LOCUS       NM_005645                814 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TATA-box binding protein associated factor 13 (TAF13),
            mRNA.
ACCESSION   NM_005645 XM_496381
VERSION     NM_005645.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 814)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 814)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 814)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    GeneRIF: In an integrative approach combining crystal coordinates,
            biochemical analyses and data from cross-linking mass-spectrometry
            (CLMS), the authors determine the architecture of the
            TAF11/TAF13/TBP complex, revealing TAF11/TAF13 interaction with the
            DNA binding surface of TBP.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 814)
  AUTHORS   Tawamie,H., Martianov,I., Wohlfahrt,N., Buchert,R., Mengus,G.,
            Uebe,S., Janiri,L., Hirsch,F.W., Schumacher,J., Ferrazzi,F.,
            Sticht,H., Reis,A., Davidson,I., Colombo,R. and Abou Jamra,R.
  TITLE     Hypomorphic Pathogenic Variants in TAF13 Are Associated with
            Autosomal-Recessive Intellectual Disability and Microcephaly
  JOURNAL   Am J Hum Genet 100 (3), 555-561 (2017)
   PUBMED   28257693
  REMARK    GeneRIF: two homozygous missense are associated with
            autosomal-recessive intellectual disability and microcephaly
REFERENCE   5  (bases 1 to 814)
  AUTHORS   Louder,R.K., He,Y., Lopez-Blanco,J.R., Fang,J., Chacon,P. and
            Nogales,E.
  TITLE     Structure of promoter-bound TFIID and model of human pre-initiation
            complex assembly
  JOURNAL   Nature 531 (7596), 604-609 (2016)
   PUBMED   27007846
  REMARK    Erratum:[Nature. 2016 Aug 4;536(7614):112. doi:
            10.1038/nature17984.. PMID: 27096372]
REFERENCE   6  (bases 1 to 814)
  AUTHORS   Mengus,G., May,M., Jacq,X., Staub,A., Tora,L., Chambon,P. and
            Davidson,I.
  TITLE     Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28:
            three subunits of the human transcription factor TFIID
  JOURNAL   EMBO J 14 (7), 1520-1531 (1995)
   PUBMED   7729427
REFERENCE   7  (bases 1 to 814)
  AUTHORS   Parada,C.A., Yoon,J.B. and Roeder,R.G.
  TITLE     A novel LBP-1-mediated restriction of HIV-1 transcription at the
            level of elongation in vitro
  JOURNAL   J Biol Chem 270 (5), 2274-2283 (1995)
   PUBMED   7836461
REFERENCE   8  (bases 1 to 814)
  AUTHORS   Zhou,Q. and Sharp,P.A.
  TITLE     Novel mechanism and factor for regulation by HIV-1 Tat
  JOURNAL   EMBO J 14 (2), 321-328 (1995)
   PUBMED   7835343
REFERENCE   9  (bases 1 to 814)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 814)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX679664.7, AU280379.1,
            X84003.1 and AV713996.1.
            
            On May 17, 2019 this sequence version replaced NM_005645.3.
