LOCUS       NM_053053               2096 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transcriptional adaptor 1 (TADA1), mRNA.
ACCESSION   NM_053053
VERSION     NM_053053.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Gloria-Bottini,F., Nicotra,M., Amante,A., Ambrosi,S., Cozzoli,E.,
            Saccucci,P., Bottini,E. and Magrini,A.
  TITLE     Effect of ADA1 mother-fetus and wife-husband phenotypic differences
            on the ratio birth weight/placental weight in fertile women and on
            reproductive success in couples with RSA
  JOURNAL   Am J Hum Biol 24 (2), 177-182 (2012)
   PUBMED   22287124
  REMARK    GeneRIF: Differences between mother and fetus in ADA(1) phenotype
            may influence the ratio BW/PW in healthy women and reproductive
            success in RSA women.
REFERENCE   2  (bases 1 to 2096)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2096)
  AUTHORS   Nagy,Z., Riss,A., Romier,C., le Guezennec,X., Dongre,A.R.,
            Orpinell,M., Han,J., Stunnenberg,H. and Tora,L.
  TITLE     The human SPT20-containing SAGA complex plays a direct role in the
            regulation of endoplasmic reticulum stress-induced genes
  JOURNAL   Mol Cell Biol 29 (6), 1649-1660 (2009)
   PUBMED   19114550
REFERENCE   4  (bases 1 to 2096)
  AUTHORS   Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
            Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
  TITLE     Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
            genetic association with bone mineral density variation
  JOURNAL   Hum Mol Genet 18 (4), 679-687 (2009)
   PUBMED   19064610
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2096)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   6  (bases 1 to 2096)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   7  (bases 1 to 2096)
  AUTHORS   Martinez,E., Kundu,T.K., Fu,J. and Roeder,R.G.
  TITLE     A human SPT3-TAFII31-GCN5-L acetylase complex distinct from
            transcription factor IID
  JOURNAL   J Biol Chem 273 (37), 23781-23785 (1998)
   PUBMED   9726987
  REMARK    Erratum:[J Biol Chem 1998 Oct 16;273(42):27755]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN399642.1 and BC015401.2.
            
            On Nov 22, 2018 this sequence version replaced NM_053053.3.
            
            Summary: TADA1L is a protein subunit of the human STAGA complex
            (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301)
            acetyltransferase complex), which is a chromatin-modifying
            multiprotein complex (Martinez et al., 2001 [PubMed
            11564863]).[supplied by OMIM, Apr 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015401.2, AK291922.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367874.5/ ENSP00000356848.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CN399642.1         156-177
            23-2045             BC015401.2         1-2023
            2046-2096           BC015401.2         2033-2083
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.1"
     gene            1..2096
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /note="transcriptional adaptor 1"
                     /db_xref="GeneID:117143"
                     /db_xref="HGNC:HGNC:30631"
                     /db_xref="MIM:612763"
     exon            1..105
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1039
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /note="transcriptional adaptor 1 (HFI1 homolog, yeast);
                     SPT3-associated factor 42 (STAF42); transcriptional
                     adapter 1-like protein"
                     /codon_start=1
                     /product="transcriptional adapter 1"
                     /protein_id="NP_444281.1"
                     /db_xref="CCDS:CCDS1255.1"
                     /db_xref="GeneID:117143"
                     /db_xref="HGNC:HGNC:30631"
                     /db_xref="MIM:612763"
                     /translation="MATFVSELEAAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFD
