LOCUS       NM_002353               1820 bp    mRNA    linear   PRI 25-FEB-2025
DEFINITION  Homo sapiens tumor associated calcium signal transducer 2
            (TACSTD2), mRNA.
ACCESSION   NM_002353
VERSION     NM_002353.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1820)
  AUTHORS   Tanegashima,K., Tanaka,Y., Ito,T., Oda,Y. and Nakahara,T.
  TITLE     TROP2 Expression and Therapeutic Implications in Cutaneous Squamous
            Cell Carcinoma: Insights From Immunohistochemical and Functional
            Analysis
  JOURNAL   Exp Dermatol 33 (10), e15196 (2024)
   PUBMED   39422290
  REMARK    GeneRIF: TROP2 Expression and Therapeutic Implications in Cutaneous
            Squamous Cell Carcinoma: Insights From Immunohistochemical and
            Functional Analysis.
REFERENCE   2  (bases 1 to 1820)
  AUTHORS   Ozalp,C.B., Akdogan,S., Cetinavci,D., Akin,M.N., Elbe,H. and
            Kasap,B.
  TITLE     Unveiling the placental secrets: Exploring histopathological
            changes and TROP2 expression in intrahepatic cholestasis of
            pregnancy
  JOURNAL   Placenta 154, 201-206 (2024)
   PUBMED   39047580
  REMARK    GeneRIF: Unveiling the placental secrets: Exploring
            histopathological changes and TROP2 expression in intrahepatic
            cholestasis of pregnancy.
REFERENCE   3  (bases 1 to 1820)
  AUTHORS   Foersch,S., Schmitt,M., Litmeyer,A.S., Tschurtschenthaler,M.,
            Gress,T., Bartsch,D.K., Pfarr,N., Steiger,K., Denkert,C. and
            Jesinghaus,M.
  TITLE     TROP2 in colorectal carcinoma: associations with histopathology,
            molecular phenotype, and patient prognosis
  JOURNAL   J Pathol Clin Res 10 (5), e12394 (2024)
   PUBMED   39177576
  REMARK    GeneRIF: TROP2 in colorectal carcinoma: associations with
            histopathology, molecular phenotype, and patient prognosis.
REFERENCE   4  (bases 1 to 1820)
  AUTHORS   Calabrese,G., Crescenzi,C., Morizio,E., Palka,G., Guerra,E. and
            Alberti,S.
  TITLE     Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21
            and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human
            chromosome 1p32 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 164-165 (2001)
   PUBMED   11306819
REFERENCE   5  (bases 1 to 1820)
  AUTHORS   Tsujikawa,M., Kurahashi,H., Tanaka,T., Nishida,K., Shimomura,Y.,
            Tano,Y. and Nakamura,Y.
  TITLE     Identification of the gene responsible for gelatinous drop-like
            corneal dystrophy
  JOURNAL   Nat Genet 21 (4), 420-423 (1999)
   PUBMED   10192395
REFERENCE   6  (bases 1 to 1820)
  AUTHORS   Ripani,E., Sacchetti,A., Corda,D. and Alberti,S.
  TITLE     Human Trop-2 is a tumor-associated calcium signal transducer
  JOURNAL   Int J Cancer 76 (5), 671-676 (1998)
   PUBMED   9610724
REFERENCE   7  (bases 1 to 1820)
  AUTHORS   El Sewedy,T., Fornaro,M. and Alberti,S.
  TITLE     Cloning of the murine TROP2 gene: conservation of a PIP2-binding
            sequence in the cytoplasmic domain of TROP-2
  JOURNAL   Int J Cancer 75 (2), 324-330 (1998)
   PUBMED   9462726
  REMARK    GeneRIF: Discusses cloning of mouse Trop2 and comparison to the
            human homolog.
REFERENCE   8  (bases 1 to 1820)
  AUTHORS   Fornaro,M., Dell'Arciprete,R., Stella,M., Bucci,C., Nutini,M.,
            Capri,M.G. and Alberti,S.
