatgggagc tgtgaggagc ctgatcccaa gttgaacacc caagacacaa gcttcagcag
     5701 catcggaaat ttccagctgg gcatggtggc tcacacctgt aatctcagca ctctgggagg
     5761 ccgaggcggg tggatcacct gaggtcagtt cgagaccagc ttggccaaca tgtcgaaact
     5821 tcatctctac taaaaataca aaaattagcc aggtgtggtg gtgcacgcct gtaatcccca
     5881 gatactcggg aggctgaagc aggagaattg cttgaacccg ggaggcagag gttgcagtga
     5941 gtggagatca cgccactgcg ctccagcctg ggcgaaagag tgagactcca tctcaaaaaa
     6001 aaagaaaatt tccaagcatg gtatcatctc acttttctaa tttacaggct ggaacagatg
     6061 agagccctcc tgctgggaca gagaattggg ttctagtgga ctctgctaca cttaaaccta
     6121 tgtgacaaac cgcccattat tttattgttt atttaattat acaatgcctc gttcctatat
     6181 ggatttgagg caaattacca taaattttga aacagc
//
