LOCUS       NP_005671                588 aa            linear   PRI 19-SEP-2024
DEFINITION  TATA box-binding protein-associated factor RNA polymerase I subunit
            B isoform a [Homo sapiens].
ACCESSION   NP_005671
VERSION     NP_005671.3
DBSOURCE    REFSEQ: accession NM_005680.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 588)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (residues 1 to 588)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 588)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 588)
  AUTHORS   Okuda,H., Kanai,A., Ito,S., Matsui,H. and Yokoyama,A.
  TITLE     AF4 uses the SL1 components of RNAP1 machinery to initiate MLL
            fusion- and AEP-dependent transcription
  JOURNAL   Nat Commun 6, 8869 (2015)
   PUBMED   26593443
  REMARK    GeneRIF: AEP coactivator complex facilitates the initiation of
            RNAP2-dependent transcription via SL1 activity by loading TBP onto
            the TATA element.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 588)
  AUTHORS   Voit,R., Seiler,J. and Grummt,I.
  TITLE     Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for
            Mitotic Repression of rRNA Synthesis
  JOURNAL   PLoS Genet 11 (5), e1005246 (2015)
   PUBMED   26023773
  REMARK    GeneRIF: hCdc14B promotes reactivation of rDNA transcription by
            dephosphorylating TAFI110.  SIRT1 becomes transiently enriched in
            nucleoli at the onset of mitosis. SIRT1 deacetylates TAFI68
            destabilizing SL1 binding to the rDNA promoter
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 588)
  AUTHORS   Muth,V., Nadaud,S., Grummt,I. and Voit,R.
  TITLE     Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA
            polymerase I transcription
  JOURNAL   EMBO J 20 (6), 1353-1362 (2001)
   PUBMED   11250901
REFERENCE   7  (residues 1 to 588)
  AUTHORS   Zhai,W. and Comai,L.
  TITLE     Repression of RNA polymerase I transcription by the tumor
            suppressor p53
  JOURNAL   Mol Cell Biol 20 (16), 5930-5938 (2000)
   PUBMED   10913176
REFERENCE   8  (residues 1 to 588)
  AUTHORS   Di Pietro,C., Rapisarda,A., Amico,V., Bonaiuto,C., Viola,A.,
            Scalia,M., Motta,S., Amato,A., Engel,H., Messina,A., Sichel,G.,
            Grzeschik,K. and Purrello,M.
  TITLE     Genomic localization of the human genes TAF1A, TAF1B and TAF1C,
            encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I
            general transcription initiation factor SL1
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 133-136 (2000)
   PUBMED   10894955
REFERENCE   9  (residues 1 to 588)
  AUTHORS   Jansa,P., Mason,S.W., Hoffmann-Rohrer,U. and Grummt,I.
  TITLE     Cloning and functional characterization of PTRF, a novel protein
            which induces dissociation of paused ternary transcription
            complexes
  JOURNAL   EMBO J 17 (10), 2855-2864 (1998)
   PUBMED   9582279
REFERENCE   10 (residues 1 to 588)
  AUTHORS   Comai,L., Zomerdijk,J.C., Beckmann,H., Zhou,S., Admon,A. and
            Tjian,R.
  TITLE     Reconstitution of transcription factor SL1: exclusive binding of
            TBP by SL1 or TFIID subunits
  JOURNAL   Science 266 (5193), 1966-1972 (1994)
   PUBMED   7801123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010969.11.
            
            On Nov 23, 2018 this sequence version replaced NP_005671.2.
            
            Summary: Initiation of transcription by RNA polymerase I requires
            the formation of a complex composed of the TATA-binding protein
            (TBP) and three TBP-associated factors (TAFs) specific for RNA
            polymerase I. This complex, known as SL1, binds to the core
            promoter of ribosomal RNA genes to position the polymerase properly
            and acts as a channel for regulatory signals. This gene encodes one
            of the SL1-specific TAFs. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018137.2, SRR1803612.109259.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263663.10/ ENSP00000263663.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..588
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     Protein         1..588
                     /product="TATA box-binding protein-associated factor RNA
                     polymerase I subunit B isoform a"
                     /note="SL1, 63kD subunit; TBP-associated factor 1B; TATA
                     box-binding protein-associated factor 1B; transcription
                     initiation factor SL1/TIF-IB subunit B; RNA polymerase
                     I-specific TBP-associated factor 63 kDa; TATA box binding
                     protein (TBP)-associated factor, RNA polymerase I, B,
                     63kD; TATA-box binding protein associated factor, RNA
                     polymerase I, B; TATA box binding protein (TBP)-associated
                     factor, RNA polymerase I, B, 63kDa"
                     /calculated_mol_wt=68701
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q53T94.1)"
     Region          7..39
                     /region_name="zf-RRN7"
                     /note="Zinc-finger of RNA-polymerase I-specific TFIIB,
                     Rrn7; pfam11781"
                     /db_xref="CDD:463348"
     Region          40..68
                     /region_name="B-reader"
                     /note="propagated from UniProtKB/Swiss-Prot (Q53T94.1)"
     Region          69..73
                     /region_name="B-linker"
                     /note="propagated from UniProtKB/Swiss-Prot (Q53T94.1)"
     Region          74..261
                     /region_name="N-terminal cyclin fold"
                     /note="propagated from UniProtKB/Swiss-Prot (Q53T94.1)"
     Region          262..372
                     /region_name="C-terminal cyclin fold"
                     /note="propagated from UniProtKB/Swiss-Prot (Q53T94.1)"
     Site            440
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q53T94.1)"
     CDS             1..588
                     /gene="TAF1B"
                     /gene_synonym="MGC:9349; RAF1B; RAFI63; SL1; TAFI63"
                     /coded_by="NM_005680.3:69..1835"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS33143.1"
                     /db_xref="GeneID:9014"
                     /db_xref="HGNC:HGNC:11533"
                     /db_xref="MIM:604904"
ORIGIN      
        1 mdleeaeefk erctqcaavs wgltdegkyy ctschnvter yqevtntdli pntqikalnr
       61 glkkknntek gwdwyvcegf qyilyqqaea lknlgvgpel kndvlhnfwk rylqkskqay
      121 cknpvyttgr kptvlednls hsdwasepel lsdvscppfl esgaesqsdi htrkpfpvsk
      181 asqsetsvcs gsldgveysq rkekgivkmt mpqtlafcyl sllwqreait lsdllrfvee
      241 dhipyinafq hfpeqmklyg rdrgifgies wpdyediykk tvevgtfldl prfpditedc
      301 ylhpnilcmk ylmevnlpde mhsltchvvk mtgmgevdfl tfdpiakmak tvkydvqava
      361 iivvvlkllf llddsfewsl snlaekhnek nkkdkpwfdf rkwyqimkka fdekkqkwee
      421 arakylwkse kplyysfvdk pvaykkremv vnlqkqfstl vestatagkk spssfqfnwt
      481 eedtdrtcfh ghslqgvlke kgqslltkns lywlstqkfc rcycthvtty eesnyslsyq
      541 filnlfsfll riktsllhee vslvekklfe kkysvkrkks rskkvrrh
//
