LOCUS       NM_004606               7599 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens TATA-box binding protein associated factor 1 (TAF1),
            transcript variant 1, mRNA.
ACCESSION   NM_004606
VERSION     NM_004606.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7599)
  AUTHORS   Herzfeld,T., Nolte,D., Grznarova,M., Hofmann,A., Schultze,J.L. and
            Muller,U.
  TITLE     X-linked dystonia parkinsonism syndrome (XDP, lubag):
            disease-specific sequence change DSC3 in TAF1/DYT3 affects genes in
            vesicular transport and dopamine metabolism
  JOURNAL   Hum Mol Genet 22 (5), 941-951 (2013)
   PUBMED   23184149
  REMARK    GeneRIF: Although d3-d4 also affect genes potentially related to
            neurodegenerative processes, their physiologic role as splice
            variants of TAF1 awaits further exploration
REFERENCE   2  (bases 1 to 7599)
  AUTHORS   Herzfeld,T., Nolte,D. and Muller,U.
  TITLE     Structural and functional analysis of the human TAF1/DYT3 multiple
            transcript system
  JOURNAL   Mamm Genome 18 (11), 787-795 (2007)
   PUBMED   17952504
  REMARK    GeneRIF: Thirty-eight exons code for TAF1. Five downstream exons of
            yet unknown function can either form transcripts with TAF1 exons or
            be transcribed independently. Splice variants can include d plus at
            least 12 TAF1 exons.
REFERENCE   3  (bases 1 to 7599)
  AUTHORS   Makino,S., Kaji,R., Ando,S., Tomizawa,M., Yasuno,K., Goto,S.,
            Matsumoto,S., Tabuena,M.D., Maranon,E., Dantes,M., Lee,L.V.,
            Ogasawara,K., Tooyama,I., Akatsu,H., Nishimura,M. and Tamiya,G.
  TITLE     Reduced neuron-specific expression of the TAF1 gene is associated
            with X-linked dystonia-parkinsonism
  JOURNAL   Am J Hum Genet 80 (3), 393-406 (2007)
   PUBMED   17273961
  REMARK    GeneRIF: Reduced neuron-specific expression of the TAF1 gene is
            associated with X-linked dystonia-parkinsonism
REFERENCE   4  (bases 1 to 7599)
  AUTHORS   Nolte,D., Niemann,S. and Muller,U.
  TITLE     Specific sequence changes in multiple transcript system DYT3 are
            associated with X-linked dystonia parkinsonism
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10347-10352 (2003)
   PUBMED   12928496
REFERENCE   5  (bases 1 to 7599)
  AUTHORS   Nakashima,T., Sekiguchi,T., Sunamoto,H., Yura,K., Tomoda,S., Go,M.,
            Kere,J., Schlessinger,D. and Nishimoto,T.
  TITLE     Structure of the human CCG1 gene: relationship between the
            exons/introns and functional domain/modules of the protein
  JOURNAL   Gene 141 (2), 193-200 (1994)
   PUBMED   8163188
  REMARK    Erratum:[Gene 1994 Oct 21;148(2):375]
REFERENCE   6  (bases 1 to 7599)
  AUTHORS   Evidente,V.G.H.
  TITLE     X-Linked Dystonia-Parkinsonism
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301662
REFERENCE   7  (bases 1 to 7599)
  AUTHORS   Cook Shukla,L., Schulze,J., Farlow,J., Pankratz,N.D., Wojcieszek,J.
            and Foroud,T.
  TITLE     Parkinson Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301402
REFERENCE   8  (bases 1 to 7599)
  AUTHORS   Klein,C., Lohmann,K., Marras,C. and Munchau,A.
  TITLE     Hereditary Dystonia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301334
REFERENCE   9  (bases 1 to 7599)
  AUTHORS   Sekiguchi,T., Nohiro,Y., Nakamura,Y., Hisamoto,N. and Nishimoto,T.
