LOCUS       NM_005643               1849 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TATA-box binding protein associated factor 11 (TAF11),
            transcript variant 1, mRNA.
ACCESSION   NM_005643
VERSION     NM_005643.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1849)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1849)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    GeneRIF: In an integrative approach combining crystal coordinates,
            biochemical analyses and data from cross-linking mass-spectrometry
            (CLMS), the authors determine the architecture of the
            TAF11/TAF13/TBP complex, revealing TAF11/TAF13 interaction with the
            DNA binding surface of TBP.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1849)
  AUTHORS   Louder,R.K., He,Y., Lopez-Blanco,J.R., Fang,J., Chacon,P. and
            Nogales,E.
  TITLE     Structure of promoter-bound TFIID and model of human pre-initiation
            complex assembly
  JOURNAL   Nature 531 (7596), 604-609 (2016)
   PUBMED   27007846
  REMARK    Erratum:[Nature. 2016 Aug 4;536(7614):112. doi:
            10.1038/nature17984.. PMID: 27096372]
REFERENCE   4  (bases 1 to 1849)
  AUTHORS   Cianfrocco,M.A., Kassavetis,G.A., Grob,P., Fang,J.,
            Juven-Gershon,T., Kadonaga,J.T. and Nogales,E.
  TITLE     Human TFIID binds to core promoter DNA in a reorganized structural
            state
  JOURNAL   Cell 152 (1-2), 120-131 (2013)
   PUBMED   23332750
REFERENCE   5  (bases 1 to 1849)
  AUTHORS   Manning,A.K., Hivert,M.F., Scott,R.A., Grimsby,J.L.,
            Bouatia-Naji,N., Chen,H., Rybin,D., Liu,C.T., Bielak,L.F.,
            Prokopenko,I., Amin,N., Barnes,D., Cadby,G., Hottenga,J.J.,
            Ingelsson,E., Jackson,A.U., Johnson,T., Kanoni,S., Ladenvall,C.,
            Lagou,V., Lahti,J., Lecoeur,C., Liu,Y., Martinez-Larrad,M.T.,
            Montasser,M.E., Navarro,P., Perry,J.R., Rasmussen-Torvik,L.J.,
            Salo,P., Sattar,N., Shungin,D., Strawbridge,R.J., Tanaka,T., van
            Duijn,C.M., An,P., de Andrade,M., Andrews,J.S., Aspelund,T.,
            Atalay,M., Aulchenko,Y., Balkau,B., Bandinelli,S., Beckmann,J.S.,
            Beilby,J.P., Bellis,C., Bergman,R.N., Blangero,J., Boban,M.,
            Boehnke,M., Boerwinkle,E., Bonnycastle,L.L., Boomsma,D.I.,
            Borecki,I.B., Bottcher,Y., Bouchard,C., Brunner,E., Budimir,D.,
            Campbell,H., Carlson,O., Chines,P.S., Clarke,R., Collins,F.S.,
            Corbaton-Anchuelo,A., Couper,D., de Faire,U., Dedoussis,G.V.,
            Deloukas,P., Dimitriou,M., Egan,J.M., Eiriksdottir,G., Erdos,M.R.,
            Eriksson,J.G., Eury,E., Ferrucci,L., Ford,I., Forouhi,N.G.,
            Fox,C.S., Franzosi,M.G., Franks,P.W., Frayling,T.M., Froguel,P.,
            Galan,P., de Geus,E., Gigante,B., Glazer,N.L., Goel,A., Groop,L.,
            Gudnason,V., Hallmans,G., Hamsten,A., Hansson,O., Harris,T.B.,
            Hayward,C., Heath,S., Hercberg,S., Hicks,A.A., Hingorani,A.,
            Hofman,A., Hui,J., Hung,J., Jarvelin,M.R., Jhun,M.A., Johnson,P.C.,
            Jukema,J.W., Jula,A., Kao,W.H., Kaprio,J., Kardia,S.L.,
            Keinanen-Kiukaanniemi,S., Kivimaki,M., Kolcic,I., Kovacs,P.,
            Kumari,M., Kuusisto,J., Kyvik,K.O., Laakso,M., Lakka,T.,
            Lannfelt,L., Lathrop,G.M., Launer,L.J., Leander,K., Li,G., Lind,L.,
            Lindstrom,J., Lobbens,S., Loos,R.J., Luan,J., Lyssenko,V., Magi,R.,
            Magnusson,P.K., Marmot,M., Meneton,P., Mohlke,K.L., Mooser,V.,
            Morken,M.A., Miljkovic,I., Narisu,N., O'Connell,J., Ong,K.K.,
            Oostra,B.A., Palmer,L.J., Palotie,A., Pankow,J.S., Peden,J.F.,
            Pedersen,N.L., Pehlic,M., Peltonen,L., Penninx,B., Pericic,M.,
            Perola,M., Perusse,L., Peyser,P.A., Polasek,O., Pramstaller,P.P.,
            Province,M.A., Raikkonen,K., Rauramaa,R., Rehnberg,E., Rice,K.,
            Rotter,J.I., Rudan,I., Ruokonen,A., Saaristo,T., Sabater-Lleal,M.,
            Salomaa,V., Savage,D.B., Saxena,R., Schwarz,P., Seedorf,U.,
            Sennblad,B., Serrano-Rios,M., Shuldiner,A.R., Sijbrands,E.J.,
            Siscovick,D.S., Smit,J.H., Small,K.S., Smith,N.L., Smith,A.V.,
            Stancakova,A., Stirrups,K., Stumvoll,M., Sun,Y.V., Swift,A.J.,
            Tonjes,A., Tuomilehto,J., Trompet,S., Uitterlinden,A.G.,
            Uusitupa,M., Vikstrom,M., Vitart,V., Vohl,M.C., Voight,B.F.,
            Vollenweider,P., Waeber,G., Waterworth,D.M., Watkins,H.,
            Wheeler,E., Widen,E., Wild,S.H., Willems,S.M., Willemsen,G.,
            Wilson,J.F., Witteman,J.C., Wright,A.F., Yaghootkar,H.,
            Zelenika,D., Zemunik,T., Zgaga,L., Wareham,N.J., McCarthy,M.I.,
            Barroso,I., Watanabe,R.M., Florez,J.C., Dupuis,J., Meigs,J.B. and
            Langenberg,C.
