LOCUS       NM_006284               5312 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TATA-box binding protein associated factor 10 (TAF10),
            mRNA.
ACCESSION   NM_006284
VERSION     NM_006284.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5312)
  AUTHORS   Xiong,Y., Wang,L., Xu,S., Fu,B., Che,Y., Zaky,M.Y., Tian,R.,
            Yao,R., Guo,D., Sha,Z., Lin,F., Lin,X. and Wu,H.
  TITLE     Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase
            TRIP12 to suppress tumour growth
  JOURNAL   Clin Transl Med 13 (1), e1153 (2023)
   PUBMED   36639831
  REMARK    GeneRIF: Small molecule Z363 co-regulates TAF10 and MYC via the E3
            ligase TRIP12 to suppress tumour growth.
REFERENCE   2  (bases 1 to 5312)
  AUTHORS   Gupta,K., Watson,A.A., Baptista,T., Scheer,E., Chambers,A.L.,
            Koehler,C., Zou,J., Obong-Ebong,I., Kandiah,E., Temblador,A.,
            Round,A., Forest,E., Man,P., Bieniossek,C., Laue,E.D., Lemke,E.A.,
            Rappsilber,J., Robinson,C.V., Devys,D., Tora,L. and Berger,I.
  TITLE     Architecture of TAF11/TAF13/TBP complex suggests novel regulation
            properties of general transcription factor TFIID
  JOURNAL   Elife 6, e30395 (2017)
   PUBMED   29111974
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5312)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 5312)
  AUTHORS   Louder,R.K., He,Y., Lopez-Blanco,J.R., Fang,J., Chacon,P. and
            Nogales,E.
  TITLE     Structure of promoter-bound TFIID and model of human pre-initiation
            complex assembly
  JOURNAL   Nature 531 (7596), 604-609 (2016)
   PUBMED   27007846
  REMARK    Erratum:[Nature. 2016 Aug 4;536(7614):112. doi:
            10.1038/nature17984.. PMID: 27096372]
REFERENCE   5  (bases 1 to 5312)
  AUTHORS   Iturbide,A., Pascual-Reguant,L., Fargas,L., Cebria,J.P., Alsina,B.,
            Garcia de Herreros,A. and Peiro,S.
  TITLE     LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes
            during Neural Progenitor Differentiation
  JOURNAL   Mol Cell 58 (5), 755-766 (2015)
   PUBMED   25959397
  REMARK    GeneRIF: Lysine oxidation of the transcription factor TAF10 by
            LOXL2 is a controlled protein modification and demonstrates a role
            for protein oxidation in regulating pluripotency genes.
REFERENCE   6  (bases 1 to 5312)
  AUTHORS   Mengus,G., May,M., Jacq,X., Staub,A., Tora,L., Chambon,P. and
            Davidson,I.
  TITLE     Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28:
            three subunits of the human transcription factor TFIID
  JOURNAL   EMBO J 14 (7), 1520-1531 (1995)
   PUBMED   7729427
REFERENCE   7  (bases 1 to 5312)
  AUTHORS   Parada,C.A., Yoon,J.B. and Roeder,R.G.
  TITLE     A novel LBP-1-mediated restriction of HIV-1 transcription at the
            level of elongation in vitro
  JOURNAL   J Biol Chem 270 (5), 2274-2283 (1995)
   PUBMED   7836461
REFERENCE   8  (bases 1 to 5312)
  AUTHORS   Zhou,Q. and Sharp,P.A.
  TITLE     Novel mechanism and factor for regulation by HIV-1 Tat
  JOURNAL   EMBO J 14 (2), 321-328 (1995)
   PUBMED   7835343
REFERENCE   9  (bases 1 to 5312)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 5312)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091564.12, BM990572.1 and
            KF510380.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006284.3.