  TITLE     The human CCG1 gene, essential for progression of the G1 phase,
            encodes a 210-kilodalton nuclear DNA-binding protein
  JOURNAL   Mol Cell Biol 11 (6), 3317-3325 (1991)
   PUBMED   2038334
REFERENCE   10 (bases 1 to 7599)
  AUTHORS   Sekiguchi,T., Miyata,T. and Nishimoto,T.
  TITLE     Molecular cloning of the cDNA of human X chromosomal gene (CCG1)
            which complements the temperature-sensitive G1 mutants, tsBN462 and
            ts13, of the BHK cell line
  JOURNAL   EMBO J 7 (6), 1683-1687 (1988)
   PUBMED   3169001
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB300418.1 and AL590763.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 24, 2019 this sequence version replaced NM_004606.4.
            
            Summary: Initiation of transcription by RNA polymerase II requires
            the activities of more than 70 polypeptides. The protein that
            coordinates these activities is the basal transcription factor
            TFIID, which binds to the core promoter to position the polymerase
            properly, serves as the scaffold for assembly of the remainder of
            the transcription complex, and acts as a channel for regulatory
            signals. TFIID is composed of the TATA-binding protein (TBP) and a
            group of evolutionarily conserved proteins known as TBP-associated
            factors or TAFs. TAFs may participate in basal transcription, serve
            as coactivators, function in promoter recognition or modify general
            transcription factors (GTFs) to facilitate complex assembly and
            transcription initiation. This gene encodes the largest subunit of
            TFIID. This subunit binds to core promoter sequences encompassing
            the transcription start site. It also binds to activators and other
            transcriptional regulators, and these interactions affect the rate
            of transcription initiation. This subunit contains two independent
            protein kinase domains at the N- and C-terminals, but also
            possesses acetyltransferase activity and can act as a
            ubiquitin-activating/conjugating enzyme. Mutations in this gene
            result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism
            disorder. Alternative splicing of this gene results in multiple
            transcript variants. This gene is part of a complex transcription
            unit (TAF1/DYT3), wherein some transcript variants share exons with
            TAF1 as well as additional downstream DYT3 exons. [provided by
            RefSeq, Oct 2013].
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 3, resulting in
            an isoform (1) that is 2 aa shorter than isoform 3. The exon
            combination of this variant is supported by mRNA annotation on DNA
            accession AY623109.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3324062.1,
                                           SRR14038197.2605477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000423759.6/ ENSP00000406549.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4956              AB300418.1         46-5001
            4957-7513           AB300418.1         5008-7564
            7514-7599           AL590763.2         7496-7581
FEATURES             Location/Qualifiers
     source          1..7599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..7599
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /note="TATA-box binding protein associated factor 1"
                     /db_xref="GeneID:6872"
                     /db_xref="HGNC:HGNC:11535"
                     /db_xref="MIM:313650"
     exon            1..138
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..5640
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /EC_number="2.3.1.48"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     complementation of cell cycle block, G1-to-S;
