LOCUS       NM_001243156            3847 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor, RNA
            polymerase I subunit C (TAF1C), transcript variant 3, mRNA.
ACCESSION   NM_001243156
VERSION     NM_001243156.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3847)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3847)
  AUTHORS   Knuutinen,O., Pyle,A., Suo-Palosaari,M., Duff,J., Froukh,T.,
            Lehesjoki,A.E., Kangas,S.M., Cassidy,J., Maraqa,L.,
            Keski-Filppula,R., Kokkonen,H., Uusimaa,J., Horvath,R. and
            Vieira,P.
  TITLE     Homozygous TAF1C variants are associated with a novel
            childhood-onset neurological phenotype
  JOURNAL   Clin Genet 98 (5), 493-498 (2020)
   PUBMED   32779182
  REMARK    GeneRIF: Homozygous TAF1C variants are associated with a novel
            childhood-onset neurological phenotype.
REFERENCE   3  (bases 1 to 3847)
  AUTHORS   Abdulwahab,R.A., Allaith,A.A.A., Shinwari,Z., Alaiya,A. and
            Giha,H.A.
  TITLE     Association of TATA box-binding protein-associated factor RNA
            polymerase I subunit C (TAF1C) with T2DM
  JOURNAL   Gene 706, 43-51 (2019)
   PUBMED   31039436
  REMARK    GeneRIF: Observed significantly higher TAF1C expression in patients
            with type 2 diabetes mellitus (T2DM), suggesting a role for
            increased protein synthesis in T2DM.
REFERENCE   4  (bases 1 to 3847)
  AUTHORS   Voit,R., Seiler,J. and Grummt,I.
  TITLE     Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for
            Mitotic Repression of rRNA Synthesis
  JOURNAL   PLoS Genet 11 (5), e1005246 (2015)
   PUBMED   26023773
  REMARK    GeneRIF: hCdc14B promotes reactivation of rDNA transcription by
            dephosphorylating TAFI110.  SIRT1 becomes transiently enriched in
            nucleoli at the onset of mitosis. SIRT1 deacetylates TAFI68
            destabilizing SL1 binding to the rDNA promoter
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3847)
  AUTHORS   Oh,H.R., An,C.H., Yoo,N.J. and Lee,S.H.
  TITLE     Frameshift mutations of TAF1C gene, a core component for
            transcription by RNA polymerase I, and its regional heterogeneity
            in gastric and colorectal cancers
  JOURNAL   Pathology 47 (2), 101-104 (2015)
   PUBMED   25551296
  REMARK    GeneRIF: Our results indicate that TAF1C gene harboured not only
            somatic frameshift mutations but also the mutational ITH, which
            together might play a role in tumourigenesis of gastric and
            colorectal cancer.
REFERENCE   6  (bases 1 to 3847)
  AUTHORS   Muth,V., Nadaud,S., Grummt,I. and Voit,R.
  TITLE     Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA
            polymerase I transcription
  JOURNAL   EMBO J 20 (6), 1353-1362 (2001)
   PUBMED   11250901
REFERENCE   7  (bases 1 to 3847)
  AUTHORS   Zhai,W. and Comai,L.
  TITLE     Repression of RNA polymerase I transcription by the tumor
            suppressor p53
  JOURNAL   Mol Cell Biol 20 (16), 5930-5938 (2000)
   PUBMED   10913176
REFERENCE   8  (bases 1 to 3847)
  AUTHORS   Di Pietro,C., Rapisarda,A., Amico,V., Bonaiuto,C., Viola,A.,
            Scalia,M., Motta,S., Amato,A., Engel,H., Messina,A., Sichel,G.,
            Grzeschik,K. and Purrello,M.
  TITLE     Genomic localization of the human genes TAF1A, TAF1B and TAF1C,
            encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I
            general transcription initiation factor SL1
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 133-136 (2000)
   PUBMED   10894955
REFERENCE   9  (bases 1 to 3847)
  AUTHORS   Jansa,P., Mason,S.W., Hoffmann-Rohrer,U. and Grummt,I.
  TITLE     Cloning and functional characterization of PTRF, a novel protein
            which induces dissociation of paused ternary transcription
            complexes
  JOURNAL   EMBO J 17 (10), 2855-2864 (1998)
   PUBMED   9582279
REFERENCE   10 (bases 1 to 3847)
  AUTHORS   Comai,L., Zomerdijk,J.C., Beckmann,H., Zhou,S., Admon,A. and
            Tjian,R.