            
            Summary: Initiation of transcription by RNA polymerase II requires
            the activities of more than 70 polypeptides. The protein that
            coordinates these activities is transcription factor IID (TFIID),
            which binds to the core promoter to position the polymerase
            properly, serves as the scaffold for assembly of the remainder of
            the transcription complex, and acts as a channel for regulatory
            signals. TFIID is composed of the TATA-binding protein (TBP) and a
            group of evolutionarily conserved proteins known as TBP-associated
            factors or TAFs. TAFs may participate in basal transcription, serve
            as coactivators, function in promoter recognition or modify general
            transcription factors (GTFs) to facilitate complex assembly and
            transcription initiation. This gene encodes one of the small
            subunits of TFIID that is associated with a subset of TFIID
            complexes. Studies with human and mammalian cells have shown that
            this subunit is required for transcriptional activation by the
            estrogen receptor, for progression through the cell cycle, and may
            also be required for certain cellular differentiation programs.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4282431.1, BM762151.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299424.9/ ENSP00000299424.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AC091564.12        9456-9714           c
            260-414             AC091564.12        9162-9316           c
            415-479             AC091564.12        8886-8950           c
            480-594             AC091564.12        8687-8801           c
            595-761             AC091564.12        8343-8509           c
            762-789             BM990572.1         18-45               c
            790-2620            AC091564.12        6484-8314           c
            2621-3011           KF510380.1         1-391
            3012-5312           AC091564.12        3791-6091           c
FEATURES             Location/Qualifiers
     source          1..5312
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..5312
                     /gene="TAF10"
                     /gene_synonym="TAF2A; TAF2H; TAFII30"
                     /note="TATA-box binding protein associated factor 10"
                     /db_xref="GeneID:6881"
                     /db_xref="HGNC:HGNC:11543"
                     /db_xref="MIM:600475"
     exon            1..259
                     /gene="TAF10"
                     /gene_synonym="TAF2A; TAF2H; TAFII30"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..684
                     /gene="TAF10"
                     /gene_synonym="TAF2A; TAF2H; TAFII30"
                     /note="TATA box binding protein (TBP)-associated factor,
                     RNA polymerase II, H, 30kD; transcription initiation
                     factor TFIID 30 kD subunit; STAF28; TAF10 RNA polymerase
                     II, TATA box binding protein (TBP)-associated factor,
                     30kDa; TAFII-30; TAF(II)30; transcription initiation
                     factor TFIID 30 kDa subunit"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit
                     10"
                     /protein_id="NP_006275.1"
                     /db_xref="CCDS:CCDS7769.1"
                     /db_xref="GeneID:6881"
                     /db_xref="HGNC:HGNC:11543"
                     /db_xref="MIM:600475"
                     /translation="MSCSGSGADPEAAPASAASAPGPAPPVSAPAALPSSTAAENKAS
                     PAGTAGGPGAGAAAGGTGPLAARAGEPAERRGAAPVSAGGAAPPEGAISNGVYVLPSA
                     ANGDVKPVVSSTPLVDFLMQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQ
                     KFISDIANDALQHCKMKGTASGSSRSKSKDRKYTLTMEDLTPALSEYGINVKKPHYFT
                     "
     exon            260..414
                     /gene="TAF10"
