LOCUS       NM_005680               2267 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor, RNA
            polymerase I subunit B (TAF1B), transcript variant 1, mRNA.
ACCESSION   NM_005680
VERSION     NM_005680.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2267)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2267)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2267)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2267)
  AUTHORS   Okuda,H., Kanai,A., Ito,S., Matsui,H. and Yokoyama,A.
  TITLE     AF4 uses the SL1 components of RNAP1 machinery to initiate MLL
            fusion- and AEP-dependent transcription
  JOURNAL   Nat Commun 6, 8869 (2015)
   PUBMED   26593443
  REMARK    GeneRIF: AEP coactivator complex facilitates the initiation of
            RNAP2-dependent transcription via SL1 activity by loading TBP onto
            the TATA element.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2267)
  AUTHORS   Voit,R., Seiler,J. and Grummt,I.
  TITLE     Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for
            Mitotic Repression of rRNA Synthesis
  JOURNAL   PLoS Genet 11 (5), e1005246 (2015)
   PUBMED   26023773
  REMARK    GeneRIF: hCdc14B promotes reactivation of rDNA transcription by
            dephosphorylating TAFI110.  SIRT1 becomes transiently enriched in
            nucleoli at the onset of mitosis. SIRT1 deacetylates TAFI68
            destabilizing SL1 binding to the rDNA promoter
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2267)
  AUTHORS   Muth,V., Nadaud,S., Grummt,I. and Voit,R.
  TITLE     Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA
            polymerase I transcription
  JOURNAL   EMBO J 20 (6), 1353-1362 (2001)
   PUBMED   11250901
REFERENCE   7  (bases 1 to 2267)
  AUTHORS   Zhai,W. and Comai,L.
  TITLE     Repression of RNA polymerase I transcription by the tumor
            suppressor p53
  JOURNAL   Mol Cell Biol 20 (16), 5930-5938 (2000)
   PUBMED   10913176
REFERENCE   8  (bases 1 to 2267)
  AUTHORS   Di Pietro,C., Rapisarda,A., Amico,V., Bonaiuto,C., Viola,A.,
            Scalia,M., Motta,S., Amato,A., Engel,H., Messina,A., Sichel,G.,
            Grzeschik,K. and Purrello,M.
  TITLE     Genomic localization of the human genes TAF1A, TAF1B and TAF1C,
            encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I
            general transcription initiation factor SL1
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 133-136 (2000)
   PUBMED   10894955
REFERENCE   9  (bases 1 to 2267)
  AUTHORS   Jansa,P., Mason,S.W., Hoffmann-Rohrer,U. and Grummt,I.
  TITLE     Cloning and functional characterization of PTRF, a novel protein
            which induces dissociation of paused ternary transcription
            complexes
  JOURNAL   EMBO J 17 (10), 2855-2864 (1998)
   PUBMED   9582279
REFERENCE   10 (bases 1 to 2267)
  AUTHORS   Comai,L., Zomerdijk,J.C., Beckmann,H., Zhou,S., Admon,A. and
            Tjian,R.
  TITLE     Reconstitution of transcription factor SL1: exclusive binding of
            TBP by SL1 or TFIID subunits
  JOURNAL   Science 266 (5193), 1966-1972 (1994)
   PUBMED   7801123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010969.11.
            
            On Nov 23, 2018 this sequence version replaced NM_005680.2.
