LOCUS       NM_152293               4369 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transcriptional adaptor 2B (TADA2B), mRNA.
ACCESSION   NM_152293 XM_001128012 XM_001128029 XM_001128049
VERSION     NM_152293.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4369)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4369)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4369)
  AUTHORS   Caliskan,G., Baris,I.C., Ayaydin,F., Dobson,M.J., Senarisoy,M.,
            Boros,I.M., Topcu,Z. and Zencir,S.
  TITLE     Che1/AATF interacts with subunits of the histone acetyltransferase
            core module of SAGA complexes
  JOURNAL   PLoS One 12 (12), e0189193 (2017)
   PUBMED   29232376
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4369)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 4369)
  AUTHORS   Nagy,Z., Riss,A., Romier,C., le Guezennec,X., Dongre,A.R.,
            Orpinell,M., Han,J., Stunnenberg,H. and Tora,L.
  TITLE     The human SPT20-containing SAGA complex plays a direct role in the
            regulation of endoplasmic reticulum stress-induced genes
  JOURNAL   Mol Cell Biol 29 (6), 1649-1660 (2009)
   PUBMED   19114550
REFERENCE   6  (bases 1 to 4369)
  AUTHORS   Gamper,A.M., Kim,J. and Roeder,R.G.
  TITLE     The STAGA subunit ADA2b is an important regulator of human GCN5
            catalysis
  JOURNAL   Mol Cell Biol 29 (1), 266-280 (2009)
   PUBMED   18936164
  REMARK    GeneRIF: ADA2a and ADA2b, two human homologues of yeast Ada2, each
            have the ability to form a heterotrimer with ADA3 and GCN5L but
            that only the ADA2b homologue is found in STAGA.
REFERENCE   7  (bases 1 to 4369)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
REFERENCE   8  (bases 1 to 4369)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   9  (bases 1 to 4369)
  AUTHORS   Barlev,N.A., Emelyanov,A.V., Castagnino,P., Zegerman,P.,
            Bannister,A.J., Sepulveda,M.A., Robert,F., Tora,L., Kouzarides,T.,
            Birshtein,B.K. and Berger,S.L.
  TITLE     A novel human Ada2 homologue functions with Gcn5 or Brg1 to
            coactivate transcription
  JOURNAL   Mol Cell Biol 23 (19), 6944-6957 (2003)
   PUBMED   12972612
REFERENCE   10 (bases 1 to 4369)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC097382.3, BC047794.1 and AK093974.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152293.2.
            
            Summary: TADA2B functions as a transcriptional adaptor protein that
            potentiates transcription through coordination of histone
            acetyltransferase (HAT) activity and by linking activation factors
            to basal transcriptional machinery (Barlev et al., 2003 [PubMed
            12972612]).[supplied by OMIM, Apr 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.41781.1,
                                           SRR1660805.231682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310074.8/ ENSP00000308022.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC097382.3         56952-57008
            58-1055             BC047794.1         8-1005
            1056-1795           AK093974.1         872-1611
            1796-4369           AC097382.3         68959-71532
FEATURES             Location/Qualifiers
     source          1..4369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..4369
                     /gene="TADA2B"
                     /gene_synonym="ADA2(beta); ADA2B"
                     /note="transcriptional adaptor 2B"
                     /db_xref="GeneID:93624"
                     /db_xref="HGNC:HGNC:30781"
                     /db_xref="MIM:608790"
     exon            1..478