                     transcription initiation factor TFIID subunit 1;
                     transcription factor TFIID p250 polypeptide; cell cycle,
                     G1 phase defect; cell cycle gene 1 protein; TBP-associated
                     factor 250 kDa; TAF1 RNA polymerase II, TATA box binding
                     protein (TBP)-associated factor, 250kDa"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 1
                     isoform 1"
                     /protein_id="NP_004597.3"
                     /db_xref="CCDS:CCDS14412.2"
                     /db_xref="GeneID:6872"
                     /db_xref="HGNC:HGNC:11535"
                     /db_xref="MIM:313650"
                     /translation="MSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDDECKK
                     HLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDESR
                     RYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
                     NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQH
                     DATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQI
                     QEVECSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTD
                     TKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEEN
                     NGTDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYN
                     VQQGFAATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDE
                     NLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPW
                     NLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKY
                     SFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILA
                     EYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQL
                     LQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSK
                     RANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRT
                     GMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEE
                     ENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNK
                     PTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVV
                     RTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDT
                     DSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAASGNNH
                     RDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDE
                     EFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLK
                     LKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVE
                     GTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRR
                     RTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVR
                     KRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEK
                     AINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLE
                     TIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDE
                     HLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQD
                     ESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDE
                     EDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYE
                     GDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGP
                     SVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE"
     exon            139..253
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            254..370
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            371..490
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            491..732
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            733..951
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1170
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1378
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1555
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1683
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1791
