LOCUS       NM_005681               1910 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor, RNA
            polymerase I subunit A (TAF1A), transcript variant 1, mRNA.
ACCESSION   NM_005681
VERSION     NM_005681.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Zhang,D.L. and Yang,N.
  TITLE     TNFAIP8 regulates cisplatin resistance through TAF-Ialpha and
            promotes malignant progression of esophageal cancer
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (9), 4775-4784 (2020)
   PUBMED   32432789
  REMARK    GeneRIF: TNFAIP8 regulates cisplatin resistance through TAF-Ialpha
            and promotes malignant progression of esophageal cancer.
REFERENCE   4  (bases 1 to 1910)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   5  (bases 1 to 1910)
  AUTHORS   Miller,G., Panov,K.I., Friedrich,J.K., Trinkle-Mulcahy,L.,
            Lamond,A.I. and Zomerdijk,J.C.
  TITLE     hRRN3 is essential in the SL1-mediated recruitment of RNA
            Polymerase I to rRNA gene promoters
  JOURNAL   EMBO J 20 (6), 1373-1382 (2001)
   PUBMED   11250903
REFERENCE   6  (bases 1 to 1910)
  AUTHORS   Muth,V., Nadaud,S., Grummt,I. and Voit,R.
  TITLE     Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA
            polymerase I transcription
  JOURNAL   EMBO J 20 (6), 1353-1362 (2001)
   PUBMED   11250901
REFERENCE   7  (bases 1 to 1910)
  AUTHORS   Zhai,W. and Comai,L.
  TITLE     Repression of RNA polymerase I transcription by the tumor
            suppressor p53
  JOURNAL   Mol Cell Biol 20 (16), 5930-5938 (2000)
   PUBMED   10913176
REFERENCE   8  (bases 1 to 1910)
  AUTHORS   Di Pietro,C., Rapisarda,A., Amico,V., Bonaiuto,C., Viola,A.,
            Scalia,M., Motta,S., Amato,A., Engel,H., Messina,A., Sichel,G.,
            Grzeschik,K. and Purrello,M.
  TITLE     Genomic localization of the human genes TAF1A, TAF1B and TAF1C,
            encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I
            general transcription initiation factor SL1
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 133-136 (2000)
   PUBMED   10894955
REFERENCE   9  (bases 1 to 1910)
  AUTHORS   Comai,L., Zomerdijk,J.C., Beckmann,H., Zhou,S., Admon,A. and
            Tjian,R.
  TITLE     Reconstitution of transcription factor SL1: exclusive binding of
            TBP by SL1 or TFIID subunits
  JOURNAL   Science 266 (5193), 1966-1972 (1994)
   PUBMED   7801123
REFERENCE   10 (bases 1 to 1910)
  AUTHORS   Rudloff,U., Eberhard,D., Tora,L., Stunnenberg,H. and Grummt,I.
  TITLE     TBP-associated factors interact with DNA and govern species
            specificity of RNA polymerase I transcription
  JOURNAL   EMBO J 13 (11), 2611-2616 (1994)
   PUBMED   8013460
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK299536.1, AL592148.7,
            BC013808.1 and CN479053.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005681.3.
            
            Summary: This gene encodes a subunit of the RNA polymerase I
            complex, Selectivity Factor I (SLI). The encoded protein is a TATA
            box-binding protein-associated factor that plays a role in the
            assembly of the RNA polymerase I preinitiation complex. Alternate
            splicing results in multiple transcript variants encoding multiple
            isoforms.[provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.189608.1,
                                           SRR1660805.235213.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352967.9/ ENSP00000327072.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AK299536.1         1-26
            27-61               AL592148.7         94224-94258         c
            62-1351             BC013808.1         42-1331
            1352-1352           AL592148.7         65812-65812         c
            1353-1899           BC013808.1         1333-1879
            1900-1910           CN479053.1         22-32               c
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1910
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /note="TATA-box binding protein associated factor, RNA
                     polymerase I subunit A"
                     /db_xref="GeneID:9015"
                     /db_xref="HGNC:HGNC:11532"
                     /db_xref="MIM:604903"
     exon            1..207
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /inference="alignment:Splign:2.1.0"
     exon            208..330
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1562
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /note="isoform 1 is encoded by transcript variant 1; SL1,
                     48kD subunit; TBP-associated factor 1A; transcription
                     factor SL1; TATA box-binding protein-associated factor 1A;
                     transcription initiation factor SL1/TIF-IB subunit A; RNA