  TITLE     Reconstitution of transcription factor SL1: exclusive binding of
            TBP by SL1 or TFIID subunits
  JOURNAL   Science 266 (5193), 1966-1972 (1994)
   PUBMED   7801123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009123.7.
            
            On Jun 2, 2019 this sequence version replaced NM_001243156.1.
            
            Summary: Initiation of transcription by RNA polymerase I requires
            the formation of a complex composed of the TATA-binding protein
            (TBP) and three TBP-associated factors (TAFs) specific for RNA
            polymerase I. This complex, known as SL1, binds to the core
            promoter of ribosomal RNA genes to position the polymerase properly
            and acts as a channel for regulatory signals. This gene encodes the
            largest SL1-specific TAF. Multiple alternatively spliced transcript
            variants encoding different isoforms have been identified.
            [provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (3) lacks an internal segment in
            the CDS, compared to variant 1. The resulting isoform (3) is
            shorter by lacking of an internal segment, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2048527.1, AK299347.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000566732.6/ ENSP00000455933.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC009123.7         46800-46956         c
            158-367             AC009123.7         44750-44959         c
            368-449             AC009123.7         43596-43677         c
            450-547             AC009123.7         43309-43406         c
            548-637             AC009123.7         43143-43232         c
            638-711             AC009123.7         42975-43048         c
            712-950             AC009123.7         42101-42339         c
            951-1067            AC009123.7         41841-41957         c
            1068-1185           AC009123.7         41645-41762         c
            1186-1257           AC009123.7         41491-41562         c
            1258-1393           AC009123.7         41227-41362         c
            1394-1537           AC009123.7         40942-41085         c
            1538-1712           AC009123.7         40069-40243         c
            1713-1850           AC009123.7         39845-39982         c
            1851-3847           AC009123.7         37754-39750         c
FEATURES             Location/Qualifiers
     source          1..3847
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..3847
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /note="TATA-box binding protein associated factor, RNA
                     polymerase I subunit C"
                     /db_xref="GeneID:9013"
                     /db_xref="HGNC:HGNC:11534"
                     /db_xref="MIM:604905"
     exon            1..157
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            158..367
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..2761
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /note="isoform 3 is encoded by transcript variant 3;
                     transcription factor SL1; SL1, 110kD subunit;
                     TBP-associated factor 1C; TATA-box binding protein
                     associated factor, RNA polymerase I, C; TATA box-binding
                     protein-associated factor 1C; transcription initiation
                     factor SL1/TIF-IB subunit C; RNA polymerase I-specific
                     TBP-associated factor 110 kDa; TATA box binding protein
                     (TBP)-associated factor, RNA polymerase I, C, 110kD; TATA
                     box binding protein (TBP)-associated factor, RNA
                     polymerase I, C, 110kDa"
                     /codon_start=1