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1965
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2139
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2244
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2445
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2587
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2718
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2799
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2949
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3069
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3245
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..3424
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3638
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3804
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..4016
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            4017..4125
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            4126..4224
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4402
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            4403..4470
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            4471..4593
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            4594..4686
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            4687..4771
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            4772..4839
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            4840..4956
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            4957..5082
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            5083..5239
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            5240..5417
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     exon            5418..7599
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7577..7582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /note="hexamer: AATAAA"
     polyA_site      7599
                     /gene="TAF1"
                     /gene_synonym="BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4;
                     MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A;
                     TAFII-250; TAFII250; XDP"
                     /note="major polyA site"
ORIGIN      
        1 atcactgctg ccgccatcat gtcagacacg gacagcgacg aagattccgc tggaggcggc
       61 ccattttctt tagcgggttt ccttttcggc aacatcaatg gagccgggca gctggagggg
      121 gaaagcgtct tggatgatga atgtaagaag cacttggcag gcttgggggc tttggggctg
      181 ggcagcctga tcactgaact cacggcaaat gaagaattga ccgggactga cggtgccttg
      241 gtaaatgatg aagggtgggt taggagtaca gaagatgctg tggactattc agacatcaat
      301 gaggtggcag aagatgaaag ccgaagatac cagcagacga tggggagctt gcagcccctt
      361 tgccactcag attatgatga agatgactat gatgctgatt gtgaagacat tgattgcaag
      421 ttgatgcctc ctccacctcc acccccggga ccaatgaaga aggataagga ccaggattct
      481 attactggtg tgtctgaaaa tggagaaggc atcatcttgc cctccatcat tgccccttcc
      541 tctttggcct cagagaaagt ggacttcagt agttcctctg actcagaatc tgagatggga
      601 cctcaggaag caacacaggc agaatctgaa gatggaaagc tgacccttcc attggctggg
      661 attatgcagc atgatgccac caagctgttg ccaagtgtca cagaactttt tccagaattt
      721 cgacctggaa aggtgttacg ttttctacgt ctttttggac cagggaagaa tgtcccatct
      781 gtttggcgga gtgctcggag aaagaggaag aagaagcacc gtgagctgat acaggaagag
      841 cagatccagg aggtggagtg ctcagtagaa tcagaagtca gccagaagtc tttgtggaac
      901 tacgactacg ctccaccacc acctccagag cagtgtctct ctgatgatga aatcacgatg
      961 atggctcctg tggagtccaa attttcccaa tcaactggag atatagataa agtgacagat
     1021 accaaaccaa gagtggctga gtggcgttat gggcctgccc gactgtggta tgatatgctg
     1081 ggtgtccctg aagatggcag tgggtttgac tatggcttca aactgagaaa gacagaacat
     1141 gaacctgtga taaaatctag aatgatagag gaatttagga aacttgagga aaacaatggc
     1201 actgatcttc tggctgatga aaacttcctg atggtgacac agctgcattg ggaggatgat
     1261 atcatctggg atggggagga tgtcaaacac aaagggacaa aacctcagcg tgcaagcctg
     1321 gcaggctggc ttccttctag catgactagg aatgcgatgg cttacaatgt tcagcaaggt