  CONSRTM   DIAbetes Genetics Replication And Meta-analysis (DIAGRAM)
            Consortium; Multiple Tissue Human Expression Resource (MUTHER)
            Consortium
  TITLE     A genome-wide approach accounting for body mass index identifies
            genetic variants influencing fasting glycemic traits and insulin
            resistance
  JOURNAL   Nat Genet 44 (6), 659-669 (2012)
   PUBMED   22581228
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1849)
  AUTHORS   Mengus,G., May,M., Jacq,X., Staub,A., Tora,L., Chambon,P. and
            Davidson,I.
  TITLE     Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28:
            three subunits of the human transcription factor TFIID
  JOURNAL   EMBO J 14 (7), 1520-1531 (1995)
   PUBMED   7729427
REFERENCE   7  (bases 1 to 1849)
  AUTHORS   Parada,C.A., Yoon,J.B. and Roeder,R.G.
  TITLE     A novel LBP-1-mediated restriction of HIV-1 transcription at the
            level of elongation in vitro
  JOURNAL   J Biol Chem 270 (5), 2274-2283 (1995)
   PUBMED   7836461
REFERENCE   8  (bases 1 to 1849)
  AUTHORS   Zhou,Q. and Sharp,P.A.
  TITLE     Novel mechanism and factor for regulation by HIV-1 Tat
  JOURNAL   EMBO J 14 (2), 321-328 (1995)
   PUBMED   7835343
REFERENCE   9  (bases 1 to 1849)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 1849)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA153455.1, BC021972.2,
            AI755269.1 and AL033520.16.
            
            On May 17, 2019 this sequence version replaced NM_005643.3.
            
            Summary: Initiation of transcription by RNA polymerase II requires
            the activities of more than 70 polypeptides. The protein that
            coordinates these activities is transcription factor IID (TFIID),
            which binds to the core promoter to position the polymerase
            properly, serves as the scaffold for assembly of the remainder of
            the transcription complex, and acts as a channel for regulatory
            signals. TFIID is composed of the TATA-binding protein (TBP) and a
            group of evolutionarily conserved proteins known as TBP-associated
            factors or TAFs. TAFs may participate in basal transcription, serve
            as coactivators, function in promoter recognition or modify general
            transcription factors (GTFs) to facilitate complex assembly and
            transcription initiation. This gene encodes a small subunit of
            TFIID that is present in all TFIID complexes and interacts with
            TBP. This subunit also interacts with another small subunit, TAF13,
            to form a heterodimer with a structure similar to the histone core
            structure. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.107942.1,
                                           SRR1803612.192492.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361288.9/ ENSP00000354633.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DA153455.1         30-44
            16-1532             BC021972.2         1-1517
            1533-1533           AI755269.1         26-26               c
            1534-1849           AL033520.16        34691-35006         c
FEATURES             Location/Qualifiers
     source          1..1849
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..1849
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
                     /note="TATA-box binding protein associated factor 11"
                     /db_xref="GeneID:6882"
                     /db_xref="HGNC:HGNC:11544"
                     /db_xref="MIM:600772"
     exon            1..256
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..721
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
                     /note="isoform 1 is encoded by transcript variant 1; TATA
                     box binding protein (TBP)-associated factor, RNA
                     polymerase II, I, 28kD; TFIID subunit p30-beta;
                     transcription initiation factor TFIID 28 kD subunit;
                     transcription initiation factor TFIID subunit 11;
                     TAFII-28; TAF(II)28; transcription initiation factor TFIID