                     /gene_synonym="TAF2A; TAF2H; TAFII30"
                     /inference="alignment:Splign:2.1.0"
     exon            415..479
                     /gene="TAF10"
                     /gene_synonym="TAF2A; TAF2H; TAFII30"
                     /inference="alignment:Splign:2.1.0"
     exon            480..594
                     /gene="TAF10"
                     /gene_synonym="TAF2A; TAF2H; TAFII30"
                     /inference="alignment:Splign:2.1.0"
     exon            595..5312
                     /gene="TAF10"
                     /gene_synonym="TAF2A; TAF2H; TAFII30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      743..748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF10"
                     /gene_synonym="TAF2A; TAF2H; TAFII30"
                     /note="hexamer: AATAAA"
     polyA_site      764
                     /gene="TAF10"
                     /gene_synonym="TAF2A; TAF2H; TAFII30"
                     /note="major polyA site"
     regulatory      5291..5296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF10"
                     /gene_synonym="TAF2A; TAF2H; TAFII30"
                     /note="hexamer: AATAAA"
     polyA_site      5312
                     /gene="TAF10"
                     /gene_synonym="TAF2A; TAF2H; TAFII30"
ORIGIN      
        1 ctgttcgccg cctctcccac cggcccgatg agctgcagcg gctccggcgc ggaccccgag
       61 gcggcgccgg cctccgccgc ctcggccccg ggccccgcgc ccccggtctc ggctcccgcc
      121 gcgctgccct ccagcaccgc cgcggagaac aaggccagcc ccgcggggac agcgggggga
      181 cctggggctg gagcagctgc tgggggcacg ggacccttgg cggcgcgggc cggggagcca
      241 gctgagcggc gtggggcggc tccggtgtcg gcgggtggcg cggcgccccc ggagggggcc
      301 atatctaacg gggtttacgt actgccgagc gcggccaacg gagacgtgaa gcccgtggtg
      361 tccagcacgc ctttggtgga cttcttgatg cagctggaag attacacgcc tacgatccca
      421 gatgcagtga ctggttacta cctgaaccgt gctggctttg aggcctcaga cccacgcata
      481 attcggctca tctccttagc tgcccagaaa ttcatctcag atattgccaa tgatgcccta
      541 cagcactgca aaatgaaggg cacggcctcc ggcagctccc ggagcaagag caaggaccgc
      601 aagtacactc taaccatgga ggacttgacc cctgccctca gcgagtatgg catcaatgtg
      661 aagaagccgc actacttcac ctgagccacc caacctaaat gtacttatct gtccccatgt
      721 ccccacacca gcctgttttc ataataaact ttattgtgac aggcggggct gatccctccc
      781 atgttgggag acaccatgtg gcaagtgaca aagctctgag cccgcccctc ttggggccac
      841 agtggtaggg atgggggaag gggatggacc ccatggctgg ggtagtacca tgactggagg
      901 cgggggaggc aaccagaggc ctgctgcttt ggggaggtgc attcccccaa ccatgtcccg
      961 acacctctgg agttcaggca aggaccttcc agtcctactt gtcctgcatc ttctcaagga
     1021 taggcacaat catgtcaaat ttgggtcgct ttgcagggtc ttcattcatg cagatcttca
     1081 tgagcttaca cacatgaggg gaaatacctg gtgggatggt aggccgaagg ccttccaatg
     1141 ccacctgcga atacaagaaa aaaagcagcc tcacaatttg agtctgtcat gtagagagaa
     1201 gccactggcc cttgggacag gattactgta tatccgaaca aatatgtgag gagccaaggc
     1261 ccactacagt tattttcacc atcaccaacc actcccgcaa cacaaatgta tgctgttgtg
     1321 ctctcacctt cattccaatc tccatattgg agaggtcagc aaagggtacc tcccgtgtca
     1381 ccagttccca cagaagcact gcaaaactcc acatgtctgc tgagcgtctg tttgtgtctt
     1441 caggcttctt ctgcagagct ggagagatag ggcttgtctg ttctggcccc cttgcctgtc
     1501 ctgtctctgc ccccttccac tacttctgag gtggtccttt tttacctccc gacatgatga
     1561 cttcactcac cttcgggggc tacccaggca ggtgcataca tgcgaccagg acattggaaa
     1621 gagaacttga catcagccat gctaattcgg gcagtcatgt cctcatcaat ctgaggaaga
     1681 gaaaacagat agaaggaggt aagtcataga taggcaaagg gcttttgggg cctgggccag
     1741 gagtgagctt gtggcctcac cattacacta cggctattga gtgcatgtcg tgggatgagg
     1801 ggctctagtg tgtgtaggaa ggccatgccc cttgccatgt ccaaagcaaa cttcacagcc
     1861 tggctctggt ccacgacgaa atctgagagg aggcaaaagt caaatagttc agagaggctc
     1921 cctctctgcc atttcctccc caaggaaatt caacatccct actcactggt gccttcatgt
     1981 agtacattgt agagggatcc atacggcatc cagtgtgtga tgagagtagg atgaggagca
     2041 ggtggagact ggcaggcacc tagcactggg agcacatttg gatgcgagaa aatcctagaa
     2101 gagggaggga gtggttgaga cccagtacaa aagatctctt tcagtgctat tcagggttcc