                     LEAHRLLTQDNVHSHNDFLLAILTRCQILVSTPDGAGSLPWPGGSAAKPGKPKGKKKL
                     SSVRQKFDHRFQPQNPLSGAQQFVAKDPQDDDDLKLCSHTMMLPTRGQLEGRMIVTAY
                     EHGLDNVTEEAVSAVVYAVENHLKDILTSVVSRRKAYRLRDGHFKYAFGSNVTPQPYL
                     KNSVVAYNNLIESPPAFTAPCAGQNPASHPPPDDAEQQAALLLACSGDTLPASLPPVN
                     MYDLFEALQVHREVIPTHTVYALNIERIITKLWHPNHEELQQDKVHRQRLAAKEGLLL
                     C"
     exon            106..197
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /inference="alignment:Splign:2.1.0"
     exon            198..263
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /inference="alignment:Splign:2.1.0"
     exon            264..361
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /inference="alignment:Splign:2.1.0"
     exon            362..571
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /inference="alignment:Splign:2.1.0"
     exon            572..723
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /inference="alignment:Splign:2.1.0"
     exon            724..886
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /inference="alignment:Splign:2.1.0"
     exon            887..2096
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /note="hexamer: AATAAA"
     polyA_site      2096
                     /gene="TADA1"
                     /gene_synonym="ADA1; hADA1; HFI1; STAF42; TADA1L"
                     /note="major polyA site"
ORIGIN      
        1 ggtctgcggt cgggctgaga cacgcggagc aatggcgacc tttgtgagcg agctggaggc
       61 ggccaagaag aacttaagcg aggccctggg ggacaacgtg aaacaatact gggctaacct
      121 aaagctgtgg ttcaagcaga agatcagcaa agaggagttt gaccttgaag ctcatagact
      181 tctcacacag gataatgtcc attctcacaa tgatttcctc ctggccattc tcacgcgttg
      241 tcagattttg gtttctacac cagatggtgc tggatctttg ccttggccag ggggttccgc
      301 agcaaaacct ggaaaaccca agggaaagaa aaagctttct tctgttcgtc agaaatttga
      361 tcatagattc cagcctcaaa atcctctctc aggagcccag caatttgtgg caaaggatcc
      421 ccaagatgat gacgacttga aactttgttc ccacacaatg atgcttccca ctcgaggcca
      481 gcttgaaggg agaatgatag tgactgctta tgagcatggg ctggacaatg tcaccgagga
      541 ggctgtttca gctgttgtct atgctgtgga gaatcacctt aaagatatac tgacgtcagt
      601 tgtgtcaaga aggaaagctt atcggttacg agatggtcat tttaaatatg cctttggcag
      661 taacgtgacc ccgcagccat acctgaagaa tagtgtagta gcttacaaca acttaataga
      721 aagccctcca gcttttactg ctccctgtgc tggtcagaat ccagcttctc acccaccccc
      781 tgatgatgct gagcagcagg ctgcactcct gctggcatgc tccggagaca ctctacctgc
      841 atctttgcct ccggtgaaca tgtacgatct ttttgaagct ttgcaggtgc acagggaagt
      901 catccctaca catactgtct atgctcttaa cattgaaagg atcatcacga aactctggca
      961 tccaaatcat gaagagctgc agcaagacaa agttcaccgc cagcgcttgg cagccaagga
     1021 ggggcttttg ctgtgctaaa ttaggatttg agggtgtggg accctcaccg aattcattga
     1081 ttactgaaaa ttgaatgttt tttgggtcca catttcaagg ctgaagtgta tagtgtatat
     1141 ataacctttc ctatggaaat gtgacattga gtacattttg tgttgctgtt gtgaagccat
     1201 taatataaat ctttggtaat gacccatatc tctatatgta tgtgttccca gttgtgggag
     1261 caggcactaa tgaaatcctg tgcctggaat ggagatattt aggtacctga ggcttagtgt
     1321 cctgtggtct gcatgtaaga tagatgacat cctagaacaa agaagctgtt ttaacttaat
     1381 ccccctgatc agcaggatat ctgtgtgttc agtgacatca tacattctgt atctagaagt
     1441 ctaaaatttc tgcctttctc ctaaagaatg tgttcttgca ttttggttga aataacctac
     1501 acagtgttaa aaatcagata cctcctttag tgaccagttc aaattttaat agcgataggt
     1561 agcccctgag aaatttatca ctataactcc acaggaaata tgacttggaa gtgctctgtg
     1621 tactaaacaa aataaagccc ctctttgcat ttaaaaccaa agtcaaaaca aaactcttgt
     1681 aatgcaatta attaacttta tgtcttccca tgactcaagt tttgttaaat atgcccaaaa
     1741 actttgattg gcagtttctt cggttaatta ttcctataga atgtatttta agaaatctat
     1801 acaaattgga tatatgcttg gtaattctcc agtttctagg aggtacctat ttctaccgtt
     1861 tcaagtgatg aagtgaaaat aatttacatt cgatagtgtt actgataaca aacctactta
     1921 agagatatgt tgctttttac ttaagggata gtgttgatag ataaattaga atgtatagat
     1981 aggtttgtga aagtctaaat aatggttgta tagatatgta tatatggttc acatatctgg
     2041 atctgtgtat ttgattttgt actttaaatg tgacaaataa accttttggg agaaaa
//
