LOCUS       NM_006354               1974 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens transcriptional adaptor 3 (TADA3), transcript variant
            1, mRNA.
ACCESSION   NM_006354
VERSION     NM_006354.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1974)
  AUTHORS   Xu,L.Q., Zhang,S.W., Zhang,R., Chen,J.J., Yuan,Z.X., Feng,J. and
            Huang,J.A.
  TITLE     Transcriptional adaptor 3 influences the proliferative and invasive
            phenotypes of non-small cell lung cancer cells via regulating EMT
  JOURNAL   Neoplasma 70 (2), 240-250 (2023)
   PUBMED   37005955
  REMARK    GeneRIF: Transcriptional adaptor 3 influences the proliferative and
            invasive phenotypes of non-small cell lung cancer cells via
            regulating EMT.
REFERENCE   2  (bases 1 to 1974)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1974)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1974)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1974)
  AUTHORS   Zhang,S., Xu,L., Tang,Z., Wang,H., Gu,J., Sun,B., Zhang,W., Niu,D.
            and Feng,J.
  TITLE     Overexpression of Alteration/Deficiency in Activation 3 correlates
            with poor prognosis in non-small cell lung cancer
  JOURNAL   Pathol Res Pract 215 (6), 152408 (2019)
   PUBMED   30954347
  REMARK    GeneRIF: ADA3 expression level elevates in non-small cell lung
            cancer and correlates with poor overall survival in non-small cell
            lung cancer patients
REFERENCE   6  (bases 1 to 1974)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
REFERENCE   7  (bases 1 to 1974)
  AUTHORS   Schiltz,R.L., Mizzen,C.A., Vassilev,A., Cook,R.G., Allis,C.D. and
            Nakatani,Y.
  TITLE     Overlapping but distinct patterns of histone acetylation by the
            human coactivators p300 and PCAF within nucleosomal substrates
  JOURNAL   J Biol Chem 274 (3), 1189-1192 (1999)
   PUBMED   9880483
REFERENCE   8  (bases 1 to 1974)
  AUTHORS   Ogryzko,V.V., Kotani,T., Zhang,X., Schiltz,R.L., Howard,T.,
            Yang,X.J., Howard,B.H., Qin,J. and Nakatani,Y.
  TITLE     Histone-like TAFs within the PCAF histone acetylase complex
  JOURNAL   Cell 94 (1), 35-44 (1998)
   PUBMED   9674425
REFERENCE   9  (bases 1 to 1974)
  AUTHORS   Struhl,K. and Moqtaderi,Z.
  TITLE     The TAFs in the HAT
  JOURNAL   Cell 94 (1), 1-4 (1998)
   PUBMED   9674419
  REMARK    Review article
REFERENCE   10 (bases 1 to 1974)
  AUTHORS   Wieczorek,E., Brand,M., Jacq,X. and Tora,L.
  TITLE     Function of TAF(II)-containing complex without TBP in transcription
            by RNA polymerase II
  JOURNAL   Nature 393 (6681), 187-191 (1998)
   PUBMED   9603525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022382.4.
            
            On Nov 19, 2020 this sequence version replaced NM_006354.4.
            
            Summary: DNA-binding transcriptional activator proteins increase
            the rate of transcription by interacting with the transcriptional
            machinery bound to the basal promoter in conjunction with adaptor
            proteins, possibly by acetylation and destabilization of
            nucleosomes. The protein encoded by this gene is a transcriptional
            activator adaptor and a component of the histone acetyl transferase
            (HAT) coactivator complex which plays a crucial role in chromatin
            modulation and cell cycle progression. Along with the other
            components of the complex, this protein links transcriptional
            activators bound to specific promoters, to histone acetylation and
            the transcriptional machinery. The protein is also involved in the
            stabilization and activation of the p53 tumor suppressor protein
            that plays a role in the cellular response to DNA damage. Alternate
            splicing results in multiple transcript variants of this gene.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) encodes the longer protein.
