LOCUS       NM_001166105            4236 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transcriptional adaptor 2A (TADA2A), transcript
            variant 3, mRNA.
ACCESSION   NM_001166105
VERSION     NM_001166105.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4236)
  AUTHORS   Cochino,A.V., Ioan,A., Farkas,O.M., Liu,M. and Lee,P.Y.
  TITLE     Novel ADA2 Variants in a Romanian Case Series of DADA2
  JOURNAL   J Clin Immunol 43 (8), 1788-1791 (2023)
   PUBMED   37783985
  REMARK    GeneRIF: Novel ADA2 Variants in a Romanian Case Series of DADA2.
REFERENCE   2  (bases 1 to 4236)
  AUTHORS   Zhang,X., Lei,G., Zhao,K., Zhang,X. and Dang,C.
  TITLE     CircTADA2A up-regulates MAPK8 by targeting MiR-214-3p and
            recruiting EIF4A3 to promote the invasion and migration of
            non-small cell lung cancer cells
  JOURNAL   Histol Histopathol 38 (7), 837-848 (2023)
   PUBMED   36193940
  REMARK    GeneRIF: CircTADA2A up-regulates MAPK8 by targeting MiR-214-3p and
            recruiting EIF4A3 to promote the invasion and migration of
            non-small cell lung cancer cells.
REFERENCE   3  (bases 1 to 4236)
  AUTHORS   Ehlers,L., Bucciol,G., Beysen,D. and Meyts,I.
  CONSRTM   KU Leuven - UZA DADA2 team
  TITLE     ADA2 Deficiency Mimicking Acute Disseminated Encephalomyelitis
  JOURNAL   J Clin Immunol 43 (3), 536-539 (2023)
   PUBMED   36472692
  REMARK    GeneRIF: ADA2 Deficiency Mimicking Acute Disseminated
            Encephalomyelitis.
REFERENCE   4  (bases 1 to 4236)
  AUTHORS   Zhang,Y., Yao,H., Li,Y., Yang,L., Zhang,L., Chen,J., Wang,Y. and
            Li,X.
  TITLE     Circular RNA TADA2A promotes proliferation and migration via
            modulating of miR-638/KIAA0101 signal in non-small cell lung cancer
  JOURNAL   Oncol Rep 46 (3) (2021)
   PUBMED   34296306
  REMARK    GeneRIF: Circular RNA TADA2A promotes proliferation and migration
            via modulating of miR638/KIAA0101 signal in nonsmall cell lung
            cancer.
REFERENCE   5  (bases 1 to 4236)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4236)
  AUTHORS   Ogryzko,V.V., Kotani,T., Zhang,X., Schiltz,R.L., Howard,T.,
            Yang,X.J., Howard,B.H., Qin,J. and Nakatani,Y.
  TITLE     Histone-like TAFs within the PCAF histone acetylase complex
  JOURNAL   Cell 94 (1), 35-44 (1998)
   PUBMED   9674425
REFERENCE   7  (bases 1 to 4236)
  AUTHORS   Henriksson,A., Almlof,T., Ford,J., McEwan,I.J., Gustafsson,J.A. and
            Wright,A.P.
  TITLE     Role of the Ada adaptor complex in gene activation by the
            glucocorticoid receptor
  JOURNAL   Mol Cell Biol 17 (6), 3065-3073 (1997)
   PUBMED   9154805
REFERENCE   8  (bases 1 to 4236)
  AUTHORS   Carter,K.C., Wang,L., Shell,B.K., Zamir,I., Berger,S.L. and
            Moore,P.A.
  TITLE     The human transcriptional adaptor genes TADA2L and GCN5L2
            colocalize to chromosome 17q12-q21 and display a similar tissue
            expression pattern
  JOURNAL   Genomics 40 (3), 497-500 (1997)
   PUBMED   9073520
REFERENCE   9  (bases 1 to 4236)
  AUTHORS   Wang,L., Mizzen,C., Ying,C., Candau,R., Barlev,N., Brownell,J.,
            Allis,C.D. and Berger,S.L.