                     28 kDa subunit; TAF11 RNA polymerase II, TATA box binding
                     protein (TBP)-associated factor, 28kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 11
                     isoform 1"
                     /protein_id="NP_005634.1"
                     /db_xref="CCDS:CCDS4797.1"
                     /db_xref="GeneID:6882"
                     /db_xref="HGNC:HGNC:11544"
                     /db_xref="MIM:600772"
                     /translation="MDDAHESPSDKGGETGESDETAAVPGDPGATDTDGIPEETDGDA
                     DVDLKEAAAEEGELESQDVSDLTTVEREDSSLLNPAAKKLKIDTKEKKEKKQKVDEDE
                     IQKMQILVSSFSEEQLNRYEMYRRSAFPKAAIKRLIQSITGTSVSQNVVIAMSGISKV
                     FVGEVVEEALDVCEKWGEMPPLQPKHMREAVRRLKSKGQIPNSKHKKIIFF"
     exon            257..405
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
                     /inference="alignment:Splign:2.1.0"
     exon            406..493
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
                     /inference="alignment:Splign:2.1.0"
     exon            494..590
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1849
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1512..1517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
                     /note="hexamer: ATTAAA"
     polyA_site      1533
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
                     /note="major polyA site"
     regulatory      1601..1606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
                     /note="hexamer: AATACA"
     polyA_site      1631
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
     regulatory      1738..1743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
                     /note="hexamer: AATAAA"
     polyA_site      1758
                     /gene="TAF11"
                     /gene_synonym="MGC:15243; PRO2134; TAF2I; TAFII28"
ORIGIN      
        1 aagatcctgg cctgtgcagc tcgggtttcc gagcttctgc ctcaggcatc tccgcgatct
       61 cctctcccct ccaatcctat ccgtgatgga cgatgcccac gagtcgccct ccgacaaagg
      121 tggagagaca ggggagtcgg atgagacggc cgctgtgccc ggggacccgg gggctaccga
      181 caccgatgga atcccagagg aaactgacgg agacgcagat gtggacttga aagaagctgc
      241 agcggaggaa ggcgagctcg agagtcagga tgtctcagat ttaacaacag ttgaaaggga
      301 agactcatca ttacttaatc ctgcagccaa aaaactgaaa atagatacca aagaaaagaa
      361 agagaaaaag cagaaagtag atgaagatga gattcagaag atgcaaatcc tggtttcttc
      421 tttttctgag gagcagctga accgttatga aatgtatcgc cgctcagctt tccctaaggc
      481 agccatcaaa aggctgatcc agtccatcac tggcacctct gtgtctcaga atgttgttat
      541 tgctatgtct ggtatttcca aggttttcgt cggggaggtg gtagaagaag cactggatgt
      601 gtgtgagaag tggggagaaa tgccaccact acaacccaaa catatgaggg aagccgttag
      661 aaggttaaag tcaaaaggac agatccctaa ctcgaagcac aaaaaaatca tcttcttcta
      721 gaccaaagtc tagaaaggcc tatgttactg acggaagaag tattggttcc agacttccta
      781 taagactgtc tgcattggtg ctttagtatc tcaggcctcc aaggattcca tgatgatttt
      841 aatgtctttc tcaaaactct gatatttgtc acacctagaa agtatgtagc ctgattgata
      901 cttgccttga ctaaattttg ggacctcttg gggcattttg aagtatttaa ctgtcttgac
      961 cagttggaag aagatacgtg ggccataagc atcttctgga caggggaact gctttcagag
     1021 agaaaacctt tccaagagag ttttgttttg ttttggtttc gttttgtttg agatagggtc
     1081 ttgctctatc acctaggctg gagtgcagcg gcatgactgc agccttgaac tcctgggctt
     1141 aagtgaccct cccacctcag tctcctgagt agctaggact acaggcacac actactgtgc
     1201 ccagctaact tatttttatt ttttatggag atggggtctt gctttgttgc ccaggctggt
     1261 cgtgaactcc tggcttcaag cagtcctcct gcctcagcct cctaaagtgc tgagggcttt
     1321 aatggtttca cattgaagcc tgaagttgct aagacttagg ttgtttctta tatctggttt
     1381 taagtagatg aaacaaccag aaacttttac ttgtgatact ctaccatgaa ggatgcggta
     1441 atggcaggaa tagcagaata attggtgctt gtaaacattt aagattctcc tgtggatttt
     1501 ggtgagtgat cattaaactg ttttccaact tgccctaggt gtattcattt tctgtctagc
     1561 tggttggaat gggaagttga tcattctttt ttggtgttcc aatacaactg gttttggcta
     1621 ttttgtgaaa atttgagcac tttttctagt agaaccatta aaattttatc tcataaaaga
     1681 gtacttcaag cactgttaaa aacagtgtaa taattccccc cccaagactg agatgaaaat
     1741 aaacaatata aaagcccata tatttcagat tcttatcaac ggatatacaa caatcattat
     1801 ggtttaatac atttaatttg ttttttcagg tggttcacag aaccagtac
//