                     /product="TATA box-binding protein-associated factor RNA
                     polymerase I subunit C isoform 3"
                     /protein_id="NP_001230085.2"
                     /db_xref="CCDS:CCDS58489.1"
                     /db_xref="GeneID:9013"
                     /db_xref="HGNC:HGNC:11534"
                     /db_xref="MIM:604905"
                     /translation="MDFPSSLRPALFLTGPLGLSDVPDLSFMCSWRDALTLPEAQPQN
                     SENGALHVTKDLLWEPATPGPLPMLPPLIDPWDPGLTARDLLFRGGCRYRKRPRVVLD
                     VTEQISRFLLDHGDVAFAPLGKLMLENFKLEGAGSRTKKKTVVSVKKLLQDLGGHQPW
                     GCPWAYLSNRQRRFSILGGPILGTSVASHLAELLHEELVLRWEQLLLDEACTGGALAW
                     VPGRTPQFGQLVYPAGGAQDRLHFQEVVLTPGDNPQFLGKPGRIQLQGPVRQVVTCTV
                     QGETLLAVRSDYHCAVWKFGKQWQPTLLQAMQVEKGATGISLSPHLPGELAICSRSGA
                     VCLWSPEDGLRQIYRDPETLVFRDSSSWRWADFTAHPRVLTVGDRTGVKMLDTQGPPG
                     CGLLLFRLGAEASCQKGERVLLTQYLGHSSPKCLPPTLHLVCTQFSLYLVDERLPLVP
                     MLKWNHGLPSPLLLARLLPPPRPSCVQPLLLGGQGGQLQLLHLAGEGASVPRLAGPPQ
                     SLPSRIDSLPAFPLLEPKIQWRLQERLKAPTIGLAAVVPPLPSAPTPGLVLFQLSAAG
                     DVFYQQLRPQVDSSLRRDAGPPGDTQPDCHAPTASWTSQDTAGCSQWLKALLKVPLAP
                     PVWTAPTFTHRQMLGSTELRREEEEGQRLGVLRKAMARGQLLLQRDLGSLPAAEPPPA
                     PESGLEDKLSERLGEAWAGRGAAWWERQQGRTSEPGRQTRRPKRRTQLSSSFSLSGHV
                     DPSEDTSSPHSPEWPPADALPLPPTTPPSQELTPDACAQGVPSEQRQMLRDYMAKLPP
                     QRDTPGCATTPPHSQASSVRATRSQQHTPVLSSSQPLRKKPRMGF"
     exon            368..449
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            450..547
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            548..637
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            638..711
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            712..950
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1067
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1185
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1257
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1393
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1537
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1712
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1850
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..3847
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3299..3304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /note="hexamer: AATACA"
     polyA_site      3323
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /note="major polyA site"
     regulatory      3826..3831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
                     /note="hexamer: ATTAAA"
     polyA_site      3847
                     /gene="TAF1C"
                     /gene_synonym="MGC:39976; SL1; TAFI110; TAFI95"
ORIGIN      
        1 ggtccaaacc ggaagaccgt gggtagctgc ggcggggctg acccgtcccg agtgccaaag
       61 ctggggttct acttgagatt tccctcgtgg tgccagggtc cggcgagcat cacgccgagg
      121 cccattttcc agacgaccac gacgaggccg gggtcacgaa ctctggcgcc ccttaccagc
      181 ttccagtctc tcgaggtggc cagtgtggtg cttggtcctt gtttccagga tggacttccc
      241 cagctccctc cgccctgcat tgtttctgac cggccccctt ggtctgagcg acgtccctga
      301 cctctctttc atgtgcagct ggcgagacgc actgactctg ccagaggccc agccccagaa
      361 ctcagagaat ggggcactgc atgtgaccaa ggacctgctg tgggagccgg caacccctgg
      421 gcctctcccc atgctgcctc ccctcatcga tccctgggac cctggcctga ctgcccggga
      481 cctgcttttc cgcggagggt gccggtatcg gaagcggccc cgagtcgtgc tggatgtgac
      541 tgagcagatc agccggttcc tcttggatca tggagacgta gcctttgcgc ccctggggaa
      601 gctgatgctg gagaatttca agctggaggg agcggggagc cgcactaaga agaagacagt
      661 ggtcagtgtg aagaagctgc tccaggacct cggtggacac cagccctggg ggtgtccctg
      721 ggcttacctc agcaaccgac agcgccgctt ctctatcctc gggggcccca tcctgggcac
      781 gtcggtggcg agccacttgg cagagctgct gcacgaggag ctggtgctgc ggtgggagca