            Variants 1 and 3 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013433.1, AK000228.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301964.7/ ENSP00000307684.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AC022382.4         43057-43314
            259-492             AC022382.4         44037-44270
            493-743             AC022382.4         45567-45817
            744-849             AC022382.4         45916-46021
            850-991             AC022382.4         48190-48331
            992-1095            AC022382.4         48421-48524
            1096-1205           AC022382.4         50105-50214
            1206-1391           AC022382.4         51317-51502
            1392-1974           AC022382.4         54981-55563
FEATURES             Location/Qualifiers
     source          1..1974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..1974
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /note="transcriptional adaptor 3"
                     /db_xref="GeneID:10474"
                     /db_xref="HGNC:HGNC:19422"
                     /db_xref="MIM:602945"
     exon            1..258
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /inference="alignment:Splign:2.1.0"
     exon            259..492
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..1584
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /note="isoform a is encoded by transcript variant 1;
                     transcriptional adapter 3; ADA3 homolog; ADA3-like
                     protein; alteration/deficiency in activation 3; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="transcriptional adapter 3 isoform a"
                     /protein_id="NP_006345.1"
                     /db_xref="CCDS:CCDS2583.1"
                     /db_xref="GeneID:10474"
                     /db_xref="HGNC:HGNC:19422"
                     /db_xref="MIM:602945"
                     /translation="MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELD
                     TLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPK
                     KQKLEGKAGHGPGPGPGRPKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEP
                     YCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAV
                     ADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISP
                     MEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRP
                     AEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVM
                     DAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG"
     exon            493..743
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /inference="alignment:Splign:2.1.0"
     exon            744..849
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /inference="alignment:Splign:2.1.0"
     exon            850..991
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1095
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1205
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1391
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1974
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1943..1948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /note="hexamer: AATAAA"
     polyA_site      1974
                     /gene="TADA3"
                     /gene_synonym="ADA3; hADA3; NGG1; STAF54; TADA3L"
                     /note="major polyA site"
ORIGIN      
        1 agttccgggg cggttgctca catcgaccgg aactccccgc cccctcccgc ggcccctggg
       61 gccgtaggag gccgcagcga ggaggtagag ggggcggggg tcgcactagg gtgtccctag
      121 agaacgagga ctctgaaggc gggacatttg ggcgaccccc gggcggggcc agccattaaa
      181 cagtcccact tctgtgccag acactgaact gggctcttga cgggcatcat ctcttaatcc
      241 tcagaacatc ccagggagct ccacaggatc cccatatcct gggccatgag tgagttgaaa
      301 gactgcccct tgcagttcca cgacttcaag tctgtggatc acctgaaggt ctgtccccgc
      361 tacacggcag tgctggcacg ctctgaggat gatggcatcg gcatcgagga gctggacacc
      421 ctgcagctgg agctggagac cctgctgtct tctgccagcc ggcgcctgcg tgtgcttgag
      481 gccgaaaccc agatcctcac cgactggcag gataagaaag gtgacagacg attcctgaag
      541 ctgggtcgag accatgaact tggagctccc cccaaacatg ggaagcccaa gaagcagaaa
      601 ctggaaggga aggcaggaca tgggccgggc cctggcccag gacggcccaa atccaaaaac
      661 cttcagccca agatccagga atatgaattc actgatgacc ctatcgacgt gccacggatc
      721 cccaaaaatg atgcccccaa caggttctgg gcttcagtgg agccctactg tgctgacatc
      781 accagcgagg aggtccgcac acttgaggag ttactgaagc ccccagaaga tgaggctgag
      841 cattacaaga tcccacccct ggggaagcac tactcccagc gctgggccca ggaggacctg
      901 ctggaggagc agaaggatgg ggcccgggca gcggctgtgg ctgacaagaa gaaaggcctc
      961 atggggccac tgaccgaact ggacactaaa gatgtggatg ccctgctgaa gaagtctgag
     1021 gcccagcatg aacagccgga agatggatgc ccctttggtg ccctgacgca gcgcctcctg
     1081 caggccctgg tggaggaaaa tattatttcc cctatggagg attctcctat tcctgacatg
     1141 tctgggaaag aatcaggggc tgacggggca agcacctccc ctcgcaatca gaacaagccc
     1201 ttcagtgtgc cgcatactaa gtccctggag agccgcatca aggaggagct aattgcccag
     1261 ggccttttgg agtctgagga ccgccccgca gaggactccg aggatgaggt ccttgctgag
     1321 cttcgcaaac ggcaggctga gctgaaggca cttagtgccc acaaccgcac caagaagcac
     1381 gacctgctga ggctggcaaa ggaggaggtg agccggcagg agctgaggca gcgggtgcgc
     1441 atggctgaca acgaggtcat ggacgccttt cgcaagatca tggctgcccg gcagaagaag
     1501 cggactccca ccaagaaaga aaaggaccag gcctggaaga ctctgaagga gcgtgagagc
     1561 atcctgaagc tgctggatgg gtagccctca cccctgcctc aggctgatta tctggcctag
     1621 gggaggggaa gggaggccca cttccttctt tgggcacagg aaacattggc ctgtggctgt
     1681 ccctcaaatg gcggcagtct ctagagggcc gtggcccttc ccctgaggtc ttttggccta
     1741 gctctgtaca accaggacac aggaagccct gctgggctag cctgaggcct agtctctgct
     1801 tggtccccga gatggggttg gaggggactt cgtttctggg tcttcctctt cccctcttta
     1861 ccatccccca ctccctaatc ccctacccct gtctcccctt caaggacttc tcccttgtgg
     1921 ttttgtaaag tgcaaactta agaataaagt gactgctgtg gtttttcaaa aaaa
//