     2161 ttggaactag cagcttccag gttacgcctt gcactacctg agccggggac actcttcatt
     2221 gaagtccctg ctcttccttg tactccagtc tcgaaccttc agcaccttca cgacaatgtc
     2281 attgccctgc cagcggccct tccatagctg caggacaggt aggggttagg aggcttgaaa
     2341 tgttgctgcc acttccttgc ccactaactg gaggaaaaac ttaaaacagg tacaaagcaa
     2401 gtaatttatg ggggtttagt gagggaaggg caagaagggc aggggtcacc tctccagagt
     2461 gattctcgtt gagcttcgtc aggaagttaa gctgtttgaa gtcaatgcca gagtgtttgt
     2521 tcagggttcc atttcctaag agtgtgggca ggtcaggtac ccagcttcac cctaacccag
     2581 ccccaagagg ccaggattat ttccttttac aacccttctt cccacagtgg tgactcacgg
     2641 ggccgagtgc gggtggtccc cttccagaat gtgtccttgt atggaatacg gttgagattc
     2701 tggcccatct tctctgcccg ctctagggaa gaaaaacaac ctaagctgtg gtacagaggg
     2761 agaagacagg tgggaaggga cgagaggaca caagctaggg gatggggaga tggacctcgg
     2821 agaagctctc tcaggggtgc cttggctttg tccacaggca tctctccata cttgttacag
     2881 atgctgacaa gggccccatt tgccaccagg tcctggaatg aaaaggccat tatgatgaga
     2941 gccactgcta cctcgctggc agtcactgaa ccaaccatga atgcacaaat gtagaactta
     3001 atcctgtaag tgtcacacag tagtactgac agaatgggtt gagggttcca aaatctccca
     3061 ccaaggctca gactttactt cctacccatc tcaggaatta agggctgagt actcacctct
     3121 gccacttgat cttggcccca aaaacaggca tagtgcaggg gcacattccc gtgttcattc
     3181 actgcattga tgtctgcctt gtactgcaat agctggaccc catggccaga caaaaagaag
     3241 aggcagaaag tacagtcagt tccaaatgag atactggtgt cagggcatgg gaaaaggggg
     3301 aagagcacac atgctttcta ctgtatgtta cagtgcctgt gactgaccct catggcatgt
     3361 atgtgatgtg gatgacgaag gagtttgtac gtaccttctg tacaatatca cggtgtccat
     3421 gactggctgc cagatgcagg ggggtgtcat ccccacggtt cattacattg atccgtgccc
     3481 cccgcatgat caacatctca accacagcag agcggccctc tcggcaggcc cagtgcaagg
     3541 gggagaagcc atgatcgtcc ctttgaggaa ggggcaatgg tcattgagct ggaggtggga
     3601 tggggcaaag gttttgattc ctgaaaaact gataattaca tactctctgg gaaggcttac
     3661 ctctctagga ctttgattct cattcatgcc agcaactccc aaagctgtcc atttcagacc
     3721 ttcccctgag cttcaaacca aaccaaccac ctagatatct caacaacctc tataaaaaaa
     3781 tgtgttatct tcaccatatc ccacatctca tttccttagg tggtagtgct cttcccctgg
     3841 tttctcttgc accccttctg caacatctat tggtcctttc tgttttccac cacatcttat
     3901 atgtccccct acttcagcac ttgttgcact ggattgtaaa aatctgttaa tggactgtct
     3961 tgtctgttag acctttaagt ttcttgaggg aatggattga cagcagctgt tcagtgcatg
     4021 ttagtggggg agaagggtgt cttggagaag gcaggccaca acttatagaa gagggaacaa
     4081 acttactatt tggctctggt actgaaacta acatctaaaa atggaatgga atttaaatga
     4141 tgttttggaa gggtttatgt tgaaaaggag aaatgctttt gactactgat gaggtagata
     4201 acaaaccacc atgcaaagca ggattcccct acttagcaat cctgtgcata gaaaacagaa
     4261 gaaaatgaga atggctgttt tgggattaaa actatacctg atttttttct tttccaagaa
     4321 atatgtattt tataaagtaa agtatacaaa caaaacaaaa caattggttt ggagctgggc
     4381 ctgcctgaca gcctggggcc ataaaaggaa attccctcca gttcggggct gcagattcaa
     4441 ggggcggagc agggggcggt ccgtggtctg ggccagcagc ctccggatgc cttagtgttg
     4501 tggtcacttc ctgtgtgcga ctctaggcaa ggcctggagc tgatcagggg tctggccatc
     4561 cagatgcccg tacagctgaa ggggttgggg ggtgtggcct ttaagttaat cattttcctc
     4621 cacaacttgc tcgcatctgc taacacagaa atagccaaaa gcttttcctt gagatgggat
     4681 tatccccagg aagcattacg ccccctgttt atcagttggt cttgcctcct agacctttaa
     4741 tttgtgccct gacttatcag cttccagtac tgcctgtggc gccagggcag gccaaactcg
     4801 gggggcaaaa gtatgggcac aagggttctg ttcactatca ggctgcctgc cacctcaggg
     4861 cctggacttc tatctcaaga agacctgcaa ggaattaacc ccctcttcat atccagcata
     4921 tagccaactt tggcccccat actttactcc tcaaaccagc accacaacct tccagtttca
     4981 ttaattccac cccttttcct tctggcagca tcttcctaga gtcttcctag actcagctag
     5041 agtcttccta gatgctaggc ccactgggca actgcctaag cctctatttc ctcaccaaca
     5101 aaacagtaac agtgcttact gtctttatca gggtaccctt tgagaattat atgaaaaatg
     5161 gaacaaatga ctttgcaaag tattaaagag aaatagtgta gaacctaatg ggaaccagtg
     5221 aagtctagac taagatgaca ggtgatcctg acctgtcaaa cctaaaaact aaactccacc
     5281 aattttaaaa aataaagaat ttgattttgc ca
//