      841 gctgcttctg gatgaggcct gcactggggg cgcgctggcc tgggttcctg gaaggacacc
      901 ccagttcggg cagctggtct accctgctgg aggcgcccag gacaggctgc atttccaaga
      961 ggtcgttctg accccaggtg acaatcccca attccttggg aaacctggac gcatccagct
     1021 ccagggacct gtccggcaag tggtgacatg caccgtccag ggagaaactc tgctggccgt
     1081 ccgctctgac taccactgtg ccgtgtggaa gtttggtaaa cagtggcagc caacccttct
     1141 gcaggcaatg caggtggaga aaggggccac ggggatcagc ctcagccctc acctgcccgg
     1201 ggagctggcc atctgcagcc gctcgggagc cgtctgcctg tggagccctg aggatgggct
     1261 gcggcaaatc tacagggacc ctgagaccct cgtgttccgg gactcctctt cgtggcgttg
     1321 ggcagacttc actgcgcacc ctcgggtgct gaccgtgggt gaccgcaccg gagtgaagat
     1381 gctggacact cagggcccgc cgggctgtgg tctgttgctt tttcgtttgg gggcagaggc
     1441 ttcgtgccag aaaggggaac gtgtcctgct tacccagtac ctggggcact ccagccccaa
     1501 atgcctcccc cctactcttc atctcgtctg tacccagttc tctctctacc tagtggacga
     1561 gcgccttccc ctggtgccga tgctgaagtg gaaccatggc ctcccctccc cgctcctgct
     1621 ggcccgactg ctgcctccgc cccggcccag ctgcgtgcag cccctgctcc tcggaggcca
     1681 gggtgggcag ctgcagctgc tgcacctggc aggagaaggg gcgtcggtgc cccgcctggc
     1741 aggccccccc cagtctcttc cttccaggat cgactccctc cctgcatttc ctctgctgga
     1801 gcctaagatc cagtggcggc tgcaggagcg cctgaaagca ccgaccatag gtctggctgc
     1861 cgtcgtcccg cccttgccct cagcgcccac accaggcctg gtgctcttcc agctctcggc
     1921 ggcgggagat gtcttctacc agcagctccg cccccaggtg gactccagcc tccgcagaga
     1981 tgctgggcct cctggcgaca cccaacctga ctgccatgcc cccacagctt cctggacctc
     2041 ccaggacact gccggctgca gccagtggct gaaggccctg ctaaaagtgc ccctggctcc
     2101 tcctgtgtgg acagcaccca ccttcaccca ccgccagatg ctgggcagca cagagctgcg
     2161 gagggaggaa gaggaagggc agcggctggg tgtgctccgc aaggccatgg cccgagggca
     2221 gctcctgctg cagagagacc tgggctccct ccctgcggca gagccacccc ctgcacccga
     2281 gtcaggccta gaggacaagc tcagtgagcg cctgggggaa gcctgggcag gccgaggggc
     2341 tgcctggtgg gagaggcagc agggcaggac ctcggagccc gggagacaga ccaggcggcc
     2401 caagcgccgg acccagctgt ccagcagctt ttcgctcagt ggccatgtgg atccctcaga
     2461 ggacaccagc tcccctcata gccctgagtg gccacctgct gatgctctgc ccctgccccc
     2521 cacgaccccg ccctcccagg agttgactcc ggatgcatgc gcccagggcg tcccatcaga
     2581 gcagcggcag atgctccgtg actacatggc caagctacca ccccagaggg acaccccagg
     2641 ctgtgccacc acacctcccc actcccaggc ctccagcgtc cgggccactc gctcccagca
     2701 gcacacaccc gtcctctcta gctctcagcc cctccggaag aagcctcgaa tgggcttctg
     2761 aggacacaag gtgggctgcc ctcaagcccc agagagcccc tcatccttcc tctgggacca
     2821 gatgtgcctt ccacagttga aacttgagaa gcagagctcg ccaccttctg gaggccactg
     2881 tgatgatgag ccaagcaatt tggagccaag ttgaagggac agggcaacaa aatacagtag
     2941 tagtttcttt tgtattttgt atattcgcct gaagatcatc ccgcaaggca ggctggaggt
     3001 gccggtgggc ctgtgttgct gggattttag tctgtgctgg gaggcagggc tccgctgcgc
     3061 ctcagctgtg ggggcctcag gcaggtccct cagttctcac gccttcctgt ccagtggaat
     3121 gggggccagg agtgctggct cctcgtgttt ggtgagggtg gagtgaggcc cctgcagagc
     3181 tgctgatgag gtgggcacag cggccgttgg cagctgctgt tgtgggttgc tttgtcaatc
     3241 tctgccccgg tctgatgttt cctacaggga gatgccttgg atccaggttc agggactaaa
     3301 tacacttggc agctgaagat gaattggaat ggtcacgttt tttaggctgg acagcgtccc
     3361 gccacagcta ctacctgaca ctgagctcat gcagagagat gatggctgat gttccttctc
     3421 ccttgggaca tgggtctggc acctgtgggc tgtcgatagt gccctctgag cagagggtca
     3481 cggtcatgtc agtttggggg aattctctgt tgtgcctcac agactccccc ctttctttcc
     3541 tccctcccct tctcattttg atgtctaaag catcaagtcc ctcttcctcg gagtttctct
     3601 agctgcagtg gaagattctg ttttcctgtg gggaaaatgc tcacttgaga ttttgcaggg
     3661 acccgggtct gtctggtttc tgatgacata gtaagagaaa ggtctttttt caggttggct
     3721 ggtgaaagga attgcatgtg actcacacaa acaggagcta gcccaatcat acactgactc
     3781 gcgtgggtgt taaaatgttt atcatgccta agggagacat ttatgattaa accatttatg
     3841 ctacata
//