            
            Summary: Initiation of transcription by RNA polymerase I requires
            the formation of a complex composed of the TATA-binding protein
            (TBP) and three TBP-associated factors (TAFs) specific for RNA
            polymerase I. This complex, known as SL1, binds to the core
            promoter of ribosomal RNA genes to position the polymerase properly
            and acts as a channel for regulatory signals. This gene encodes one
            of the SL1-specific TAFs. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018137.2, SRR1803612.109259.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263663.10/ ENSP00000263663.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC010969.11        14174-14259
            87-185              AC010969.11        15920-16018
            186-273             AC010969.11        20073-20160
            274-371             AC010969.11        22241-22338
            372-467             AC010969.11        25026-25121
            468-621             AC010969.11        38976-39129
            622-775             AC010969.11        46565-46718
            776-875             AC010969.11        53406-53505
            876-1023            AC010969.11        75559-75706
            1024-1201           AC010969.11        81436-81613
            1202-1248           AC010969.11        82211-82257
            1249-1339           AC010969.11        83859-83949
            1340-1410           AC010969.11        89741-89811
            1411-1633           AC010969.11        90298-90520
            1634-2267           AC010969.11        104483-105116
FEATURES             Location/Qualifiers
     source          1..2267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..2267
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /note="TATA-box binding protein associated factor, RNA
                     polymerase I subunit B"
                     /db_xref="GeneID:9014"
                     /db_xref="HGNC:HGNC:11533"
                     /db_xref="MIM:604904"
     exon            1..86
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1835
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /note="isoform a is encoded by transcript variant 1; SL1,
                     63kD subunit; TBP-associated factor 1B; TATA box-binding
                     protein-associated factor 1B; transcription initiation
                     factor SL1/TIF-IB subunit B; RNA polymerase I-specific
                     TBP-associated factor 63 kDa; TATA box binding protein
                     (TBP)-associated factor, RNA polymerase I, B, 63kD;
                     TATA-box binding protein associated factor, RNA polymerase
                     I, B; TATA box binding protein (TBP)-associated factor,
                     RNA polymerase I, B, 63kDa"
                     /codon_start=1
                     /product="TATA box-binding protein-associated factor RNA
                     polymerase I subunit B isoform a"
                     /protein_id="NP_005671.3"
                     /db_xref="CCDS:CCDS33143.1"
                     /db_xref="GeneID:9014"
                     /db_xref="HGNC:HGNC:11533"
                     /db_xref="MIM:604904"
                     /translation="MDLEEAEEFKERCTQCAAVSWGLTDEGKYYCTSCHNVTERYQEV
                     TNTDLIPNTQIKALNRGLKKKNNTEKGWDWYVCEGFQYILYQQAEALKNLGVGPELKN
                     DVLHNFWKRYLQKSKQAYCKNPVYTTGRKPTVLEDNLSHSDWASEPELLSDVSCPPFL
                     ESGAESQSDIHTRKPFPVSKASQSETSVCSGSLDGVEYSQRKEKGIVKMTMPQTLAFC
                     YLSLLWQREAITLSDLLRFVEEDHIPYINAFQHFPEQMKLYGRDRGIFGIESWPDYED
                     IYKKTVEVGTFLDLPRFPDITEDCYLHPNILCMKYLMEVNLPDEMHSLTCHVVKMTGM
                     GEVDFLTFDPIAKMAKTVKYDVQAVAIIVVVLKLLFLLDDSFEWSLSNLAEKHNEKNK
                     KDKPWFDFRKWYQIMKKAFDEKKQKWEEARAKYLWKSEKPLYYSFVDKPVAYKKREMV
                     VNLQKQFSTLVESTATAGKKSPSSFQFNWTEEDTDRTCFHGHSLQGVLKEKGQSLLTK
                     NSLYWLSTQKFCRCYCTHVTTYEESNYSLSYQFILNLFSFLLRIKTSLLHEEVSLVEK
                     KLFEKKYSVKRKKSRSKKVRRH"
     exon            87..185