  TITLE     Cloning of the gene encoding Trop-2, a cell-surface glycoprotein
            expressed by human carcinomas
  JOURNAL   Int J Cancer 62 (5), 610-618 (1995)
   PUBMED   7665234
REFERENCE   9  (bases 1 to 1820)
  AUTHORS   Linnenbach,A.J., Seng,B.A., Wu,S., Robbins,S., Scollon,M.,
            Pyrc,J.J., Druck,T. and Huebner,K.
  TITLE     Retroposition in a family of carcinoma-associated antigen genes
  JOURNAL   Mol Cell Biol 13 (3), 1507-1515 (1993)
   PUBMED   8382772
REFERENCE   10 (bases 1 to 1820)
  AUTHORS   Linnenbach,A.J., Wojcierowski,J., Wu,S.A., Pyrc,J.J., Ross,A.H.,
            Dietzschold,B., Speicher,D. and Koprowski,H.
  TITLE     Sequence investigation of the major gastrointestinal
            tumor-associated antigen gene family, GA733
  JOURNAL   Proc Natl Acad Sci U S A 86 (1), 27-31 (1989)
   PUBMED   2911574
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW052118.1, CV027795.1,
            BM765888.1, CD722224.1 and AI201870.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002353.2.
            
            Summary: This intronless gene encodes a carcinoma-associated
            antigen. This antigen is a cell surface receptor that transduces
            calcium signals. Mutations of this gene have been associated with
            gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7346977.534454.1,
                                        SRR7346977.611447.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371225.4/ ENSP00000360269.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AW052118.1         1-243               c
            244-872             CV027795.1         14-642
            873-1344            BM765888.1         218-689
            1345-1624           CD722224.1         233-512             c
            1625-1820           AI201870.1         19-214              c
FEATURES             Location/Qualifiers
     source          1..1820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.1"
     gene            1..1820
                     /gene="TACSTD2"
                     /gene_synonym="EGP-1; EGP1; GA733-1; GA7331; GP50; M1S1;
                     TROP2"
                     /note="tumor associated calcium signal transducer 2"
                     /db_xref="GeneID:4070"
                     /db_xref="HGNC:HGNC:11530"
                     /db_xref="MIM:137290"
     exon            1..1820
                     /gene="TACSTD2"
                     /gene_synonym="EGP-1; EGP1; GA733-1; GA7331; GP50; M1S1;
                     TROP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1068
                     /gene="TACSTD2"
                     /gene_synonym="EGP-1; EGP1; GA733-1; GA7331; GP50; M1S1;
                     TROP2"
                     /note="epithelial glycoprotein-1; membrane component,
                     chromosome 1, surface marker 1; gastrointestinal
                     tumor-associated antigen GA7331; 40kD glycoprotein,
                     identified by monoclonal antibody GA733; pancreatic
                     carcinoma marker protein GA7331; cell surface glycoprotein
                     TROP2; cell surface glycoprotein Trop-2; pancreatic
                     carcinoma marker protein GA733-1; trophoblast cell surface
                     antigen 2"
                     /codon_start=1
                     /product="tumor-associated calcium signal transducer 2
                     precursor"
                     /protein_id="NP_002344.2"