     1381 tttgcagcca ctcttgatga tgacaaacct tggtactcca tttttcccat tgacaatgag
     1441 gatctggtat atggacgctg ggaggacaat atcatttggg atgctcaggc catgccccgg
     1501 ctgttggaac ctcctgtttt gacacttgat cccaatgatg agaacctcat tttggaaatt
     1561 cctgatgaga aggaagaggc cacctctaac tccccctcca aggagagtaa gaaggaatca
     1621 tctctgaaga agagtcgaat tctcttaggg aaaacaggag tcatcaagga ggaaccacag
     1681 cagaacatgt ctcagccaga agtgaaagat ccatggaatc tctccaatga tgagtattat
     1741 tatcccaagc aacagggtct tcgaggcacc tttggaggga atattatcca gcattcaatt
     1801 cctgctgtgg aattacggca gcccttcttt cccacccaca tggggcccat caaactccgg
     1861 cagttccatc gcccacctct gaaaaagtac tcatttggtg cactttctca gccaggtccc
     1921 cactcagtcc aacctttgct aaagcacatc aaaaaaaagg ccaagatgag agaacaagag
     1981 aggcaagctt caggtggtgg agagatgttt tttatgcgca cacctcagga cctcacaggc
     2041 aaagatggtg atcttattct tgcagaatat agtgaggaaa atggaccctt aatgatgcag
     2101 gttggcatgg caaccaagat aaagaactat tataaacgga aacctggaaa agatcctgga
     2161 gcaccagatt gtaaatatgg ggaaactgtt tactgccata catctccttt cctgggttct
     2221 ctccatcctg gccaattgct gcaagcattt gagaacaacc tttttcgtgc tccaatttat
     2281 cttcataaga tgccagaaac tgatttcttg atcattcgga caagacaggg ttactatatt
     2341 cgggaattag tggatatttt tgtggttggc cagcagtgtc ccttgtttga agttcctggg
     2401 cctaactcca aaagggccaa tacgcatatt cgagactttc tacaggtttt tatttaccgc
     2461 cttttctgga aaagtaaaga tcggccacgg aggatacgaa tggaagatat aaaaaaagcc
     2521 tttccttccc attcagaaag cagcatccgg aagaggctaa agctctgcgc tgacttcaaa
     2581 cgcacaggga tggactcaaa ctggtgggtg cttaagtctg attttcgttt accaacggaa
     2641 gaagagatca gagctatggt gtcaccagag cagtgctgtg cttattatag catgatagct
     2701 gcagagcaac gactgaagga tgctggctat ggtgagaaat ccttttttgc tccagaagaa
     2761 gaaaatgagg aagatttcca gatgaagatt gatgatgaag ttcgcactgc cccttggaac
     2821 accacaaggg ccttcattgc tgccatgaag ggcaagtgtc tgctagaggt gactggggtg
     2881 gcagatccca cggggtgtgg tgaaggattc tcctatgtga agattccaaa caaaccaaca
     2941 cagcagaagg atgataaaga accgcagcca gtgaagaaga cagtgacagg aacagatgca
     3001 gaccttcgtc gcctttccct gaaaaatgcc aagcaacttc tacgtaaatt tggtgtgcct
     3061 gaggaagaga ttaaaaagtt gtcccgctgg gaagtgattg atgtggtgcg cacaatgtca
     3121 acagaacagg ctcgttctgg agaggggccc atgagtaaat ttgcccgtgg atcaaggttt
     3181 tctgtggctg agcatcaaga gcgttacaaa gaggaatgtc agcgcatctt tgacctacag
     3241 aacaaggttc tgtcatcaac tgaagtctta tcaactgaca cagacagcag ctcagctgaa
     3301 gatagtgact ttgaagaaat gggaaagaac attgagaaca tgttgcagaa caagaaaacc
     3361 agctctcagc tttcacgtga acgggaggaa caggagcgga aggaactaca gcgaatgcta
     3421 ctggcagcag gctcagcagc atccggaaac aatcacagag atgatgacac agcttccgtg
     3481 actagcctta actcttctgc cactggacgc tgtctcaaga tttatcgcac gtttcgagat
     3541 gaagagggga aagagtatgt tcgctgtgag acagtccgaa aaccagctgt cattgatgcc
     3601 tatgtgcgca tacggactac aaaagatgag gaattcattc gaaaatttgc cctttttgat
     3661 gaacaacatc gggaagagat gcgaaaagaa cggcggagga ttcaagagca actgaggcgg
     3721 cttaagagga accaggaaaa ggagaagctt aagggtcctc ctgagaagaa gcccaagaaa
     3781 atgaaggagc gtcctgacct aaaactgaaa tgtggggcat gtggtgccat tggacacatg
     3841 aggactaaca aattctgccc cctctattat caaacaaatg cgccaccttc caaccctgtt
     3901 gccatgacag aagaacagga ggaggagttg gaaaagacag tcattcataa tgataatgaa
     3961 gaacttatca aggttgaagg gaccaaaatt gtcttgggga aacagctaat tgagagtgcg
     4021 gatgaggttc gcagaaaatc tctggttctc aagtttccta aacagcagct tcctccaaag
     4081 aagaaacggc gagttggaac cactgttcac tgtgactatt tgaatagacc tcataagtcc
     4141 atccaccggc gccgcacaga ccctatggtg acgctgtcgt ccatcttgga gtctatcatc
     4201 aatgacatga gagatcttcc aaatacatac cctttccaca ctccagtcaa tgcaaaggtt
     4261 gtaaaggact actacaaaat catcactcgg ccaatggacc tacaaacact ccgcgaaaac
     4321 gtgcgtaaac gcctctaccc atctcgggaa gagttcagag agcatctgga gctaattgtg
     4381 aaaaatagtg caacctacaa tgggccaaaa cactcattga ctcagatctc tcaatccatg
     4441 ctggatctct gtgatgaaaa actcaaagag aaagaagaca aattagctcg cttagagaaa