                     /gene="TADA2B"
                     /gene_synonym="ADA2(beta); ADA2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1471
                     /gene="TADA2B"
                     /gene_synonym="ADA2(beta); ADA2B"
                     /note="transcriptional adaptor 2 (ADA2 homolog,
                     yeast)-beta; ADA2-beta; ADA2-like protein beta"
                     /codon_start=1
                     /product="transcriptional adapter 2-beta"
                     /protein_id="NP_689506.2"
                     /db_xref="CCDS:CCDS47007.1"
                     /db_xref="GeneID:93624"
                     /db_xref="HGNC:HGNC:30781"
                     /db_xref="MIM:608790"
                     /translation="MAELGKKYCVYCLAEVSPLRFRCTECQDIELCPECFSAGAEIGH
                     HRRYHGYQLVDGGRFTLWGPEAEGGWTSREEQLLLDAIEQFGFGNWEDMAAHVGASRT
                     PQEVMEHYVSMYIHGNLGKACIPDTIPNRVTDHTCPSGGPLSPSLTTPLPPLDISVAE
                     QQQLGYMPLRDDYEIEYDQDAETLISGLSVNYDDDDVEIELKRAHVDMYVRKLKERQR
                     RKNIARDYNLVPAFLGKDKKEKEKALKRKITKEEKELRLKLRPLYQFMSCKEFDDLFE
                     NMHKEKMLRAKIRELQRYRRNGITKMEESAEYEAARHKREKRKENKNLAGSKRGKEDG
                     KDSEFAAIENLPGFELLSDREKVLCSSLNLSPARYVTVKTIIIKDHLQKRQGIPSKSR
                     LPSYLDKVLKKRILNFLTESGWISRDAS"
     exon            479..4369
                     /gene="TADA2B"
                     /gene_synonym="ADA2(beta); ADA2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4352..4357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TADA2B"
                     /gene_synonym="ADA2(beta); ADA2B"
                     /note="hexamer: AACAAG"
     polyA_site      4369
                     /gene="TADA2B"
                     /gene_synonym="ADA2(beta); ADA2B"
                     /note="major polyA site"
ORIGIN      
        1 ggacggcgcc tgcgtactga ggggggacgc ggcccggctg gctggctctg gcggcggctg
       61 ggctggggcc gcggtggcgg cagccgcggc ggcgggcggc ggttgctcgt gcgcggcggc
      121 ggcggcgggt cccgcgggcg gcggggcgct gacggccggg ggcgcggcgg ctgcggcggg
      181 ccgggcggcg ggcggcgagc gggggaagat ggcggagctg gggaagaagt actgcgtgta
      241 ctgcctggcc gaggtgagcc cgctgcgctt ccgctgcacc gagtgccagg acatcgagct
      301 gtgccccgag tgcttctcgg ccggcgccga gatcggccac caccgccgct accacggcta
      361 ccagctggtg gacggcgggc gcttcacgct ctgggggccc gaggccgagg gcggctggac
      421 cagtcgcgag gagcagctgc tgctggacgc catcgagcag ttcggcttcg gaaactggga
      481 agatatggct gcccacgttg gtgcttcccg gactccccaa gaggtgatgg agcattacgt
      541 gagcatgtac atccacggga acctggggaa ggcctgcatc cccgacacca tccccaaccg
      601 cgtgacagac cacacctgtc ccagcggagg ccccctctca cccagcctca ccaccccgct
      661 gcccccgctg gacatctctg tggctgagca gcagcagctg ggctacatgc cgctgcggga
      721 tgattacgag atcgagtatg accaggatgc cgagacgctc atcagcgggc tctctgtcaa
      781 ctatgatgac gacgacgtgg agatcgagct gaagcgcgcc cacgtggaca tgtacgtgcg
      841 gaagctgaaa gagagacagc ggcggaagaa catcgcccgt gactacaatc tggtgccagc
      901 cttcctgggg aaggacaaga aggagaagga aaaggcgctg aagcgcaaga tcaccaagga
      961 ggagaaggag ctgcgcctga agctgaggcc gctgtaccag ttcatgtcat gcaaggagtt
     1021 tgatgacctt tttgaaaaca tgcacaaaga aaaaatgctc cgggccaaga tccgagaact
     1081 gcagcggtac cggcgaaacg ggatcaccaa gatggaagag tcggcagagt acgaggcagc
     1141 gcggcataaa cgggagaaga ggaaggagaa caaaaaccta gccggctcca aacggggaaa
     1201 ggaggacggc aaagacagcg agttcgccgc cattgagaac cttccaggct tcgagctcct
     1261 gtcagatcgc gagaaggtgc tctgcagctc tttaaacttg agtccagccc gctacgtgac
     1321 tgtgaagact attataatta aagaccacct ccagaagcgg caaggaatcc cctccaaaag
     1381 ccgccttcct agctacctgg acaaagtcct aaagaaaagg attttgaatt tcctcacaga