  TITLE     Histone acetyltransferase activity is conserved between yeast and
            human GCN5 and is required for complementation of growth and
            transcriptional activation
  JOURNAL   Mol Cell Biol 17 (1), 519-527 (1997)
   PUBMED   8972232
REFERENCE   10 (bases 1 to 4236)
  AUTHORS   Candau,R., Moore,P.A., Wang,L., Barlev,N., Ying,C.Y., Rosen,C.A.
            and Berger,S.L.
  TITLE     Identification of human proteins functionally conserved with the
            yeast putative adaptors ADA2 and GCN5
  JOURNAL   Mol Cell Biol 16 (2), 593-602 (1996)
   PUBMED   8552087
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA244842.1, AK225918.1,
            BC011753.2 and AC243654.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001166105.2.
            
            Summary: Many DNA-binding transcriptional activator proteins
            enhance the initiation rate of RNA polymerase II-mediated gene
            transcription by interacting functionally with the general
            transcription machinery bound at the basal promoter. Adaptor
            proteins are usually required for this activation, possibly to
            acetylate and destabilize nucleosomes, thereby relieving chromatin
            constraints at the promoter. The protein encoded by this gene is a
            transcriptional activator adaptor and has been found to be part of
            the PCAF histone acetylase complex. Several alternatively spliced
            transcript variants encoding different isoforms of this gene have
            been described, but the full-length nature of some of these
            variants has not been determined. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1 and 3 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.30005.1,
                                           SRR1803617.101202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615182.5/ ENSP00000481091.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DA244842.1         1-4
            5-1358              AK225918.1         2-1355
            1359-1632           BC011753.2         1306-1579
            1633-4236           AC243654.3         193596-196199
FEATURES             Location/Qualifiers
     source          1..4236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..4236
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /note="transcriptional adaptor 2A"
                     /db_xref="GeneID:6871"
                     /db_xref="HGNC:HGNC:11531"
                     /db_xref="MIM:602276"
     exon            1..64
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            65..186
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1493
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /note="isoform a is encoded by transcript variant 3;
                     transcriptional adaptor 2 alpha; transcriptional adapter
                     2-alpha; ADA2-like protein"
                     /codon_start=1
                     /product="transcriptional adapter 2-alpha isoform a"
                     /protein_id="NP_001159577.2"
                     /db_xref="CCDS:CCDS11319.1"
                     /db_xref="GeneID:6871"
                     /db_xref="HGNC:HGNC:11531"
                     /db_xref="MIM:602276"
                     /translation="MDRLGSFSNDPSDKPPCRGCSSYLMEPYIKCAECGPPPFFLCLQ
                     CFTRGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQM
                     CTKTKEECEKHYMKHFINNPLFASTLLNLKQAEEAKTADTAIPFHSTDDPPRPTFDSL
                     LSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKER
                     QRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALE
                     FELRREIKRLQEYRTAGITNFCSARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQ
                     QWLRRQADIDSGLSPSIPMASNSGRRSAPPLNLTGLPGTEKLNEKEKELCQMVRLVPG
                     AYLEYKSALLNECNKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYITKG"
     exon            187..293
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            294..353
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            354..445
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            446..603
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            604..692
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            693..765
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            766..829
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            830..873
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            874..984
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1056
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1189
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1233
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1307
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..4236
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2757..2762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /note="hexamer: ATTAAA"
     polyA_site      2778
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /note="major polyA site"
     regulatory      3251..3256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /note="hexamer: ATTAAA"
     polyA_site      3290
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
     regulatory      4214..4219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
                     /note="hexamer: AATAAA"
     polyA_site      4236
                     /gene="TADA2A"
                     /gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
ORIGIN      
        1 acgcaaagcc cggaggcgcg cgcgaccggc ggctctttgg cgcggattag ggggtctcgg
       61 cgagggagtc atcaagcttt ggtgtatgtg ttggccggtt ctgaagtctt gaagaagctc
      121 tgctgaggaa gaccaaagca gcactcgttg ccaattaggg aatggaccgt ttgggttcct
      181 ttagcaatga tccctctgat aagccacctt gccgaggctg ctcctcctac ctcatggagc
      241 cttatatcaa gtgtgctgaa tgtgggccac ctcctttttt cctctgcttg cagtgtttca
      301 ctcgaggctt tgagtacaag aaacatcaaa gcgatcatac ttatgaaata atgacttcag
      361 attttcctgt ccttgatccc agctggactg ctcaagaaga aatggccctt ttagaagctg
      421 tgatggactg tggctttgga aattggcagg atgtagccaa tcaaatgtgc accaagacca
      481 aggaggagtg tgagaagcac tatatgaagc atttcatcaa taaccctctg tttgcatcta
      541 ccctgctgaa cctgaaacaa gcagaggaag caaaaactgc tgacacagcc attccatttc
      601 actctacaga tgaccctccc cgacctacct ttgactcctt gctttctcgg gacatggccg
      661 ggtacatgcc agctcgagca gatttcattg aggaatttga caattatgca gaatgggact
      721 tgagagacat tgattttgtt gaagatgact cggacatttt acatgctctg aagatggctg
      781 tggtagatat ctatcattcc aggttaaagg agagacaaag acgaaaaaaa attataagag
      841 accatggatt aatcaacctt agaaagtttc aattaatgga acggcggtat cccaaggagg
      901 tccaggacct gtatgaaaca atgaggcgat ttgcaagaat tgtggggcca gtggaacatg
      961 acaaattcat tgaaagccat gcattggaat ttgaactccg aagggaaatc aagaggctcc
     1021 aagaatacag gacagcaggc attaccaatt tttgtagtgc cagaacctac gatcacctca
     1081 agaagacacg ggaggaagag cgccttaaac gcactatgct ctcagaagtt ctccagtata
     1141 tccaggacag tagtgcttgc cagcagtggc tccgccggca agctgacatt gattccggcc
     1201 tgagtccttc cattccaatg gcttcgaatt caggtagacg gagtgcacca cccttgaacc
     1261 tcactggcct ccctggcaca gagaagctga atgaaaaaga aaaggagctc tgtcagatgg
     1321 tgaggttggt ccctggagcc tatttagaat acaaatctgc tctattgaac gaatgtaaca