     4501 gctatcaacc ccttgctgga tgatgatgac caagtggcgt tttctttcat tctggacaac
     4561 attgtcaccc agaaaatgat ggcagttcca gattcttggc catttcatca cccagttaat
     4621 aagaaatttg ttccagatta ttacaaagtg attgtcaatc caatggattt agagaccata
     4681 cgtaagaaca tctccaagca caagtatcag agtcgggaga gctttctgga tgatgtaaac
     4741 cttattctgg ccaacagtgt taagtataat ggacctgaga gtcagtatac taagactgcc
     4801 caggagattg tgaacgtctg ttaccagaca ttgactgagt atgatgaaca tttgactcaa
     4861 cttgagaagg atatttgtac tgctaaagaa gcagctttgg aggaagcaga attagaaagc
     4921 ctggacccaa tgaccccagg gccctacacg cctcagcctc ctgatttgta tgataccaac
     4981 acatccctca gtatgtctcg agatgcctct gtatttcaag atgagagcaa tatgtctgtc
     5041 ttggatattc ccagtgccac tccagaaaag caggtaacac aggaaggtga agatggagat
     5101 ggtgatcttg cagatgaaga ggaaggaact gtacaacagc ctcaagccag tgtcctgtat
     5161 gaggatttgc ttatgtctga aggagaagat gatgaggaag atgctgggag tgatgaagaa
     5221 ggagacaatc ctttctctgc tatccagctg agtgaaagtg gaagtgactc tgatgtggga
     5281 tctggtggaa taagacccaa acaaccccgc atgcttcagg agaacacaag gatggacatg
     5341 gaaaatgaag aaagcatgat gtcctatgag ggagacggtg gggaggcttc ccatggtttg
     5401 gaggatagca acatcagtta tgggagctat gaggagcctg atcccaagtc gaacacccaa
     5461 gacacaagct tcagcagcat cggtgggtat gaggtatcag aggaggaaga agatgaggag
     5521 gaggaagagc agcgctctgg gccgagcgta ctaagccagg tccacctgtc agaggacgag
     5581 gaggacagtg aggatttcca ctccattgct ggggacagtg acttggactc tgatgaatga
     5641 ggcttccttt gggcctcctt ggtcagcctt ccctgttctc cagcctaggt ggttcacctt
     5701 tccccaattt gttcatattt gtacagtatc tgatcctgaa atcatgaaat taactaacac
     5761 cttagccttt ttaaaagtag taagtaaatg ataataaatc acctctccta atcttcctgg
     5821 ggcaatgtca ccctttgatt taaaacaaag caaccccctt tcccctacca ctacggaaaa
     5881 gagcaagctc atttttccgt gtcctccttt atttaactcc atttattgct tttggtataa
     5941 tttttccctg gggaaggagg ggaaattatg aaagaactag taactttatg tcctcttgat
     6001 gtattaggaa atttccggcc aggcgtggtg gctcacacct gtaatctcag cactctggga
     6061 ggccgaggcg ggcagatcac ctgaggtcag aagttcgaga ccagcttggc caacatggcg
     6121 aaaccgcatc tctactaaaa atacaaaaat tagccaggtg tggtggcgta tgcctgttaa
     6181 tcctagctac tcgggaggct gaggcaggag aattacttga acccgggagg cagaggttgc
     6241 agtgagtgga ggtcacgcca ctgcactcca gcctgggcga aagagtgaga ttcagtctca
     6301 aaaaaaaaaa aatttccaag catggtatca tctcactttt ctaatttaca ggctggagca
     6361 gatgagagcc ctcctgctgg gacagagaat tgggttctag tggactctgt gctacactta
     6421 aacctgtgag acaaaccgcc cattatttta ttatttaatt atgcaatgcc tagttcctaa
     6481 atggattgga ggcaaattac cgtaaatttt gaaacagcct atatgtcaga aatgataatg
     6541 ttgccaccta aatgttttct gtccccccca ccctccccag gggaaatggt aggaaaatgg
     6601 taagtttctt agggcaaaga ctgtgtcttc tgtttctttt catgcttagg atatggttct
     6661 gtgcatagta ggtactcagt aaatgttcct agaatcataa aatcctcaac agatatgtta
     6721 ctgagcatct gcttttcatg ataagcactc tatcagatcc ttgggatgca aaggtaaata
     6781 agacaaatcc cttttaccca aagagctcac catcaagttg ggggagggaa agtggaattc
     6841 aaaacatgtt aataaatcat catagtactg tgagataagt gcaattaaga agctagttat
     6901 aaagtatagg ggaaatagag gagtaatcat gtctgaaaag tcaggaaagt cttcctagag
     6961 gtaattttta agctgattgt tttagaatta gtagaagctt gccagatgga aaagtccagg
     7021 caaagtgtaa catgaatggg aaaggccaca gtctagaaat ggcagagtgt gttcctagtt
     7081 tgtttgtttg tttgtttgta cctgccttgt tccaggaagg atttaatgtg gtttatattc
     7141 cagtccttta atgctggaag ggctgagatg agactgaaag atgggcagga agtatatcat
     7201 cacaagcttt gtgtttgatg ttaatgtgta tgatttttat attatgggaa ataagctctt
     7261 agaggagtga tataatcagg tttgtgtttt agaaatctgt gtaatgaatg aatgaagaaa
     7321 gaaattgaag aatcatgtaa catatgtgat cgcatttttg taaaagaacc atgtgtgttt
     7381 atatgtgttt atatatatac ttgtgtatgc aaaggtaaaa gtctgaaagg atatatgcta
     7441 actgttcaca atgataaccc cccaggaatg ggattggagg ggagggggct tctgtgtttg
     7501 ttatgtatgc tgggtgggat attgtgcttt tatttctata ttgtttgaat ttttttacag
     7561 tatgtattat ttttgtaata aaaattttaa aaaattcca
//