                     polymerase I-specific TBP-associated factor 48 kDa;
                     TATA-box binding protein associated factor, RNA polymerase
                     I, A; TATA box binding protein (TBP)-associated factor,
                     RNA polymerase I, A, 48kD; TATA box binding protein
                     (TBP)-associated factor, RNA polymerase I, A, 48kDa"
                     /codon_start=1
                     /product="TATA box-binding protein-associated factor RNA
                     polymerase I subunit A isoform 1"
                     /protein_id="NP_005672.1"
                     /db_xref="CCDS:CCDS1531.1"
                     /db_xref="GeneID:9015"
                     /db_xref="HGNC:HGNC:11532"
                     /db_xref="MIM:604903"
                     /translation="MSDFSEELKGPVTDDEEVETSVLSGAGMHFPWLQTYVETVAIGG
                     KRRKDFAQTTSACLSFIQEALLKHQWQQAAEYMYSYFQTLEDSDSYKRQAAPEIIWKL
                     GSEILFYHPKSNMESFNTFANRMKNIGVMNYLKISLQHALYLLHHGMLKDAKRNLSEA
                     ETWRHGENTSSREILINLIQAYKGLLQYYTWSEKKMELSKLDKDDYAYNAVAQDVFNH
                     SWKTSANISALIKIPGVWDPFVKSYVEMLEFYGDRDGAQEVLTNYAYDEKFPSNPNAH
                     IYLYNFLKRQKAPRSKLISVLKILYQIVPSHKLMLEFHTLLRKSEKEEHRKLGLEVLF
                     GVLDFAGCTKNITAWKYLAKYLKNILMGNHLAWVQEEWNSRKNWWPGFHFSYFWAKSD
                     WKEDTALACEKAFVAGLLLGKGCRYFRYILKQDHQILGKKIKRMKRSVKKYSIVNPRL
                     "
     exon            331..500
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /inference="alignment:Splign:2.1.0"
     exon            501..614
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /inference="alignment:Splign:2.1.0"
     exon            615..813
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /inference="alignment:Splign:2.1.0"
     exon            814..944
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1103
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1170
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1294
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1449
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1910
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /note="hexamer: AATAAA"
     polyA_site      1910
                     /gene="TAF1A"
                     /gene_synonym="MGC:17061; RAFI48; SL1; TAFI48"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggg tcgaggcgag gccaacgata cgcctgctgc agcaggagga gttacgagcc
       61 gggccgcgcg ctgcctaaat acctaaacca ggtttagcgc ctgctcatat aaagctctcc
      121 taactcgtct tccggtggga atttcttcac gtgggccgga gtcggagact gagtttagct
      181 ttactgagga gctctaaatt taggcgggta tgagtgattt cagtgaagaa ttaaaagggc
      241 ctgtgacaga tgatgaagaa gtggaaacat ctgtgctcag tggtgcagga atgcattttc
      301 cttggcttca aacatacgta gaaactgtgg ccattggagg gaaaaggagg aaggattttg
      361 ctcagacaac aagtgcttgt ttaagtttta tccaagaagc tctgctgaag caccaatggc
      421 agcaagctgc agaatacatg tacagttatt ttcagacctt ggaagattca gatagctaca
      481 aaaggcaggc tgcacctgag attatttgga agctcggaag tgaaattcta ttttatcatc
      541 ccaaaagcaa catggagagt ttcaatactt ttgctaaccg gatgaaaaat attggcgtca
      601 tgaattattt aaagatctcc ttacaacatg cattatacct tctgcatcat ggaatgctta
      661 aagatgctaa gagaaatctg agtgaggcag agacatggag acatggtgaa aatacgtctt
      721 cccgggaaat attaatcaac cttattcagg cctataaagg gcttttacag tattatacct
      781 ggtctgaaaa gaagatggaa ttgtcaaagc ttgataagga tgattatgct tacaatgcag
      841 tagcccagga tgtgttcaac cacagctgga agacatctgc aaatatttct gcattgatta
      901 aaattcctgg agtttgggac ccttttgtga agagttatgt agaaatgctg gaattctatg
      961 gggatcgaga tggagcccaa gaggtactca ccaattatgc atatgatgaa aagtttccat
     1021 caaatccaaa tgcccatatc tacttataca actttctaaa gagacagaag gcaccaagat
     1081 caaaattgat aagtgtgctt aagattttgt atcagattgt accatctcat aaattgatgt
     1141 tggaattcca tacattactt agaaaatcag aaaaagaaga acaccgtaaa ctggggttgg
     1201 aggtattatt tggagtctta gattttgccg gatgcactaa gaatataact gcttggaaat
     1261 acttggcaaa atatctgaaa aatatcttaa tgggaaacca ccttgcgtgg gttcaagaag
     1321 agtggaactc caggaaaaac tggtggccag gctttcattt cagctacttt tgggcaaaaa
     1381 gtgattggaa ggaagataca gctttggcct gtgagaaagc ttttgtggct ggtttactgt
     1441 taggaaaagg ttgtagatat ttccggtata ttttaaagca agatcaccaa atcttaggga
     1501 agaaaattaa gcggatgaag agatctgtga aaaaatacag tattgtaaat ccaagactct
     1561 gatactgaat tttagttatt tcacagttgt agctacacag taagtagctt ggtagatagt
     1621 tattgaatgt atttatgtag tgtattaaga agcttatatt actacaaaaa acttattttt
     1681 atatattttt atatttttgt attatttata gctagagaaa caatattact gcctttgctc
     1741 tttgtaacta tgtctgtttt cttttttgta atgttaaatg ttacatttgt taaggaataa
     1801 ttcttcaaat gacaaactaa ttacagaata tagctctaca gcagttattg tttgcaaata
     1861 ctttgcctct tgctattgtg taataaactg taacttgtag tgctgtgaaa
//
