LOCUS       NM_139215               2162 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens TATA-box binding protein associated factor 15 (TAF15),
            transcript variant 1, mRNA.
ACCESSION   NM_139215
VERSION     NM_139215.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2162)
  AUTHORS   Fu,X.L., He,F.T., Li,M.H., Fu,C.Y. and Chen,J.Z.
  TITLE     circZNF532 promotes endothelial-to-mesenchymal transition in
            diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD
  JOURNAL   Endocr J 71 (7), 675-686 (2024)
   PUBMED   38811189
  REMARK    GeneRIF: circZNF532 promotes endothelial-to-mesenchymal transition
            in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.
REFERENCE   2  (bases 1 to 2162)
  AUTHORS   Yang,H., He,P., Luo,W., Liu,S. and Yang,Y.
  TITLE     circRNA TATA-box binding protein associated factor 15 acts as an
            oncogene to facilitate bladder cancer progression through targeting
            miR-502-5p/high mobility group box 3
  JOURNAL   Mol Carcinog 63 (4), 629-646 (2024)
   PUBMED   38226841
  REMARK    GeneRIF: circRNA TATA-box binding protein associated factor 15 acts
            as an oncogene to facilitate bladder cancer progression through
            targeting miR-502-5p/high mobility group box 3.
REFERENCE   3  (bases 1 to 2162)
  AUTHORS   Couthouis,J., Hart,M.P., Shorter,J., DeJesus-Hernandez,M.,
            Erion,R., Oristano,R., Liu,A.X., Ramos,D., Jethava,N.,
            Hosangadi,D., Epstein,J., Chiang,A., Diaz,Z., Nakaya,T.,
            Ibrahim,F., Kim,H.J., Solski,J.A., Williams,K.L.,
            Mojsilovic-Petrovic,J., Ingre,C., Boylan,K., Graff-Radford,N.R.,
            Dickson,D.W., Clay-Falcone,D., Elman,L., McCluskey,L., Greene,R.,
            Kalb,R.G., Lee,V.M., Trojanowski,J.Q., Ludolph,A., Robberecht,W.,
            Andersen,P.M., Nicholson,G.A., Blair,I.P., King,O.D., Bonini,N.M.,
            Van Deerlin,V., Rademakers,R., Mourelatos,Z. and Gitler,A.D.
  TITLE     A yeast functional screen predicts new candidate ALS disease genes
  JOURNAL   Proc Natl Acad Sci U S A 108 (52), 20881-20890 (2011)
   PUBMED   22065782
  REMARK    GeneRIF: Missense mutations of TAF-15, an RNA-binding protein, were
            found in patients with amyotrophic lateral sclerosis, and gene
            conferred neurodegeneration when expressend in Drosophila.
            Erratum:[Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2220845120.
            doi: 10.1073/pnas.2220845120.. PMID: 36577079]
REFERENCE   4  (bases 1 to 2162)
  AUTHORS   Martini,A., La Starza,R., Janssen,H., Bilhou-Nabera,C.,
            Corveleyn,A., Somers,R., Aventin,A., Foa,R., Hagemeijer,A.,
            Mecucci,C. and Marynen,P.
  TITLE     Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its
            homologue, TAF15, with the transcription factor CIZ/NMP4 in acute
            leukemia
  JOURNAL   Cancer Res 62 (19), 5408-5412 (2002)
   PUBMED   12359745
  REMARK    GeneRIF: The transcription factor gene CIZ/NMP4 is recurrently
            involved in acute leukemia through fusion with either EWSR1 or
            TAF15.
REFERENCE   5  (bases 1 to 2162)
  AUTHORS   Panagopoulos,I., Mencinger,M., Dietrich,C.U., Bjerkehagen,B.,
            Saeter,G., Mertens,F., Mandahl,N. and Heim,S.
  TITLE     Fusion of the RBP56 and CHN genes in extraskeletal myxoid
            chondrosarcomas with translocation t(9;17)(q22;q11)
  JOURNAL   Oncogene 18 (52), 7594-7598 (1999)
   PUBMED   10602519
REFERENCE   6  (bases 1 to 2162)
  AUTHORS   Morohoshi,F., Ootsuka,Y., Arai,K., Ichikawa,H., Mitani,S.,
            Munakata,N. and Ohki,M.