     1381 agcaaggagg cttaagactg gcgcaggcaa gagcactcat caagatagat gtgaacaaaa
     1441 cccggaaaat ctatgatttc ctcatcagag aaggatacat cactaaaggc taaggctcca
     1501 agagcttggg atcagaagtc agaagtttgg aatgtggtgg gtcaaaggac aatatgggtg
     1561 ggcattctgg agagttgttt ttcagctgaa ttctcatggt gaaaacaggg gaaaggacaa
     1621 aggaaacctt aagttgtatt gtctactttc ttctccatcc tgctttaaaa cactcctgtt
     1681 gttggtatta tgctgcagag ttgtgtgcta cataagctat tattaaatgt gagtgggcat
     1741 tcattcctaa cacctcttgt aactaaaaga accatagtac ctcacatcac agtgctggta
     1801 gaaatggaac taaaccacag tctgtaatcc caggagtcca gctcagatcc ttatattgcg
     1861 aggtaagttt gctgattatc tgtcttgcct tcaaacactg cagacagatt taaaataaag
     1921 agaaaggttt tagagcataa gaaagctctc gttgaaggat tttttaagct gacaactttt
     1981 tttttttttt tttgagacag agtttgctct tgtcctccag gctggagtgt gatggcaaga
     2041 tctcagctca ctacaacctc tgcctcccag gttcaagtga ttctcctgcc tcagcctccc
     2101 gaatagctgg gactacaggt gtccaccacc acacctggct aattttgtat ttttagtaga
     2161 gacagggttt tgtcatgttg gccaggctgg tcacaaactc ctgacctcag gtgatctgcc
     2221 cgcctcagcc tcccaaagta ctaggattac aggcgtgagc catcgcgccc ggcctaagct
     2281 gacaactttt atgagtaaag gggaagaaaa tatccttatg atggtcttat cccaaactgc
     2341 atctttaact tcggccgggc aaggtggctc acctgtaatc ccagcacttt gggaggctaa
     2401 ggtgggcgga tcacgaagtc aggagttcaa gaccagcctg accaacatgg tgaaacagtc
     2461 tctactaaaa atacaaaaat tagctgagtg tggtggcaca cgcctgtaat cccagctact
     2521 caggaggctg aggcaggaga attgcttgaa cacaggaggc agaggttgca gcgagctgag
     2581 atcacgccac tgtgctccag cctgggcaac aaagtgagac tctgtctcaa aaaaaaaaaa
     2641 acaaaaaaaa acctttaatg tctggctttg tactttgcag tctgcctgtc taatctgcag
     2701 tagtcttttg aggaggtggc accggatata acatgtctct gttattttta gaattaatta
     2761 aaatgttttg ctatttaatt tgtgggtgtg tcaaatattc tggtaactga aacacactta
     2821 aggtgttgga tgcctgcccc atcacgctgc actgtctgct gtcacatgtg tcctgaactc
     2881 accctgtttt tgccctgggt ttcccaggat accaagcccc tgaggatgga gatgatgcaa
     2941 caaacctcag ctttgcttgg attgtgactt gaaccctatt tctcaatggt gaaaggctag
     3001 cctgcaataa aagctgcttt taaaacagaa gtaaagcagc tttatatatg ggactcacta
     3061 gatatgaggg taagtagccc caccacatgt aaaacttggt cctcaaacgt ttctgcagaa
     3121 taagaagcca aacttatggt tatcttgttt ctgttagaaa caaagttgta tatagaaata
     3181 acttcgtcag aatcgacaca aatcacatcg aatagttgac tgtttaattc cttctacatt
     3241 caaatatcta attaaaatac tgtgtgcttt gttggaagca tctgctcaaa cttttgactg
     3301 ttgtaaatat gcatgcagct gggaagggat tcatctaagg gataagaaat gaaaaagaca
     3361 ctctaaggac ctgagggaat tcaaatagag gacttcgatt ttttaaaaag aatgacgtgg
     3421 aaatgacctg ttttccttgt aaaatcatat ctcgtagaaa acattttacc actaccatca
     3481 cccctagttg gttgtgaagt gattgcctct tatccctgaa aggaaactcc tgttctgaaa
     3541 agttgggatg cattagccat cagtgttagg tgacgtctgt tgtagtctga agagtcctta
     3601 accttgatta aggaaggctt cctgggagag gtgggctttt ggggcaatta tatgatagag
     3661 aagagagaga aaaatggcag atggaagtgg gagacaattc cacacacagg gggtggagaa
     3721 tgatgtggag gcagcagtgg gtgtaaggac aatggtgcca agagatttat ttggctagaa
     3781 cacaaggggc agctgggtag ttaggagtgg gaggatggta ggacagtctg acagaaacct
     3841 tggaaacagt tgaactctga aaagctgatg gcaaatcaga tttcatgagg aaaatggcat
     3901 ggttgaaaat agtaatagaa aaataagact gaagttttaa atgactggat ttttgaaagt
     3961 aggattatta tttctttggt ataccgaact ttgcaaagat acgtagcatt gcatccttcc
     4021 tctttgcttc tagacagggt tggccataaa ccaactacac tgatagaggt ctctccagat
     4081 tgtctcagaa gagagagttt accctgaaac ttaatgacat gaataaaacc tgtttactga
     4141 aatttttatt gcaatttaac gttaaaagtt tctgctggag ttttatgcat atttttctct
     4201 ctaagtggtg ggaaataaag aacaaatctc tttcca
//