                     /db_xref="CCDS:CCDS609.1"
                     /db_xref="GeneID:4070"
                     /db_xref="HGNC:HGNC:11530"
                     /db_xref="MIM:137290"
                     /translation="MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVC
                     SPDGPGGRCQCRALGSGMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDG
                     LYDPDCDPEGRFKARQCNQTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRH
                     RPTAGAFNHSDLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVD
                     IGDAAYYFERDIKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAG
                     LIAVIVVVVVALVAGMAVLVITNRRKSGKYKKVEIKELGELRKEPSL"
     regulatory      1785..1790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TACSTD2"
                     /gene_synonym="EGP-1; EGP1; GA733-1; GA7331; GP50; M1S1;
                     TROP2"
                     /note="hexamer: AATAAA"
     polyA_site      1820
                     /gene="TACSTD2"
                     /gene_synonym="EGP-1; EGP1; GA733-1; GA7331; GP50; M1S1;
                     TROP2"
                     /note="major polyA site"
ORIGIN      
        1 agacgcctgc agaccatccc agacgccgga gcccgagccc cgacgagtcc ccgcgcctca
       61 tccgcccgcg tccggtccgc gttcctccgc cccaccatgg ctcggggccc cggcctcgcg
      121 ccgccaccgc tgcggctgcc gctgctgctg ctggtgctgg cggcggtgac cggccacacg
      181 gccgcgcagg acaactgcac gtgtcccacc aacaagatga ccgtgtgcag ccccgacggc
      241 cccggcggcc gctgccagtg ccgcgcgctg ggctcgggca tggcggtcga ctgctccacg
      301 ctgacctcca agtgtctgct gctcaaggcg cgcatgagcg cccccaagaa cgcccgcacg
      361 ctggtgcggc cgagtgagca cgcgctcgtg gacaacgatg gcctctacga ccccgactgc
      421 gaccccgagg gccgcttcaa ggcgcgccag tgcaaccaga cgtcggtgtg ctggtgcgtg
      481 aactcggtgg gcgtgcgccg cacggacaag ggcgacctga gcctacgctg cgatgagctg
      541 gtgcgcaccc accacatcct cattgacctg cgccaccgcc ccaccgccgg cgccttcaac
      601 cactcagacc tggacgccga gctgaggcgg ctcttccgcg agcgctatcg gctgcacccc
      661 aagttcgtgg cggccgtgca ctacgagcag cccaccatcc agatcgagct gcggcagaac
      721 acgtctcaga aggccgccgg tgacgtggat atcggcgatg ccgcctacta cttcgagagg
      781 gacatcaagg gcgagtctct attccagggc cgcggcggcc tggacttgcg cgtgcgcgga
      841 gaacccctgc aggtggagcg cacgctcatc tattacctgg acgagattcc cccgaagttc
      901 tccatgaagc gcctcaccgc cggcctcatc gccgtcatcg tggtggtcgt ggtggccctc
      961 gtcgccggca tggccgtcct ggtgatcacc aaccggagaa agtcggggaa gtacaagaag
     1021 gtggagatca aggaactggg ggagttgaga aaggaaccga gcttgtaggt acccggcggg
     1081 gcaggggatg gggtggggta ccggatttcg gtatcgtccc agacccaagt gagtcacgct
     1141 tcctgattcc tcggcgcaaa ggagacgttt atcctttcaa attcctgcct tccccctccc
     1201 ttttgcgcac acaccaggtt taatagatcc tggcctcagg gtctcctttc tttctcactt
     1261 ctgtcttgaa ggaagcattt ctaaaatgta tcccctttcg gtccaacaac aggaaacctg
     1321 actggggcag tgaaggaagg gatggcatag cgttatgtgt aaaaaacaag tatctgtatg
     1381 acaacccggg atcgtttgca agtaactgaa tccattgcga cattgtgaag gcttaaatga
     1441 gtttagatgg gaaatagcgt tgttatcgcc ttgggtttaa attatttgat gagttccact
     1501 tgtatcatgg cctacccgag gagaagagga gtttgttaac tgggcctatg tagtagcctc
     1561 atttaccatc gtttgtatta ctgaccacat atgcttgtca ctgggaaaga agcctgtttc
     1621 agctgcctga acgcagtttg gatgtctttg aggacagaca ttgcccggaa actcagtcta
     1681 tttattcttc agcttgccct tactgccact gatattggta atgttctttt ttgtaaaatg
     1741 tttgtacata tgttgtcttt gataatgttg ctgtaatttt ttaaaataaa acacgaattt
     1801 aataaaatat gggaaaggca
//