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            186..273
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            274..371
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            372..467
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            468..621
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            622..775
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            776..875
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1023
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1201
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1248
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1339
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1410
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1633
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..2267
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2218..2223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /note="hexamer: TATAAA"
     regulatory      2237..2242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /note="hexamer: AACAAA"
     polyA_site      2242
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /note="major polyA site"
     polyA_site      2267
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
ORIGIN      
        1 ctttcccgga agctgcgctc gctacccggg taacgggtcc cggctgtgga agctcccgcg
       61 gcgccgcgat ggacctcgag gaggcggaag agtttaaaga acgctgtact cagtgtgctg
      121 ctgtctcatg gggtcttact gatgaaggca aatattattg cacttcttgc cacaatgtta
      181 cagagagata tcaggaagtt acaaacactg atcttattcc taatacccaa ataaaagccc
      241 tcaaccgggg gcttaaaaaa aaaaacaata ctgaaaaagg ctgggattgg tatgtgtgtg
      301 aaggtttcca gtatattctt tatcaacaag cagaagcctt aaagaacctt ggagtaggcc
      361 cagagttaaa gaacgatgtt ttacataatt tttggaagcg ctaccttcag aagagcaagc
      421 aggcatattg taagaaccca gtttatacca ctggaaggaa acctacggta ttagaagata
      481 atctaagtca ttcagactgg gctagtgagc ctgagctgct aagtgatgtc agctgtcctc
      541 cttttcttga aagtggagcg gagtctcagt ctgacatcca cactcgaaaa cctttccccg
      601 tcagcaaagc atcacaatca gaaacgtctg tctgctctgg atctctggat ggagttgaat
      661 actcacaacg aaaggagaag ggaatcgtga agatgaccat gccacagaca cttgccttct
      721 gttatctgtc cttactttgg cagagagaag caataacact ttcagatctt ttgaggtttg
      781 ttgaagagga ccatattcct tacataaatg cttttcagca ttttccagaa cagatgaaat
      841 tatatggacg tgacagagga atctttggta tagagtcttg gcctgactac gaggacatct
      901 acaaaaaaac agtagaagtt ggaacatttt tagatttgcc tcgttttcca gacataactg
      961 aagactgcta tcttcatccc aacatactgt gtatgaaata cttgatggaa gtcaacctcc
     1021 ctgatgaaat gcatagctta acttgccacg tggtaaaaat gactggaatg ggagaagtgg
     1081 attttctgac atttgatcct atagctaaaa tggcaaaaac tgttaagtac gatgtacaag
     1141 ctgtagctat cattgtggtg gtattgaaac tgctctttct attggatgac agtttcgagt
     1201 ggtctttgtc taatcttgct gaaaagcata atgaaaagaa caaaaaagat aagccatggt
     1261 ttgatttcag aaagtggtac caaattatga agaaagcttt tgatgagaaa aaacaaaaat
     1321 gggaagaagc aagggccaag tacctgtgga aaagtgaaaa gccactctac tactcatttg
     1381 tcgacaaacc agtagcatat aaaaaaagag aaatggtggt gaatctacag aaacaattta
     1441 gcacactggt cgagtcaaca gcaactgctg gaaaaaaaag cccttcaagt tttcagttca
     1501 actggactga agaggacact gatagaacgt gtttccatgg acacagcctt cagggagtcc
     1561 tgaaagagaa aggccaatca ctgctgacta agaattcatt atattggctt agtacacaga
     1621 aattctgcag atgctattgt acacatgtga caacctatga agaatcaaat tattctctga
     1681 gttatcagtt tatactaaat ctcttctcct tcctgctcag aataaagact tcccttctcc
     1741 atgaagaagt gagcttagtt gagaagaaac tttttgagaa aaaatacagt gtaaaaagaa
     1801 agaaatcaag atccaagaaa gtgagacgac attgagaaaa tgaaatagaa actttctgga
     1861 aaaatatttt aatagtgata ataacatcag attttaatat aacattccag agaattgtgg
     1921 aaaatactgc atatatatgt atagactctg acacatattt acatatatat caagtgtgct
     1981 tagaaaaatg tatattgtaa agcaggtgag cttcatttga ttttattttt cagagtatga
     2041 acattctaag agaaagttaa aacaatagca aattgtataa ttgtatccag aaatgtatac
     2101 tcatcgtatt ttaaagctaa atttattttt taaactagat cccttcatta ttctttatgc
     2161 cccagagtaa atcccagatg gatcaaagat ctaaacataa tctttcatat gtaaaaatat
     2221 aaaagtatta gtagaaaaca aatatgaatg ctttgatgat cttggaa
//