            
            Summary: Initiation of transcription by RNA polymerase II requires
            the activities of more than 70 polypeptides. The protein that
            coordinates these activities is transcription factor IID (TFIID),
            which binds to the core promoter to position the polymerase
            properly, serves as the scaffold for assembly of the remainder of
            the transcription complex, and acts as a channel for regulatory
            signals. TFIID is composed of the TATA-binding protein (TBP) and a
            group of evolutionarily conserved proteins known as TBP-associated
            factors or TAFs. TAFs may participate in basal transcription, serve
            as coactivators, function in promoter recognition or modify general
            transcription factors (GTFs) to facilitate complex assembly and
            transcription initiation. This gene encodes a small subunit
            associated with a subset of TFIID complexes. This subunit interacts
            with TBP and with two other small subunits of TFIID, TAF10 and
            TAF11. There is a pseudogene located on chromosome 6. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.374035.1,
                                           SRR1660807.313507.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142670 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338366.6/ ENSP00000355051.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BX679664.7         104324-104324       c
            2-45                AU280379.1         1-44
            46-458              X84003.1           1-413
            459-578             AV713996.1         405-524
            579-814             BX679664.7         92461-92696         c
FEATURES             Location/Qualifiers
     source          1..814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..814
                     /gene="TAF13"
                     /gene_synonym="MRT60; TAF(II)18; TAF2K; TAFII-18; TAFII18"
                     /note="TATA-box binding protein associated factor 13"
                     /db_xref="GeneID:6884"
                     /db_xref="HGNC:HGNC:11546"
                     /db_xref="MIM:600774"
     exon            1..83
                     /gene="TAF13"
                     /gene_synonym="MRT60; TAF(II)18; TAF2K; TAFII-18; TAFII18"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..431
                     /gene="TAF13"
                     /gene_synonym="MRT60; TAF(II)18; TAF2K; TAFII-18; TAFII18"
                     /note="TATA box binding protein (TBP)-associated factor,
                     RNA polymerase II, K, 18kD; transcription initiation
                     factor TFIID 18 kD subunit; transcription initiation
                     factor TFIID 18 kDa subunit; TAF13 RNA polymerase II, TATA
                     box binding protein (TBP)-associated factor, 18kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit
                     13"
                     /protein_id="NP_005636.1"
                     /db_xref="CCDS:CCDS30788.1"
                     /db_xref="GeneID:6884"
                     /db_xref="HGNC:HGNC:11546"
                     /db_xref="MIM:600774"
                     /translation="MADEEEDPTFEEENEEIGGGAEGGQGKRKRLFSKELRCMMYGFG
                     DDQNPYTESVDILEDLVIEFITEMTHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKD
                     LLTMNEELKRARKAFDEANYGS"
     exon            84..162
                     /gene="TAF13"
                     /gene_synonym="MRT60; TAF(II)18; TAF2K; TAFII-18; TAFII18"
                     /inference="alignment:Splign:2.1.0"
     exon            163..260
                     /gene="TAF13"
                     /gene_synonym="MRT60; TAF(II)18; TAF2K; TAFII-18; TAFII18"
                     /inference="alignment:Splign:2.1.0"
     exon            261..814
                     /gene="TAF13"
                     /gene_synonym="MRT60; TAF(II)18; TAF2K; TAFII-18; TAFII18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      525..530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF13"
                     /gene_synonym="MRT60; TAF(II)18; TAF2K; TAFII-18; TAFII18"
                     /note="hexamer: AATGAA"
     polyA_site      531
                     /gene="TAF13"
                     /gene_synonym="MRT60; TAF(II)18; TAF2K; TAFII-18; TAFII18"
     polyA_site      547
                     /gene="TAF13"
                     /gene_synonym="MRT60; TAF(II)18; TAF2K; TAFII-18; TAFII18"
                     /note="major polyA site"
     polyA_site      683
                     /gene="TAF13"
                     /gene_synonym="MRT60; TAF(II)18; TAF2K; TAFII-18; TAFII18"
ORIGIN      
        1 agtgtaacca gctgggagcc agccggcagg acgctgtgag ttggcgtgct agtgggatgg
       61 cagatgagga agaagacccc acgtttgagg aagaaaatga agaaattgga ggaggtgcag
      121 aaggtggaca gggtaaaaga aagagacttt tttctaaaga attgcgatgt atgatgtatg
      181 gctttgggga tgaccagaat ccttatactg agtcagtgga tattcttgaa gatcttgtca
      241 tagagtttat cactgaaatg actcacaagg caatgtcaat tggaagacaa ggtcgagtac
      301 aagttgaaga tatcgtcttc ttgattcgaa aggacccaag gaagtttgcc agggttaaag
      361 acttgcttac tatgaatgaa gaattgaaac gagctagaaa agcatttgat gaagcaaatt
      421 atggatcttg acactttttg tagtttccga aaattaccat ctggggaaac catatataat
      481 aattgtatat tttctaaagt aagattctga tatctagcca tgtaaatgaa agatggagaa
      541 acacaaagtt ttcagccttt atttttatgc ctttgatttt agggtgatat tggtgcatgt
      601 aattgcctgc ctttatatta ccatacttga attacttact gggttttaat gaccacacat
      661 aagtcaaagt accttgcaaa ccatgccgtt gttctgactt ttgactattt aaaggataaa
      721 gtagtattta atgtgttagg tatgtttatg cccttgtaag ctatactgta gctttttttt
      781 tttttttttt tttttttgag atggagtctc acta
//