     1441 aagcggctgg atctccaggg acgcgtcttg aagctgagac gctttgaaag ccagggtgat
     1501 gctcagacag tgtgccagcc aaaatgactt gggggagggg agccgcttcc ccactgttgc
     1561 tcttttttaa acaaattgag ttcctttttt taagatagaa attcttttca tggtcctctg
     1621 aaagaagcaa tagtaacaat cttatattgg atcatggggg aagcaaatgt gtgtatttta
     1681 agtgagttcc tgcgagtcat acactgcgat gatgctccgc ctttacccgt tcagttggga
     1741 gcttattgtg agattggatc atttcctttt gagtgttctt ctctttggta caaaagctat
     1801 tgtgggtgac aggagcagtg ttttcctgct ggacccgcaa gccaccagct atttcctggt
     1861 gacacaagct cttctcaggc ggggctgcct gcaggctccc gttttctgag cccacgctgc
     1921 ccacagctga ccccagcgca gccccgggca cgcggcactt tacatggggg cagcttgggc
     1981 ccagactcct ccgctgtgta gcagatgagg aaaatcaggc cagaggacaa caggctggcg
     2041 ttttgttggg aactgaagag gaatctgttg aacacagcga ccagatgacc ttccatttca
     2101 ccggcggcag cagtttcagc gtgcagttcc caaaccccaa agctgaccct gcgccccatt
     2161 tgaatacggc cagagcctgc tggttcactt tgggtagagc cgtgcctctt gggcaggctc
     2221 ccatagtgac cacgtcccca cgaatgggaa agcacgttag tgggagggac gtaggacacg
     2281 tgtggaccgc caggccctct cagtccattt tccggggctg ctcggtgctg ctgttaagac
     2341 gtgagtgcat ttcacttgga agaacccatt gtacaaagtt caaggctaag agttctgaat
     2401 tctggcgtca gcttcctcag gattttcttc agttgcaagt acctttccac tgaaaatatg
     2461 agcatgcccg cctggctagt aggcatctgt aagagtgtcg ccaggcccgc gccagctgag
     2521 gcctcagact agccaggcaa gagccgtctg accagttggc tggcggtggt tctggtggag
     2581 cacgagggag cccgggtggt gccctgagcc tcgagctgct ctctgtcact gtcttgaatc
     2641 agactcagaa atggcttctt cccagccctg cctacaagtt tttctctggg gtcctctttc
     2701 aaggatgtcc acggtacctt cctcctgaaa cttgaggaag tcttttgtct tccagctgct
     2761 cagggttctc tggtccaaga ccctgcttta aagagagtct ttggcgtgct cagactccag
     2821 cgctccgttc ttcaaggagg ttgacttgcc tctcgggccc cgtaggtacc aagagactgt
     2881 ttacctccca gaatgtttgg gcttgaagtt acattaaagt gaagttattt gaaagaaaga
     2941 aaacctcatc atttctaagg atgacttaat tactgtgcct tttcctttct ttttacacat
     3001 cctactgtcc cttagggtaa aattttcagc attaaataaa acatttcaaa tatattgtat
     3061 atggctttag ttgtaaacta tactgcatgc tgacagagaa gcgctctttt agctaagccc
     3121 agaacttctc ttttgacaat aaagtactga gcagtggtat catgagggcc acctccacat
     3181 tgtcccctgc agaataaatg cggatgacag aaagcttatg ctgtctacca ctgaacagtg
     3241 atggagatgg tgctaagttt ttacagttgt cttagcccca gtggttctca aggtggggct
     3301 cctggcccag cagcagcaac ttgtttgtta gaatgcagac gcgcaggccc cacctggcct
     3361 cctgaatcaa aatggtgtgc ggcagggtgc agcgagctgt tttcacgagg cctccaggtg
     3421 actggatgta agcttgcttg agaactatgg gttttagcta ttctggtgtc tccctgattt
     3481 tctacagcgc caggatccta gtttggtgag gttttaaatt taatcttatt tttatataaa
     3541 atgattgcca gacgtactat attaagcttg aagaagcaga agatccctgt taatgtgtat
     3601 ggcccaggcc aagagctgtc aaatgaaaaa ctttgtgctg aagcaggttt ttagtatgta
     3661 tatctttttg atggtatgaa gaatttattt aggcttgact gttttaaaac accataatga
     3721 atgtataatt aatttatgtt aaagtattaa ccctttgtca caaaggaatg gtaatgtgat
     3781 tggctgcctg ttagcccatc gactattccc gtcacggtag tccttacctc tgtcggcagc
     3841 tcagagcctc cacattttta tatttaattc tcatgataaa ttagccacca taatcccatg
     3901 gaattaggtc ttgttaaaat ctagtccggg cgcagtggct cacgcctgta atcccagcac
     3961 tttgggaggc caaggcgggc tgatcacgag gtcaagagat cgagaccatc ctggccaaca
     4021 tggtgaaacc ctgtctctac taaaaataca aaaattagct gggtgtggtg gtgcatgcct
     4081 gtagtcccag ctacttggga ggctgaggta ggagaattgc ttgaacctgg gaggcggagg
     4141 ttgcggtgag ctgagatcac gccactacac tccagcctgg tgacagagca agactccatc
     4201 tcaaaaaaaa tctaagcaaa ctatctttga gtcaaaaaaa gttggataac tcatctatat
     4261 ttgaaataat gctgtctgaa tggccaacat cccaagaatg tattaaaaac agcaaccctg
     4321 cctaccgttt tgatgacctt tttccatatt aaacaagttg agaacaaaa
//