  TITLE     Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes
  JOURNAL   Gene 221 (2), 191-198 (1998)
   PUBMED   9795213
REFERENCE   7  (bases 1 to 2162)
  AUTHORS   Morohoshi,F., Arai,K., Takahashi,E.I., Tanigami,A. and Ohki,M.
  TITLE     Cloning and mapping of a human RBP56 gene encoding a putative RNA
            binding protein similar to FUS/TLS and EWS proteins
  JOURNAL   Genomics 38 (1), 51-57 (1996)
   PUBMED   8954779
REFERENCE   8  (bases 1 to 2162)
  AUTHORS   Parada,C.A., Yoon,J.B. and Roeder,R.G.
  TITLE     A novel LBP-1-mediated restriction of HIV-1 transcription at the
            level of elongation in vitro
  JOURNAL   J Biol Chem 270 (5), 2274-2283 (1995)
   PUBMED   7836461
REFERENCE   9  (bases 1 to 2162)
  AUTHORS   Zhou,Q. and Sharp,P.A.
  TITLE     Novel mechanism and factor for regulation by HIV-1 Tat
  JOURNAL   EMBO J 14 (2), 321-328 (1995)
   PUBMED   7835343
REFERENCE   10 (bases 1 to 2162)
  AUTHORS   Siddique,N. and Siddique,T.
  TITLE     Amyotrophic Lateral Sclerosis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314194.1, BG403710.1,
            BC046099.1 and AI351964.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_139215.2.
            
            Summary: This gene encodes a member of the TET family of
            RNA-binding proteins. The encoded protein plays a role in RNA
            polymerase II gene transcription as a component of a distinct
            subset of multi-subunit transcription initiation factor TFIID
            complexes. Translocations involving this gene play a role in acute
            leukemia and extraskeletal myxoid chondrosarcoma, and mutations in
            this gene may play a role in amyotrophic lateral sclerosis.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, May
            2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51334.1, SRR3476690.1086746.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000605844.6/ ENSP00000474096.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1321              AK314194.1         1-1321
            1322-1847           BG403710.1         103-628
            1848-2154           BC046099.1         1809-2115
            2155-2162           AI351964.1         27-34               c
FEATURES             Location/Qualifiers
     source          1..2162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2162
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /note="TATA-box binding protein associated factor 15"
                     /db_xref="GeneID:8148"
                     /db_xref="HGNC:HGNC:11547"
                     /db_xref="MIM:601574"
     exon            1..93
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1865
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /note="isoform 1 is encoded by transcript variant 1; TATA
                     box-binding protein-associated factor 2N (RNA-binding
                     protein 56); TATA box binding protein (TBP)-associated
                     factor, RNA polymerase II, N, 68kD (RNA-binding protein
                     56); RBP56/CSMF fusion; TBP-associated factor 15; TAF15
                     RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 68kDa"
                     /codon_start=1
                     /product="TATA-binding protein-associated factor 2N
                     isoform 1"
                     /protein_id="NP_631961.1"
                     /db_xref="CCDS:CCDS32623.1"
                     /db_xref="GeneID:8148"
                     /db_xref="HGNC:HGNC:11547"
                     /db_xref="MIM:601574"
                     /translation="MSDSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDS
                     SYGQNYSGYSSYGQSQSGYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRA
                     PSYDQPDYGQQDSYDQQSGYDQHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHT
                     QDDRRDVSRYGEDNRGYGGSQGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDY
                     GPRTDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTD
                     KDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGR
                     RGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGG
                     DFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDR
                     SGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGY
                     GGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGY
                     GGDRGGYGGKMGGRNDYRNDQRNRPY"
     exon            94..133
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            134..185
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            186..270
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            271..376
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            377..570
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            571..691
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            692..726
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            727..759
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            760..869
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            870..999
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1092
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1174
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1263
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1825
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..2162
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2130..2135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /note="hexamer: AATAAA"
     polyA_site      2162
                     /gene="TAF15"
                     /gene_synonym="Npl3; RBP56; TAF2N; TAFII68"
                     /note="major polyA site"
ORIGIN      
        1 agtacagctc cggccgccgc gccgcctggc tttcgtattc gttgttctcg gcgggctgtg
       61 gggcctccgc gccgcggccg ttagtcatgt cggattctgg aagttacggt cagtctgggg
      121 gtgagcagca aagttattct acctatggaa atccaggcag ccaaggctat ggacaagcat
      181 cacaaagcta ttctggctat gggcaaacga ctgattcctc ttatggacag aactacagcg
      241 gttactccag ttatggacaa agtcagtcag gttattcaca gtcctatggt ggttatgaga
      301 atcaaaagca gagctcatat agccagcaac catataataa ccagggacag cagcaaaaca
      361 tggaatcatc aggaagccaa ggtggaagag caccttccta tgaccagcca gactatggtc
      421 aacaagattc atatgaccag cagtcaggct atgatcaaca tcaaggctca tatgatgagc
      481 agtcaaatta tgatcagcag catgattcct atagtcaaaa ccagcagtcc tatcattcac
      541 aaagggaaaa ctacagccac cacacacaag atgaccgtcg tgatgtgagt aggtatggag
      601 aagataatag aggatatggc gggtcacagg gaggaggtag agggcgtggg ggatatgaca
      661 aggatggaag aggtcctatg acaggatcaa gtggtggtga ccgcggtggc ttcaaaaatt
      721 ttggtggtca cagggattat ggacccagaa cagatgctga ttcagaatct gataattcag
      781 ataacaacac aatctttgtg caaggacttg gggagggtgt gtctacagat caagttgggg
      841 agttctttaa acaaatagga attatcaaga caaataagaa gaccggaaaa ccaatgataa
      901 atctttatac agacaaggac acaggaaagc caaaggggga ggcaacagtg tcatttgatg
      961 accctccttc agctaaggca gccattgact ggtttgatgg aaaagaattc catggcaaca
     1021 tcattaaagt gtcctttgcc actagaagac ctgaattcat gagaggaggt ggaagtggag
     1081 gtgggcggcg aggccgtgga ggatatagag gtcgtggagg ctttcaaggg agaggtggag
     1141 accccaaaag tggggattgg gtttgcccta atccgtcatg cggaaatatg aactttgctc
     1201 gaaggaattc ctgcaatcag tgcaatgagc ctagaccaga ggactctcgt ccctcaggag
     1261 gagatttccg ggggagaggc tacggtggag agaggggcta cagaggtcgt gggggcagag
     1321 gtggagaccg aggcggctat ggtggagaca gaagtggggg tggctatggt ggagacagaa
     1381 gcagcggtgg tggctacagc ggagatagaa gtgggggcgg ctatggtgga gacagaagtg
     1441 ggggtggcta tggtggggac agaggcggcg gctatggtgg ggacagagga ggcggctatg
     1501 gaggagaccg aggaggtggc tatggaggag atcgaggtgg ctatggagga gaccgaggtg
     1561 gaggctatgg tggagaccga ggaggctatg gaggagatcg aggaggttac ggaggagatc
     1621 gaggaggtta tggaggagat cgaggaggct atggaggaga cagaagccgg gggggctatg
     1681 gaggagaccg tggtggtggc agtggctacg gtggagaccg aagtggaggc tatggaggag
     1741 acaggagtgg tggcggctat ggaggagacc gaggtggggg ctacggagga gaccgaggtg
     1801 gctatggagg caaaatggga ggaagaaacg actacagaaa tgatcagcgc aaccgaccat
     1861 actgatgact gttttgaatg ttcctttgtc tctgacatga tccatagtga aattgccaga
     1921 gttttgcctg ctgctttcct cgtggcctct tcttgggtag tgaaattaag tgacatttgg
     1981 atttttattt gggtgggagg gctgggacag tttttcttct agaaatgtct gttgagattt
     2041 ccccctttag tttccaacct tctccccaac ccttggagct aaatgcgttg taaaatattg
     2101 ccaaaatgaa aagtgttttg taatactgca ataaaggctg cttgtttttg tggacttttg
     2161 ta
//
